Clinical trial • Phase III • Infectious Disease
MOLNUPIRAVIR for COVID-19 | SARS-CoV-2 infection
Phase III trial of MOLNUPIRAVIR for COVID-19 | SARS-CoV-2 infection.
Overview
- Trial Therapeutic Area
- Infectious Disease
- Trial Disease
- COVID-19 | SARS-CoV-2 infection
- Trial Stage
- Phase III
- Drug Modality
- Small molecule
Key dates
- Initial CTIS Submission Date
- 08-10-2024
- First CTIS Authorization Date
- 06-02-2025
Trial design
Randomised, molnupiravir matching placebo tablets (placebo arm); dose and schedule not specified in provided documents-controlled Phase III trial across 49 sites in Finland, Poland, France and others.
- Randomised
- Yes
- Comparator
- Molnupiravir Matching placebo tablets (placebo arm); dose and schedule not specified in provided documents
- Target Sample Size
- 2315
- Trial Duration For Participant
- 29
Eligibility
Recruits 2315 No vulnerable population selected; participants are adults (≥18 years of age). Consent is obtained from the participant (no assent procedures described)..
- Vulnerable Population
- No vulnerable population selected; participants are adults (≥18 years of age). Consent is obtained from the participant (no assent procedures described).
Inclusion criteria
- {"criterion_text":"- Is an individual of any sex/gender, ≥18 years of age\n- Has documentation of SARS-CoV-2 infection with sample collection ≤4 days prior to randomization\n- Has initial onset of signs/symptoms attributable to COVID-19 for ≤4 days prior to the day of randomization and ≥2 of the following signs/symptoms attributable to COVID-19 on the day of randomization: cough, sore throat, nasal congestion, shortness of breath or difficulty breathing with exertion, muscle or body aches, fatigue, fever >38.0°C or chills, nausea or vomiting or diarrhea, change in sense of smell or change in sense of taste, or headache\n- Has ≥1 of the following characteristics or medical conditions associated with the highest risk of severe illness from COVID-19: 1) advanced age of ≥75 years of age, 2) Immunocompromised, 3) Neurocognitive or physical disability or has ≥3 characteristics or medical conditions which increase the risk of severe illness due to COVID-19 (e.g. diabetes, obesity with body mass index (BMI) ≥ 35, chronic lung diseases)\n- Is unable or unwilling to receive treatment with nirmatrelvir/ritonavir (NMV/r) due to 1 or more of the following: 1) Is receiving drug(s) highly dependent on cytochrome P450 (CYP3A) for clearance and for which elevated concentrations are associated with serious and/or life-threatening consequences or drug(s) with a clinically significant drug-drug interaction for which co-administration is not possible, 2) Is receiving potent CYP3A inducers where significantly reduces nirmatrelvir or ritonavir plasma concentrations may be associated with the potential for loss of virologic response and possible resistance, 3) Has severe hepatic impairment, 4) Has experienced prior adverse reactions or hepatotoxicity to NMV/r that would preclude future use, 5) Has known or suspected NMV/r resistance, 6) Has uncontrolled HIV infection, 7) NMV/r is not approved/authorized in the participant’s country or it is not accessible to participant (e.g. drug shortage), 8) Is unwilling to receive treatment with NMV/r"}
Exclusion criteria
- {"criterion_text":"- Is currently hospitalized or is expected to need hospitalization for COVID-19 imminently\n- Has received or plans to receive SARS-CoV-2 directed oral antivirals or monoclonal antibodies for current episode of COVID-19 (other than study intervention and, if applicable, remdesivir as standard of care)\n- Has ≥1 of the following signs/symptoms that are attributable to severe or critical COVID-19: 1) shortness of breath at rest, 2) respiratory rate ≥30 breaths per minute, 3) heart rate ≥125 beats per minute, 4) peripheral oxygen saturation (SpO2) ≤93% on room air or on supplemental oxygen for a reason other than COVID-19 which has not increased since onset of COVID-19 signs/symptoms, 5) New or increasing need for supplemental oxygen: Receiving >4 liters/min supplemental oxygen due to COVID-19 OR on supplemental oxygen for a reason other than COVID-19 which has increased due to COVID-19\n- Has received a COVID-19 vaccine within 30 days prior to randomization\n- Has a history of confirmed influenza, respiratory syncytial virus (RSV), or SARS-CoV-2 infection (with or without symptoms; excluding current infection) within 30 days prior to randomization\n- Has known or suspected hypersensitivity to active or inactive ingredients of MOV"}
