Clinical trial • Phase III • Immunology|Musculoskeletal
JNJ-77242113 for Psoriatic arthritis|Active Psoriatic Arthritis
Phase III trial of JNJ-77242113 for Psoriatic arthritis|Active Psoriatic Arthritis.
Overview
- Trial Therapeutic Area
- Immunology|Musculoskeletal
- Trial Disease
- Psoriatic arthritis|Active Psoriatic Arthritis
- Trial Stage
- Phase III
- Drug Modality
- Monoclonal antibody|Peptide/protein/enzyme
Key dates
- Initial CTIS Submission Date
- 05-12-2024
- First CTIS Authorization Date
- 02-04-2025
Trial design
Randomised, placebo-controlled: placebo tablet (jnj-77242113-aac placebo tablet) is specified as the control for jnj-77242113; placebo injections ("solution for injection in pre-filled syringe without ustekinumab 45/90") are provided as matching placebo for ustekinumab formulations. active study arms are jnj-77242113 200 mg and 400 mg (oral film-coated tablet) versus placebo; specific dosing schedule details are not provided in the ctis metadata. Phase III trial across 75 sites in Bulgaria, Czechia, Denmark and others.
- Randomised
- Yes
- Comparator
- Placebo-controlled: placebo tablet (JNJ-77242113-AAC Placebo tablet) is specified as the control for JNJ-77242113; placebo injections ("Solution for injection in pre-filled syringe without Ustekinumab 45/90") are provided as matching placebo for ustekinumab formulations. Active study arms are JNJ-77242113 200 mg and 400 mg (oral film-coated tablet) versus placebo; specific dosing schedule details are not provided in the CTIS metadata.
- Target Sample Size
- 210
- Trial Duration For Participant
- 700
Eligibility
Recruits 210 Vulnerable population flag is selected in the trial record. Participants must be adults (≥18 years). Subject information sheets and informed consent forms (L1 SIS and ICF) and several addenda are provided (multiple country-specific and language versions are listed among the study documents), indicating formal informed consent procedures; however the CTIS record does not provide detailed text excerpts describing special assent/consent handling for vulnerable subgroups in the available metadata..
- Vulnerable Population
- Vulnerable population flag is selected in the trial record. Participants must be adults (≥18 years). Subject information sheets and informed consent forms (L1 SIS and ICF) and several addenda are provided (multiple country-specific and language versions are listed among the study documents), indicating formal informed consent procedures; however the CTIS record does not provide detailed text excerpts describing special assent/consent handling for vulnerable subgroups in the available metadata.
Inclusion criteria
- {"criterion_text":"- 1. At least 18 (or the legal age of consent in the jurisdiction in which the study is taking place) years of age.\n- 2. Have a diagnosis of PsA for at least 3 months before the first administration of study intervention and meet classification criteria for Psoriatic Arthritis (CASPAR) at screening.\n- 3. Have active PsA as defined by: a. At least 3 swollen joints and at least 3 tender joints at screening and at baseline; and b. C-reactive protein (CRP) ≥0.1 mg/dL at screening from the central laboratory. NOTE: A one-time repeat assessment of CRP level is allowed during the screening phase and the Investigator may consider the participant eligible if the test result is within acceptable range on repeat testing in the central laboratory.\n- 4. Have at least 1 of the PsA subsets: distal interphalangeal joint involvement, polyarticular arthritis with absence of rheumatoid nodules, arthritis mutilans, asymmetric peripheral arthritis, or spondylitis with peripheral arthritis.\n- 5. Have active plaque psoriasis with at least one psoriatic plaque of ≥2 cm diameter or nail changes consistent with psoriasis.\n- 6. Participants must be considered in the opinion of the investigator, to be a suitable candidate for treatment with ustekinumab per locally-approved labeling and have no contraindications to receive ustekinumab per local label.\n- 7. Have active PsA despite current or previous non-biologic DMARD and/or apremilast. Non-biologic DMARD (limited to MTX, SSZ, HCQ, or LEF) therapy is defined as taking a non-biologic DMARD for at least 12 weeks before first administration of study intervention, or evidence of non-biologic DMARD intolerance. Apremilast therapy is defined as taking apremilast at the marketed dose approved in the country where the study is being conducted for at least 12 weeks before first administration of study intervention, or evidence of apremilast intolerance.