Clinical trial • Phase II • Ophthalmology
XELAFASLATIDE for Atrophic age-related macular degeneration (geographic atrophy)
Phase II trial of XELAFASLATIDE for Atrophic age-related macular degeneration (geographic atrophy).
Overview
- Trial Therapeutic Area
- Ophthalmology
- Trial Disease
- Atrophic age-related macular degeneration (geographic atrophy)
- Trial Stage
- Phase II
- Drug Modality
- Peptide/protein/enzyme|Other
Key dates
- Initial CTIS Submission Date
- 14-04-2025
- First CTIS Authorization Date
- 05-08-2025
Trial design
Randomised, sham injection (placebo) — sham intravitreal injection; dose/schedule not specified-controlled Phase II trial across 64 sites in Spain, Portugal, Germany and others.
- Randomised
- Yes
- Comparator
- Sham injection (placebo) — sham intravitreal injection; dose/schedule not specified
- Target Sample Size
- 142
- Trial Duration For Participant
- 60
Eligibility
Recruits 142 Vulnerable populations selected (isVulnerablePopulationSelected: true). No further explicit details on consent or assent handling are provided in the available metadata/documents..
- Pregnancy Exclusion
- Individuals who are currently pregnant, planning to become pregnant, or are nursing at Screening or during the study period.
- Vulnerable Population
- Vulnerable populations selected (isVulnerablePopulationSelected: true). No further explicit details on consent or assent handling are provided in the available metadata/documents.
Inclusion criteria
- {"criterion_text":"- 55 years of age or older at Screening."}
- {"criterion_text":"- If currently using Age-related Eye Disease Study 2 (AREDS, AREDS2, or similar [see Protocol for formulation]) nutraceutical therapy at Screening, patient must be willing to continue use for the duration of the study. If not currently using AREDS2 or similar, patient must be willing to continue not to use therapy for the duration of the study. Patient must agree to choose either approach."}
- {"criterion_text":"- Non-foveal GA associated with AMD without eMNV in the study eye per Investigator’s evaluation and as confirmed by the central RC."}
- {"criterion_text":"- BCVA of 24 letters or more using ETDRS charts in the study eye at Screening."}
- {"criterion_text":"- BCVA of 19 letters or more using ETDRS charts in the fellow eye at Screening."}
Exclusion criteria
- {"criterion_text":"- Any ocular or systemic condition that, in the opinion of the Investigator, makes the patient unsuitable for treatment with an investigational drug or that would compromise the safety or efficacy assessments of the study."}
- {"criterion_text":"- Individuals who are currently pregnant, planning to become pregnant, or are nursing at Screening or during the study period."}
- {"criterion_text":"- Previous IVT pharmaceutical treatment in the study eye with any agent except regionally approved complement inhibitors and treatment with regionally approved complement inhibitors within 12 weeks prior to Screening."}
- {"criterion_text":"- Any current evidence or history in the study eye of exudative (“wet”) AMD, including any RPE rips or evidence of actively leaking neovascularization anywhere in the retina based on the FA or SD-OCT as assessed per the Investigator’s evaluation and confirmed by the central RC."}
- {"criterion_text":"- Intraocular surgery in the study eye (including lens replacement surgery) within 3 months prior to Screening. See Exclusion Criteria 13 and 14 pertaining to retinal and glaucoma surgery, respectively."}
- {"criterion_text":"- Planned or expected IVT injection in the fellow eye for treatment of GA with agents other than regionally approved complement inhibitors during the study period."}
- {"criterion_text":"- Active intraocular inflammation in either eye or a history of uveitis or endophthalmitis in either eye."}
- {"criterion_text":"- GA in either eye due to causes other than AMD."}
- {"criterion_text":"- Any ophthalmic condition in either eye that is likely to require surgery during the study period."}
Endpoints
Primary endpoints
- {"endpoint_text":"- GA lesion area assessment","definition_or_measurement_approach":"No explicit endpoint definition provided in the endpoint listing. Imaging modalities listed in sponsor/third-party duties (FAF, FP, FA, OCT, OCTA and AI imaging) are available and likely used for lesion area assessment."}
Recruitment
- Registry Or Advocacy Recruitment
- True; Fundacion De Oftalmologia Medica De La Comunitat Valenciana; Konvent Der Barmherzigen Brueder
- Digital Remote Recruitment
- True; PatientGO app materials, advocacy PAG enewsletters, online clinical trial listing and digital patient brochures
- Planned Sample Size
- 142
- Recruitment Window Months
- 31
- Consent Approach
- Written informed consent obtained from participating subjects. Study ICF (L1_SIS and ICF) documents and related subject information are provided in multiple language versions (examples in the dossier: English, Spanish, Italian, Polish, Portuguese, Greek, Hungarian, Czech). Pregnancy-specific ICFs and 'Pregnant Partner' ICFs are included where relevant. No assent process described (participants are adults).
