Clinical trial • Phase III • Immunology
NIPOCALIMAB for Sjögren's disease | Sjögren's syndrome
Phase III trial of NIPOCALIMAB for Sjögren's disease | Sjögren's syndrome.
Overview
- Trial Therapeutic Area
- Immunology
- Trial Disease
- Sjögren's disease | Sjögren's syndrome
- Trial Stage
- Phase III
- Drug Modality
- Monoclonal antibody
Key dates
- Initial CTIS Submission Date
- 19-05-2025
- First CTIS Authorization Date
- 05-06-2025
Trial design
Randomised, placebo subcutaneous without nipocalimab (placebo comparator arm). dose and schedule not specified in the available record.-controlled Phase III trial in Austria, Italy, Bulgaria and others.
- Randomised
- Yes
- Comparator
- Placebo subcutaneous without Nipocalimab (placebo comparator arm). Dose and schedule not specified in the available record.
- Target Sample Size
- 507
- Trial Duration For Participant
- 336
Eligibility
Recruits 507 The record indicates isVulnerablePopulationSelected = true and subject information and informed consent forms (SIS and ICF) are provided (country-specific versions listed). Additional ICF documents are present for 'Pregnant Partner' and for 'Child exposed to IP' (country-specific files listed), indicating special information materials for these situations. Consent is obtained via the provided subject information and informed consent forms; country and language-specific ICFs are available (examples in English, German, Italian, Spanish, French, Bulgarian, Hungarian, Portuguese, Romanian, Polish and others as listed in the documents). No explicit description of assent procedures for minors is provided in the available text..
- Pregnancy Exclusion
- Participants of childbearing potential must have a negative highly sensitive serum (beta-hCG) pregnancy test at screening and a negative urine pregnancy test at Week 0 prior to randomization.
- Vulnerable Population
- The record indicates isVulnerablePopulationSelected = true and subject information and informed consent forms (SIS and ICF) are provided (country-specific versions listed). Additional ICF documents are present for 'Pregnant Partner' and for 'Child exposed to IP' (country-specific files listed), indicating special information materials for these situations. Consent is obtained via the provided subject information and informed consent forms; country and language-specific ICFs are available (examples in English, German, Italian, Spanish, French, Bulgarian, Hungarian, Portuguese, Romanian, Polish and others as listed in the documents). No explicit description of assent procedures for minors is provided in the available text.
Inclusion criteria
- {"criterion_text":"- 1. Medically stable on the basis of physical examination, medical history, vital signs, 12-lead electrocardiogram (ECG) and clinical laboratory tests performed at screening.\n- 2. Meets criteria for diagnosis of SjD by the 2016 American College of Rheumatology/European Alliance of Associations for Rheumatology (ACR/EULAR) classification criteria.\n- 3. Seropositive for antibodies to Ro/SSA at screening.\n- 4. Total ClinESSDAI score greater than or equal to (>=) 5 at screening.\n- 5. Participants of childbearing potential must have a negative highly sensitive serum (beta-hCG) pregnancy test at screening and a negative urine pregnancy test at Week 0 prior to randomization."}
Exclusion criteria
- {"criterion_text":"- 1. Has a history of severe, progressive and/or uncontrolled hepatic, gastrointestinal, renal, pulmonary, cardiovascular, psychiatric, neurological or musculoskeletal disorder, hypertension, and/or any other medical or uncontrolled autoimmune disorder or clinically significant abnormalities in screening laboratory.\n- 2. Known allergies, hypersensitivity, or intolerance to nipocalimab or its excipients or excipients used in the placebo formulation.\n- 3. Has any confirmed or suspected clinical immunodeficiency syndrome not related to treatment of his/her SjD or has a family history of congenital or hereditary immunodeficiency.\n- 4. Has shown a previous severe immediate hypersensitivity reaction, such as anaphylaxis, to therapeutic proteins (for example [e.g.], monoclonal antibodies, intravenous immunoglobulin).\n- 5. Has any unstable or progressive manifestation of SjD that is likely to warrant escalation in therapy beyond permitted background medications."}
Endpoints
Primary endpoints
- {"endpoint_text":"- Change from Baseline in Clinical European League Against Rheumatism Sjogren’s Syndrome Disease Activity Index (ClinESSDAI) Score at Week 48.","definition_or_measurement_approach":"Change from baseline measured by the ClinESSDAI score at Week 48."}
Recruitment
- Digital Remote Recruitment
- Yes
- Planned Sample Size
- 507
- Recruitment Window Months
- 59
- Consent Approach
- Informed consent is obtained using subject information sheets and informed consent forms (SIS and ICF). Country-specific and language-specific ICF documents are provided (examples include English, German, Italian, Spanish, French, Bulgarian, Hungarian, Portuguese, Romanian, Polish, Dutch, Norwegian and Slovak versions listed). Separate/additional ICF documents are provided for topics such as pregnancy/pregnant partner, optional genetic samples, withdrawal, and child exposed to IP. The ICFs and SIS materials are the mechanism for obtaining consent from adult participants; no explicit textual detail on assent for minors is provided in the available record.
Methods
- Country-specific recruitment arrangements documents submitted (K1 files) are present for multiple countries (examples: Austria, Italy, Bulgaria, Portugal, Romania, Denmark, Spain, France, Germany, Poland, Hungary, Netherlands, Norway, Czechia, Slovakia).
- Digital advertising and online recruitment (document titles include 'Digital Ad', 'Digital Ad visuals', 'Search Ads', 'Landing Page Copy screenshot', 'ClinLife digital campaign', 'ClinLife Portal' — e.g. Poland and other country-specific K2 materials).
- Printed materials and site-based materials: recruitment brochures, recruitment posters (document titles 'Recruitment Poster', 'Recruitment Brochure').
- Clinician-to-patient outreach: doctor-to-patient emails (document titles 'Dr to Patient Email' / 'Doctor to Patient Email').
- Pre-screening and call-center scripts: 'Master WS Script', 'Master Pre-screening Script', 'Pre-screening Script' (Poland and other country materials listed).
- Other channels mentioned in materials: patient messaging, adverts for subject recruitment and adverts for subject recruitment visuals (country-specific K2 files).