Endpoints
Primary endpoints
- {"endpoint_text":"- Percentage of Participants Who Experienced One or More of following through Day 29: Hospitalization, All-cause Mortality, or COVID-19 Related Medically Attended Visit (MAV)","definition_or_measurement_approach":"Assessed in the mITT population from randomization through Day 29; measured as the percentage of participants with one or more of: hospitalization (all-cause), death (all-cause), or a COVID-19-related medically attended visit (MAV)."}
- {"endpoint_text":"- Percentage of Participants Who Experienced an Adverse Event (AE)","definition_or_measurement_approach":"Safety endpoint assessed in the APaT population as the percentage of participants reporting one or more adverse events during the study period."}
- {"endpoint_text":"- Percentage of Participants Who Discontinued Study Intervention Due to AE","definition_or_measurement_approach":"Measured as the percentage of participants who discontinued the study intervention because of adverse events during the study."}
Secondary endpoints
- {"endpoint_text":"- Time to Sustained Alleviation (without relapse) of all selected 8 (5 prespecified and 3 determined by baseline prevalence), self-reported COVID-19 signs/symptoms","definition_or_measurement_approach":"Time-to-event measured from randomization through Day 29 in the mITT population (time to sustained alleviation without relapse)."}
- {"endpoint_text":"- Change From Baseline in SARS-CoV-2 RNA titer","definition_or_measurement_approach":"Change from baseline in SARS-CoV-2 RNA titer measured in nasopharyngeal (NP) swabs at Day 3, End of Treatment (EOT), and Days 10, 14, and 29 in the mITT population."}
- {"endpoint_text":"- Percentage of Participants With Undetectable SARS-CoV-2 RNA","definition_or_measurement_approach":"Measured as the percentage of participants with undetectable SARS-CoV-2 RNA in NP swabs at specified timepoints (Day 3, EOT, Days 10, 14, 29) in the mITT population."}
- {"endpoint_text":"- Percentage of Participants Who Experienced One or More of following through Day 29: All-cause Hospitalization or All-cause Mortality","definition_or_measurement_approach":"Assessed in the mITT population from randomization through Day 29 as the percentage experiencing hospitalization (all-cause) or death (all-cause)."}
- {"endpoint_text":"- Percentage of Participants With Clinically Important Medical Interventions Associated with COVID-19 related MAV or COVID-19 related hospitalization through Day 29","definition_or_measurement_approach":"Measured as the percentage of participants with clinically important medical interventions associated with a COVID-19-related medically attended visit (MAV) or hospitalization from randomization through Day 29 in mITT participants with MAV and/or hospitalization."}
- {"endpoint_text":"- Time to Sustained Alleviation (without relapse) of all 15 self-reported COVID-19 signs/symptoms through Day 29","definition_or_measurement_approach":"Time-to-event measured from randomization through Day 29 in the mITT population (sustained alleviation without relapse of 15 self-reported signs/symptoms)."}
- {"endpoint_text":"- Time to Sustained Resolution Without Relapse of all 8 (5 prespecified and 3 determined by baseline prevalence) self-reported COVID-19 signs/symptoms through Day 29","definition_or_measurement_approach":"Time-to-event measured from randomization through Day 29 in the mITT population (sustained resolution without relapse of the 8 selected self-reported signs/symptoms)."}
Recruitment
- Digital Remote Recruitment
- Yes
- Planned Sample Size
- 2315
- Recruitment Window Months
- 74
- Consent Approach
- Informed consent obtained from each participant (adults ≥18 years). Subject information and ICF documents are provided (local language and English versions available per country). Optional/ancillary consent forms (e.g., pregnancy follow-up, infant follow-up, optional procedures) are available in some countries. No assent procedures described (adult-only population).
