Clinical trial • Phase III • Gastroenterology
Mirikizumab for Crohn's disease | Obesity or Overweight
Phase III trial of Mirikizumab for Crohn's disease | Obesity or Overweight.
Overview
- Trial Therapeutic Area
- Gastroenterology
- Trial Disease
- Crohn's disease | Obesity or Overweight
- Trial Stage
- Phase III
- Drug Modality
- Monoclonal antibody | Peptide/protein/enzyme
Key dates
- Initial CTIS Submission Date
- 30-04-2025
- First CTIS Authorization Date
- 26-08-2025
Trial design
Randomised, mirikizumab + placebo (placebo to match tirzepatide) versus mirikizumab concomitantly administered with tirzepatide (tirzepatide up to mtd of 15 mg as stated); specific mirikizumab dosing schedule not detailed in the provided record.-controlled Phase III trial in Greece, Italy, Poland and others.
- Randomised
- Yes
- Comparator
- Mirikizumab + placebo (placebo to match Tirzepatide) versus Mirikizumab concomitantly administered with Tirzepatide (Tirzepatide up to MTD of 15 mg as stated); specific Mirikizumab dosing schedule not detailed in the provided record.
- Target Sample Size
- 128
- Trial Duration For Participant
- 364
Eligibility
Recruits 128 Vulnerable populations not selected (isVulnerablePopulationSelected: false). Study enrols adults only; informed consent required from each adult participant. eConsent platforms and translated ICFs are provided; no parental consent or child assent processes described..
- Vulnerable Population
- Vulnerable populations not selected (isVulnerablePopulationSelected: false). Study enrols adults only; informed consent required from each adult participant. eConsent platforms and translated ICFs are provided; no parental consent or child assent processes described.
Inclusion criteria
- {"criterion_text":"- Have had a diagnosis of Crohn’s disease (CD) or perianal fistulizing CD established at least 3 months prior to enrollment with tests confirming the diagnosis."}
- {"criterion_text":"- Have moderately to severely active CD defined by a CDAI score of at least 220 at baseline."}
- {"criterion_text":"- SES-CD score of at least 6 or 4 (isolated ileal)"}
- {"criterion_text":"- Participants with a history of CD involving only or predominantly the colon for greater than or equal to 8 years with a surveillance colonoscopy within 1 year prior to baseline must have documented negative results for colorectal dysplasia and cancer."}
- {"criterion_text":"- Be obese with a body mass index (BMI) of 30 or higher or be overweight with a BMI between 27 and 30 and have at least one of the following conditions related to weight: high blood pressure, type 2 diabetes, abnormal cholesterol levels, sleep apnea (a condition where you stop breathing for short periods during sleep), or heart disease."}
- {"criterion_text":"- Have tried and not responded well to at least one conventional CD medication (like oral such as corticosteroids or azathioprine) and also not respond well to advanced CD therapies (like biologics or JAK inhibitors)."}
Exclusion criteria
- {"criterion_text":"- Have a current diagnosis of Ulcerative Colitis (UC), inflammatory bowel disease-unclassified (formerly known as indeterminate colitis), or primary sclerosing cholangitis."}
- {"criterion_text":"- Have more than 2 missing segments of the following 5 segments: terminal ileum, right colon, transverse colon, left colon, and rectum."}
- {"criterion_text":"- Have a stoma, ileoanal pouch, or ostomy."}
- {"criterion_text":"- Have a history of more than 3 small bowel resections, total resection of small bowel greater than 100 centimeters (cm), diagnosis of short bowel syndrome, or any intestinal or non-intestinal intra-abdominal surgery within 3 months of baseline."}
- {"criterion_text":"- Have Type 1 diabetes or Type 2 diabetes treated with insulin."}
- {"criterion_text":"- Have had severe low blood sugar or unawareness of low blood sugar in the past 6 months."}
- {"criterion_text":"- Have had more than 5% body weight change in the past 3 months."}
- {"criterion_text":"- Have a current or recent serious infection."}
Endpoints
Primary endpoints
- {"endpoint_text":"- Percentage of participants who simultaneously achieve clinical remission by Crohn’s Disease Activity Index (CDAI), endoscopic remission, and at least 10% weight reduction.","definition_or_measurement_approach":"Clinical remission measured by Crohn’s Disease Activity Index (CDAI); endoscopic remission assessed by endoscopy (SES‑CD scoring); weight change measured as percent change from baseline (endpoint requires ≥10% weight reduction)."}
Recruitment
- Digital Remote Recruitment
- Yes
- Planned Sample Size
- 128
- Recruitment Window Months
- 31
- Consent Approach
- Informed consent obtained from adult participants (no vulnerable/paediatric consent indicated). eConsent is used/available (IQVIA/ZoomHealth eConsent materials and eConsent submission letter present). Multiple language ICFs and subject information sheets are provided (examples observed: Greek, Italian, Polish, Bulgarian, English, French, Dutch, Czech, Spanish, Hungarian, German), and participant-facing guidance and privacy/security addenda are included.
