Clinical trial • Phase III • Gastroenterology
Filgotinib for Ulcerative colitis
Phase III trial of Filgotinib for Ulcerative colitis. open-label. 20 participants.
Overview
- Trial Therapeutic Area
- Gastroenterology
- Trial Disease
- Ulcerative colitis
- Trial Stage
- Phase III
- Drug Modality
- Small molecule
- Paediatric Trial
- Yes
Key dates
- Initial CTIS Submission Date
- 17-07-2024
- First CTIS Authorization Date
- 11-11-2024
Trial design
open-label Phase III trial in Ireland, Belgium, Romania and others.
- Open Label
- Yes
- Target Sample Size
- 20
- Trial Duration For Participant
- 434
Eligibility
Recruits 20 paediatric patients.
- Pregnancy Exclusion
- Female subject is pregnant or breast feeding or intending to become pregnant or breastfeed during the study.
- Vulnerable Population
- Paediatric participants (age 8 to <18 years) are included. Parental/guardian informed consent is required and age-appropriate assent is used: assent forms for non-readers, early readers, and young adult readers are provided, as well as parental ICFs. There are dedicated adolescent pregnancy assent/ICF documents and guidance for participants turning 18. eConsent materials (videos, participation invitation emails, on-screen text and security/data custody information) are available to support consent/assent processes.
Inclusion criteria
- {"criterion_text":"- Subject must have a minimum BW of 15 kg\n- Subject: a.\thas documented diagnosis of UC with a minimum duration of 3 months, b.\thas mMCS of 5 to 9, and an MCS endoscopic score >=2, rectal bleeding >=1, and stool frequency >=1, c.\thas had an inadequate response, loss of response, intolerance, or has medical contraindications to corticosteroids, immunosuppressants, and/or biologic therapy. This includes subjects who depend on corticosteroids to control their symptoms and who experience worsening of their disease when attempting to wean off corticosteroids.\n- Female or male subjects from 8 to <18 years of age, on the date of signing the ICF."}
Exclusion criteria
- {"criterion_text":"- Subject has a diagnosis of inflammatory bowel disease (IBD)-unclassified or indeterminate colitis, isolated proctitis, or toxic megacolon\n- Subject has a history of colectomy or extensive small bowel resection.\n- Subject with psychological or cognitive difficulties that might interfere with study participation.\n- Subject has any previous exposure to a Janus kinase (JAK) inhibitor or medication with a similar mode of action (e.g. tofacitinib, baricitinib, upadacitinib).\n- Female subject is pregnant or breast feeding or intending to become pregnant or breastfeed during the study.\n- Subject has an active infection.\n- Subject with a history of complicated herpes zoster infection (with multi-dermatomal, disseminated, ophthalmic, or central nervous system involvement).\n- Currently on any therapy for chronic infection (such as pneumocystis, cytomegalovirus, herpes simplex, herpes zoster, or atypical mycobacteria)."}
Endpoints
Primary endpoints
- {"endpoint_text":"- Proportion of subjects achieving clinical remission based on modified Mayo Clinical Score (mMCS) at Week 10","definition_or_measurement_approach":"Clinical remission assessed by modified Mayo Clinical Score (mMCS) at Week 10."}
- {"endpoint_text":"- Proportion of subjects achieving clinical remission based on mMCS2 at Week 58","definition_or_measurement_approach":"Clinical remission assessed by mMCS2 at Week 58."}
Secondary endpoints
- {"endpoint_text":"- Incidence of treatment-emergent adverse events (TEAEs), adverse events of interest, and laboratory abnormalities through follow-up (Week 62)","definition_or_measurement_approach":"Incidence of TEAEs, specified adverse events of interest and lab abnormalities up to follow-up at Week 62."}
- {"endpoint_text":"- Change from baseline in body mass index (BMI) at Week 58","definition_or_measurement_approach":"Change from baseline BMI measured at Week 58."}
- {"endpoint_text":"- Change from baseline in height velocity at Week 58","definition_or_measurement_approach":"Change from baseline in height velocity measured at Week 58."}
- {"endpoint_text":"- Proportion of subjects achieving clinical remission defined by Pediatric Ulcerative Colitis Activity Index (PUCAI) <10 at Week 10","definition_or_measurement_approach":"Proportion meeting PUCAI <10 at Week 10."}