Methods
- Poster (site posters) — patient-facing printed posters used in participating sites (documents present for multiple countries, e.g., POL, FRA, ESP, ITA, DEU)
- Patient flyer / Patient brochure — printed patient information flyers used at sites and for distribution to potential participants (country-specific versions present e.g., POL, FRA, ESP, ITA, DEU, ROU, BGR, FIN)
- Social media (posts and social media text) — digital recruitment via social media channels (country-specific social media materials available, e.g., POL, FRA, ITA)
- Website — study-specific website content/pages for recruitment (documents for Poland and others)
- Advertisement (online/print) — advertisements prepared for recruitment (country-specific advertising materials present, e.g., FRA, DEU)
- Patient letter / invitation — letters to potential participants (documents available e.g., FRA)
Geography
- Total Number Of Sites
- 49
- Total Number Of Participants
- 767
Finland
- Earliest CTIS Part Ii Submission Date
- 16-01-2025
- Latest Decision Or Authorization Date
- 19-12-2025
- Processing Time Days
- 337
- Number Of Sites
- 1
- Number Of Participants
- 15
Sites
- Site Name
- HUS-Yhtymae
- Department Name
- MeVac – Meilahti Vaccine Research Center
- Principal Investigator Name
- Hanna Välimaa
- Principal Investigator Email
- hanna.valimaa@hus.fi
- Contact Person Name
- Hanna Välimaa
- Contact Person Email
- hanna.valimaa@hus.fi
Poland
- Earliest CTIS Part Ii Submission Date
- 15-01-2025
- Latest Decision Or Authorization Date
- 04-01-2026
- Processing Time Days
- 354
- Number Of Sites
- 7
- Number Of Participants
- 120
Sites
- Site Name
- EMC Instytut Medyczny S.A.
- Department Name
- PL Certus Szpital Nr 1, PL Certus Ambulatorium
- Principal Investigator Name
- Małgorzata Stasiak-Paczkowska
- Principal Investigator Email
- Kinga.kieronczyk@emc-sa.pl
- Contact Person Name
- Małgorzata Stasiak-Paczkowska
- Contact Person Email
- Kinga.kieronczyk@emc-sa.pl
- Site Name
- Clinical Medical Research Sp. z o.o.
- Principal Investigator Name
- Piotr Wilczek
- Principal Investigator Email
- contact@clinicalmedicalresearch.pl
- Contact Person Name
- Piotr Wilczek
- Contact Person Email
- contact@clinicalmedicalresearch.pl
- Site Name
- Gyncentrum Sp. z o.o. (Katowice)
- Department Name
- NZOZ Holsamed - Oddział Libero
- Principal Investigator Name
- Jakub Kwiatkowski
- Principal Investigator Email
- badaniakliniczne@holsaclinical.pl
- Contact Person Name
- Jakub Kwiatkowski
- Contact Person Email
- badaniakliniczne@holsaclinical.pl
- Site Name
- Gyncentrum Sp. z o.o. (Cracow)
- Department Name
- NZOZ GynCentrum - Oddział Kraków
- Principal Investigator Name
- Wojciech Sydor
- Principal Investigator Email
- badaniakliniczne@holsaclinical.pl
- Contact Person Name
- Wojciech Sydor
- Contact Person Email
- badaniakliniczne@holsaclinical.pl
- Site Name
- Gyncentrum Sp. z o.o. (Bielsko-Biala)
- Department Name
- NZOZ GynCentrum - Oddział Bielsko-Biała
- Principal Investigator Name
- Adrianna Gęga-Czarnota
- Principal Investigator Email
- badaniakliniczne@holsaclinical.pl
- Contact Person Name
- Adrianna Gęga-Czarnota
- Contact Person Email
- badaniakliniczne@holsaclinical.pl
- Site Name
- In Vivo Sp. z o.o.