Methods
- Posters with flyer (document titles: poster with flyer / poster_with_flyer)
- Dr-to-patient letters (dr_to_pt_letter)
- Dr-to-dr letters (dr to dr letter)
- Patient brochures (patient brochure / Patient_Brochure)
- Clinical trial listing / clinical trial listing documents
- Advocacy / PAG enewsletter content (advocacy PAG enewsletter content)
- Lunch and Learn slides
- Visit reminder cards
- PatientGO app materials (PatientGO App, EULA, Privacy Policy)
Geography
- Total Number Of Sites
- 64
- Total Number Of Participants
- 182
Spain
- Earliest CTIS Part Ii Submission Date
- 03-07-2025
- Latest Decision Or Authorization Date
- 08-08-2025
- Processing Time Days
- 36
- Number Of Sites
- 9
- Number Of Participants
- 21
Sites
- Site Name
- Fundacion De Oftalmologia Medica De La Comunitat Valenciana
- Department Name
- Ophthalmology
- Principal Investigator Name
- Maria Carmen Desco Esteban
- Principal Investigator Email
- carmen.desco@uv.es
- Contact Person Name
- Maria Carmen Desco Esteban
- Contact Person Email
- carmen.desco@uv.es
- Site Name
- Hospital Universitario Virgen De La Macarena
- Department Name
- Ophthalmology
- Principal Investigator Name
- Estanislao Gutiérrez Sánchez
- Principal Investigator Email
- esgusan@hotmail.com
- Contact Person Name
- Estanislao Gutiérrez Sánchez
- Contact Person Email
- esgusan@hotmail.com
- Site Name
- Clinica De Oftalmologia De Cordoba S.L.
- Department Name
- Ophthalmology
- Principal Investigator Name
- Juan Manuel Cubero Parra
- Principal Investigator Email
- jmcp@hospitalarruzafa.com
- Contact Person Name
- Juan Manuel Cubero Parra
- Contact Person Email
- jmcp@hospitalarruzafa.com
- Site Name
- Centro De Oftalmologia Barraquer S.A.
- Department Name
- Ophthalmology
- Principal Investigator Name
- Santiago Abengoechea Hernandez
- Principal Investigator Email
- sah@barraquer.com
- Contact Person Name
- Santiago Abengoechea Hernandez
- Contact Person Email
- sah@barraquer.com
- Site Name
- Hospital Universitario Puerta De Hierro De Majadahonda
- Department Name
- Ophthalmology
- Principal Investigator Name
- José María Ruiz Moreno
- Principal Investigator Email
- josemaria.ruiz@uclm.es
- Contact Person Name
- José María Ruiz Moreno
- Contact Person Email
- josemaria.ruiz@uclm.es
- Site Name
- Hospital Universitario Miguel Servet
- Department Name
- Ophthalmology
- Principal Investigator Name
- Luis Emilio Pablo Júlvez
- Principal Investigator Email
- lpablo@unizar.es
- Contact Person Name
- Luis Emilio Pablo Júlvez
- Contact Person Email
- lpablo@unizar.es
- Site Name
- Bilboftal S.L.