Geography
- Total Number Of Sites
- 109
- Total Number Of Participants
- 309
Austria
- Earliest CTIS Part Ii Submission Date
- 16-05-2025
- Latest Decision Or Authorization Date
- 05-06-2025
- Processing Time Days
- 20
- Number Of Sites
- 4
- Number Of Participants
- 26
Sites
- Site Name
- Medical University Of Vienna
- Department Name
- Department of Internal Medicine III, Division of Rheumatology
- Principal Investigator Name
- Paul Studenic
- Principal Investigator Email
- paul.studenic@meduniwien.ac.at
- Contact Person Name
- Paul Studenic
- Contact Person Email
- paul.studenic@meduniwien.ac.at
- Site Name
- Landesklinikum Stockerau
- Department Name
- 2. Med. Department, with main focus on Rheumatology
- Principal Investigator Name
- Judith Sautner
- Principal Investigator Email
- judith.sautner@stockerau.lknoe.at
- Contact Person Name
- Judith Sautner
- Contact Person Email
- judith.sautner@stockerau.lknoe.at
- Site Name
- SCRI CCCIT Ges.m.b.H.
- Department Name
- III Med
- Principal Investigator Name
- Ildiko Toth
- Principal Investigator Email
- i.toth@salk.at
- Contact Person Name
- Ildiko Toth
- Contact Person Email
- i.toth@salk.at
- Site Name
- Medical University Of Graz
- Department Name
- Division of Rheumatology and Immunology
- Principal Investigator Name
- Martin Stradner
- Principal Investigator Email
- martin.stradner@medunigraz.at
- Contact Person Name
- Martin Stradner
- Contact Person Email
- martin.stradner@medunigraz.at
Italy
- Earliest CTIS Part Ii Submission Date
- 16-05-2025
- Latest Decision Or Authorization Date
- 19-06-2025
- Processing Time Days
- 34
- Number Of Sites
- 11
- Number Of Participants
- 18
Sites
- Site Name
- Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone
- Department Name
- Clinica Reumatologica
- Principal Investigator Name
- Giuliana Guggino
- Principal Investigator Email
- giuliana.guggino@unipa.it
- Contact Person Name
- Giuliana Guggino
- Contact Person Email
- giuliana.guggino@unipa.it
- Site Name
- Azienda Sanitaria Universitaria Friuli Centrale
- Department Name
- S.O.C. Clinica di Reumatologia - ASUFC
- Principal Investigator Name
- Luca Quartuccio
- Principal Investigator Email
- luca.quartuccio@asufc.sanita.fvg.it
- Contact Person Name
- Luca Quartuccio
- Contact Person Email
- luca.quartuccio@asufc.sanita.fvg.it
- Site Name
- Hospital Santa Maria Della Misericordia
- Department Name
- Medicine and Surgery
- Principal Investigator Name
- Elena Bartoloni Bocci
- Principal Investigator Email
- elena.bartolonibocci@unipg.it
- Contact Person Name
- Elena Bartoloni Bocci
- Contact Person Email
- elena.bartolonibocci@unipg.it
- Site Name
- Ospedale San Raffaele S.r.l.
- Department Name
- Clinical Unit of Immunology, Rheumatology, Allergy and Rare diseases
- Principal Investigator Name
- Lorenzo Dagna
- Principal Investigator Email
- dagna.lorenzo@hsr.it
- Contact Person Name
- Lorenzo Dagna
- Contact Person Email
- dagna.lorenzo@hsr.it
- Site Name
- Asst Centro Specialistico Ortopedico Traumatologico Gaetano Pini Cto
- Department Name
- U.O.C. Reumatologia Clinica
- Principal Investigator Name
- Nicoletta Del Papa
- Principal Investigator Email
- nicoletta.delpapa@asst-pini-cto.it
- Contact Person Name
- Nicoletta Del Papa
- Contact Person Email
- nicoletta.delpapa@asst-pini-cto.it
- Site Name
- Humanitas Mirasole S.p.A.
- Department Name
- U.O.C. Rheumatology
- Principal Investigator Name
- Serena Colafrancesco
- Principal Investigator Email
- serena.colafrancesco@humanitasresearch.it
- Contact Person Name
- Serena Colafrancesco
- Contact Person Email
- serena.colafrancesco@humanitasresearch.it
- Site Name
- Azienda Ospedaliero-Universitaria Policlinico Umberto I
- Department Name
- Scienze Cliniche Internistiche Anestesiologiche Cardiovascolari -UOC Reumatologia
- Principal Investigator Name
- Fabrizio Conti
- Principal Investigator Email
- fabrizio.conti@uniroma1.it
- Contact Person Name
- Fabrizio Conti
- Contact Person Email
- fabrizio.conti@uniroma1.it
- Site Name
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
- Department Name
- U.O.C. Rheumatology
- Principal Investigator Name
- Maria Antonietta D’gostino
- Principal Investigator Email
- mariaantonietta.dagostino@policlinicogemelli.it
- Contact Person Name
- Maria Antonietta D’gostino
- Contact Person Email
- mariaantonietta.dagostino@policlinicogemelli.it
- Site Name
- Azienda Ospedaliero Universitaria Di Modena
- Department Name
- S.C. Reumatologia
- Principal Investigator Name
- Dilia Giuggioli
- Principal Investigator Email
- dilia.giuggioli@unimore.it
- Contact Person Name
- Dilia Giuggioli
- Contact Person Email
- dilia.giuggioli@unimore.it
- Site Name
- Azienda Ospedaliero Universitaria Pisana
- Department Name
- Medicina Clinica e Sperimentale - U.O. di Reumatologia
- Principal Investigator Name
- Chiara Baldini
- Principal Investigator Email
- chiara.baldini74@gmail.com
- Contact Person Name
- Chiara Baldini
- Contact Person Email
- chiara.baldini74@gmail.com
- Site Name
- Fondazione Policlinico Universitario Campus Bio-medico In Forma A Bbreviata Fon
- Department Name
- U.O.C di Immunoreumatologia