- Principal Investigator Name
- Piotr Piasecki
- Principal Investigator Email
- kontakt@in-vivo.pl
- Contact Person Name
- Piotr Piasecki
- Contact Person Email
- kontakt@in-vivo.pl
- Site Name
- EMC Instytut Medyczny S.A. (Wroclaw)
- Department Name
- Penta Hospitals Przychodnie, Wrocław Wejherowska
- Principal Investigator Name
- Wojciech Gandecki
- Principal Investigator Email
- badania.kliniczne@pentahospitals.pl
- Contact Person Name
- Wojciech Gandecki
- Contact Person Email
- badania.kliniczne@pentahospitals.pl
France
- Earliest CTIS Part Ii Submission Date
- 10-01-2025
- Latest Decision Or Authorization Date
- 28-01-2026
- Processing Time Days
- 383
- Number Of Sites
- 4
- Number Of Participants
- 120
Sites
- Site Name
- Centre Hospitalier Universitaire De Dijon
- Department Name
- Centre d'investigation clinique
- Principal Investigator Name
- Marc BARDOU
- Principal Investigator Email
- marc.bardou@u-bourgogne.fr
- Contact Person Name
- Marc BARDOU
- Contact Person Email
- marc.bardou@u-bourgogne.fr
- Site Name
- Hopitaux Universitaires Pitie Salpetriere
- Department Name
- Maladies infectieuses
- Principal Investigator Name
- Valérie POURCHER
- Principal Investigator Email
- valerie.martinez@aphp.fr
- Contact Person Name
- Valérie POURCHER
- Contact Person Email
- valerie.martinez@aphp.fr
- Site Name
- Centre Hospitalier Universitaire De Saint Etienne
- Department Name
- Urgences
- Principal Investigator Name
- Alain VIALLON
- Principal Investigator Email
- alain.viallon@chu-st-etienne.fr
- Contact Person Name
- Alain VIALLON
- Contact Person Email
- alain.viallon@chu-st-etienne.fr
- Site Name
- Hospices Civils De Lyon
- Department Name
- Allergologie et Immunologie Clinique - LYREC
- Principal Investigator Name
- Fréderic BERARD
- Principal Investigator Email
- frederic.berard@chu-lyon.fr
- Contact Person Name
- Fréderic BERARD
- Contact Person Email
- frederic.berard@chu-lyon.fr
Spain
- Earliest CTIS Part Ii Submission Date
- 14-11-2024
- Latest Decision Or Authorization Date
- 20-01-2026
- Processing Time Days
- 432
- Number Of Sites
- 11
- Number Of Participants
- 180
Sites
- Site Name
- Hospital General Universitario Santa Lucia
- Department Name
- Internal Medicine
- Principal Investigator Name
- Francisco Vera Méndez
- Principal Investigator Email
- franciscovera72@gmail.com
- Contact Person Name
- Francisco Vera Méndez
- Contact Person Email
- franciscovera72@gmail.com
- Site Name
- Complexo Hospitalario Universitario De Santiago
- Department Name
- Pneumology
- Principal Investigator Name
- Francisco Javier González Barcala
- Principal Investigator Email
- francisco.javier.gonzalez.barcala@sergas.es
- Contact Person Name
- Francisco Javier González Barcala
- Contact Person Email
- francisco.javier.gonzalez.barcala@sergas.es
- Site Name
- Hospital Universitario Infanta Leonor
- Department Name
- Internal Medicine
- Principal Investigator Name
- Jorge Antonio Valencia La Rosa
- Principal Investigator Email
- jorge_vlr@yahoo.es
- Contact Person Name
- Jorge Antonio Valencia La Rosa
- Contact Person Email
- jorge_vlr@yahoo.es
- Site Name
- Hospital Universitari Vall D Hebron
- Department Name
- Infectious diseases
- Principal Investigator Name
- Oscar Manual Len Abad
- Principal Investigator Email
- oscarmanuel.len@vallhebron.cat
- Contact Person Name
- Oscar Manual Len Abad
- Contact Person Email
- oscarmanuel.len@vallhebron.cat
- Site Name
- Hospital General Universitario De Elche
- Department Name
- Infectious diseases
- Principal Investigator Name
- Sergio Padilla Urrea
- Principal Investigator Email
- sergiopadurr@gmail.com
- Contact Person Name
- Sergio Padilla Urrea
- Contact Person Email
- sergiopadurr@gmail.com
- Site Name
- Hospital Germans Trias I Pujol
- Department Name
- Internal Medicine
- Principal Investigator Name
- Lourdes Mateu Pruñonosa
- Principal Investigator Email
- lmateu@lluita.org
- Contact Person Name
- Lourdes Mateu Pruñonosa
- Contact Person Email
- lmateu@lluita.org
- Site Name
- Hospital Universitario Fundacion Alcorcon
- Department Name
- Internal Medicine
- Principal Investigator Name
- Juan Emilio Losa García
- Principal Investigator Email
- juanemilio.losa@salud.madrid.org
- Contact Person Name
- Juan Emilio Losa García
- Contact Person Email
- juanemilio.losa@salud.madrid.org
- Site Name
- Eap Osona Sud Alt Congost S.L.P.
- Principal Investigator Name
- Silvia Narejos Pérez
- Principal Investigator Email
- snarejos@ebacentelles.cat
- Contact Person Name
- Silvia Narejos Pérez
- Contact Person Email
- snarejos@ebacentelles.cat
- Site Name
- Complexo Hospitalario Universitario A Coruna
- Department Name
- Internal Medicine
- Principal Investigator Name
- Enrique Miguez Rey
- Principal Investigator Email
- enrique.miguez.rey@sergas.es
- Contact Person Name
- Enrique Miguez Rey
- Contact Person Email
- enrique.miguez.rey@sergas.es
- Site Name
- University Hospital Virgen Del Rocio S.L.