- Department Name
- Ophthalmology
- Principal Investigator Name
- José Javier Araiz Iribarren
- Principal Investigator Email
- araiz@icqo.org
- Contact Person Name
- José Javier Araiz Iribarren
- Contact Person Email
- araiz@icqo.org
- Site Name
- Institut Catala De Retina S.L.
- Department Name
- Ophthalmology
- Principal Investigator Name
- Ignasi Jürgens Mestre
- Principal Investigator Email
- ignasi.jurgens@icrcat.com
- Contact Person Name
- Ignasi Jürgens Mestre
- Contact Person Email
- ignasi.jurgens@icrcat.com
- Site Name
- Clinica De Oftalmologia De Cordoba S.L. (duplicate entry not expected?)
- Department Name
- Ophthalmology
- Principal Investigator Name
- Juan Manuel Cubero Parra
- Principal Investigator Email
- jmcp@hospitalarruzafa.com
- Contact Person Name
- Juan Manuel Cubero Parra
- Contact Person Email
- jmcp@hospitalarruzafa.com
Portugal
- Earliest CTIS Part Ii Submission Date
- 06-06-2025
- Latest Decision Or Authorization Date
- 06-08-2025
- Processing Time Days
- 61
- Number Of Sites
- 4
- Number Of Participants
- 15
Sites
- Site Name
- Unidade Local De Saude De Coimbra E.P.E.
- Department Name
- Ophthalmology
- Principal Investigator Name
- Cláudia Farinha
- Principal Investigator Email
- claudia.farinha@hotmail.com
- Contact Person Name
- Cláudia Farinha
- Contact Person Email
- claudia.farinha@hotmail.com
- Site Name
- Unidade Local De Saude De Gaia/Espinho E.P.E.
- Department Name
- Ophthalmology
- Principal Investigator Name
- Catarina Ferreira
- Principal Investigator Email
- catarina.ferreira@ulsge.min-saude.pt
- Contact Person Name
- Catarina Ferreira
- Contact Person Email
- catarina.ferreira@ulsge.min-saude.pt
- Site Name
- Unidade Local De Saude De Santo Antonio E.P.E.
- Department Name
- Ophthalmology
- Principal Investigator Name
- Miguel Lume
- Principal Investigator Email
- miguellume.oftalmologia@chporto.min-saude.pt
- Contact Person Name
- Miguel Lume
- Contact Person Email
- miguellume.oftalmologia@chporto.min-saude.pt
- Site Name
- Association For Innovation And Biomedical Research On Light And Image
- Department Name
- Ophthalmology
- Principal Investigator Name
- Inês Marques
- Principal Investigator Email
- ipmarques@aibili.pt
- Contact Person Name
- Inês Marques
- Contact Person Email
- ipmarques@aibili.pt
Germany
- Earliest CTIS Part Ii Submission Date
- 09-07-2025
- Latest Decision Or Authorization Date
- 05-08-2025
- Processing Time Days
- 27
- Number Of Sites
- 11
- Number Of Participants
- 19
Sites
- Site Name
- Universitaetsklinikum Bonn AöR
- Department Name
- Dep. Of Ophtolmology
- Principal Investigator Name
- Kristina Pfau
- Principal Investigator Email
- Kristina.Pfau@ukbonn.de
- Contact Person Name
- Kristina Pfau
- Contact Person Email
- Kristina.Pfau@ukbonn.de
- Site Name
- Augenzentrum Prof. Dr. Koch GmbH
- Principal Investigator Name
- Frank Koch
- Principal Investigator Email
- f.koch@azffm.de
- Contact Person Name
- Frank Koch
- Contact Person Email
- f.koch@azffm.de
- Site Name
- Augen-Zentrum-Nordwest
- Principal Investigator Name
- Greta Stefanie Schmickler
- Principal Investigator Email
- st.schmickler@augen-zentrum-nordwest.de
- Contact Person Name
- Greta Stefanie Schmickler
- Contact Person Email
- st.schmickler@augen-zentrum-nordwest.de
- Site Name
- Universitaetsklinikum Aachen AöR
- Principal Investigator Name
- Sabine Baumgarten
- Principal Investigator Email
- sabaumgarten@ukaachen.de
- Contact Person Name
- Sabine Baumgarten
- Contact Person Email
- sabaumgarten@ukaachen.de
- Site Name
- Philipps-Universitaet Marburg
- Department Name
- Klinik für Augenheilkunde
- Principal Investigator Name
- Walter Sekundo
- Principal Investigator Email
- walter.sekundo@staff.uni-marburg.de
- Contact Person Name
- Walter Sekundo
- Contact Person Email
- walter.sekundo@staff.uni-marburg.de
- Site Name
- Internationale Innovative Ophthalmochirurgie GbR (I.I.O.)