- Principal Investigator Name
- Roberto Giacomelli
- Principal Investigator Email
- r.giacomelli@policlinicocampus.it
- Contact Person Name
- Roberto Giacomelli
- Contact Person Email
- r.giacomelli@policlinicocampus.it
Bulgaria
- Earliest CTIS Part Ii Submission Date
- 16-05-2025
- Latest Decision Or Authorization Date
- 17-06-2025
- Processing Time Days
- 32
- Number Of Sites
- 9
- Number Of Participants
- 26
Sites
- Site Name
- Diagnostic-Consultative Center Alexandrovska EOOD
- Department Name
- Not Applicable
- Principal Investigator Name
- Delina Ivanova
- Principal Investigator Email
- delina_ivanov@abv.bg
- Contact Person Name
- Delina Ivanova
- Contact Person Email
- delina_ivanov@abv.bg
- Site Name
- University Multiprofile Hospital For Active Treatment Kaspela EOOD
- Department Name
- Rheumatology Clinic
- Principal Investigator Name
- Anastas Batalov
- Principal Investigator Email
- abatalov@hotmail.com
- Contact Person Name
- Anastas Batalov
- Contact Person Email
- abatalov@hotmail.com
- Site Name
- Diagnostic Consultative Center Equita OOD
- Department Name
- Not Applicable
- Principal Investigator Name
- Daniela Kamburova
- Principal Investigator Email
- dkamburova5@gmail.com
- Contact Person Name
- Daniela Kamburova
- Contact Person Email
- dkamburova5@gmail.com
- Site Name
- Medical Center Teodora EOOD
- Department Name
- Not Applicable
- Principal Investigator Name
- Margarita Velkova
- Principal Investigator Email
- dr_margarita_velkova@mail.bg
- Contact Person Name
- Margarita Velkova
- Contact Person Email
- dr_margarita_velkova@mail.bg
- Site Name
- University Multiprofile Hospital For Active Treatment St. Ivan Rilski EAD
- Department Name
- Clinic of Rheumatology
- Principal Investigator Name
- Rasho Rashkov
- Principal Investigator Email
- proff_rashkov@yahoo.com
- Contact Person Name
- Rasho Rashkov
- Contact Person Email
- proff_rashkov@yahoo.com
- Site Name
- Mbal Lyulin EAD
- Department Name
- Rheumatology Department
- Principal Investigator Name
- Aneliya Radikova
- Principal Investigator Email
- a.radikova@mail.bg
- Contact Person Name
- Aneliya Radikova
- Contact Person Email
- a.radikova@mail.bg
- Site Name
- Military Medical Academy
- Department Name
- Rheumatology Department
- Principal Investigator Name
- Boycho Oparanov
- Principal Investigator Email
- oparanov@abv.bg
- Contact Person Name
- Boycho Oparanov
- Contact Person Email
- oparanov@abv.bg
- Site Name
- Medical Center Artmed Ltd.
- Department Name
- Not Applicable
- Principal Investigator Name
- Mariela Geneva-Popova
- Principal Investigator Email
- genevapopova@yahoo.com
- Contact Person Name
- Mariela Geneva-Popova
- Contact Person Email
- genevapopova@yahoo.com
- Site Name
- MBAL Sveta Marina EAD
- Department Name
- Rheumatology Clinic
- Principal Investigator Name
- Tsvetoslav Georgiev
- Principal Investigator Email
- ts.a.georgiev@gmail.com
- Contact Person Name
- Tsvetoslav Georgiev
- Contact Person Email
- ts.a.georgiev@gmail.com
Portugal
- Earliest CTIS Part Ii Submission Date
- 16-05-2025
- Latest Decision Or Authorization Date
- 11-06-2025
- Processing Time Days
- 26
- Number Of Sites
- 4
- Number Of Participants
- 10
Sites
- Site Name
- Unidade Local De Saude De Lisboa Ocidental E.P.E.
- Department Name
- Rheumatology
- Principal Investigator Name
- Fernando Pimentel dos Santos
- Principal Investigator Email
- pimentel.santos@gmail.com
- Contact Person Name
- Fernando Pimentel dos Santos
- Contact Person Email
- pimentel.santos@gmail.com
- Site Name
- Instituto Portugues De Reumatologia
- Department Name
- Rheumatology
- Principal Investigator Name
- Filipe Barcelos
- Principal Investigator Email
- fduartebarcelos@gmail.com
- Contact Person Name
- Filipe Barcelos
- Contact Person Email
- fduartebarcelos@gmail.com
- Site Name
- Unidade Local De Saude De Santa Maria E.P.E.
- Department Name
- Rheumatology
- Principal Investigator Name
- Nikita Khmelinskii
- Principal Investigator Email
- nkhmelinskii@gmail.com
- Contact Person Name
- Nikita Khmelinskii
- Contact Person Email
- nkhmelinskii@gmail.com
- Site Name
- Unidade Local De Saude De Gaia/Espinho E.P.E.
- Department Name
- Rheumatology
- Principal Investigator Name
- Tiago Meirinhos
- Principal Investigator Email
- tiago.meirinhos@ulsge.min-saude.pt
- Contact Person Name
- Tiago Meirinhos
- Contact Person Email
- tiago.meirinhos@ulsge.min-saude.pt
Romania
- Earliest CTIS Part Ii Submission Date
- 12-06-2025
- Latest Decision Or Authorization Date
- 30-06-2025
- Processing Time Days
- 18
- Number Of Sites
- 7
- Number Of Participants
- 16
Sites
- Site Name
- Selfmed Clinique S.R.L.
- Principal Investigator Name
- Viorica Crisan
- Principal Investigator Email
- viocrisan2002@yahoo.com
- Contact Person Name
- Viorica Crisan
- Contact Person Email
- viocrisan2002@yahoo.com
- Site Name
- Spitalul Clinic Judetean De Urgenta Cluj
- Department Name
- Rheumatology
- Principal Investigator Name
- Simona Rednic
- Principal Investigator Email
- srednic@umfcluj.ro
- Contact Person Name
- Simona Rednic
- Contact Person Email
- srednic@umfcluj.ro
- Site Name
- Medisof Diagnostic S.R.L.