- Department Name
- Infecious diseases
- Principal Investigator Name
- Manuel Francisco Liroa Romero
- Principal Investigator Email
- manlirrom@gmail.com
- Contact Person Name
- Manuel Francisco Liroa Romero
- Contact Person Email
- manlirrom@gmail.com
- Site Name
- Equip D'Atencio Primaria Barcelona Sardenya S.L.P.
- Department Name
- Primary Care
- Principal Investigator Name
- Carlen Reyes Reyes
- Principal Investigator Email
- creyes@eapsardenya.cat
- Contact Person Name
- Carlen Reyes Reyes
- Contact Person Email
- creyes@eapsardenya.cat
Romania
- Earliest CTIS Part Ii Submission Date
- 14-01-2025
- Latest Decision Or Authorization Date
- 12-01-2026
- Processing Time Days
- 363
- Number Of Sites
- 6
- Number Of Participants
- 64
Sites
- Site Name
- Spitalul Clinic De Boli Infectioase Cluj-Napoca
- Department Name
- Boli Infectioase
- Principal Investigator Name
- Violeta Briciu
- Principal Investigator Email
- contact@infectioasecluj.ro
- Contact Person Name
- Violeta Briciu
- Contact Person Email
- contact@infectioasecluj.ro
- Site Name
- Sana Monitoring S.R.L.
- Principal Investigator Name
- Adrian Sarbu
- Principal Investigator Email
- adrian.sarbu@sana.ro
- Contact Person Name
- Adrian Sarbu
- Contact Person Email
- adrian.sarbu@sana.ro
- Site Name
- Spitalul Clinic De Boli Infectioase Constanta
- Department Name
- Boli Infectioase Adulti II
- Principal Investigator Name
- Irina Dumitru
- Principal Investigator Email
- contact@infectioaseconstanta.ro
- Contact Person Name
- Irina Dumitru
- Contact Person Email
- contact@infectioaseconstanta.ro
- Site Name
- Spitalul Clinic De Boli Infectioase Si Tropicale Dr. Victor Babes
- Principal Investigator Name
- Simona Tetradov
- Principal Investigator Email
- office@spitalulbabes.ro
- Contact Person Name
- Simona Tetradov
- Contact Person Email
- office@spitalulbabes.ro
- Site Name
- Institutul National De Boli Infectioase Prof.Dr.Matei Bals
- Principal Investigator Name
- Anca Streinu-Cercel
- Principal Investigator Email
- secretariatinbi@mateibals.ro
- Contact Person Name
- Anca Streinu-Cercel
- Contact Person Email
- secretariatinbi@mateibals.ro
- Site Name
- Institutul National De Boli Infectioase Prof.Dr.Matei Bals (additional site)
- Department Name
- Boli Infectioase Adulti II
- Principal Investigator Name
- Liliana Preotescu
- Principal Investigator Email
- secretariatinbi@mateibals.ro
- Contact Person Name
- Liliana Preotescu
- Contact Person Email
- secretariatinbi@mateibals.ro
Germany
- Earliest CTIS Part Ii Submission Date
- 19-12-2024
- Latest Decision Or Authorization Date
- 23-12-2025
- Processing Time Days
- 369
- Number Of Sites
- 4
- Number Of Participants
- 35
Sites
- Site Name
- University Hospital Cologne AöR
- Department Name
- Innere Medizin I, Infektionsambulanz und Tagesklinik
- Principal Investigator Name
- Clara Lehmann
- Principal Investigator Email
- infektiologie-studienbuero@uk-koeln.de
- Contact Person Name
- Clara Lehmann
- Contact Person Email
- infektiologie-studienbuero@uk-koeln.de
- Site Name
- Charite Universitaetsmedizin Berlin KöR
- Department Name
- Medizinische Klinik mit Schwerpunkt Nephrologie und Internistische Intensivmedizin
- Principal Investigator Name
- Eva Schrezenmeier
- Principal Investigator Email
- nephrologie-studien@charite.de
- Contact Person Name
- Eva Schrezenmeier
- Contact Person Email
- nephrologie-studien@charite.de
- Site Name
- Klinikum rechts der Isar der TU Muenchen AöR
- Department Name
- Klinik und Poliklinik für Innere Medizin II
- Principal Investigator Name
- Jochen Schneider
- Principal Investigator Email
- annette.schuster@mri.tum.de
- Contact Person Name
- Jochen Schneider
- Contact Person Email
- annette.schuster@mri.tum.de