Methods
- Digital advertising: search ads and digital ad copy/visuals (documents named 'Search Ads', 'Digital Ad Copy', 'Digital Ad Visuals') targeting potential participants online (country-specific masters present e.g., _ITA, _PL, _HU).
- Social media campaigns: social media video assets (documents 'Social Media Video 1/2') for patient-facing recruitment.
- Printed materials and local site outreach: posters and brochures (K2 Recruitment material Poster / Brochure) for clinic/site-based recruitment.
- Physician referral: doctor referral letters (K2_Recruitment material_Letter Doctor Referral_Master_EN, country-specific referral letters) to engage clinicians to refer eligible patients.
- Exclusive database messaging and targeted patient messaging (documents 'Exclusive Database Messaging', 'Patient Messaging') to reach pre‑existing patient lists/databases.
- Patient landing pages and patient-facing materials (patient landing page documents) to funnel interested participants to study screening.
- eConsent and remote/teleconsent platforms (e.g., IQVIA eConsent materials, ZoomHealth screenshots and Terms of Service) to enable remote consent and participant-facing screenshots and guides.
- Country-specific tailored recruitment packs: country/language-specific masters and localized materials (e.g., _ITA, _PL, _GR, _HU versions).
Geography
- Total Number Of Sites
- 101
- Total Number Of Participants
- 171
Greece
- Earliest CTIS Part Ii Submission Date
- 29-07-2025
- Latest Decision Or Authorization Date
- 09-03-2026
- Processing Time Days
- 223
- Number Of Sites
- 5
- Number Of Participants
- 13
Sites
- Site Name
- University General Hospital Of Heraklion
- Department Name
- Department of Gastroenterology
- Contact Person Name
- Ioannis Koutroubakis
- Contact Person Email
- ikoutroubakis@gmail.com
- Site Name
- Thoracic General Hospital Of Athens I Sotiria
- Department Name
- 3rd Internal Medicine Clinic, Gastroenterology Unit
- Contact Person Name
- Georgios Bamias
- Contact Person Email
- gbamias@gmail.com
- Site Name
- Evangelismos S.A.
- Department Name
- Department of Gastroenterology
- Contact Person Name
- Nikolaos Viazis
- Contact Person Email
- nikos.viazis@gmail.com
- Site Name
- Ippokratio General Hospital Of Thessaloniki
- Department Name
- 2nd Propaedeutic Internal Medicine Clinic, Department of Gastroenterology
- Contact Person Name
- Olga Giouleme
- Contact Person Email
- giouleme@auth.gr
- Site Name
- University General Hospital Of Ioannina
- Department Name
- Internal Medicine Sector, Gastroenterology Department
- Contact Person Name
- Konstantinos Katsanos
- Contact Person Email
- khkostas@hotmail.com
Italy
- Earliest CTIS Part Ii Submission Date
- 24-07-2025
- Latest Decision Or Authorization Date
- 31-03-2026
- Processing Time Days
- 250
- Number Of Sites
- 10
- Number Of Participants
- 12
Sites
- Site Name
- Azienda Ospedaliero Universitaria Pisana
- Department Name
- UO Gastroenterologia
- Contact Person Name
- Francesco Costa
- Contact Person Email
- fcosta@med.unipi.it
- Site Name
- Azienda Ospediera Ospedali Riuniti Villa Sofia Cervello
- Department Name
- U.O.S.D. Malattie Infiammatorie Croniche Intestinali (M.I.C.I)
- Contact Person Name
- Ambrogio Orlando
- Contact Person Email
- ambrogiorlando@gmail.com
- Site Name
- Ospedale San Raffaele S.r.l.