\n- 8. If currently using non-biologic DMARDs (limited to MTX, SSZ, HCQ, or LEF), participants should have started treatment at least 12 weeks prior and the dose must be stable for at least 4 weeks before first administration of study intervention and should have no serious toxic side effects attributable to the non-biologic DMARD. If currently not using MTX, SSZ, or HCQ, must not have received for at least 4 weeks before first administration of study intervention. If currently not using LEF, must not have received for at least 12 weeks before first administration of study intervention. a) If using MTX, the route of administration and dose must be stable and the dose must be ≤ 25 mg/week. b) If receiving SSZ, the dose must be stable and ≤ 3 g/day c) If receiving HCQ, the dose must be stable and ≤ 400 mg/day d) If receiving LEF, the dose must be stable and ≤ 20 mg/day (NOTE: use of LEF and MTX combination therapy is not allowed) If using apremilast at baseline, participants must be on a stable dose and ≤ 30 mg twice daily for at least 12 weeks before first administration of study intervention. If currently not using apremilast, the participant must not have received apremilast within 4 weeks before first administration of study intervention. If using NSAIDs for PsA at baseline, participants must be on a stable dose for at least 2 weeks before first administration of study intervention. If currently not using NSAIDs for PsA, must not have received NSAIDs for PsA within 2 weeks before first administration of study intervention. If using oral corticosteroids at baseline, participants must be on a stable dose equivalent to ≤10 mg of prednisone/day for at least 2 weeks before first administration of study intervention. If currently not using oral corticosteroids, the participant must not have received oral corticosteroids within 2 weeks before first administration of study intervention."}
Exclusion criteria
- {"criterion_text":"- 1. Has a history or current signs or symptoms of severe, progressive, or uncontrolled renal, hepatic, cardiac, vascular, pulmonary, gastrointestinal, endocrine, neurologic, hematologic, rheumatologic (with the exception of PsA), psychiatric, genitourinary, or metabolic disturbances.\n- 2. Currently has a malignancy or has a history of malignancy within 5 years prior to screening (with the exception of a nonmelanoma skin cancer that has been adequately treated with no evidence of recurrence for at least 12 weeks prior to the first study intervention administration or cervical carcinoma in situ that has been adequately treated with no evidence of recurrence for at least 12 weeks prior to the first study intervention administration).\n- 3. Has known allergies, hypersensitivity, or intolerance to JNJ-77242113 or its excipients, or to ustekinumab excipients (refer to the IB).\n- 4. Has unstable cardiovascular disease, defined as a clinical deterioration (eg, unstable angina, rapid atrial fibrillation, or transient ischemic attack) in the last 12 weeks prior to screening or a cardiac hospitalization within the last 12 weeks prior to screening.\n- 5. Has other inflammatory diseases that might confound the evaluations of benefit of JNJ-77242113 therapy, including but not limited to RA, systemic lupus erythematosus, or Lyme disease (confirmed by Western blot).\n- 6. Participants with fibromyalgia or osteoarthritis symptoms that, in the investigator’s opinion, would have potential to interfere with efficacy assessments.\n- 27. Restricted or Prohibited Medication or Class of Medications: Has previously received the following agents for PsA or psoriasis: - JAK inhibitors, -TYK inhibitors (such as deucravacitinib) Restriction Duration: Ever (ie, any previous use is exclusionary)\n- 28. Restricted or Prohibited Medication or Class of Medications: Has previously received any biologic DMARDs for PsA or psoriasis such as: -Anti-IL-23 agents or biosimilars -Anti-IL-12/23 agents or biosimilars -Abatacept or biosimilars -Anti-IL-17 agent or biosimilars -Anti-TNFα agent or biosimilars Restriction Duration: Ever (ie, any previous use is exclusionary)"}
Endpoints
Primary endpoints
- {"endpoint_text":"- The primary endpoint is the American College of Rheumatology (ACR) 20 response at Week 16","definition_or_measurement_approach":"Measured as the American College of Rheumatology (ACR) 20 response at Week 16 (ACR20) as stated in the endpoint description."}
Recruitment
- Digital Remote Recruitment
- Yes
- Planned Sample Size
- 210
- Recruitment Window Months
- 31
- Consent Approach
- Informed consent is via subject information sheets and informed consent forms (L1 SIS and ICF) with country- and language-specific versions and addenda provided (documents listed for BG, CZ, DK, DE, PL, ES, HU and English versions). Participants are adults (≥18) who provide their own consent; no assent process is described in the CTIS metadata.
Methods
- Germany: multiple recruitment materials documented including awareness flyers, brochures, digital ads, print ads, letters and flyers (documents: 'REDACTED_K2_Recruitment material', 'Digital Ads', 'Print Ads', 'Flyer', 'Letter' in German).
- Spain: awareness flyers, brochures and flyers for participant recruitment (documents: 'REDACTED_K2_Recruitment material' in Spanish).
- Poland: digital outreach ads and participant recruitment flyers ('Digital Outreach Ads', 'Participant Recruitment Flyer').
- Denmark: participant recruitment brochure and flyer (country-specific K1/K2 documents).