- Department Name
- Rheumatology
- Principal Investigator Name
- Anca Emanuela Musetescu
- Principal Investigator Email
- anca_musetescu@yahoo.com
- Contact Person Name
- Anca Emanuela Musetescu
- Contact Person Email
- anca_musetescu@yahoo.com
- Site Name
- Saint Maria Hospital
- Department Name
- Rheumatology
- Principal Investigator Name
- Florian Berghea
- Principal Investigator Email
- berghea1@gmail.com
- Contact Person Name
- Florian Berghea
- Contact Person Email
- berghea1@gmail.com
- Site Name
- Policlinica CCBR S.R.L.
- Principal Investigator Name
- Sorica Mustatea
- Principal Investigator Email
- sorica.mustatea@clinicaccbr.com
- Contact Person Name
- Sorica Mustatea
- Contact Person Email
- sorica.mustatea@clinicaccbr.com
- Site Name
- Hiperdia S.A.
- Principal Investigator Name
- Camelia Georgeta Badea
- Principal Investigator Email
- camelia.badea@affidea.com
- Contact Person Name
- Camelia Georgeta Badea
- Contact Person Email
- camelia.badea@affidea.com
- Site Name
- Spitalul Clinic Colentina Bucuresti
- Department Name
- IIIrd Internal Medicine
- Principal Investigator Name
- Razvan Adrian Ionescu
- Principal Investigator Email
- tane67@gmail.com
- Contact Person Name
- Razvan Adrian Ionescu
- Contact Person Email
- tane67@gmail.com
Denmark
- Earliest CTIS Part Ii Submission Date
- 16-05-2025
- Latest Decision Or Authorization Date
- 11-06-2025
- Processing Time Days
- 26
- Number Of Sites
- 4
- Number Of Participants
- 18
Sites
- Site Name
- Sygehus Lillebaelt Vejle Sygehus
- Department Name
- Reumatologisk Afdeling-Medicinsk Afdeling
- Principal Investigator Name
- Tine Lottenburger
- Principal Investigator Email
- tine.lottenburger@rsyd.dk
- Contact Person Name
- Tine Lottenburger
- Contact Person Email
- tine.lottenburger@rsyd.dk
- Site Name
- Rigshospitalet
- Department Name
- Reumatology Department
- Principal Investigator Name
- Soren Jacobsen
- Principal Investigator Email
- soeren.jacobsen.01@regionh.dk
- Contact Person Name
- Soren Jacobsen
- Contact Person Email
- soeren.jacobsen.01@regionh.dk
- Site Name
- Aarhus University Hospital
- Department Name
- Reumatology Department
- Principal Investigator Name
- Anne Troldborg
- Principal Investigator Email
- annetrol@rm.dk
- Contact Person Name
- Anne Troldborg
- Contact Person Email
- annetrol@rm.dk
- Site Name
- Region Sjaelland
- Department Name
- Reumatology Department
- Principal Investigator Name
- Ada Colic
- Principal Investigator Email
- adco@regionsjaelland.dk
- Contact Person Name
- Ada Colic
- Contact Person Email
- adco@regionsjaelland.dk
Spain
- Earliest CTIS Part Ii Submission Date
- 16-05-2025
- Latest Decision Or Authorization Date
- 06-06-2025
- Processing Time Days
- 21
- Number Of Sites
- 8
- Number Of Participants
- 21
Sites
- Site Name
- Hospital De La Santa Creu I Sant Pau
- Department Name
- Rheumatology
- Principal Investigator Name
- Hector Corominas Macias
- Principal Investigator Email
- hcorominas@santpau.cat
- Contact Person Name
- Hector Corominas Macias
- Contact Person Email
- hcorominas@santpau.cat
- Site Name
- Sanitas S.A. De Hospitales
- Department Name
- Internal Medicine
- Principal Investigator Name
- Pilar Brito Zeron
- Principal Investigator Email
- mpbrito@sanitas.es
- Contact Person Name
- Pilar Brito Zeron
- Contact Person Email
- mpbrito@sanitas.es
- Site Name
- Hospital Universitario Juan Ramon Jimenez
- Department Name
- Rheumatology
- Principal Investigator Name
- Marta Llanes Gomez
- Principal Investigator Email
- martam.llanes.sspa@juntadeandalucia.es
- Contact Person Name
- Marta Llanes Gomez
- Contact Person Email
- martam.llanes.sspa@juntadeandalucia.es
- Site Name
- Hospital Universitari Vall D Hebron
- Department Name
- Internal Medicine
- Principal Investigator Name
- Roser Solans i Laque
- Principal Investigator Email
- mariaroser.solans@vallhebron.cat
- Contact Person Name
- Roser Solans i Laque
- Contact Person Email
- mariaroser.solans@vallhebron.cat
- Site Name
- Hospital Quironsalud Infanta Luisa
- Department Name
- Rheumatology
- Principal Investigator Name
- Juan Miguel Sanchez Burson
- Principal Investigator Email
- reujsb@gmail.com
- Contact Person Name
- Juan Miguel Sanchez Burson
- Contact Person Email
- reujsb@gmail.com
- Site Name
- Hospital Universitario Marques De Valdecilla
- Department Name
- Rheumatology
- Principal Investigator Name
- Ricardo Blanco Alonso
- Principal Investigator Email
- rblanco@humv.es
- Contact Person Name
- Ricardo Blanco Alonso
- Contact Person Email
- rblanco@humv.es
- Site Name
- Hospital Universitario De Navarra
- Department Name
- Rheumatology
- Principal Investigator Name
- Ruben Arnaez Solis
- Principal Investigator Email
- ruben.arnaez.solis@navarra.es
- Contact Person Name
- Ruben Arnaez Solis
- Contact Person Email
- ruben.arnaez.solis@navarra.es
- Site Name
- Hospital Universitario 12 De Octubre
- Department Name
- Rheumatology
- Principal Investigator Name
- Sheila Melchor Diaz
- Principal Investigator Email
- sheila.melchor@salud.madrid.org
- Contact Person Name
- Sheila Melchor Diaz
- Contact Person Email
- sheila.melchor@salud.madrid.org
France
- Earliest CTIS Part Ii Submission Date
- 04-07-2025
- Latest Decision Or Authorization Date
- 07-07-2025
- Processing Time Days
- 3
- Number Of Sites
- 9
- Number Of Participants
- 17
Sites
- Site Name