- Site Name
- Goethe University Frankfurt
- Department Name
- Medizinische Klinik II, Infektiologie und Therapie der HIV-Infektionen
- Principal Investigator Name
- Maria Vehreschild
- Principal Investigator Email
- maria.vehreschild@kgu.de
- Contact Person Name
- Maria Vehreschild
- Contact Person Email
- maria.vehreschild@kgu.de
Italy
- Earliest CTIS Part Ii Submission Date
- 04-02-2025
- Latest Decision Or Authorization Date
- 23-04-2026
- Processing Time Days
- 443
- Number Of Sites
- 4
- Number Of Participants
- 83
Sites
- Site Name
- ASST Fatebenefratelli Sacco
- Department Name
- UO Malattie Infettive 3
- Principal Investigator Name
- Agostino Riva
- Principal Investigator Email
- agostino.riva@asst-fbf-sacco.it
- Contact Person Name
- Agostino Riva
- Contact Person Email
- agostino.riva@asst-fbf-sacco.it
- Site Name
- Azienda Ospedaliero Universitaria Pisana
- Department Name
- UO Malattie Infettive, Dipartimento di Medicina Clinica e Sperimentale -
- Principal Investigator Name
- Marco Falcone
- Principal Investigator Email
- marco.falcone@unipi.it
- Contact Person Name
- Marco Falcone
- Contact Person Email
- marco.falcone@unipi.it
- Site Name
- IRCCS Azienda Ospedaliera Metropolitana
- Department Name
- Clinica Malattie Infettive
- Principal Investigator Name
- Matteo Bassetti
- Principal Investigator Email
- matteo.bassetti@hsanmartino.it
- Contact Person Name
- Matteo Bassetti
- Contact Person Email
- matteo.bassetti@hsanmartino.it
- Site Name
- Azienda Ospedaliero-Universitaria Di Bologna IRCCS Istituto Di Ricerca E Di Cura A Carattere Scientifico
- Department Name
- UO Malattie Infettive
- Principal Investigator Name
- Caterina Campoli
- Principal Investigator Email
- caterina.campoli@aosp.bo.it
- Contact Person Name
- Caterina Campoli
- Contact Person Email
- caterina.campoli@aosp.bo.it
Bulgaria
- Earliest CTIS Part Ii Submission Date
- 31-01-2025
- Latest Decision Or Authorization Date
- 29-04-2026
- Processing Time Days
- 453
- Number Of Sites
- 12
- Number Of Participants
- 150
Sites
- Site Name
- Medical Center Medconsult Burgas EOOD
- Principal Investigator Name
- Kristiyan Kostov
- Principal Investigator Email
- medconsultburgas@abv.bg
- Contact Person Name
- Kristiyan Kostov
- Contact Person Email
- medconsultburgas@abv.bg
- Site Name
- Medical Centre Pratia Clinic EOOD
- Principal Investigator Name
- Iskra Velichkova
- Principal Investigator Email
- varna@leoclinics.com
- Contact Person Name
- Iskra Velichkova
- Contact Person Email
- varna@leoclinics.com
- Site Name
- DCC V Plovdiv EOOD
- Principal Investigator Name
- Viktoria Dimova
- Principal Investigator Email
- dkc5_plovdiv@abv.bg
- Contact Person Name
- Viktoria Dimova
- Contact Person Email
- dkc5_plovdiv@abv.bg
- Site Name
- Medical Center Hera EOOD (Montana)
- Principal Investigator Name
- Vanko Vankov
- Principal Investigator Email
- office@heraclinics.com
- Contact Person Name
- Vanko Vankov
- Contact Person Email
- office@heraclinics.com
- Site Name
- Medical Center Medconsult Pleven OOD
- Principal Investigator Name
- Maria Tzekova
- Principal Investigator Email
- mcpleven@abv.bg
- Contact Person Name
- Maria Tzekova
- Contact Person Email
- mcpleven@abv.bg
- Site Name
- Specialized Hospital For Active Treatment Of Pneumo-Phthisiatric Diseases Dr. Dimitar Gramatikov-Ruse
- Department Name
- Pneumology Department
- Principal Investigator Name
- Hristo Metev
- Principal Investigator Email
- pulmo_dispaser@rousse.spnet.net
- Contact Person Name
- Hristo Metev
- Contact Person Email
- pulmo_dispaser@rousse.spnet.net
- Site Name
- Medical Center Medconsult Pleven OOD (Lovech)
- Principal Investigator Name
- Ana Kostadinovska
- Principal Investigator Email