- Department Name
- Gastroenterology and Gastrointestinal Endoscopy
- Contact Person Name
- Silvio Danese
- Contact Person Email
- ibd.trials@hsr.it
- Site Name
- Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico
- Department Name
- Gastroenterology and Endoscopy Unit
- Contact Person Name
- Flavio Caprioli
- Contact Person Email
- flavio.caprioli@unimi.it
- Site Name
- Azienda Socio Sanitaria Territoriale Rhodense
- Department Name
- U.O.C. di Gastroenterologia ed Endoscopia Digestiva
- Contact Person Name
- Simone Saibeni
- Contact Person Email
- saibo@tiscali.it
- Site Name
- IRCCS Azienda Ospedaliero-Universitaria di Bologna - Policlinico di Sant'Orsola
- Department Name
- SSD Malattie Infiammatorie Croniche Intestinali
- Contact Person Name
- Fernando Rizzello
- Contact Person Email
- fernando.rizzello@unibo.it
- Site Name
- Universita Degli Studi Di Padova
- Department Name
- Surgery Oncology and Gastroenterology
- Contact Person Name
- Edoardo Savarino
- Contact Person Email
- edoardosavarino@gmail.com
- Site Name
- National Institute Of Gastroenterology Saverio De Bellis Research Hospital
- Department Name
- Gastroenterology
- Contact Person Name
- Mastronardi Mauro
- Contact Person Email
- mauro21mastronardi@gmail.com
- Site Name
- Policlinico universitario Agostino Gemelli IRCCS
- Department Name
- Dipartimento di Medicina Interna e Gastroenterologia
- Contact Person Name
- Franco Scaldaferri
- Contact Person Email
- franco.scaldaferri@policlinicogemelli.it
- Site Name
- IRCCS Humanitas Research Hospital
- Department Name
- IBD center
- Contact Person Name
- Alessandro Armuzzi
- Contact Person Email
- clinicaltrialsibd@humanitas.it
Poland
- Earliest CTIS Part Ii Submission Date
- 12-08-2025
- Latest Decision Or Authorization Date
- 07-03-2026
- Processing Time Days
- 207
- Number Of Sites
- 12
- Number Of Participants
- 23
Sites
- Site Name
- Medrise Sp. z o.o.
- Contact Person Name
- Wit Danilkiewicz
- Contact Person Email
- wit.danilkiewicz@medrise.pl
- Site Name
- Korczowski Bartosz, Gabinet Lekarski
- Contact Person Name
- Bartosz Korczowski
- Contact Person Email
- korczowski@op.pl
- Site Name
- Irmed Klimkiewicz Rudziewicz-Kowalska sp. j.
- Contact Person Name
- Katarzyna Ostrowska
- Contact Person Email
- gastrolog1@ir-med.pl
- Site Name
- Uniwersyteckie Centrum Stomatologii I Medycyny Specjalistycznej Sp. z o.o.
- Contact Person Name
- Piotr Eder
- Contact Person Email
- piotreder@ump.edu.pl
- Site Name
- Twoja Przychodnia Szczecinskie Centrum Medyczne Sp. z o.o.
- Contact Person Name
- Beata Gawdis-Wojnarska
- Contact Person Email
- gawdis@twojaprzychodnia.com
- Site Name
- Twoja Przychodnia Poznanskie Centrum Medyczne Sp. z o.o.
- Contact Person Name
- Ewa Furmanowska-Ladorska
- Contact Person Email
- furmanowska@twojaprzychodnia.com
- Site Name
- Gyncentrum Sp. z o.o.
- Contact Person Name
- Alina Kuryłowicz
- Contact Person Email
- a.kurylowicz@holsaclinical.com
- Site Name
- Medical Network Sp. z o.o.
- Contact Person Name
- Jarosław Kierkuś
- Contact Person Email
- j.kierkus@med-net.pl
- Site Name
- Vivamed Sp. z o.o.
- Contact Person Name
- Robert Petryka
- Contact Person Email
- robert@petrykamed.com
- Site Name
- Etg Zamosc Sp. z o.o.
- Contact Person Name
- Katarzyna Wójcik
- Contact Person Email
- k.wojcik@etg-network.com
- Site Name
- Twoja Przychodnia Opolskie Centrum Medyczne
- Contact Person Name
- Agata Lukawska
- Contact Person Email
- alukawska@opolemed.com
- Site Name
- Melita Medical Sp. z o.o.
- Contact Person Name
- Janusz Leszczyszyn
- Contact Person Email
- j.leszczyszyn@melitamedical.pl
Hungary
- Earliest CTIS Part Ii Submission Date
- 07-07-2025
- Latest Decision Or Authorization Date
- 27-03-2026
- Processing Time Days
- 263
- Number Of Sites
- 4
- Number Of Participants
- 7
Sites
- Site Name
- Semmelweis Egyetem
- Department Name
- Belgyógyászati és Hematológiai Klinika
- Contact Person Name
- Zsolt Tulassay
- Contact Person Email
- tulassay.zsolt@semmelweis.hu
- Site Name
- Semmelweis University
- Department Name
- Sebészeti, Transzplantációs és Gasztroenterológiai Klinika
- Contact Person Name
- Pal Miheller
- Contact Person Email
- pmiheller@gmail.com
- Site Name
- University Of Szeged
- Department Name
- Szent-Györgyi Albert Klinikai Központ, Belgyógyászati Klinika
- Contact Person Name
- Tamas Molnar
- Contact Person Email
- molnar.tamas@med.u-szeged.hu
- Site Name
- Clinfan Kft.