- {"endpoint_text":"- Proportion of subjects achieving clinical remission defined by PUCAI <10 at Week 58","definition_or_measurement_approach":"Proportion meeting PUCAI <10 at Week 58."}
- {"endpoint_text":"- Proportion of subjects achieving endoscopic remission defined by Mayo endoscopic subscore of 0 at Week 10","definition_or_measurement_approach":"Endoscopic remission defined by Mayo endoscopic subscore = 0 at Week 10."}
- {"endpoint_text":"- Proportion of subjects achieving endoscopic remission defined by Mayo endoscopic subscore of 0 at Week 58","definition_or_measurement_approach":"Endoscopic remission defined by Mayo endoscopic subscore = 0 at Week 58."}
- {"endpoint_text":"- Proportion of subjects achieving mMCS response defined as mMCS reduction by >=2 points and >=30% from induction baseline, with decrease in rectal bleeding subscore of >=1 or absolute rectal bleeding subscore of 0 or 1 at Week 10","definition_or_measurement_approach":"mMCS response defined as >=2 point and >=30% reduction from induction baseline plus rectal bleeding subscore decrease >=1 or absolute rectal bleeding subscore 0 or 1 at Week 10."}
- {"endpoint_text":"- Proportion of subjects achieving MCS response defined as mMCS reduction by >=2 points and >=30% from induction baseline, with decrease in rectal bleeding subscore of >=1 or absolute rectal bleeding subscore of 0 or 1 at Week 58","definition_or_measurement_approach":"mMCS response defined as >=2 point and >=30% reduction from induction baseline plus rectal bleeding subscore decrease >=1 or absolute rectal bleeding subscore 0 or 1 at Week 58."}
- {"endpoint_text":"- Proportion of subjects achieving 6-month corticosteroid-free mMCS remission at Week 58","definition_or_measurement_approach":"Proportion achieving mMCS remission without corticosteroids for 6 months at Week 58."}
- {"endpoint_text":"- Change from baseline in TUMMY-UC score at Week 10 and Week 58","definition_or_measurement_approach":"Change from baseline in TUMMY-UC patient-reported score at Weeks 10 and 58."}
- {"endpoint_text":"- Proportion of subjects with TUMMY-UC remission at Week 10 and Week 58","definition_or_measurement_approach":"Proportion meeting TUMMY-UC remission at Weeks 10 and 58."}
- {"endpoint_text":"- Change from baseline in IMPACT-III score at Week 10 and Week 58","definition_or_measurement_approach":"Change from baseline in IMPACT-III quality-of-life score at Weeks 10 and 58."}
- {"endpoint_text":"- PK parameters of filgotinib and its primary metabolite GS-829845 (including maximum observed plasma concentration at steady state [Cmax,ss], area under the plasma concentration-time curve over the dosing interval at steady state [AUC0-24,ss], and area under the plasma concentration-time curve over the dosing interval at steady state for the effective exposure [AUCeff,ss])","definition_or_measurement_approach":"Pharmacokinetic parameters for filgotinib and GS-829845 including Cmax,ss, AUC0-24,ss and AUCeff,ss."}
- {"endpoint_text":"- Acceptability of the age-appropriate pediatric film-coated tablet formulation assessed by Pediatric Oral Medicine Acceptability Questionnaire for Patients (POMAQ-P)","definition_or_measurement_approach":"Acceptability assessed using POMAQ-P for pediatric formulation."}
- {"endpoint_text":"- Acceptability of the adult tablet formulation assessed by POMAQ-P","definition_or_measurement_approach":"Acceptability assessed using POMAQ-P for adult tablet formulation."}
Recruitment
- Digital Remote Recruitment
- Yes
- Planned Sample Size
- 68
- Recruitment Window Months
- 43
- Consent Approach
- Parental/guardian informed consent is required for paediatric participants; age-appropriate assent documents are used (assent for non-readers, early readers, young adult readers). Dedicated parental ICFs and adolescent/participant-facing information sheets are provided. eConsent is supported (custom videos, invite/update emails, product description and security/data custody information). Specific materials are provided for adolescent pregnancy and for participants turning 18. Documents are available in multiple languages across country-specific submissions.
Methods
- Recruitment materials for patients/adolescents: Adolescent Brochure, Parent/Guardian Brochure, Patient Poster (site-facing recruitment materials) to be distributed at sites and to families.
- Clinician channel: 'Dr to Parent-Guardian' letters provided for investigators/clinicians to invite eligible patients.