- mcloveck@abv.vg
- Contact Person Name
- Ana Kostadinovska
- Contact Person Email
- mcloveck@abv.vg
- Site Name
- Medical Center Zdrave-1 OOD
- Principal Investigator Name
- Rumen Tiholov
- Principal Investigator Email
- zdrave1_kozloduy@abv.bg
- Contact Person Name
- Rumen Tiholov
- Contact Person Email
- zdrave1_kozloduy@abv.bg
- Site Name
- Medical Center Hera EOOD (Sofiya)
- Principal Investigator Name
- Kiril Palaveev
- Principal Investigator Email
- office@heraclinics.com
- Contact Person Name
- Kiril Palaveev
- Contact Person Email
- office@heraclinics.com
- Site Name
- Multi-Profile Hospital For Active Treatment Dr. Stamen Iliev AD
- Department Name
- Department of Pneumology and Phthisiatry
- Principal Investigator Name
- Lidiya Nikolcheva-Todorova
- Principal Investigator Email
- mbalmont@net-surf.net
- Contact Person Name
- Lidiya Nikolcheva-Todorova
- Contact Person Email
- mbalmont@net-surf.net
- Site Name
- Diagnostic-Consultative Center 22 Sofia EOOD
- Principal Investigator Name
- Rumyana Gudzeva
- Principal Investigator Email
- info@22dkc.com
- Contact Person Name
- Rumyana Gudzeva
- Contact Person Email
- info@22dkc.com
- Site Name
- Medical Center Asclepius Ltd.
- Principal Investigator Name
- Savka Vaklyova
- Principal Investigator Email
- lybkadafova@abv.bg
- Contact Person Name
- Savka Vaklyova
- Contact Person Email
- lybkadafova@abv.bg
Sponsor
Primary sponsor
- Full Name
- Merck Sharp & Dohme LLC
- Organisation Type
- Pharmaceutical company
- Country Of Registered Address
- United States
Contract research organisations
- Name
- Pharmaceutical Product Development LLC
- Responsibilities
- code:4
- Name
- Parexel International Corp.
- Responsibilities
- EUB services (call center and medical services)
- Name
- Almac Clinical Services LLC
- Responsibilities
- code:3
Third parties
- {"country":"United States","full_name":"Pharmaceutical Product Development LLC","duties_or_roles":"code:4","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Almac Clinical Services LLC","duties_or_roles":"code:3","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Parexel International Corp.","duties_or_roles":"EUB services (call center and medical services)","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Azenta US Inc.","duties_or_roles":"Biorepository","organisation_type":"Pharmaceutical company"}
- {"country":"Netherlands","full_name":"DDL Diagnostic Laboratory B.V.","duties_or_roles":"code:4","organisation_type":"Laboratory/Research/Testing facility"}
- {"country":"United States","full_name":"Axio Research","duties_or_roles":"Statistical analysis","organisation_type":"SME"}
- {"country":"United States","full_name":"Infinity Biologix LLC","duties_or_roles":"code:4","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Labcorp Early Development Laboratories Inc.","duties_or_roles":"code:4","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Omnitrace Corp.","duties_or_roles":"Patient Locator for follow up","organisation_type":"Non-Pharmaceutical company"}
- {"country":"United States","full_name":"Medidata Solutions Inc.","duties_or_roles":"code:7","organisation_type":"Non-Pharmaceutical company"}
Investigational products
- Investigational Product Name
- molnupiravir
- Active Substance
- MOLNUPIRAVIR
- Modality
- Small molecule
- Routes Of Administration
- ORAL
- Route
- ORAL
- Authorisation Status
- Authorized (prodAuthStatus=1; EU MP number PRD11141081)
- Maximum Dose
- Max daily dose 1600 mg; max total dose 8000 mg; max treatment period 5 days
- Investigational Product Name
- Molnupiravir Matching placebo tablets
- Modality
- Other
- Authorisation Status
- Not applicable / matching placebo
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