- Department Name
- Gasztroenterológiai Rendelő
- Contact Person Name
- Agnes Salamon
- Contact Person Email
- salamonagidr@gmail.com
Bulgaria
- Earliest CTIS Part Ii Submission Date
- 20-08-2025
- Latest Decision Or Authorization Date
- 06-04-2026
- Processing Time Days
- 229
- Number Of Sites
- 3
- Number Of Participants
- 3
Sites
- Site Name
- Uniteversity Muliprofile Hospital For Active Treatment Tsaritsa Yoanna-Isul EAD
- Department Name
- Gastroenterology
- Contact Person Name
- Plamen Ivanov Penchev
- Contact Person Email
- penchev.dr@gmail.com
- Site Name
- Multiprofile Hospital For Active Treatment Knyaginya Klementina Sofia EAD
- Department Name
- Gastroenterology
- Contact Person Name
- Nikolay Tsonev
- Contact Person Email
- dr.n.tsonev@abv.bg
- Site Name
- Multiprofile Hospital For Active Treatment St. Ivan Rilski Gorna Oriahovitsa EOOD
- Department Name
- First Internal Department
- Contact Person Name
- Ilko Kosturkov
- Contact Person Email
- ikosturkov@mcmedicaplus.com
Netherlands
- Earliest CTIS Part Ii Submission Date
- 13-08-2025
- Latest Decision Or Authorization Date
- 02-03-2026
- Processing Time Days
- 201
- Number Of Sites
- 5
- Number Of Participants
- 9
Sites
- Site Name
- Radboud universitair medisch centrum Stichting
- Department Name
- Gasteroenterology
- Contact Person Name
- Marjolijn Duijvestein
- Contact Person Email
- Marjolijn.Duijvestein@radboudumc.nl
- Site Name
- Amsterdam UMC
- Department Name
- IBD trial Unit
- Contact Person Name
- Mark Lowenberg
- Contact Person Email
- m.lowenberg@amsterdamumc.nl
- Site Name
- Erasmus Universitair Medisch Centrum Rotterdam (Erasmus MC)
- Department Name
- Gastroenterology and Hepatology
- Contact Person Name
- Annemarie de Vries
- Contact Person Email
- a.c.devries@erasmusmc.nl
- Site Name
- Ikazia Ziekenhuis
- Department Name
- Gastroenterology - Hepatology
- Contact Person Name
- Geert Bezemer
- Contact Person Email
- g.bezemer@ikazia.nl
- Site Name
- Universitair Medisch Centrum Utrecht
- Department Name
- Gastroenterology
- Contact Person Name
- Herma Fidder
- Contact Person Email
- h.h.fidder@umcutrecht.nl
Belgium
- Earliest CTIS Part Ii Submission Date
- 30-07-2025
- Latest Decision Or Authorization Date
- 20-03-2026
- Processing Time Days
- 233
- Number Of Sites
- 7
- Number Of Participants
- 7
Sites
- Site Name
- Centre hospitalier universitaire de Liege
- Department Name
- Gastroenterology Department
- Contact Person Name
- Edouard Louis
- Contact Person Email
- edouard.louis@uliege.be
- Site Name
- CHC MontLegia
- Department Name
- Gastroenterology
- Contact Person Name
- Arnaud Colard
- Contact Person Email
- arnaud.colard@chc.be
- Site Name
- Hopital Erasme
- Department Name
- Clinical Research - Gastroenterology Department
- Contact Person Name
- Denis Franchimont
- Contact Person Email
- denis.franchimont@erasme.ulb.ac.be
- Site Name
- CHC Azorg
- Department Name
- Gastroenterology
- Contact Person Name
- Stijn Vanden Branden
- Contact Person Email
- stijn.vanden.branden@olvz-aalst.be
- Site Name
- Algemeen Ziekenhuis Groeninge
- Department Name
- gastroenterology
- Contact Person Name
- Wouter Van Moerkercke
- Contact Person Email
- wouter.vanmoerkercke@azgroeninge.be
- Site Name
- UZ Leuven
- Department Name
- Gastroenterology - Inflammatory Bowel Disease
- Contact Person Name
- João Guedelha Sabino
- Contact Person Email
- joao.sabino@uzleuven.be
- Site Name
- Centre hospitalier universitaire de Liege (second site listed)
- Department Name
- Gastroenterology
France
- Earliest CTIS Part Ii Submission Date
- 01-08-2025
- Latest Decision Or Authorization Date
- 03-03-2026
- Processing Time Days
- 214
- Number Of Sites
- 11
- Number Of Participants
- 19
Sites
- Site Name
- Centre Hospitalier Universitaire De Montpellier
- Department Name
- HGEA
- Contact Person Name
- Anne Bozon
- Contact Person Email
- aan-bozon@chu-montpellier.fr
- Site Name
- Centre Medico Chirurgical Ambroise Pare Hartmann
- Department Name
- Institut des MICI
- Contact Person Name
- Xavier Treton
- Contact Person Email
- xavier.treton@institutdesmici.fr
- Site Name
- Centre Hospitalier Universitaire Rouen
- Department Name
- Gastroentérologie
- Contact Person Name
- Nicolas Richard
- Contact Person Email
- nicolas.richard@chu-rouen.fr
- Site Name
- Centre Hospitalier Departemental Vendee
- Department Name
- Gastroenterology
- Contact Person Name
- Astrid De Maissin
- Contact Person Email
- astrid.demaissin@ght85.fr
- Site Name
- Centre Hospitalier Universitaire De Toulouse
- Department Name
- GASTROENTEROLOGY
- Contact Person Name
- Cyrielle Gilletta
- Contact Person Email
- gilletta.c@chu-toulouse.fr
- Site Name
- Clinique Des Cedres.