- Principal Investigator Name
- Hakan Kaymak
- Principal Investigator Email
- studien.h.kaymak@augenchirurgie.clinic
- Contact Person Name
- Hakan Kaymak
- Contact Person Email
- studien.h.kaymak@augenchirurgie.clinic
- Site Name
- Universitaetsklinikum Wuerzburg AöR
- Department Name
- Augen- und Poliklinik / Raum 0171
- Principal Investigator Name
- Andreas Berlin
- Principal Investigator Email
- berlin_a@ukw.de
- Contact Person Name
- Andreas Berlin
- Contact Person Email
- berlin_a@ukw.de
- Site Name
- Internationale Innovative Ophthalmochirurgie GbR (I.I.O.) (Duesseldorf - Oberkassel)
- Principal Investigator Name
- Hakan Kaymak
- Principal Investigator Email
- studien.h.kaymak@augenchirurgie.clinic
- Contact Person Name
- Hakan Kaymak
- Contact Person Email
- studien.h.kaymak@augenchirurgie.clinic
- Site Name
- Dr. med. Stefan Scholl und Prof. Dr. med. Albert J. Augustin Augenarztpraxis
- Principal Investigator Name
- Albert Augustin
- Principal Investigator Email
- albertjaugustin@gmail.com
- Contact Person Name
- Albert Augustin
- Contact Person Email
- albertjaugustin@gmail.com
- Site Name
- Universitaetsklinikum Bonn AöR (duplicate entry not expected?)
- Department Name
- Dep. Of Ophtolmology
- Principal Investigator Name
- Kristina Pfau
- Principal Investigator Email
- Kristina.Pfau@ukbonn.de
- Contact Person Name
- Kristina Pfau
- Contact Person Email
- Kristina.Pfau@ukbonn.de
- Site Name
- Augenzentrum Prof. Dr. Koch GmbH (duplicate entry)
- Principal Investigator Name
- Frank Koch
- Principal Investigator Email
- f.koch@azffm.de
- Contact Person Name
- Frank Koch
- Contact Person Email
- f.koch@azffm.de
Greece
- Earliest CTIS Part Ii Submission Date
- 29-07-2025
- Latest Decision Or Authorization Date
- 11-08-2025
- Processing Time Days
- 13
- Number Of Sites
- 5
- Number Of Participants
- 14
Sites
- Site Name
- General Hospital Of Athens G Gennimatas
- Department Name
- 1st University Eye Clinic
- Principal Investigator Name
- Ilias Georgalas
- Principal Investigator Email
- igeorgalas@yahoo.gr
- Contact Person Name
- Ilias Georgalas
- Contact Person Email
- igeorgalas@yahoo.gr
- Site Name
- General University Hospital Of Patras
- Department Name
- Ophthalmology Clinic
- Principal Investigator Name
- Konstantinos Georgakopoulos
- Principal Investigator Email
- cgeorg@med.upatras.gr
- Contact Person Name
- Konstantinos Georgakopoulos
- Contact Person Email
- cgeorg@med.upatras.gr
- Site Name
- University General Hospital Of Ioannina
- Department Name
- Ophthalmologic Clinic
- Principal Investigator Name
- Asproudis Ioannis
- Principal Investigator Email
- asproudisi@yahoo.gr
- Contact Person Name
- Asproudis Ioannis
- Contact Person Email
- asproudisi@yahoo.gr
- Site Name