- Digital/eConsent channel: eConsent participation invitation emails, custom eConsent videos, trial introduction videos and on-screen eConsent materials to invite and consent participants remotely.
- Site materials and supportive guides: Participant ID cards, study guides, parent study guides, visit reminder cards and study medication instruction cards available for sites to support retention and recruitment.
Geography
- Total Number Of Sites
- 43
- Total Number Of Participants
- 68
Ireland
- Earliest CTIS Part Ii Submission Date
- 24-10-2024
- Latest Decision Or Authorization Date
- 03-11-2025
- Processing Time Days
- 375
- Number Of Sites
- 1
- Number Of Participants
- 1
Sites
- Site Name
- Children's Health Ireland
- Department Name
- Paediatric Gastroenterolgy
- Principal Investigator Name
- Seamus Hussey
- Principal Investigator Email
- seamus.hussey@olchc.ie
- Contact Person Name
- Seamus Hussey
- Contact Person Email
- seamus.hussey@olchc.ie
Belgium
- Earliest CTIS Part Ii Submission Date
- 24-10-2024
- Latest Decision Or Authorization Date
- 03-11-2025
- Processing Time Days
- 375
- Number Of Sites
- 3
- Number Of Participants
- 3
Sites
- Site Name
- Association Hospitaliere De Bruxelles Hopital Universitaire Des Enfants Reine Fabiola
- Department Name
- gastroenterology
- Principal Investigator Name
- Patrick Bontems
- Principal Investigator Email
- patrick.bontems@huderf.be
- Contact Person Name
- Patrick Bontems
- Contact Person Email
- patrick.bontems@huderf.be
- Site Name
- Centre Hospitalier Regional De La Citadelle
- Department Name
- gastro-entérologie, hépatologie et nutrition pédiatrique
- Principal Investigator Name
- Marie Leonard
- Principal Investigator Email
- marie.leonard@citadelle.be
- Contact Person Name
- Marie Leonard
- Contact Person Email
- marie.leonard@citadelle.be
- Site Name
- Centre Hospitalier Universitaire Dinant Godinne Sainte-Elisabeth-UCL-Namur
- Department Name
- Pédiatrie générale, Gastro-entérologie pédiatrique
- Principal Investigator Name
- Sabine Jespers
- Principal Investigator Email
- sabine.jespers@chuuclnamur.uclouvain.be
- Contact Person Name
- Sabine Jespers
- Contact Person Email
- sabine.jespers@chuuclnamur.uclouvain.be
Romania
- Earliest CTIS Part Ii Submission Date
- 05-08-2024
- Latest Decision Or Authorization Date
- 10-11-2025
- Processing Time Days
- 462
- Number Of Sites
- 2
- Number Of Participants
- 3
Sites
- Site Name
- Spitalul Clinic De Urgenta Pentru Copii Louis Turcanu Timisoara
- Department Name
- Pediatrie III
- Principal Investigator Name
- Oana Belei
- Principal Investigator Email
- oana22_99@yahoo.com
- Contact Person Name
- Oana Belei
- Contact Person Email
- oana22_99@yahoo.com
- Site Name
- Dr. Victor Gomoiu Clinical Children Hospital
- Department Name
- Pediatrie 2
- Principal Investigator Name
- Iulia Florentina Tincu
- Principal Investigator Email
- if_boian@yahoo.com
- Contact Person Name
- Iulia Florentina Tincu
- Contact Person Email
- if_boian@yahoo.com
Poland
- Earliest CTIS Part Ii Submission Date
- 29-10-2024
- Latest Decision Or Authorization Date
- 07-11-2025
- Processing Time Days
- 374
- Number Of Sites
- 5
- Number Of Participants
- 20
Sites
- Site Name
- Gabinet Lekarski Bartosz Korczowski
- Principal Investigator Name
- Bartosz Korczowski
- Principal Investigator Email
- korczowski@op.pl
- Contact Person Name
- Bartosz Korczowski
- Contact Person Email
- korczowski@op.pl
- Site Name
- Instytut Centrum Zdrowia Matki Polki
- Department Name
- Klinika Gastroenterologii, Alergologii i Pediatrii
- Principal Investigator Name
- Elżbieta Czkwianianc
- Principal Investigator Email
- elzbieta.czkwianianc@iczmp.edu.pl
- Contact Person Name
- Elżbieta Czkwianianc
- Contact Person Email
- elzbieta.czkwianianc@iczmp.edu.pl
- Site Name
- In Vivo Sp. z o.o.