- Department Name
- MICI Institut Privé
- Contact Person Name
- Nicolas Mathieu
- Contact Person Email
- nicolas.mathieu@miciinstitutprive.com
- Site Name
- Centre Hospitalier Universitaire De Saint Etienne
- Department Name
- Service Gastro entérologie
- Contact Person Name
- Mathilde Barrau
- Contact Person Email
- mathilde.barrau@chu-st-etienne.fr
- Site Name
- Centre Hospitalier Universitaire De Nice
- Department Name
- Unité de recherche clinique gastroentérologie et nutrition clinique
- Contact Person Name
- Stephane Schneider
- Contact Person Email
- schneider.s@chu-nice.fr
- Site Name
- Hopital Saint Antoine
- Department Name
- Gastroenterologie et nutrition
- Contact Person Name
- Julien Kirchgesner
- Contact Person Email
- julien.kirchgesner@aphp.fr
- Site Name
- Clinique Pasteur
- Department Name
- Gastro-hepato-entérologie
- Contact Person Name
- Patrick Faure
- Contact Person Email
- pfaure@clinique-pasteur.com
- Site Name
- Bicetre Hospital
- Department Name
- Hépato-gastroentérologie
- Contact Person Name
- Aurelien Amiot
- Contact Person Email
- aurelien.amiot@aphp.fr
Spain
- Earliest CTIS Part Ii Submission Date
- 07-07-2025
- Latest Decision Or Authorization Date
- 04-03-2026
- Processing Time Days
- 240
- Number Of Sites
- 11
- Number Of Participants
- 15
Sites
- Site Name
- Hospital General Universitario Gregorio Maranon
- Department Name
- Digestive
- Contact Person Name
- Ignacio Marin Jimenez
- Contact Person Email
- ignacio.marin@salud.madrid.org
- Site Name
- Hospital Universitario Virgen De La Macarena
- Department Name
- Gastroenterology
- Contact Person Name
- Federico Argüelles-Arias
- Contact Person Email
- farguelles@telefonica.net
- Site Name
- Area Sanitaria De Ferrol
- Department Name
- GASTROENTEROLOGY DEPARTMENT
- Contact Person Name
- Ana Echarri Piudo
- Contact Person Email
- ana.echarri.piudo@sergas.es
- Site Name
- Hospital Universitario De Navarra
- Department Name
- Digestive
- Contact Person Name
- Cristina Rodriguez Gutierrez
- Contact Person Email
- cristina.rodriguez.gutierrez@navarra.es
- Site Name
- Hospital Universitario Y Politecnico La Fe
- Department Name
- Enfermedad Inflamatoria Intestinal
- Contact Person Name
- Marisa Iborra Colomino
- Contact Person Email
- marisaiborra@hotmail.com
- Site Name
- Hospital Universitario Central De Asturias
- Department Name
- Digestive
- Contact Person Name
- Ruth De Francisco
- Contact Person Email
- ruthdefrancisco@hotmail.com
- Site Name
- Hospital De Galdakao Usansolo
- Department Name
- Digestive
- Contact Person Name
- Iago Rodríguez-Lago
- Contact Person Email
- iago.r.lago@gmail.com
- Site Name
- Hospital Universitario La Paz
- Department Name
- Unidad de Enfermedad Inflamatoria Intestinal
- Contact Person Name
- Maria Dolores Martin Arranz
- Contact Person Email
- martinarranz.lapaz@gmail.com
- Site Name
- Centro Medico Teknon-Grupo Quironsalud
- Department Name
- Gastroenterology
- Contact Person Name
- Miquel Sans Cuffi
- Contact Person Email
- miquelsanscuffi@gmail.com
- Site Name
- Hospital Universitari Vall D Hebron
- Department Name
- Crohn's and Colitis Attention Unit
- Contact Person Name
- Natalia Borruel
- Contact Person Email