- Czechia, Bulgaria, Hungary, Poland: country-specific recruitment brochures and participant recruitment materials (K1/K2 documents listed).
- Digital channels are explicitly included (documents titled 'Digital Ads' / 'Digital Outreach Ads').
Geography
- Total Number Of Sites
- 75
- Total Number Of Participants
- 337
Bulgaria
- Earliest CTIS Part Ii Submission Date
- 10-01-2025
- Latest Decision Or Authorization Date
- 23-03-2026
- Processing Time Days
- 437
- Number Of Sites
- 4
- Number Of Participants
- 16
Sites
- Site Name
- Medical Center Exacta Medica OOD
- Principal Investigator Name
- Krasimira Tsoneva
- Principal Investigator Email
- ktsoneva2011@abv.bg
- Contact Person Name
- Krasimira Tsoneva
- Contact Person Email
- ktsoneva2011@abv.bg
- Site Name
- Medical Center Medtech Services Ltd.
- Principal Investigator Name
- Krasimir Kraev
- Principal Investigator Email
- kkraev@hotmail.com
- Contact Person Name
- Krasimir Kraev
- Contact Person Email
- kkraev@hotmail.com
- Site Name
- Medical Center Artmed Ltd.
- Principal Investigator Name
- Mariela Geneva-Popova
- Principal Investigator Email
- genevapopova@yahoo.com
- Contact Person Name
- Mariela Geneva-Popova
- Contact Person Email
- genevapopova@yahoo.com
- Site Name
- Medical Center Teodora EOOD
- Principal Investigator Name
- Margarita Velkova
- Principal Investigator Email
- dr_margarita_velkova@gmai.bg
- Contact Person Name
- Margarita Velkova
- Contact Person Email
- dr_margarita_velkova@gmai.bg
Czechia
- Earliest CTIS Part Ii Submission Date
- 28-02-2025
- Latest Decision Or Authorization Date
- 19-03-2026
- Processing Time Days
- 384
- Number Of Sites
- 13
- Number Of Participants
- 63
Sites
- Site Name
- MUDr. Zuzana Stejfova
- Principal Investigator Name
- Zuzana Stejfova
- Principal Investigator Email
- revma.ste@seznam.cz
- Contact Person Name
- Zuzana Stejfova
- Contact Person Email
- revma.ste@seznam.cz
- Site Name
- Medical Plus s.r.o.
- Principal Investigator Name
- Eva Dokoupilova
- Principal Investigator Email
- evadokoupil@gmail.com
- Contact Person Name
- Eva Dokoupilova
- Contact Person Email
- evadokoupil@gmail.com
- Site Name
- Revmatologie s.r.o.
- Principal Investigator Name
- Leona Prochazkova
- Principal Investigator Email
- revmatologie.prochazkova@seznam.cz
- Contact Person Name
- Leona Prochazkova
- Contact Person Email
- revmatologie.prochazkova@seznam.cz
- Site Name
- Fakultni Nemocnice V Motole
- Department Name
- Oddeleni revmatologie deti a dospelych
- Principal Investigator Name
- Rudolf Horvath
- Principal Investigator Email
- rudolf.horvath@fnmotol.cz
- Contact Person Name
- Rudolf Horvath
- Contact Person Email
- rudolf.horvath@fnmotol.cz
- Site Name
- Rheuma s.r.o.
- Principal Investigator Name
- Jaroslava Spevakova
- Principal Investigator Email
- spevako.revma@seznam.cz
- Contact Person Name
- Jaroslava Spevakova
- Contact Person Email
- spevako.revma@seznam.cz
- Site Name
- Revmacentrum MUDr. Mostera s.r.o.
- Principal Investigator Name
- Erik Moster
- Principal Investigator Email
- info@revmacentrum.cz
- Contact Person Name
- Erik Moster
- Contact Person Email
- info@revmacentrum.cz
- Site Name
- L.K.N. Arthrocentrum s.r.o.
- Principal Investigator Name
- Libor Novosad
- Principal Investigator Email
- arthrocentrum@email.cz
- Contact Person Name
- Libor Novosad
- Contact Person Email
- arthrocentrum@email.cz
- Site Name
- PV Medical Services s.r.o.
- Principal Investigator Name
- Petr Vitek
- Principal Investigator Email
- pv.medical@seznam.cz
- Contact Person Name
- Petr Vitek
- Contact Person Email
- pv.medical@seznam.cz
- Site Name
- MUDr. Rosypalova s.r.o.