- Principal Investigator Name
- Piotr Korbal
- Principal Investigator Email
- kontakt@in-vivo.pl
- Contact Person Name
- Piotr Korbal
- Contact Person Email
- kontakt@in-vivo.pl
- Site Name
- Copernicus Podmiot Leczniczy Sp. z o.o.
- Department Name
- Szpital im. M. Kopernika, Kliniczny Oddział Gastroenterologii, Alergologii i Żywienia Dzieci GUMed
- Principal Investigator Name
- Michał Brzeziński
- Principal Investigator Email
- mbrzezinski@copernicus.gda.pl
- Contact Person Name
- Michał Brzeziński
- Contact Person Email
- mbrzezinski@copernicus.gda.pl
- Site Name
- Instytut Pomnik Centrum Zdrowia Dziecka
- Department Name
- Klinika Gastroenterologii, Hepatologii, Zaburzeń odżywiania i Pediatrii
- Principal Investigator Name
- Jarosław Kierkuś
- Principal Investigator Email
- j.kierkus@wip.waw.pl
- Contact Person Name
- Jarosław Kierkuś
- Contact Person Email
- j.kierkus@wip.waw.pl
Norway
- Earliest CTIS Part Ii Submission Date
- 25-10-2024
- Latest Decision Or Authorization Date
- 03-11-2025
- Processing Time Days
- 374
- Number Of Sites
- 2
- Number Of Participants
- 2
Sites
- Site Name
- Sykehuset I Vestfold HF
- Department Name
- Pediatric
- Principal Investigator Name
- Johannes Rolin
- Principal Investigator Email
- rolijo@siv.no
- Contact Person Name
- Johannes Rolin
- Contact Person Email
- rolijo@siv.no
- Site Name
- Oslo University Hospital HF
- Department Name
- Pediatric
- Principal Investigator Name
- Gori Perminow
- Principal Investigator Email
- goeper@ous-hf.no
- Contact Person Name
- Gori Perminow
- Contact Person Email
- goeper@ous-hf.no
Spain
- Earliest CTIS Part Ii Submission Date
- 25-10-2024
- Latest Decision Or Authorization Date
- 05-11-2025
- Processing Time Days
- 376
- Number Of Sites
- 2
- Number Of Participants
- 3
Sites
- Site Name
- Hospital Germans Trias I Pujol
- Department Name
- Pediatría
- Principal Investigator Name
- Alba Alcaraz Hurtado
- Principal Investigator Email
- aalcaraz.germanstrias@gencat.cat
- Contact Person Name
- Alba Alcaraz Hurtado
- Contact Person Email
- aalcaraz.germanstrias@gencat.cat
- Site Name
- Hospital Universitario Reina Sofia
- Department Name
- Pediatría
- Principal Investigator Name
- Rafael González de Caldas
- Principal Investigator Email
- rgonzalezdecaldasmarchal@gmail.com
- Contact Person Name
- Rafael González de Caldas
- Contact Person Email
- rgonzalezdecaldasmarchal@gmail.com
Germany
- Earliest CTIS Part Ii Submission Date
- 23-10-2024
- Latest Decision Or Authorization Date
- 04-11-2025
- Processing Time Days
- 377
- Number Of Sites
- 4
- Number Of Participants
- 7
Sites
- Site Name
- Universitaetsklinikum Tuebingen AöR
- Department Name
- Kinder- und Jugendmedizin, Abt. I
- Principal Investigator Name
- Johannes Hilberath
- Principal Investigator Email
- johannes.hilberath@med.uni-tuebingen.de
- Contact Person Name
- Johannes Hilberath
- Contact Person Email
- johannes.hilberath@med.uni-tuebingen.de
- Site Name
- Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz KöR
- Department Name
- Zentrum für Kinder- und Jugendmedizin
- Principal Investigator Name
- Stephan Gehring
- Principal Investigator Email
- stephan.gehring@uni-mainz.de
- Contact Person Name
- Stephan Gehring
- Contact Person Email
- stephan.gehring@uni-mainz.de
- Site Name
- Universitaetsklinikum Aachen AöR
- Department Name
- Klinik für Kinder- und Jugendmedizin
- Principal Investigator Name
- Tobias Wenzl
- Principal Investigator Email
- twenzl@ukaachen.de
- Contact Person Name
- Tobias Wenzl
- Contact Person Email
- twenzl@ukaachen.de
- Site Name
- Universitaetsklinikum Leipzig AöR
- Department Name
- Klinik und Poliklinik für Kinder- und Jugendmedizin