- University General Hospital Of Heraklion
- Department Name
- Ophthalmology Clinic
- Principal Investigator Name
- Tsilimbaris Miltiadis
- Principal Investigator Email
- tsilimb@med.uoc.gr
- Contact Person Name
- Tsilimbaris Miltiadis
- Contact Person Email
- tsilimb@med.uoc.gr
- Site Name
- University General Hospital Attikon
- Department Name
- 2nd Department of Opthalmology,"University of Athens"
- Principal Investigator Name
- Irini Chatziralli
- Principal Investigator Email
- eirchat@yahoo.gr
- Contact Person Name
- Irini Chatziralli
- Contact Person Email
- eirchat@yahoo.gr
Poland
- Earliest CTIS Part Ii Submission Date
- 01-07-2025
- Latest Decision Or Authorization Date
- 11-08-2025
- Processing Time Days
- 41
- Number Of Sites
- 10
- Number Of Participants
- 22
Sites
- Site Name
- Optimum Profesorskie Centrum Okulistyki Sp. z o.o.
- Principal Investigator Name
- Dorota Raczynska
- Principal Investigator Email
- draczynska@op.pl
- Contact Person Name
- Dorota Raczynska
- Contact Person Email
- draczynska@op.pl
- Site Name
- Klinika Okulistyczna Jasne Blonia Sp. z o.o.
- Principal Investigator Name
- Zofia Nawrocka
- Principal Investigator Email
- jasneblonia@interia.pl
- Contact Person Name
- Zofia Nawrocka
- Contact Person Email
- jasneblonia@interia.pl
- Site Name
- Samodzielny Publiczny Zaklad Opieki Zdrowotnej Szpital Uniwersytecki W Krakowie
- Department Name
- Oddział Kliniczny Okulistyki i Onkologii Okulistycznej
- Principal Investigator Name
- Bożena Romanowska-Dixon
- Principal Investigator Email
- bromanowska@su.krakow.pl
- Contact Person Name
- Bożena Romanowska-Dixon
- Contact Person Email
- bromanowska@su.krakow.pl
- Site Name
- Szpital Sw. Rozy Sp. z o.o. S.K.
- Principal Investigator Name
- Małgorzata Siewierska
- Principal Investigator Email
- szpital@swroza.pl
- Contact Person Name
- Małgorzata Siewierska
- Contact Person Email
- szpital@swroza.pl
- Site Name
- Oculomedica Sp. z o.o.
- Principal Investigator Name
- Bartosz Sikorski
- Principal Investigator Email
- sikorski@doctors.org.uk
- Contact Person Name
- Bartosz Sikorski
- Contact Person Email
- sikorski@doctors.org.uk
- Site Name
- Centrum Diagnostyki I Mikrochirurgii Oka Lens Sp. z o.o.
- Principal Investigator Name
- Dominik Zalewski
- Principal Investigator Email
- kobak.lens@gmail.com
- Contact Person Name
- Dominik Zalewski
- Contact Person Email
- kobak.lens@gmail.com
- Site Name
- Bonifraterskie Centrum Medyczne Sp. z o.o.
- Department Name
- Poradnia Okulistyczna
- Principal Investigator Name
- Dominik Odrobina
- Principal Investigator Email
- lodz@bcmbonifratrzy.pl
- Contact Person Name
- Dominik Odrobina
- Contact Person Email
- lodz@bcmbonifratrzy.pl
- Site Name
- Centrum Medyczne Dietla 19 Sp. z o.o.
