Clinical trial • Phase II • Gastroenterology

Mesalamine for Ulcerative colitis

Phase II trial of Mesalamine for Ulcerative colitis.

Overview

Trial Therapeutic Area
Gastroenterology
Trial Disease
Ulcerative colitis
Trial Stage
Phase II
Drug Modality
Small molecule

Key dates

Initial CTIS Submission Date
28-02-2025
First CTIS Authorization Date
25-06-2025

Trial design

Randomised, open-label, mesalamine delayed release capsules 400 mg manufactured by sun pharmaceutical industries limited, india compared with mesalamine delayed-release capsules 400 mg manufactured for teva pharmaceuticals usa, inc.; single-dose, crossover fully replicate design (two-treatment, four-period, two-sequence, single-dose).-controlled, crossover Phase II trial across 1 site in Romania.

Randomised
Yes
Open Label
Yes
Comparator
Mesalamine delayed release capsules 400 mg manufactured by Sun Pharmaceutical Industries Limited, India compared with Mesalamine Delayed-Release Capsules 400 mg manufactured for Teva Pharmaceuticals USA, Inc.; single-dose, crossover fully replicate design (two-treatment, four-period, two-sequence, single-dose).
Crossover
Yes
Target Sample Size
112

Eligibility

Recruits 112 Vulnerable population selected: true; no details on consent or assent handling provided in source..

Vulnerable Population
Vulnerable population selected: true; no details on consent or assent handling provided in source.

Recruitment

Planned Sample Size
112
Recruitment Window Months
4

Geography

Total Number Of Sites
1
Total Number Of Participants
112

Romania

Earliest CTIS Part Ii Submission Date
21-02-2025
Latest Decision Or Authorization Date
25-06-2025
Processing Time Days
124
Number Of Sites
1
Number Of Participants
112

Sites

Site Name
Terapia S.A.
Department Name
Clinical Pharmacology and Pharmacokinetics
Contact Person Name
Elena Timofte
Contact Person Email
Elena.Timofte@sunpharma.com

Sponsor

Primary sponsor

Full Name
Sun Pharmaceutical Industries Limited
Organisation Type
Pharmaceutical company
Country Of Registered Address
India

Investigational products

Investigational Product Name
Mesalamine delayed release capsules 400 mg manufactured by Sun Pharmaceutical Industries Limited, India
Active Substance
Mesalamine
Modality
Small molecule
Routes Of Administration
Oral (capsule)
Route
oral
Starting Dose
400 mg
Dose Levels
400 mg
Frequency
single-dose
Maximum Dose
400 mg
Investigational Product Name
Mesalamine Delayed-Release Capsules 400 mg, manufactured for Teva Pharmaceuticals USA, Inc. Parsippany, NJ 07054
Active Substance
Mesalamine
Modality
Small molecule
Routes Of Administration
Oral (capsule)
Route
oral
Starting Dose
400 mg
Dose Levels
400 mg
Frequency
single-dose
Maximum Dose
400 mg

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