- Principal Investigator Name
- Gunter Flemming
- Principal Investigator Email
- gunter.flemming@medizin.uni-leipzig.de
- Contact Person Name
- Gunter Flemming
- Contact Person Email
- gunter.flemming@medizin.uni-leipzig.de
Croatia
- Earliest CTIS Part Ii Submission Date
- 25-10-2024
- Latest Decision Or Authorization Date
- 10-11-2025
- Processing Time Days
- 381
- Number Of Sites
- 3
- Number Of Participants
- 4
Sites
- Site Name
- Children's Hospital Zagreb
- Department Name
- Pediatric
- Principal Investigator Name
- Iva Hojsak
- Principal Investigator Email
- ivahojsak@gmail.com
- Contact Person Name
- Iva Hojsak
- Contact Person Email
- ivahojsak@gmail.com
- Site Name
- University Hospital Centre Zagreb
- Department Name
- Pediatric
- Principal Investigator Name
- Irena Senečić Čala
- Principal Investigator Email
- isenecic@yahoo.com
- Contact Person Name
- Irena Senečić Čala
- Contact Person Email
- isenecic@yahoo.com
- Site Name
- Klinicki Bolnicki Centar Osijek
- Department Name
- Pediatric
- Principal Investigator Name
- Vlatka Konjik
- Principal Investigator Email
- vlatkajurkovic@yahoo.com
- Contact Person Name
- Vlatka Konjik
- Contact Person Email
- vlatkajurkovic@yahoo.com
Portugal
- Earliest CTIS Part Ii Submission Date
- 23-10-2024
- Latest Decision Or Authorization Date
- 07-11-2025
- Processing Time Days
- 380
- Number Of Sites
- 3
- Number Of Participants
- 3
Sites
- Site Name
- Unidade Local De Saude De Coimbra E.P.E.
- Department Name
- Gastroenterology
- Principal Investigator Name
- Juliana Roda
- Principal Investigator Email
- juroda@ulscoimbra.min-saude.pt
- Contact Person Name
- Juliana Roda
- Contact Person Email
- juroda@ulscoimbra.min-saude.pt
- Site Name
- CCAB Centro Clinico Academico Braga Associacao
- Department Name
- Pediatric
- Principal Investigator Name
- Henedina Antunes
- Principal Investigator Email
- henedina.antunes@hb.min-saude.pt
- Contact Person Name
- Henedina Antunes
- Contact Person Email
- henedina.antunes@hb.min-saude.pt
- Site Name
- Unidade Local De Saude Do Alto Minho E.P.E.
- Department Name
- Gastroenterology
- Principal Investigator Name
- Isabel Martinho
- Principal Investigator Email
- isabel.martinho@ulsam.min-saude.pt
- Contact Person Name
- Isabel Martinho
- Contact Person Email
- isabel.martinho@ulsam.min-saude.pt
Italy
- Earliest CTIS Part Ii Submission Date
- 05-08-2024
- Latest Decision Or Authorization Date
- 06-02-2026
- Processing Time Days
- 550
- Number Of Sites
- 7
- Number Of Participants
- 10
Sites
- Site Name
- Azienda Ospedaliero-Universitaria Ss Antonio E Biagio E Cesare Arrigo
- Department Name
- Pediatric Unit
- Principal Investigator Name
- Enrico Felici
- Principal Investigator Email
- enrico.felici@ospedale.al.it
- Contact Person Name
- Enrico Felici
- Contact Person Email
- enrico.felici@ospedale.al.it
- Site Name
- ASST Fatebenefratelli Sacco
- Department Name
- Department of Paediatrics – Gastroenterology and Nutrition
- Principal Investigator Name
- Lorenzo Norsa
- Principal Investigator Email
- lorenzo.norsa@asst-fbf-sacco.it
- Contact Person Name
- Lorenzo Norsa
- Contact Person Email
- lorenzo.norsa@asst-fbf-sacco.it
- Site Name
- Azienda Ospedaliera Universitaria Federico II Di Napoli
- Department Name
- Department of Translation al Medical Science, Section of Pediatrics
- Principal Investigator Name
- Erasmo Miele
- Principal Investigator Email
- erasmo.miele@unina.it
- Contact Person Name
- Erasmo Miele
- Contact Person Email
- erasmo.miele@unina.it
- Site Name
- Ospedale Pediatrico Bambino Gesu
- Department Name
- Hepatogastroenterology and Nutrition
- Principal Investigator Name
