Clinical trial • Phase III • Immunology | Dermatology

RITLECITINIB TOSILATE for Alopecia areata

Phase III trial of RITLECITINIB TOSILATE for Alopecia areata.

Overview

Trial Therapeutic Area
Immunology | Dermatology
Trial Disease
Alopecia areata
Trial Stage
Phase III
Drug Modality
Small molecule
Paediatric Trial
Yes

Key dates

Initial CTIS Submission Date
25-06-2025
First CTIS Authorization Date
14-10-2025

Trial design

Randomised, placebo to match ritlecitinib 50 mg; placebo to match ritlecitinib 30 mg-controlled Phase III trial across 33 sites in Czechia, France, Italy and others.

Randomised
Yes
Comparator
Placebo to match ritlecitinib 50 mg; Placebo to match ritlecitinib 30 mg
Target Sample Size
157
Trial Duration For Participant
730

Eligibility

Recruits 157 paediatric patients.

Vulnerable Population
Pediatric population selected. The trial enrolls children aged 6 to <12 years. Informed consent is obtained from the parent/legal guardian and age‑appropriate assent is obtained from child participants using specific assent forms (examples of documents listed: 'L1_1_ICF Main_Parent', 'L2_1_ICF_Assent 6-11', 'L3_1_EU Privacy Supplement Notice', country-specific assent/ICF documents are provided for France, Italy, Poland, Spain and Czechia).

Inclusion criteria

  • {"criterion_text":"- Participants who are 6 to <12 years old at the time of the screening visit.\n- A diagnosis of AA (including AT and AU) with at least 50% scalp hair loss due to AA (ie, a SALT score of ≥50) at both the screening and baseline visits, without evidence of terminal hair regrowth within the previous 12 months.\n- History of clinical response failure to AA treatment (such as topical, off-label pharmacologic, or hairpiece prosthetics)"}

Exclusion criteria

  • {"criterion_text":"- Other (non-AA) types of alopecia; any present or history of malignancies or lymphoproliferative disorders; evidence of untreated or inadequately treated active or latent Mycobacterium tuberculosis (TB) infection; history (one or more episodes) of severe or serious cytomegalovirus (CMV) infection, herpes zoster (shingles) or disseminated herpes simplex; history of any infection requiring hospitalization, parenteral antimicrobial therapy, or as otherwise judged clinically significant within prior 3 months; infection with hepatitis B virus (HBV) or hepatitis C virus (HCV)."}

Endpoints

Primary endpoints

  • {"endpoint_text":"- Response based on achieving an absolute SALT score ≤10 at Week 24.","definition_or_measurement_approach":"SALT score (Severity of Alopecia Tool) assessed at Week 24; response defined as achieving an absolute SALT score ≤10 at Week 24."}