- Centre Hospitalier Universitaire De Bordeaux
- Department Name
- Internal Medicine and Clinical Immunology
- Principal Investigator Name
- Noemie GENSOUS
- Principal Investigator Email
- noemie.gensous@chu-bordeaux.fr
- Contact Person Name
- Noemie GENSOUS
- Contact Person Email
- noemie.gensous@chu-bordeaux.fr
- Site Name
- Assistance Publique Hopitaux De Paris
- Department Name
- Rheumatology Department
- Principal Investigator Name
- Raphaelle SEROR
- Principal Investigator Email
- Raphaele.seror@aphp.fr
- Contact Person Name
- Raphaelle SEROR
- Contact Person Email
- Raphaele.seror@aphp.fr
- Site Name
- Centre Hospitalier Universitaire De Dijon
- Department Name
- Internal Medicine and Clinical Immunology
- Principal Investigator Name
- Bernard BONNOTTE
- Principal Investigator Email
- bernard.bonnotte@chu-dijon.fr
- Contact Person Name
- Bernard BONNOTTE
- Contact Person Email
- bernard.bonnotte@chu-dijon.fr
- Site Name
- Assistance Publique Hopitaux De Paris
- Department Name
- Rheumatology Department
- Principal Investigator Name
- Damien SENE
- Principal Investigator Email
- damien.sene@aphp.fr
- Contact Person Name
- Damien SENE
- Contact Person Email
- damien.sene@aphp.fr
- Site Name
- Centre Hospitalier Universitaire De Saint Etienne
- Department Name
- Rheumatology Department
- Principal Investigator Name
- Martin KILLIAN
- Principal Investigator Email
- martin.killian@chu-st-etienne.fr
- Contact Person Name
- Martin KILLIAN
- Contact Person Email
- martin.killian@chu-st-etienne.fr
- Site Name
- Les Hopitaux Universitaires De Strasbourg
- Department Name
- Rheumatology Department
- Principal Investigator Name
- Jacques-Eric GOTTENBERG
- Principal Investigator Email
- jacques-eric.gottenberg@chru-strasbourg.fr
- Contact Person Name
- Jacques-Eric GOTTENBERG
- Contact Person Email
- jacques-eric.gottenberg@chru-strasbourg.fr
- Site Name
- Centre Hospitalier Universitaire De Montpellier
- Department Name
- Rheumatology Department
- Principal Investigator Name
- Jacques MOREL
- Principal Investigator Email
- j-morel@chu-montpellier.fr
- Contact Person Name
- Jacques MOREL
- Contact Person Email
- j-morel@chu-montpellier.fr
- Site Name
- Centre Hospitalier Regional Et Universitaire De Brest
- Department Name
- Rheumatology Department
- Principal Investigator Name
- Valerie DEVAUCHELLE-PENSEC
- Principal Investigator Email
- valerie.devauchelle-pensec@chu-brest.fr
- Contact Person Name
- Valerie DEVAUCHELLE-PENSEC
- Contact Person Email
- valerie.devauchelle-pensec@chu-brest.fr
- Site Name
- Centre Hospitalier Universitaire De Lille
- Department Name
- Rheumatology Department
- Principal Investigator Name
- Eric HACHULLA
- Principal Investigator Email
- Eric.hachulla@chru-lille.fr
- Contact Person Name
- Eric HACHULLA
- Contact Person Email
- Eric.hachulla@chru-lille.fr
Germany
- Earliest CTIS Part Ii Submission Date
- 16-05-2025
- Latest Decision Or Authorization Date
- 13-06-2025
- Processing Time Days
- 28
- Number Of Sites
- 12
- Number Of Participants
- 45
Sites
- Site Name
- Universitaetsklinikum Erlangen AöR
- Department Name
- Rheumatologie and Immunology
- Principal Investigator Name
- Ricardo Grieshaber-Bouyer
- Principal Investigator Email
- ricardo.grieshaber@fau.de
- Contact Person Name
- Ricardo Grieshaber-Bouyer
- Contact Person Email
- ricardo.grieshaber@fau.de
- Site Name
- Krankenhaus Porz Am Rhein gGmbH
- Department Name
- Klinik für Rheumatologie
- Principal Investigator Name
- Johannes Strunk
- Principal Investigator Email
- j.strunk@khporz.de
- Contact Person Name
- Johannes Strunk
- Contact Person Email
- j.strunk@khporz.de
- Site Name
- Universitaetsklinikum Wuerzburg AöR
- Department Name
- Medical Department III, Rheumatology and Immunology
- Principal Investigator Name
- Marc Schmalzing
- Principal Investigator Email
- schmalzing_m@ukw.de
- Contact Person Name
- Marc Schmalzing
- Contact Person Email
- schmalzing_m@ukw.de
- Site Name
- Studienambulanz Rheumazentrum Ratingen GbR
- Principal Investigator Name
- Siegfried Wassenberg
- Principal Investigator Email
- wassenberg@rhzr.de
- Contact Person Name
- Siegfried Wassenberg
- Contact Person Email
- wassenberg@rhzr.de
- Site Name
- MVZ Rheumatologie und Autoimmunmedizin Hamburg GmbH
- Department Name
- Hamburger Rheuma Forschungszentrum II
- Principal Investigator Name
- Andrea Everding
- Principal Investigator Email
- Everding@hotmail.de
- Contact Person Name
- Andrea Everding
- Contact Person Email
- Everding@hotmail.de
- Site Name
- Medicover GmbH
- Department Name
- Medicover Muenchen Ost MVZ
- Principal Investigator Name
- David Kofler
- Principal Investigator Email
- david.kofler@medicover.de
- Contact Person Name
- David Kofler
- Contact Person Email
- david.kofler@medicover.de
- Site Name
- Medizinische Hochschule Hannover
- Department Name
- Klinik für Rheumatologie & Immunologie
- Principal Investigator Name
- Torsten Witte
- Principal Investigator Email
- witte.torsten@mh-hannover.de
- Contact Person Name
- Torsten Witte
- Contact Person Email
- witte.torsten@mh-hannover.de
- Site Name
- Medical Center - University Of Freiburg
- Department Name
- Department of Rheumatology and clinical Immunology
- Principal Investigator Name
- Stephanie Finzel
- Principal Investigator Email
- stephanie.finzel@uniklinik-freiburg.de
- Contact Person Name