- Daniela Knafelz
- Principal Investigator Email
- aniela.knafelz@opbg.net
- Contact Person Name
- Daniela Knafelz
- Contact Person Email
- aniela.knafelz@opbg.net
- Site Name
- Azienda Ospedaliero-Universitaria Policlinico Umberto I
- Department Name
- U.O.C. Pediatric Gastroenterology
- Principal Investigator Name
- Salvatore Oliva
- Principal Investigator Email
- salvatore.oliva@uniroma1.it
- Contact Person Name
- Salvatore Oliva
- Contact Person Email
- salvatore.oliva@uniroma1.it
- Site Name
- Istituto Di Ricovero E Cura A Carattere Scientifico Materno Infantile Burlo Garofolo
- Department Name
- Pediatric Digestive Endoscopy and Nutrition Unit
- Principal Investigator Name
- Matteo Bramuzzo
- Principal Investigator Email
- matteo.bramuzzo@burlo.trieste.it
- Contact Person Name
- Matteo Bramuzzo
- Contact Person Email
- matteo.bramuzzo@burlo.trieste.it
- Site Name
- Azienda Ospedaliero Universitaria Ospedali Riuniti Umberto I G M Lancisi G Salesi
- Department Name
- DISCO
- Principal Investigator Name
- Simona Gatti
- Principal Investigator Email
- s.gatti@staff.univpm.it
- Contact Person Name
- Simona Gatti
- Contact Person Email
- s.gatti@staff.univpm.it
France
- Earliest CTIS Part Ii Submission Date
- 05-08-2024
- Latest Decision Or Authorization Date
- 23-01-2026
- Processing Time Days
- 536
- Number Of Sites
- 7
- Number Of Participants
- 7
Sites
- Site Name
- Centre Hospitalier Universitaire De Rennes
- Department Name
- Service d'hépato-gastoentérologie et de nutrition pédiatrique
- Principal Investigator Name
- Laure Bridoux-Henno
- Principal Investigator Email
- laure.bridoux-henno@chu-rennes.fr
- Contact Person Name
- Laure Bridoux-Henno
- Contact Person Email
- laure.bridoux-henno@chu-rennes.fr
- Site Name
- Centre Hospitalier Regional Universitaire De Tours
- Department Name
- Service de pédiatrie
- Principal Investigator Name
- Stéphanie Willot
- Principal Investigator Email
- s.willot@chu-tours.fr
- Contact Person Name
- Stéphanie Willot
- Contact Person Email
- s.willot@chu-tours.fr
- Site Name
- Groupement Des Hopitaux De L'Institut Catholique De Lille
- Department Name
- Service de pédiatrie médicale et urgences pédiatriques
- Principal Investigator Name
- Ahlem Bouazza
- Principal Investigator Email
- bouazza.ahlem@ghicl.net
- Contact Person Name
- Ahlem Bouazza
- Contact Person Email
- bouazza.ahlem@ghicl.net
- Site Name
- CHU de Montpellier
- Department Name
- Service d'Hépatologie gastroentérologie et nutrition pédiatrique
- Principal Investigator Name
- Grégoire Lavaud
- Principal Investigator Email
- Gregoire.lavaud@chu-montpellier.fr
- Contact Person Name
- Grégoire Lavaud
- Contact Person Email
- Gregoire.lavaud@chu-montpellier.fr
- Site Name
- Centre Hospitalier Universitaire De Dijon
- Department Name
- Service de pédiatrie
- Principal Investigator Name
- Raphaëlle Maudinas
- Principal Investigator Email
- raphaelle.maudinas@chu-dijon.fr
- Contact Person Name
- Raphaëlle Maudinas
- Contact Person Email
- raphaelle.maudinas@chu-dijon.fr
- Site Name
- Hospital Femme Mere Enfant
- Department Name
- Service de gastroentérologie, hépatologie et nutrition pédiatriques
- Principal Investigator Name
- Remi Duclaux-Loras
- Principal Investigator Email
- remi.duclaux-loras@chu-lyon.fr
- Contact Person Name
- Remi Duclaux-Loras
- Contact Person Email
- remi.duclaux-loras@chu-lyon.fr
- Site Name
- Centre Hospitalier Universitaire De Rennes (additional listed site)
- Department Name
- Service d'hépato-gastoentérologie et de nutrition pédiatrique
- Principal Investigator Name
- Laure Bridoux-Henno
- Principal Investigator Email
- laure.bridoux-henno@chu-rennes.fr