Secondary endpoints

  • {"endpoint_text":"- PGI‑C response defined as a score of “moderately improved” or “greatly improved” at Week 24.","definition_or_measurement_approach":"Patient's Global Impression of Change (PGI‑C) assessed at Week 24; response defined as 'moderately improved' or 'greatly improved'."}
  • {"endpoint_text":"- •\tChange from baseline (CFB) in SALT score at all visits. •\tResponse based on achieving absolute SALT score ≤10 at all visits (except for that included as the primary endpoint). •\tResponse based on achieving absolute SALT score ≤20 at all visits (except for that included as the primary endpoint).","definition_or_measurement_approach":"CFB = change from baseline in SALT at each visit; binary responses defined by absolute SALT thresholds ≤10 and ≤20 at all visits (excluding the primary endpoint visit where specified)."}
  • {"endpoint_text":"- PGI-C response at all visits (except for that included as a key secondary endpoint).","definition_or_measurement_approach":"PGI‑C measured at each visit; assessed as response/non-response across visits (excluding the key secondary timepoint)."}
  • {"endpoint_text":"- •Response based on improvement from baseline for each AAPPO Item (11 endpoints). •CFB in AAPPO activity limitation and emotional symptoms scores at all visits. •\tCFB in PROMIS Parent Proxy Depressive Symptoms T-score at all visits.","definition_or_measurement_approach":"AAPPO item-level improvement from baseline; change from baseline in AAPPO domain scores and PROMIS Parent Proxy Depressive Symptoms T-score measured at all visits."}
  • {"endpoint_text":"- •CFB in PROMIS Parent Proxy Anxiety Symptoms T-score at all visits. •CFB in BRIEF®2 T-scores for the 3 index scores (Behavior Regulation Index [BRI], Emotional Regulation Index [ERI], Cognitive Regulation Index [CRI]) at all visits. •CFB in modified CDLQI total score at all visits.","definition_or_measurement_approach":"Change from baseline in PROMIS Parent Proxy Anxiety T-score, BRIEF®2 index T-scores, and modified CDLQI total score measured at each visit."}
  • {"endpoint_text":"- •\tResponse based on achieving at least 2 grade improvement or a score of 3 in EBA score at all visits in participants with an abnormal EBA at baseline.","definition_or_measurement_approach":"Eyebrow Assessment (EBA) response defined as ≥2-grade improvement or score of 3 at visits for participants with abnormal baseline EBA."}
  • {"endpoint_text":"- Response based on achieving at least 2 grade improvement or a score of 3 in ELA score at all visits in participants with an abnormal ELA at baseline.","definition_or_measurement_approach":"Eyelash Assessment (ELA) response defined as ≥2-grade improvement or score of 3 at visits for participants with abnormal baseline ELA."}
  • {"endpoint_text":"- Plasma concentration of ritlecitinib at 1 hr (±15 min) and 3 hr (±30 min) post-dose at Week 4 or Week 8.","definition_or_measurement_approach":"PK sampling: plasma ritlecitinib concentration measured at ~1 hr (±15 min) and ~3 hr (±30 min) post-dose at Week 4 or Week 8."}
  • {"endpoint_text":"- •Incidence of treatment-emergent adverse events (AEs) (including audiological and neurological treatment-emergent AEs). •Incidence of serious AEs (SAEs) and AEs leading to permanent discontinuation from the study.","definition_or_measurement_approach":"Safety endpoints: incidence counts and rates of TEAEs, SAEs, and AEs leading to permanent discontinuation; includes specified audiological and neurological events."}
  • {"endpoint_text":"- Acceptability and palatability assessment.","definition_or_measurement_approach":"Assessment of acceptability and palatability of the age‑appropriate formulation (methods/ratings as per protocol)."}

Recruitment

Registry Or Advocacy Recruitment
True: 'Advocacy Group Alert' documents present for multiple countries (specific group names not provided in the public documents list).
Digital Remote Recruitment
True: digital adverts pack and animated video materials are included (country-specific digital adverts/animated video documents for IT, PL, ES and others).
Planned Sample Size
157
Recruitment Window Months
22
Consent Approach
Consent is obtained from parent/legal guardian (parent ICF documents listed, e.g. 'L1_1_ICF Main_Parent' and country-specific parent ICFs). Child assent is obtained with age-appropriate assent forms (e.g. 'L2_1_ICF_Assent 6-11', 'L3_1_ICF_Assent 12-14', and other country-specific assent documents). Subject information and consent materials are provided per country (documents exist in Czech, French, Italian, Polish, Spanish and English versions where applicable) and include an EU privacy supplement.

Methods

  • Posters (country-specific recruitment materials present: e.g. K2_Recruitment Material_Poster for CZ/FR/IT/PL/ES).
  • Flyers (country-specific recruitment flyers present).
  • Patient brochures (country-specific patient brochure documents).
  • Animated videos (country-specific 'Animated Video' recruitment materials listed).
  • Digital adverts pack (documented for Italy, Poland, Spain: 'Digital Adverts Pack'/'Digital Adverts Pack_B7981027_IT/PL/ES').
  • Advocacy group alerts (documents titled 'Advocacy Group Alert' present for multiple countries).
  • Recruitment arrangements documentation (country-specific K1 recruitment arrangements files).