- Principal Investigator Name
- Piotr Oleksy
- Principal Investigator Email
- piotroleksy@yahoo.pl
- Contact Person Name
- Piotr Oleksy
- Contact Person Email
- piotroleksy@yahoo.pl
- Site Name
- Centrum Diagnostyki I Mikrochirurgii Oka Lens Sp. z o.o. (duplicate)
- Principal Investigator Name
- Dominik Zalewski
- Principal Investigator Email
- kobak.lens@gmail.com
- Contact Person Name
- Dominik Zalewski
- Contact Person Email
- kobak.lens@gmail.com
- Site Name
- Optimum Profesorskie Centrum Okulistyki Sp. z o.o. (duplicate)
- Principal Investigator Name
- Dorota Raczynska
- Principal Investigator Email
- draczynska@op.pl
- Contact Person Name
- Dorota Raczynska
- Contact Person Email
- draczynska@op.pl
Austria
- Earliest CTIS Part Ii Submission Date
- 23-06-2025
- Latest Decision Or Authorization Date
- 11-08-2025
- Processing Time Days
- 49
- Number Of Sites
- 3
- Number Of Participants
- 11
Sites
- Site Name
- Konvent Der Barmherzigen Brueder
- Department Name
- Abteilung für Augenheilkunde
- Principal Investigator Name
- Peter Reinelt
- Principal Investigator Email
- p.reinelt@bblinz.at
- Contact Person Name
- Peter Reinelt
- Contact Person Email
- p.reinelt@bblinz.at
- Site Name
- Institut Fuer Forschung Und Innovation In Der Augenchirurgie
- Principal Investigator Name
- Oliver Findl
- Principal Investigator Email
- oliver@findl.at
- Contact Person Name
- Oliver Findl
- Contact Person Email
- oliver@findl.at
- Site Name
- Medical University Of Vienna
- Department Name
- Department of Ophthalmology and Optometry
- Principal Investigator Name
- Stefan Sacu
- Principal Investigator Email
- stefan.sacu@meduniwien.ac.at
- Contact Person Name
- Stefan Sacu
- Contact Person Email
- stefan.sacu@meduniwien.ac.at
Italy
- Earliest CTIS Part Ii Submission Date
- 06-06-2025
- Latest Decision Or Authorization Date
- 06-08-2025
- Processing Time Days
- 61
- Number Of Sites
- 7
- Number Of Participants
- 21
Sites
- Site Name
- Azienda Ospedaliero Universitaria Delle Marche
- Department Name
- Dipartimento di Medicina Sperimentale e Clinica, Clinica Oculistica
- Principal Investigator Name
- Marco Lupidi
- Principal Investigator Email
- marco.lupidi@ospedaliriuniti.marche.it
- Contact Person Name
- Marco Lupidi
- Contact Person Email
- marco.lupidi@ospedaliriuniti.marche.it
- Site Name
- ASST Fatebenefratelli Sacco
- Department Name
- Dipartimento di Scienze Cliniche e Biomediche
- Principal Investigator Name
- Giovanni Staurenghi
- Principal Investigator Email
- giovanni.staurenghi@unimi.it
- Contact Person Name
- Giovanni Staurenghi
- Contact Person Email
- giovanni.staurenghi@unimi.it
- Site Name
- Azienda Ospedaliero-Universitaria Di Bologna IRCCS
- Department Name
- U.O. Oftalmologia
- Principal Investigator Name
- Antonio Pasquale Ciardella
- Principal Investigator Email
- antonio.ciardella@aosp.bo.it
- Contact Person Name
- Antonio Pasquale Ciardella
- Contact Person Email
- antonio.ciardella@aosp.bo.it
- Site Name
- Azienda Ospedaliera Policlinico Universitario Tor Vergata
- Department Name
- Experimental Medicine
- Principal Investigator Name
- Federico Ricci
- Principal Investigator Email
- federico.ricci@uniroma2.it
- Contact Person Name
- Federico Ricci
- Contact Person Email
- federico.ricci@uniroma2.it
- Site Name
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
- Department Name
- UOC Oculistica
- Principal Investigator Name
- Stanislao Rizzo
- Principal Investigator Email
- stanislao.rizzo@policlinicogemelli.it201
- Contact Person Name
- Stanislao Rizzo
- Contact Person Email
- stanislao.rizzo@policlinicogemelli.it201
- Site Name
- IRCCS Ospedale Sacro Cuore Don Calabria
- Department Name
- Ophthalmology
- Principal Investigator Name
- Grazia Pertile
- Principal Investigator Email
- grazia.pertile@sacrocuore.it
- Contact Person Name
- Grazia Pertile
- Contact Person Email
- grazia.pertile@sacrocuore.it
- Site Name
- Azienda Ospedaliera Universitaria Citta Della Salute E Della Scienza Di Torino
- Department Name
- Deptartment Surgical Sciences
- Principal Investigator Name
- Chiara Maria Eandi
- Principal Investigator Email
- chiara.eandi@unito.it
- Contact Person Name
- Chiara Maria Eandi
- Contact Person Email
- chiara.eandi@unito.it
Hungary
- Earliest CTIS Part Ii Submission Date
- 12-06-2025
- Latest Decision Or Authorization Date
- 07-08-2025
- Processing Time Days
- 56
- Number Of Sites
- 10
- Number Of Participants
- 36
Sites
- Site Name
- Budapest Retina Associates Kft.