- Stephanie Finzel
- Contact Person Email
- stephanie.finzel@uniklinik-freiburg.de
- Site Name
- St. Elisabeth Gruppe GmbH Katholische Kliniken Rhein-Ruhr
- Department Name
- Rheumazentrum Ruhrgebiet
- Principal Investigator Name
- Ioana Andreica
- Principal Investigator Email
- ioana.andreica@elisabethgruppe.de
- Contact Person Name
- Ioana Andreica
- Contact Person Email
- ioana.andreica@elisabethgruppe.de
- Site Name
- LMU Klinikum Muenchen AöR
- Department Name
- Klinik f. Rheumatologie
- Principal Investigator Name
- Hendrik Schulze-Koops
- Principal Investigator Email
- Hendrik.Schulze-Koops@med.uni-muenchen.de
- Contact Person Name
- Hendrik Schulze-Koops
- Contact Person Email
- Hendrik.Schulze-Koops@med.uni-muenchen.de
- Site Name
- Universitaetsklinikum Regensburg AöR
- Department Name
- Clinic and Polyclinic for Rheumatology and Clinical Immunology
- Principal Investigator Name
- Martin Fleck
- Principal Investigator Email
- m.fleck@asklepios.com
- Contact Person Name
- Martin Fleck
- Contact Person Email
- m.fleck@asklepios.com
- Site Name
- Universitaetsklinikum Carl Gustav Carus Dresden an der Technischen Universitaet Dresden AöR
- Department Name
- Medical Department III, Rheumatology
- Principal Investigator Name
- Anne-Kathrin Tausche-Wunderlich
- Principal Investigator Email
- anne-kathrin.tausche@uniklinikum-dresden.de
- Contact Person Name
- Anne-Kathrin Tausche-Wunderlich
- Contact Person Email
- anne-kathrin.tausche@uniklinikum-dresden.de
Poland
- Earliest CTIS Part Ii Submission Date
- 16-05-2025
- Latest Decision Or Authorization Date
- 23-06-2025
- Processing Time Days
- 38
- Number Of Sites
- 14
- Number Of Participants
- 60
Sites
- Site Name
- Etyka Osrodek Badan Klinicznych Tomasz Pesta S.K.A.
- Principal Investigator Name
- Magdalena Krajewska-Wlodarczyk
- Principal Investigator Email
- magdalenakrajewska@etykaosrodek.pl
- Contact Person Name
- Magdalena Krajewska-Wlodarczyk
- Contact Person Email
- magdalenakrajewska@etykaosrodek.pl
- Site Name
- Futuremeds Sp. z o.o. (Wroclaw)
- Department Name
- Futuremeds - Wroclaw
- Principal Investigator Name
- Ewa Krecipro-Nizinska
- Principal Investigator Email
- ewa.krecipro-nizinska@futuremeds.com
- Contact Person Name
- Ewa Krecipro-Nizinska
- Contact Person Email
- ewa.krecipro-nizinska@futuremeds.com
- Site Name
- Ai Centrum Medyczne Sp. z o.o.
- Principal Investigator Name
- Anna Rychlewska-Hanczewska
- Principal Investigator Email
- info@aiklinika.com
- Contact Person Name
- Anna Rychlewska-Hanczewska
- Contact Person Email
- info@aiklinika.com
- Site Name
- Centrum Medyczne Oporow
- Principal Investigator Name
- Maria Misterska-Skora
- Principal Investigator Email
- badania@cmoporow.com
- Contact Person Name
- Maria Misterska-Skora
- Contact Person Email
- badania@cmoporow.com
- Site Name
- Malopolskie Badania Kliniczne Sp. z o.o.
- Principal Investigator Name
- Bogdan Batko
- Principal Investigator Email
- biuro@mbk.clinic
- Contact Person Name
- Bogdan Batko
- Contact Person Email
- biuro@mbk.clinic
- Site Name
- Medicover Integrated Clinical Services Sp. z o.o. (Bydgoszcz)
- Department Name
- MICS Centrum Medyczne Bydgoszcz
- Principal Investigator Name
- Katarzyna Kolossa
- Principal Investigator Email
- k.kolossa@naszlekarz.pl
- Contact Person Name
- Katarzyna Kolossa
- Contact Person Email
- k.kolossa@naszlekarz.pl
- Site Name
- Futuremeds Sp. z o.o. (Warsaw)
- Department Name
- Futuremeds - Targowek
- Principal Investigator Name
- Agnieszka Jurek-Urbanowska
- Principal Investigator Email
- agnieszka.urbanowska@futuremeds.com
- Contact Person Name
- Agnieszka Jurek-Urbanowska
- Contact Person Email
- agnieszka.urbanowska@futuremeds.com
- Site Name
- ETG Lublin Sp. z o.o. (Debica)
- Department Name
- ETG Debica
- Principal Investigator Name
- Katarzyna Surmacz
- Principal Investigator Email
- k.surmacz@etg-network.com
- Contact Person Name
- Katarzyna Surmacz
- Contact Person Email
- k.surmacz@etg-network.com
- Site Name
- ETG Lublin Sp. z o.o. (Lublin)
- Department Name
- ETG Lublin
- Principal Investigator Name
- Katarzyna Zelazowska
- Principal Investigator Email
- k.zelazowska@etg-network.com
- Contact Person Name
- Katarzyna Zelazowska
- Contact Person Email
- k.zelazowska@etg-network.com
- Site Name
- Futuremeds Sp. z o.o. (Cracow)
- Department Name
- Futuremeds - Krakow
- Principal Investigator Name
- Weronika Kleczynska-Szpakiewicz
- Principal Investigator Email
- weronika.szpakiewicz@futuremeds.com
- Contact Person Name
- Weronika Kleczynska-Szpakiewicz
- Contact Person Email
- weronika.szpakiewicz@futuremeds.com
- Site Name
- Medicover Integrated Clinical Services Sp. z o.o. (Warsaw Wronia)
- Department Name
- MICS Centrum Medyczne Warszawa
- Principal Investigator Name
- Malgorzata Gryka-Marton
- Principal Investigator Email
- malgorzatagrykamarton@medycynakliniczna.pl
- Contact Person Name
- Malgorzata Gryka-Marton
- Contact Person Email
- malgorzatagrykamarton@medycynakliniczna.pl
- Site Name
- Szpital Uniwersytecki Nr 2 Im Dr Jana Biziela W Bydgoszczy
- Department Name
- Klinika Reumatolgii i Ukladowych Chorob Tkanki Łacznej
- Principal Investigator Name
- Piotr Ignaczak
- Principal Investigator Email
- pmi@autograf.pl
- Contact Person Name
- Piotr Ignaczak
- Contact Person Email
- pmi@autograf.pl
- Site Name
- Lukmed 2 Sp. z o.o.