Geography

Total Number Of Sites
33
Total Number Of Participants
68

Czechia

Earliest CTIS Part Ii Submission Date
11-09-2025
Latest Decision Or Authorization Date
19-11-2025
Processing Time Days
69
Number Of Sites
4
Number Of Participants
8

Sites

Site Name
Fakultni Nemocnice Brno
Department Name
Detska nemocnice Detske kozni oddeleni PeK
Principal Investigator Name
Blanka Pinkova
Principal Investigator Email
pinkova.blanka@fnbrno.cz
Contact Person Name
Blanka Pinkova
Contact Person Email
pinkova.blanka@fnbrno.cz
Site Name
Fakultni Nemocnice Plzen
Department Name
Dermatovenerologicka klinika
Principal Investigator Name
Jan Ricar
Principal Investigator Email
ricarj@fnplzen.cz
Contact Person Name
Jan Ricar
Contact Person Email
ricarj@fnplzen.cz
Site Name
Prof. MUDr. Petr Arenberger, DrSc., MBA
Principal Investigator Name
Monika Arenbergerová
Principal Investigator Email
arenbergerova@email.cz
Contact Person Name
Monika Arenbergerová
Contact Person Email
arenbergerova@email.cz
Site Name
Fakultni Nemocnice Bulovka
Department Name
Dermatovenerologicka klinika
Principal Investigator Name
Filip Rob
Principal Investigator Email
filip.rob@gmail.com
Contact Person Name
Filip Rob
Contact Person Email
filip.rob@gmail.com

France

Earliest CTIS Part Ii Submission Date
15-09-2025
Latest Decision Or Authorization Date
21-11-2025
Processing Time Days
67
Number Of Sites
8
Number Of Participants
15

Sites

Site Name
Hospices Civils De Lyon
Department Name
Service de Dermatologie Pedriatrique
Principal Investigator Name
Alice Phan
Principal Investigator Email
alice.phan@chu-lyon.fr
Contact Person Name
Alice Phan
Contact Person Email
alice.phan@chu-lyon.fr
Site Name
Centre Hospitalier Universitaire De Nice
Department Name
service de Dermatologie
Principal Investigator Name
Thierry Passeron
Principal Investigator Email
passeron.t@chu-nice.fr
Contact Person Name
Thierry Passeron
Contact Person Email
passeron.t@chu-nice.fr
Site Name
Assistance Publique Hopitaux De Paris
Department Name
Service de Dermatologie
Principal Investigator Name
Chrisitine Bodemer
Principal Investigator Email
chrisitine.bodemer@aphp.fr
Contact Person Name
Chrisitine Bodemer
Contact Person Email
chrisitine.bodemer@aphp.fr
Site Name
Groupement Des Hopitaux De L'Institut Catholique De Lille
Department Name
Service de Dermatologie
Principal Investigator Name
Audrey Lasek
Principal Investigator Email
Lasek.Audrey@ghicl.net
Contact Person Name
Audrey Lasek
Contact Person Email
Lasek.Audrey@ghicl.net
Site Name
Centre Hospitalier Universitaire Rouen
Department Name
Service de Dermatologie
Principal Investigator Name
Vivien Hebert
Principal Investigator Email
vivien.hebert@chu-rouen.fr
Contact Person Name
Vivien Hebert
Contact Person Email
vivien.hebert@chu-rouen.fr
Site Name
Centre Hospitalier Universitaire De Dijon
Department Name
Service de Dermatologie
Principal Investigator Name
Bertille Bonnieaud
Principal Investigator Email
bertille.bonniaud@chu-dijon.fr
Contact Person Name
Bertille Bonnieaud
Contact Person Email
bertille.bonniaud@chu-dijon.fr
Site Name
Hopitaux Drome Nord
Department Name
Service de Dermatologie
Principal Investigator Name
Francois Skowron
Principal Investigator Email
f.skowron@ch-hdn.fr
Contact Person Name
Francois Skowron
Contact Person Email
f.skowron@ch-hdn.fr
Site Name
Centre Hospitalier Universitaire De Toulouse
Department Name
Service de Dermatologie
Principal Investigator Name
Juliette Mazereeuw-Hautier
Principal Investigator Email
mazereeuw-hautier.j@chu-toulouse.fr
Contact Person Name
Juliette Mazereeuw-Hautier

Italy

Earliest CTIS Part Ii Submission Date
07-07-2025
Latest Decision Or Authorization Date
30-01-2026
Processing Time Days
207
Number Of Sites
4
Number Of Participants
8