- Department Name
- Ophtalmology
- Principal Investigator Name
- András Seres
- Principal Investigator Email
- seres@budapestretina.hu
- Contact Person Name
- András Seres
- Contact Person Email
- seres@budapestretina.hu
- Site Name
- Central Hospital Of Northern Pest Military Hospital
- Department Name
- Ophtalmology
- Principal Investigator Name
- Gábor Vogt
- Principal Investigator Email
- gabor.vogt@tosho.hu
- Contact Person Name
- Gábor Vogt
- Contact Person Email
- gabor.vogt@tosho.hu
- Site Name
- Semmelweis University
- Department Name
- Ophtalmology
- Principal Investigator Name
- András Papp
- Principal Investigator Email
- papp.andras1@med.semmelweis-univ.hu
- Contact Person Name
- András Papp
- Contact Person Email
- papp.andras1@med.semmelweis-univ.hu
- Site Name
- University Of Debrecen
- Department Name
- Ophtalmology
- Principal Investigator Name
- Attila Vajas
- Principal Investigator Email
- vajasa@gmail.com
- Contact Person Name
- Attila Vajas
- Contact Person Email
- vajasa@gmail.com
- Site Name
- Budapesti Jahn Ferenc Del Pesti Korhaz Es Rendelointezet
- Department Name
- Ophtalmology
- Principal Investigator Name
- Norbert Czumbel
- Principal Investigator Email
- czumbel@gmail.com
- Contact Person Name
- Norbert Czumbel
- Contact Person Email
- czumbel@gmail.com
- Site Name
- University Of Pecs
- Department Name
- Ophtalmology
- Principal Investigator Name
- Adrienne Csutak
- Principal Investigator Email
- csutak.adrienne@pte.hu
- Contact Person Name
- Adrienne Csutak
- Contact Person Email
- csutak.adrienne@pte.hu
- Site Name
- Budapesti Bajcsy-Zsilinszky Korhaz Es Rendelointezet
- Department Name
- Ophtalmology
- Principal Investigator Name
- Ágnes Kerényi
- Principal Investigator Email
- agneskerenyi@gmail.com
- Contact Person Name
- Ágnes Kerényi
- Contact Person Email
- agneskerenyi@gmail.com
- Site Name
- University Of Szeged
- Department Name
- Ophtalmology
- Principal Investigator Name
- Edit Tóth-Molnár
- Principal Investigator Email
- toth-molnar.edit@med.u-szeged.hu
- Contact Person Name
- Edit Tóth-Molnár
- Contact Person Email
- toth-molnar.edit@med.u-szeged.hu
- Site Name
- Semmelweis University (duplicate entry)
- Department Name
- Ophtalmology
- Principal Investigator Name
- András Papp
- Principal Investigator Email
- papp.andras1@med.semmelweis-univ.hu
- Contact Person Name
- András Papp
- Contact Person Email
- papp.andras1@med.semmelweis-univ.hu
- Site Name
- Central Hospital Of Northern Pest Military Hospital (duplicate)
- Department Name
- Ophtalmology
- Principal Investigator Name
- Gábor Vogt
- Principal Investigator Email
- gabor.vogt@tosho.hu
- Contact Person Name
- Gábor Vogt
- Contact Person Email
- gabor.vogt@tosho.hu
Czechia
- Earliest CTIS Part Ii Submission Date
- 30-04-2025
- Latest Decision Or Authorization Date
- 06-08-2025
- Processing Time Days
- 98
- Number Of Sites
- 5
- Number Of Participants
- 23
Sites
- Site Name
- Visus spol. s r.o.