- natalia.borruel@vallhebron.cat
- Site Name
- Hospital Universitario De Cabuenes
- Department Name
- Digestive
- Contact Person Name
- Pilar Varela Trastoy
- Contact Person Email
- trastoy@hotmail.com
Austria
- Earliest CTIS Part Ii Submission Date
- 30-07-2025
- Latest Decision Or Authorization Date
- 09-03-2026
- Processing Time Days
- 222
- Number Of Sites
- 3
- Number Of Participants
- 5
Sites
- Site Name
- Medical University Of Vienna
- Department Name
- Department of Internal Medicine III, Division of Gastroenterology and Hepatology
- Contact Person Name
- Walter Reinisch
- Contact Person Email
- Walter.Reinisch@meduniwien.ac.at
- Site Name
- Medical University Of Graz
- Department Name
- Department of Internal Medicine, Division of Gastroenterology and Hepatology
- Contact Person Name
- Christoph Hoegenauer
- Contact Person Email
- christoph.hoegenauer@medunigraz.at
- Site Name
- Medizinische Universitaet Innsbruck
- Department Name
- Internal Medicine 1
- Contact Person Name
- Robert Koch
- Contact Person Email
- robert.koch@i-med.ac.at
Romania
- Earliest CTIS Part Ii Submission Date
- 12-06-2025
- Latest Decision Or Authorization Date
- 05-03-2026
- Processing Time Days
- 266
- Number Of Sites
- 7
- Number Of Participants
- 6
Sites
- Site Name
- Spitalul Clinic Judetean De Urgenta Sfantul Apostol Andrei Constanta
- Department Name
- Gastroenterology
- Contact Person Name
- Eugen Dumitru
- Contact Person Email
- eugen.dumitru@yahoo.com
- Site Name
- Centrul De Gastroenterologie Dr. Goldis S.R.L.
- Department Name
- Gastroenterology
- Contact Person Name
- Adrian Eugen Goldis
- Contact Person Email
- goldisadi@yahoo.com
- Site Name
- Spitalul Clinic Colentina Bucuresti
- Department Name
- Gastroenterology
- Contact Person Name
- Radu Bogdan Mateescu
- Contact Person Email
- bogmateescu@gmail.com
- Site Name
- Spitalul Universitar De Urgenta Bucuresti
- Department Name
- Gastroenterology
- Contact Person Name
- Lucian Negreanu
- Contact Person Email
- negreanu_99@yahoo.com
- Site Name
- Spitalul Clinic Judetean De Urgenta Craiova
- Department Name
- Gastroenterology
- Contact Person Name
- Dan Ionut Gheonea
- Contact Person Email
- digheonea@gmail.com
- Site Name
- Spitalul Judetean De Urgenta Bacau
- Department Name
- Gastroenterology
- Contact Person Name
- Elena Luminita Popovici
- Contact Person Email
- elenaluminitapopovici@yahoo.com
- Site Name
- Spitalul Clinic Judetean De Urgenta Craiova (duplicate listing context)
- Department Name
- Gastroenterology
Slovakia
- Earliest CTIS Part Ii Submission Date
- 31-07-2025
- Latest Decision Or Authorization Date
- 03-03-2026
- Processing Time Days
- 215
- Number Of Sites
- 4
- Number Of Participants
- 10
Sites
- Site Name
- Cliniq s.r.o.
- Contact Person Name
- Tibor Hlavaty
- Contact Person Email
- hlavaty.studie@cliniq.sk
- Site Name
- F D Roosevelt University General Hospital Of Banska Bystrica
- Department Name
- Gastroenterology
- Contact Person Name
- Jozef Balaz
- Contact Person Email
- balaz78@gmail.com
- Site Name
- Gastro LM s.r.o.
- Contact Person Name
- Lubomir Mihalkanin
- Contact Person Email
- mihalkanin@gmail.com
- Site Name
- Endomed s.r.o.