Sites

Site Name
Azienda Ospedaliero-Universitaria Di Bologna IRCCS Istituto Di Ricerca E Di Cura A Carattere Scientifico
Department Name
UOC Dermatologia
Principal Investigator Name
Michela Starace
Principal Investigator Email
michela.starace2@unibo.it
Contact Person Name
Michela Starace
Contact Person Email
michela.starace2@unibo.it
Site Name
Azienda Ospedaliera Universitaria Universita' Degli Studi Della Campania Luigi Vanvitelli
Department Name
UOC Clinica Dermatologica
Principal Investigator Name
Giuseppe Argenziano
Principal Investigator Email
g.argenziano@gmail.com
Contact Person Name
Giuseppe Argenziano
Contact Person Email
g.argenziano@gmail.com
Site Name
Azienda Socio Sanitaria Territoriale Degli Spedali Civili Di Brescia
Department Name
UO Dermatologia
Principal Investigator Name
Valeria Boccaletti
Principal Investigator Email
valeria.boccaletti@gmail.com
Contact Person Name
Valeria Boccaletti
Contact Person Email
valeria.boccaletti@gmail.com
Site Name
Azienda Ospedaliero-Universitaria Policlinico G. Rodolico-San Marco Di Catania
Department Name
UOC Dermatologia
Principal Investigator Name
Giuseppe Micali
Principal Investigator Email
gmicalitrial@gmail.com
Contact Person Name
Giuseppe Micali
Contact Person Email
gmicalitrial@gmail.com

Poland

Earliest CTIS Part Ii Submission Date
12-09-2025
Latest Decision Or Authorization Date
05-12-2025
Processing Time Days
84
Number Of Sites
14
Number Of Participants
31

Sites

Site Name
Royalderm Agnieszka Nawrocka
Principal Investigator Name
Witold Owczarek
Principal Investigator Email
witold.owczarek@dermedicus.pl
Contact Person Name
Witold Owczarek
Contact Person Email
witold.owczarek@dermedicus.pl
Site Name
Cityclinic Przychodnia Lekarsko-Psychologiczna Matusiak sp.p.
Principal Investigator Name
Jacek Szepietowski
Principal Investigator Email
jacek.szepietowski.work@gmail.com
Contact Person Name
Jacek Szepietowski
Site Name
Dermedic Iwona Zdybska
Principal Investigator Name
Jacek Zdybski
Principal Investigator Email
jacek_z@icloud.com
Contact Person Name
Jacek Zdybski
Contact Person Email
jacek_z@icloud.com
Site Name
Labderm Essence Sp. z o.o.
Principal Investigator Name
Beata Bergler-Czop
Principal Investigator Email
bbergler-czop@sum.edu.pl
Contact Person Name
Beata Bergler-Czop
Contact Person Email
bbergler-czop@sum.edu.pl
Site Name
Provita Sp. z o.o.
Principal Investigator Name
Anita Lewartowska-Bialek
Principal Investigator Email
a.bialek@angelius.org
Contact Person Name
Anita Lewartowska-Bialek
Contact Person Email
a.bialek@angelius.org
Site Name
Panstwowy Instytut Medyczny Ministerstwa Spraw Wewnetrznych I Administracji
Department Name
Klinika Dermatologii
Principal Investigator Name
Irena Walecka Herniczek
Principal Investigator Email
irena.walecka@cskmswia.gov.pl
Contact Person Name
Irena Walecka Herniczek
Contact Person Email
irena.walecka@cskmswia.gov.pl
Site Name
NZOZ Specjalistyczny Osrodek Dermatologiczny ”Dermal”
Principal Investigator Name
Adam Wronski
Principal Investigator Email
adam.wronski@dermal.pl
Contact Person Name
Adam Wronski
Contact Person Email
adam.wronski@dermal.pl
Site Name
Dermoklinika Centrum Medyczne s.c. M. Kierstan, J. Narbutt, A. Lesiak
Principal Investigator Name
Joanna Narbutt
Principal Investigator Email
joanna.narbutt@onet.pl
Contact Person Name
Joanna Narbutt
Contact Person Email
joanna.narbutt@onet.pl
Site Name
Klinika Osipowicz & Turkowski Sp. z o.o.
Principal Investigator Name
Katarzyna Osipowicz
Principal Investigator Email
osipowicz.kasia@gmail.com
Contact Person Name
Katarzyna Osipowicz
Contact Person Email
osipowicz.kasia@gmail.com
Site Name
Specjalistyczny Gabinet Dermatologiczny Aplikacyjno-Badawczy Marek Brzewski, Paweł Brzewski S.C.
Principal Investigator Name
Pawel Brzewski
Principal Investigator Email
brzewski@gmail.com
Contact Person Name
Pawel Brzewski
Contact Person Email
brzewski@gmail.com
Site Name
Uniwersytecki Szpital Kliniczny Im.Fryderyka Chopina W Rzeszowie
Principal Investigator Name
Adam Reich
Principal Investigator Email
adamandrzejreich@gmail.com
Contact Person Name
Adam Reich
Contact Person Email
adamandrzejreich@gmail.com
Site Name
Klinika Ambroziak Sp. z o.o.
Principal Investigator Name
Justyna Skibinska
Principal Investigator Email
principalskibinska@klinikaambroziak.pl
Contact Person Name
Justyna Skibinska
Site Name
Provita Poliklinika Sp. z o.o.
Principal Investigator Name
Mariusz Sikora
Principal Investigator Email
drmariuszsikora@gmail.com
Contact Person Name
Mariusz Sikora
Contact Person Email
drmariuszsikora@gmail.com
Site Name
Uniwersyteckie Centrum Kliniczne Warszawskiego Uniwersytetu Medycznego
Department Name
Klinika Dermatologiczna
Principal Investigator Name
Lidia Rudnicka
Principal Investigator Email
lidiarudnicka@gmail.com
Contact Person Name
Lidia Rudnicka
Contact Person Email
lidiarudnicka@gmail.com