- Principal Investigator Name
- Jan Studnicka
- Principal Investigator Email
- jan.studnicka@post.cz
- Contact Person Name
- Jan Studnicka
- Contact Person Email
- jan.studnicka@post.cz
- Site Name
- Fakultni Nemocnice Kralovske Vinohrady
- Department Name
- Oftalmologicka klinika
- Principal Investigator Name
- Jan Hamouz
- Principal Investigator Email
- jan.hamouz@fnkv.cz
- Contact Person Name
- Jan Hamouz
- Contact Person Email
- jan.hamouz@fnkv.cz
- Site Name
- Medical Private Care s.r.o.
- Principal Investigator Name
- Andrej Farkas
- Principal Investigator Email
- andrej.farkas@nemocnicesokolov.cz
- Contact Person Name
- Andrej Farkas
- Contact Person Email
- andrej.farkas@nemocnicesokolov.cz
- Site Name
- Axon Clinical s.r.o.
- Principal Investigator Name
- Jan Ernest
- Principal Investigator Email
- jan.ernest@axon-clinical.com
- Contact Person Name
- Jan Ernest
- Contact Person Email
- jan.ernest@axon-clinical.com
- Site Name
- Vseobecna Fakultni Nemocnice V Praze
- Department Name
- Ocni klinika
- Principal Investigator Name
- Bohdan Kousal
- Principal Investigator Email
- bohdan.kousal@vfn.cz
- Contact Person Name
- Bohdan Kousal
- Contact Person Email
- bohdan.kousal@vfn.cz
Sponsor
Primary sponsor
- Full Name
- ONL Therapeutics Inc.
- Organisation Type
- Laboratory/Research/Testing facility
- Country Of Registered Address
- United States
Contract research organisations
- Name
- Syneos Health Inc.
- Responsibilities
- sponsorDuties codes: 1,10,11,12,13,14,2,3,5,6,7,8
- Name
- Syneos Health Hellas Single Member S.A.
- Responsibilities
- sponsorDuties codes: 1,12,2,5
Third parties
- {"country":"Belgium","full_name":"PPD Global Central Labs","duties_or_roles":"sponsorDuties codes: 4","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Doheny Eye Institute","duties_or_roles":"Imaging: FAF, FP, FA, OCT, OCTA","organisation_type":"Educational Institution"}
- {"country":"United States","full_name":"Cleveland Clinic Foundation","duties_or_roles":"AI Imaging","organisation_type":"Hospital/Clinic/Other health care facility"}
- {"country":"United States","full_name":"Syneos Health Inc.","duties_or_roles":"sponsorDuties codes: 1,10,11,12,13,14,2,3,5,6,7,8","organisation_type":"Pharmaceutical company"}
- {"country":"Greece","full_name":"Syneos Health Hellas Single Member S.A.","duties_or_roles":"sponsorDuties codes: 1,12,2,5","organisation_type":"Pharmaceutical company"}
Investigational products
- Investigational Product Name
- ONL1204 Ophthalmic Solution
- Active Substance
- XELAFASLATIDE
- Modality
- Peptide/protein/enzyme
- Routes Of Administration
- INTRAVITREAL USE
- Route
- Intravitreal
- Maximum Dose
- 1200 µg (total)
- Investigational Product Name
- Sham injection
- Modality
- Other
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