- Contact Person Name
- Laure Bridoux-Henno
- Contact Person Email
- laure.bridoux-henno@chu-rennes.fr
Greece
- Earliest CTIS Part Ii Submission Date
- 05-08-2024
- Latest Decision Or Authorization Date
- 08-04-2026
- Processing Time Days
- 611
- Number Of Sites
- 4
- Number Of Participants
- 5
Sites
- Site Name
- Hippokration Hospital
- Department Name
- 3rd Pediatric Department
- Principal Investigator Name
- Ioannis Xinias
- Principal Investigator Email
- xinias@email.com
- Contact Person Name
- Ioannis Xinias
- Contact Person Email
- xinias@email.com
- Site Name
- Athens General Children's Hospital Panagioti And Aglaia Kyriakou
- Department Name
- Second Department Pediatrics
- Principal Investigator Name
- Ioanna Argyri
- Principal Investigator Email
- ioarg@yahoo.gr
- Contact Person Name
- Ioanna Argyri
- Contact Person Email
- ioarg@yahoo.gr
- Site Name
- General Hospital Of Thessaloniki Papageorgiou
- Department Name
- 4th Department of Pediatrics
- Principal Investigator Name
- Maria Fotoulaki
- Principal Investigator Email
- mfotoul@otenet.gr
- Contact Person Name
- Maria Fotoulaki
- Contact Person Email
- mfotoul@otenet.gr
- Site Name
- University General Hospital Attikon General Hospital Of West Attica H Agia Varvara
- Department Name
- 3rd Department of Pediatrics
- Principal Investigator Name
- Smaragdi Fessatou
- Principal Investigator Email
- sfessatou@gmail.com
- Contact Person Name
- Smaragdi Fessatou
- Contact Person Email
- sfessatou@gmail.com
Sponsor
Primary sponsor
- Full Name
- Alfasigma S.p.A.
- Organisation Type
- Pharmaceutical company
- Country Of Registered Address
- Italy
Contract research organisations
- Name
- IQVIA RDS Hellas Single Member S.A.
- Responsibilities
- CRO
- Name
- Iqvia Biotech Limited
- Responsibilities
- CRO
Third parties
- {"country":"United States","full_name":"Bioclinica Inc.","duties_or_roles":"Endoscopy","organisation_type":"Laboratory/Research/Testing facility"}
- {"country":"Switzerland","full_name":"Labcorp Central Laboratory Services SARL","duties_or_roles":"","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Signant Health Global LLC","duties_or_roles":"eCOA","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Suvoda LLC","duties_or_roles":"","organisation_type":"Non-Pharmaceutical company"}
- {"country":"Greece","full_name":"IQVIA RDS Hellas Single Member S.A.","duties_or_roles":"CRO","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Signant Health Global LLC (eConsent)","duties_or_roles":"eConsent","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Medidata Solutions Inc.","duties_or_roles":"","organisation_type":"Non-Pharmaceutical company"}
- {"country":"United Kingdom","full_name":"Iqvia Biotech Limited","duties_or_roles":"CRO","organisation_type":"Pharmaceutical company"}
Investigational products
- Investigational Product Name
- Jyseleca 100 mg film-coated tablets
- Active Substance
- Filgotinib
- Modality
- Small molecule
- Routes Of Administration
- ORAL
- Route
- ORAL
- Authorisation Status
- Marketing authorisation (EU/1/20/1480/001) indicated in product record
- Investigational Product Name
- Jyseleca 200 mg film-coated tablets
- Active Substance
- Filgotinib
- Modality
- Small molecule
- Routes Of Administration
- ORAL
- Route
- ORAL
- Authorisation Status
- Marketing authorisation (EU/1/20/1480/003) indicated in product record
- Investigational Product Name
- GLPG0634
- Active Substance
- Filgotinib
- Modality
- Small molecule
- Routes Of Administration
- ORAL
- Route
- ORAL
- Authorisation Status
- Not marketed product record (sponsor product code GLPG0634)
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