- Contact Person Name
- Miroslav Fedurco
- Contact Person Email
- fedurco@endomed.sk
Germany
- Earliest CTIS Part Ii Submission Date
- 08-08-2025
- Latest Decision Or Authorization Date
- 07-04-2026
- Processing Time Days
- 242
- Number Of Sites
- 6
- Number Of Participants
- 13
Sites
- Site Name
- Praxiszentrum für Gastroenterologie und Endoskopie
- Contact Person Name
- Axel Naumann
- Contact Person Email
- naumann.axel@t-online.de
- Site Name
- Klinikum Ernst von Bergmann gGmbH
- Department Name
- Department of Gastroenterology, Hepatology, Infectious Diseases and Rheumatology
- Contact Person Name
- Daniel Baumgart
- Contact Person Email
- daniel.baumgart@uni-potsdam.de
- Site Name
- Studiengesellschaft BSF UG (haftungsbeschraenkt)
- Contact Person Name
- Lars Fechner
- Contact Person Email
- dr.fechner@gastro-halle.de
- Site Name
- Medizinische Hochschule Hannover
- Department Name
- Klinik für Gastroenterologie, Endokrinologie und Hepatologie - CED Ambulanz
- Contact Person Name
- Ursula Seidler
- Contact Person Email
- seidler.ursula@mh-hannover.de
- Site Name
- Universitaetsklinikum Frankfurt AöR
- Contact Person Name
- Irina Blumenstein
- Contact Person Email
- irina.blumenstein@unimedizin-ffm.de
- Site Name
- Eugastro GmbH
- Contact Person Name
- Ingolf Schiefke
- Contact Person Email
- ingolf.schiefke@eugastro.de
Czechia
- Earliest CTIS Part Ii Submission Date
- 23-07-2025
- Latest Decision Or Authorization Date
- 07-04-2026
- Processing Time Days
- 258
- Number Of Sites
- 7
- Number Of Participants
- 18
Sites
- Site Name
- Gastroenterologie s.r.o.
- Contact Person Name
- Milan Široký
- Contact Person Email
- m.sirokydr@gmail.com
- Site Name
- EndoArt s.r.o.
- Contact Person Name
- Radka Košková
- Contact Person Email
- mudr.koskova@seznam.cz
- Site Name
- Iscare a.s.
- Department Name
- Klinické a výzkumné centrum pro střevní záněty
- Contact Person Name
- Milan Lukáš
- Contact Person Email
- studie.lukas@email.cz
- Site Name
- SurGal Clinic s.r.o.
- Contact Person Name
- Jan Ulbrych
- Contact Person Email
- ulbrych.jan@surgalclinic.cz
- Site Name
- Krajska zdravotni a.s.
- Department Name
- Oddělení gastroenterologie
- Contact Person Name
- Michal Tichý
- Contact Person Email
- michal.tichy@kzcr.eu
- Site Name
- ResTrial GastroEndo s.r.o.
- Department Name
- Gastroenterologie
- Contact Person Name
- Luděk Hrdlička
- Contact Person Email
- ludek.hrdlicka@restrial.com
- Site Name
- Additional Czech participating site (listed)
Denmark
- Earliest CTIS Part Ii Submission Date
- 19-08-2025
- Latest Decision Or Authorization Date
- 08-05-2026
- Processing Time Days
- 262
- Number Of Sites
- 6
- Number Of Participants
- 11
Sites
- Site Name
- Aalborg University Hospital
- Department Name
- Department of Medical Gastroenterology
- Contact Person Name
- Jan Fallingborg
- Contact Person Email
- jaf@rn.dk
- Site Name
- Rigshospitalet
- Department Name
- Department of Digestive Diseases, Transplantation and General Surgery
- Contact Person Name
- Anja Poulsen
- Contact Person Email
- anja.poulsen@regionh.dk
- Site Name
- Odense University Hospital
- Department Name
- Department of Medical Gastroenterology
- Contact Person Name
- Jens Kjeldsen
- Contact Person Email
- jens.kjeldsen@rsyd.dk
- Site Name
- Herlev Hospital
- Department Name
- Department of Gastroenterology and Hepatology
- Contact Person Name
- Jakob Wium Bjerrum
- Contact Person Email
- Jacob.Wium.Bjerrum@regionh.dk
- Site Name
- Aarhus University Hospital
- Department Name
- Department of Hepatology and Gastroenterology
- Contact Person Name
- Anders Kirch Dige
- Contact Person Email
- andedige@rm.dk
- Site Name
- Lillebaelt Hospital
- Department Name
- Department of Internal Medicine, Section of Gastroenterology
- Contact Person Name
- Maiken Thyregod Jørgensen
- Contact Person Email
- maiken.t.joergensen@rsyd.dk
Sponsor
Primary sponsor
- Full Name
- Eli Lilly & Co.
- Organisation Type
- Pharmaceutical company
- Country Of Registered Address
- United States
Contract research organisations
- Name
- WCG Clinical Inc.
- Responsibilities
- Study Development/Conduct_Study Training
- Name
- Icon Development Solutions LLC
- Responsibilities
- Study development/conduct responsibilities (operational/CRO support)
- Name
- Iqvia Rds Inc.
- Responsibilities
- Clinical operations support / data services
- Name
- Bioclinica Inc.