- Department Name
- ETG Siedlce
- Principal Investigator Name
- Tomasz Bocianowski
- Principal Investigator Email
- t.bocianowski@etg-network.com
- Contact Person Name
- Tomasz Bocianowski
- Contact Person Email
- t.bocianowski@etg-network.com
- Site Name
- Narodowy Instytut Geriatrii Reumatologii I Rehabilitacji Im Prof. Dr Hab. Med. Eleonory Reicher
- Department Name
- Centrum Wsparcia Badan Klinicznych
- Principal Investigator Name
- Brygida Kwiatkowska
- Principal Investigator Email
- cwbk.brygidakwiatkowska@spartanska.pl
- Contact Person Name
- Brygida Kwiatkowska
- Contact Person Email
- cwbk.brygidakwiatkowska@spartanska.pl
Hungary
- Earliest CTIS Part Ii Submission Date
- 04-06-2025
- Latest Decision Or Authorization Date
- 03-07-2025
- Processing Time Days
- 29
- Number Of Sites
- 7
- Number Of Participants
- 32
Sites
- Site Name
- University Of Szeged
- Principal Investigator Name
- Attila Balog
- Principal Investigator Email
- balog.attila@med.u-szeged.hu
- Contact Person Name
- Attila Balog
- Contact Person Email
- balog.attila@med.u-szeged.hu
- Site Name
- Del-Pesti Centrumkorhaz Orszagos Hematologiai Es Infektologiai Intezet
- Department Name
- Internal medicine- immunology ambulance
- Principal Investigator Name
- János Kádár
- Principal Investigator Email
- drkadarj@t-online.hu
- Contact Person Name
- János Kádár
- Contact Person Email
- drkadarj@t-online.hu
- Site Name
- Semmelweis University
- Department Name
- Reumatológiai és Immunológiai Klinika
- Principal Investigator Name
- Nóra Anna Szabó
- Principal Investigator Email
- szabnora@yahoo.com
- Contact Person Name
- Nóra Anna Szabó
- Contact Person Email
- szabnora@yahoo.com
- Site Name
- Clinexpert Kft.
- Principal Investigator Name
- István Láng
- Principal Investigator Email
- prof.lang.istvan@clinexpert.hu
- Contact Person Name
- István Láng
- Contact Person Email
- prof.lang.istvan@clinexpert.hu
- Site Name
- Betegapolo Irgalmasrend Budai Irgalmasrendi Korhaz
- Principal Investigator Name
- Bernadette Rojkovich
- Principal Investigator Email
- dr.rojkovich.bernadette@gmail.com
- Contact Person Name
- Bernadette Rojkovich
- Contact Person Email
- dr.rojkovich.bernadette@gmail.com
- Site Name
- University Of Debrecen
- Department Name
- Clinic of Internal Medicine, Department of Clinical Immunology
- Principal Investigator Name
- Antónia Szántó
- Principal Investigator Email
- szantonia77@gmail.com
- Contact Person Name
- Antónia Szántó
- Contact Person Email
- szantonia77@gmail.com
- Site Name
- Vita Verum Medical Bt.
- Principal Investigator Name
- Tünde Varga
- Principal Investigator Email
- vargatundedr1@gmail.com
- Contact Person Name
- Tünde Varga
- Contact Person Email
- vargatundedr1@gmail.com
Netherlands
- Earliest CTIS Part Ii Submission Date
- 09-01-2026
- Latest Decision Or Authorization Date
- 19-01-2026
- Processing Time Days
- 10
- Number Of Sites
- 4
- Number Of Participants
- 3
Sites
- Site Name
- Universitair Medisch Centrum Groningen
- Department Name
- Rheumatology and Clinical Immunology
- Principal Investigator Name
- Hendrika Bootsma
- Principal Investigator Email
- systeemziektenstudies@reuma.umcg.nl
- Contact Person Name
- Hendrika Bootsma
- Contact Person Email
- systeemziektenstudies@reuma.umcg.nl
- Site Name
- Frisius MC
- Department Name
- Rheumatology
- Principal Investigator Name
- Reinhard Bos
- Principal Investigator Email
- r.bos@frisiusmc.nl
- Contact Person Name
- Reinhard Bos
- Contact Person Email
- r.bos@frisiusmc.nl
- Site Name
- Medisch Spectrum Twente
- Department Name
- Rheumatology
- Principal Investigator Name
- Harald Vonkeman
- Principal Investigator Email
- reumatologie@mst.nl
- Contact Person Name
- Harald Vonkeman
- Contact Person Email
- reumatologie@mst.nl
- Site Name
- Academisch Ziekenhuis Maastricht
- Department Name
- Rheumatology and Clinical Immunology
- Principal Investigator Name
- Ivette Essers
- Principal Investigator Email
- ivette.essers@mumc.nl
- Contact Person Name
- Ivette Essers
- Contact Person Email
- ivette.essers@mumc.nl
Norway
- Earliest CTIS Part Ii Submission Date
- 05-12-2025
- Latest Decision Or Authorization Date
- 19-01-2026
- Processing Time Days
- 45
- Number Of Sites
- 2
- Number Of Participants
- 3
Sites
- Site Name
- Helse Stavanger HF
- Department Name
- Dept of Rheumatology
- Principal Investigator Name
- Jens Vikse
- Principal Investigator Email
- jens.vikse@sus.no
- Contact Person Name
- Jens Vikse
- Contact Person Email
- jens.vikse@sus.no
- Site Name
- Oslo Universitetssykehus HF
- Department Name
- Dept of Rheumatology
- Principal Investigator Name
- Oyvind Molberg
- Principal Investigator Email
- oyvind.molberg@medisin.uio.no
- Contact Person Name
- Oyvind Molberg
- Contact Person Email
- oyvind.molberg@medisin.uio.no
Czechia
- Earliest CTIS Part Ii Submission Date
- 12-12-2025
- Latest Decision Or Authorization Date
- 14-01-2026
- Processing Time Days
- 33
- Number Of Sites
- 7
- Number Of Participants
- 7
Sites
- Site Name
- Revimex pro s.r.o.