Spain

Earliest CTIS Part Ii Submission Date
10-09-2025
Latest Decision Or Authorization Date
23-03-2026
Processing Time Days
194
Number Of Sites
3
Number Of Participants
6

Sites

Site Name
Hospital De La Santa Creu I Sant Pau
Department Name
Dermatology
Principal Investigator Name
Caridad Elena Morales Munera
Principal Investigator Email
CMorales@santpau.cat
Contact Person Name
Caridad Elena Morales Munera
Contact Person Email
CMorales@santpau.cat
Site Name
Hospital Universitario Miguel Servet
Department Name
Dermatology
Principal Investigator Name
Fermina Yolanda Gilaberte Calzada
Principal Investigator Email
ygilaberte@salud.aragon.es
Contact Person Name
Fermina Yolanda Gilaberte Calzada
Contact Person Email
ygilaberte@salud.aragon.es
Site Name
Hospital Sant Joan De Deu Barcelona
Department Name
Pediatric Dermatology
Principal Investigator Name
Carolina Prat Torres
Principal Investigator Email
carolinasusana.prat@sjd.es
Contact Person Name
Carolina Prat Torres
Contact Person Email
carolinasusana.prat@sjd.es

Sponsor

Primary sponsor

Full Name
Pfizer Inc.
Organisation Type
Pharmaceutical company
Country Of Registered Address
United States

Contract research organisations

Name
Syneos Health Inc.
Responsibilities
Operational CRO/vendor (sponsorDuties code: 5)
Name
PPD International Holdings LLC / Pharmaceutical Product Development LLC / Ppd Laboratories (Suzhou) Co. Ltd. / PPD Global Central Labs
Responsibilities
Clinical operations / central lab services / vendor activities (sponsorDuties codes: 4 and lab services)
Name
Icon Clinical Research Limited
Responsibilities
Training and clinical operations support (sponsorDuties code: 15; value: Training)
Name
QPS LLC
Responsibilities
Vendor/operational support (sponsorDuties code: 4)