- Responsibilities
- Operational support / data services
Third parties
- {"country":"United States","full_name":"The Hibbert Co.","duties_or_roles":"Distribution of Recruitment and Retention items to clinical research sites globally. Including serving as Importer of Record on Lilly's behalf.","organisation_type":"Non-Pharmaceutical company"}
- {"country":"United States","full_name":"Greenphire LLC","duties_or_roles":"Study Development/Conduct _Patient Reimbursement and Travel Services","organisation_type":"Non-Pharmaceutical company"}
- {"country":"United States","full_name":"WCG Clinical Inc.","duties_or_roles":"Study Development/Conduct_Study Training","organisation_type":"Industry"}
- {"country":"United States","full_name":"Tier 1 Impact Pbc Inc.","duties_or_roles":"Study Development/Conduct_Study Training","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Cleveland Clinic Foundation","duties_or_roles":"Study Development/conduct_Adjudication","organisation_type":"Hospital/Clinic/Other health care facility"}
- {"country":"United States","full_name":"Icon Development Solutions LLC","duties_or_roles":"Sponsor duty code: 4 (role detail not provided in summary)","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Professional Case Management Clinical Trials LLC","duties_or_roles":"Study Development/Conduct_Patient Monitoring","organisation_type":"Laboratory/Research/Testing facility"}
- {"country":"United States","full_name":"RWS Life Sciences Inc.","duties_or_roles":"Study Development/Conduct_Standard Translations","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"RWS Life Sciences Inc. (duplicate entry)","duties_or_roles":"Data Management_Linguistically Validated Translations","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Iterative Health, Inc","duties_or_roles":"Study Development/Conduct_Patient Screening Recruitment and/or Retention","organisation_type":"Health care"}
- {"country":"United States","full_name":"Iqvia Rds Inc.","duties_or_roles":"Sponsor duty code: 6 (role detail not provided in summary) / Study Development/Conduct support in other entries","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Clinical Trial Media Inc.","duties_or_roles":"Study Development/Conduct_ Patient Screening Recruitment and/or Retention","organisation_type":"Pharmaceutical company"}
- {"country":"Greece","full_name":"Pharmaserve Lilly S.A.C.I.","duties_or_roles":"Negotiation and Execution of Clinical Trial Agreements with the participating sites, make study payments based on invoices; other sponsor responsibilities (codes 1,12,15,2,5 listed).","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Bioagilytix Labs LLC","duties_or_roles":"Study Development/Conduct_Adjudication (code 4)","organisation_type":"Pharmaceutical company"}
- {"country":"Switzerland","full_name":"Lionbridge AG","duties_or_roles":"Translation of PE materials","organisation_type":"Health care (translation vendor)"}
- {"country":"United States","full_name":"Bioclinica Inc.","duties_or_roles":"Study Development/Conduct_ (code 4 - training or operational support)","organisation_type":"Laboratory/Research/Testing facility"}
- {"country":"Canada","full_name":"Alimentiv Inc.","duties_or_roles":"Study Development/Conduct_ (code 4)","organisation_type":"Pharmaceutical company"}
- {"country":"Switzerland","full_name":"Labcorp Central Laboratory Services Sàrl","duties_or_roles":"Study Development/Conduct_ (code 4)","organisation_type":"Health care"}
- {"country":"United States","full_name":"Veeva Systems Inc.","duties_or_roles":"Data management / CDMS support (code 6)","organisation_type":"Non-Pharmaceutical company"}
- {"country":"United States/Canada/Switzerland/Greece","full_name":"Professional vendor and laboratories (additional listed third parties)","duties_or_roles":"Multiple roles including translations, patient reimbursement/travel services, study training, adjudication, patient monitoring, data management and translations as listed in sponsor third-party duties.","organisation_type":"Various (industry, health care, laboratory, translation)"}
Investigational products
- Investigational Product Name
- Mirikizumab
- Active Substance
- Mirikizumab
- Modality
- Monoclonal antibody
- Routes Of Administration
- Intravenous administration | Subcutaneous use
- Route
- Intravenous / Subcutaneous
- Authorisation Status
- Authorised (prodAuthStatus: 1 indicated in product dictionary)
- Maximum Dose
- 900 mg (maxDailyDoseAmount listed as 900 mg in product record)
- Investigational Product Name
- Tirzepatide
- Active Substance
- Tirzepatide
- Modality
- Peptide/protein/enzyme
- Routes Of Administration
- Subcutaneous use
- Route
- Subcutaneous
- Authorisation Status
- Authorised (prodAuthStatus: 1 indicated in product dictionary)
- Maximum Dose
- 15 mg (maxDailyDoseAmount listed as 15 mg, trial objective references MTD up to 15 mg)
- Investigational Product Name
- to match Tirzepatide (placebo)
- Modality
- Other
- Combination Treatment
- Yes
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