- Principal Investigator Name
- Gabriela Stolarz
- Principal Investigator Email
- revimex@email.cz
- Contact Person Name
- Gabriela Stolarz
- Contact Person Email
- revimex@email.cz
- Site Name
- Artroscan s.r.o.
- Principal Investigator Name
- Ladislav Bortlik
- Principal Investigator Email
- bor-med@volny.cz
- Contact Person Name
- Ladislav Bortlik
- Contact Person Email
- bor-med@volny.cz
- Site Name
- Fakultni Nemocnice Brno
- Department Name
- Revmatologicka ambulance
- Principal Investigator Name
- Zdenek Fojtik
- Principal Investigator Email
- fojtik.zdenek@fnbrno.cz
- Contact Person Name
- Zdenek Fojtik
- Contact Person Email
- fojtik.zdenek@fnbrno.cz
- Site Name
- Revmatologie s.r.o.
- Principal Investigator Name
- Petr Nemec
- Principal Investigator Email
- revmatologie.nemec@seznam.cz
- Contact Person Name
- Petr Nemec
- Contact Person Email
- revmatologie.nemec@seznam.cz
- Site Name
- MEDICAL PLUS Research s.r.o.
- Principal Investigator Name
- Eva Dokoupilova
- Principal Investigator Email
- evadokoupil@gmail.com
- Contact Person Name
- Eva Dokoupilova
- Contact Person Email
- evadokoupil@gmail.com
- Site Name
- MUDr. Zuzana Stejfova
- Principal Investigator Name
- Zuzana Stejfova
- Principal Investigator Email
- stejfova.zuzana@seznam.cz
- Contact Person Name
- Zuzana Stejfova
- Contact Person Email
- stejfova.zuzana@seznam.cz
- Site Name
- Other listed Czech site
Slovakia
- Earliest CTIS Part Ii Submission Date
- 19-12-2025
- Latest Decision Or Authorization Date
- 20-01-2026
- Processing Time Days
- 32
- Number Of Sites
- 7
- Number Of Participants
- 7
Sites
- Site Name
- Reumex s.r.o.
- Principal Investigator Name
- Viola Husarova
- Principal Investigator Email
- reumexrecepty@gmail.com
- Contact Person Name
- Viola Husarova
- Contact Person Email
- reumexrecepty@gmail.com
- Site Name
- Artromac N.O.
- Principal Investigator Name
- Michaele Zarikova
- Principal Investigator Email
- m.zarikova@gmail.com
- Contact Person Name
- Michaele Zarikova
- Contact Person Email
- m.zarikova@gmail.com
- Site Name
- Narodny Ustav Reumatickych Chorob
- Principal Investigator Name
- Roman Stancik
- Principal Investigator Email
- roman.stancik@nurch.sk
- Contact Person Name
- Roman Stancik
- Contact Person Email
- roman.stancik@nurch.sk
- Site Name
- Thermium s.r.o.
- Principal Investigator Name
- Ivan Rybar
- Principal Investigator Email
- thermium@thermium.sk
- Contact Person Name
- Ivan Rybar
- Contact Person Email
- thermium@thermium.sk
- Site Name
- Medman s.r.o.
- Principal Investigator Name
- Viliam Manka
- Principal Investigator Email
- medmansro@gmail.com
- Contact Person Name
- Viliam Manka
- Contact Person Email
- medmansro@gmail.com
- Site Name
- Reumamed Poprad s.r.o.
- Principal Investigator Name
- Daniela Tkacova
- Principal Investigator Email
- reumapoprad@gmail.com
- Contact Person Name
- Daniela Tkacova
- Contact Person Email
- reumapoprad@gmail.com
- Site Name
- Other listed Slovakia site
Sponsor
Primary sponsor
- Full Name
- Janssen Cilag International
- Organisation Type
- Pharmaceutical company
- Country Of Registered Address
- Belgium
Contract research organisations
- Name
- Labcorp Central Laboratory Services LP
- Responsibilities
- sponsorDuties code: 4
- Name
- Clario Medical Imaging Inc.
- Responsibilities
- ePRO and ClinROs
- Name
- 4g Clinical LLC
- Responsibilities
- sponsorDuties code: 3
Third parties
- {"country":"United States","full_name":"Labcorp Central Laboratory Services LP","duties_or_roles":"sponsorDuties code: 4","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Clario Medical Imaging Inc.","duties_or_roles":"ePRO and ClinROs","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"4g Clinical LLC","duties_or_roles":"sponsorDuties code: 3","organisation_type":"Non-Pharmaceutical company"}
Investigational products
- Investigational Product Name
- JNJ-80202135
- Active Substance
- NIPOCALIMAB
- Modality
- Monoclonal antibody
- Routes Of Administration
- SUBCUTANEOUS USE
- Route
- SUBCUTANEOUS
- Investigational Product Name
- Placebo subcutaneous without Nipocalimab
- Modality
- Other
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