Third parties

  • {"country":"United States","full_name":"Syneos Health Inc.","duties_or_roles":"sponsorDuties codes: 5","organisation_type":"Pharmaceutical company"}
  • {"country":"Belgium","full_name":"PPD International Holdings LLC","duties_or_roles":"sponsorDuties codes: 4","organisation_type":"Pharmaceutical company"}
  • {"country":"Ireland","full_name":"Almac Clinical Services (Ireland) Limited","duties_or_roles":"sponsorDuties codes: 14","organisation_type":"Pharmaceutical company"}
  • {"country":"United States","full_name":"Pharmaceutical Product Development LLC","duties_or_roles":"sponsorDuties codes: 4","organisation_type":"Pharmaceutical company"}
  • {"country":"United States","full_name":"Scout Clinical","duties_or_roles":"sponsorDuties codes: 15 (Participant Reimbursement)","organisation_type":"Hospital/Clinic/Other health care facility"}
  • {"country":"China","full_name":"Ppd Laboratories (Suzhou) Co. Ltd.","duties_or_roles":"sponsorDuties codes: 4","organisation_type":"Pharmaceutical company"}
  • {"country":"United Kingdom (Northern Ireland)","full_name":"Almac Clinical Services Limited","duties_or_roles":"sponsorDuties codes: 14","organisation_type":"Pharmaceutical company"}
  • {"country":"United States","full_name":"Almac Clinical Services LLC","duties_or_roles":"sponsorDuties codes: 14","organisation_type":"Pharmaceutical company"}
  • {"country":"Singapore","full_name":"PPD Global Central Labs (S) Pte Ltd","duties_or_roles":"sponsorDuties codes: 4","organisation_type":"Pharmaceutical company"}
  • {"country":"United States","full_name":"Almac Clinical Services LLC (alternate address)","duties_or_roles":"sponsorDuties codes: 14","organisation_type":"Pharmaceutical company"}
  • {"country":"United States","full_name":"Almac Clinical Services LLC (25 Fretz Road)","duties_or_roles":"sponsorDuties codes: 14","organisation_type":"Pharmaceutical company"}
  • {"country":"Ireland","full_name":"Icon Clinical Research Limited","duties_or_roles":"sponsorDuties codes: 15 (Training)","organisation_type":"Pharmaceutical company"}
  • {"country":"Singapore","full_name":"Almac Pharmaceutical Services Pte Ltd","duties_or_roles":"sponsorDuties codes: 14","organisation_type":"Pharmaceutical company"}
  • {"country":"United States","full_name":"Almac Clinical Services LLC (4204 Technology Drive)","duties_or_roles":"sponsorDuties codes: 14","organisation_type":"Pharmaceutical company"}
  • {"country":"United States","full_name":"Canfield Scientific Inc.","duties_or_roles":"sponsorDuties codes: 7","organisation_type":"Pharmaceutical company"}
  • {"country":"United Kingdom","full_name":"Innovative Trials Limited","duties_or_roles":"sponsorDuties codes: 15 (Recruitment Materials)","organisation_type":"Pharmaceutical company"}
  • {"country":"United States","full_name":"QPS LLC","duties_or_roles":"sponsorDuties codes: 4","organisation_type":"Pharmaceutical company"}
  • {"country":"United Kingdom","full_name":"York Bioanalytical Solutions Limited","duties_or_roles":"sponsorDuties codes: 4","organisation_type":"Laboratory/Research/Testing facility"}
  • {"country":"United States","full_name":"Signant Health Global LLC","duties_or_roles":"sponsorDuties codes: 7","organisation_type":"Pharmaceutical company"}
  • {"country":"United Kingdom","full_name":"Syneos Health UK Limited","duties_or_roles":"sponsorDuties codes: 1","organisation_type":"Pharmaceutical company"}
  • {"country":"","full_name":"Other vendor/partner entries (various Almac/PPD/PPD labs/Almac affiliates)","duties_or_roles":"Multiple operational/vendor roles (laboratory, clinical supply, regulatory, etc.) as listed (codes 4,7,14,15, etc.).","organisation_type":"Various"}

Investigational products

Investigational Product Name
Ritlecitinib tosilate
Active Substance
RITLECITINIB TOSILATE
Modality
Small molecule
Routes Of Administration
ORAL
Route
ORAL
Authorisation Status
Authorized product records exist in productDictionary (prodAuthStatus:1) for EU entries
Dose Levels
50 mg
Maximum Dose
50 mg
Investigational Product Name
Ritlecitinib
Active Substance
RITLECITINIB TOSILATE
Modality
Small molecule
Routes Of Administration
ORAL
Route
ORAL
Authorisation Status
Authorized product records exist in productDictionary (prodAuthStatus:1) for EU entries
Dose Levels
30 mg
Maximum Dose
30 mg
Investigational Product Name
Placebo to match ritlecitinib 50 mg
Modality
Other
Investigational Product Name
Placebo to match ritlecitinib 30 mg
Modality
Other

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