- Principal Investigator Name
- Miroslava Rosypalova
- Principal Investigator Email
- mirka.rosypalova@seznam.cz
- Contact Person Name
- Miroslava Rosypalova
- Contact Person Email
- mirka.rosypalova@seznam.cz
- Site Name
- Fakultni Thomayerova nemocnice
- Department Name
- Klinika revmatologie a rehabilitace 3. LF UK a FTN
- Principal Investigator Name
- Petr Kopsa
- Principal Investigator Email
- petr.kopsa@ftn.cz
- Contact Person Name
- Petr Kopsa
- Contact Person Email
- petr.kopsa@ftn.cz
- Site Name
- Revmatologicky Ustav
- Principal Investigator Name
- Jana Tomasova Studynkova
- Principal Investigator Email
- tomasova@revma.cz
- Contact Person Name
- Jana Tomasova Studynkova
- Contact Person Email
- tomasova@revma.cz
- Site Name
- Revimex pro s.r.o.
- Principal Investigator Name
- Gabriela Stolarz
- Principal Investigator Email
- revimex@email.cz
- Contact Person Name
- Gabriela Stolarz
- Contact Person Email
- revimex@email.cz
- Site Name
- CCR Ostrava s.r.o.
- Principal Investigator Name
- Sylva Brtnikova
- Principal Investigator Email
- sylva.brtnikova@ccrostrava.com
- Contact Person Name
- Sylva Brtnikova
- Contact Person Email
- sylva.brtnikova@ccrostrava.com
Denmark
- Earliest CTIS Part Ii Submission Date
- 26-03-2025
- Latest Decision Or Authorization Date
- 18-03-2026
- Processing Time Days
- 357
- Number Of Sites
- 6
- Number Of Participants
- 6
Sites
- Site Name
- Lillebaelt Hospital
- Department Name
- Reumatogy department
- Principal Investigator Name
- Myriam Liz Grana
- Principal Investigator Email
- myriam.liz.grana@rsyd.dk
- Contact Person Name
- Myriam Liz Grana
- Contact Person Email
- myriam.liz.grana@rsyd.dk
- Site Name
- Region Midtjylland
- Department Name
- Klinik for Led og bindevævssygdomme
- Principal Investigator Name
- Ellen Margrethe Hauge
- Principal Investigator Email
- ellen.hauge@aarhus.rm.dk
- Contact Person Name
- Ellen Margrethe Hauge
- Contact Person Email
- ellen.hauge@aarhus.rm.dk
- Site Name
- Odense University Hospital
- Department Name
- Reumatologisk Ambulatorium
- Principal Investigator Name
- Soeren Andreas Just
- Principal Investigator Email
- Soeren.Andreas.Just@rsyd.dk
- Contact Person Name
- Soeren Andreas Just
- Contact Person Email
- Soeren.Andreas.Just@rsyd.dk
- Site Name
- Region Midtjylland
- Department Name
- Medicinsk afdeling
- Principal Investigator Name
- René Oestgaard
- Principal Investigator Email
- reneoest@rm.dk
- Contact Person Name
- René Oestgaard
- Contact Person Email
- reneoest@rm.dk
- Site Name
- Esbjerg Og Grindsted Sygehus
- Department Name
- Department of Rheumatology
- Principal Investigator Name
- Philip Rask Lage-Hansen
- Principal Investigator Email
- philip.rask.lage-hansen3@rsyd.dk
- Contact Person Name
- Philip Rask Lage-Hansen
- Contact Person Email
- philip.rask.lage-hansen3@rsyd.dk
- Site Name
- Frederiksberg Hospital
- Department Name
- Department of Rheumatology
- Principal Investigator Name
- Bjarke Brandt Hansen
- Principal Investigator Email
- bjarke.brandt.hansen@regionh.dk
- Contact Person Name
- Bjarke Brandt Hansen
- Contact Person Email
- bjarke.brandt.hansen@regionh.dk
Germany
- Earliest CTIS Part Ii Submission Date
- 19-03-2025
- Latest Decision Or Authorization Date
- 20-03-2026
- Processing Time Days
- 366
- Number Of Sites
- 10
- Number Of Participants
- 29
Sites
- Site Name
- MVZ Rheumatologie und Autoimmunmedizin Hamburg GmbH
- Department Name
- Hamburger Rheuma Forschungszentrum II Dr. Andrea Everding GmbH GbR
- Principal Investigator Name
- Andrea Everding
- Principal Investigator Email
- everding@hotmail.de
- Contact Person Name
- Andrea Everding
- Contact Person Email
- everding@hotmail.de
- Site Name
- Technische Universitaet Dresden
- Department Name
- Universitaetsklinikum Carl Gustav Carus Dresden Klinik und Poliklinik für Dermatologie
- Principal Investigator Name
- Stefan Beissert
- Principal Investigator Email
- Stefan.Beissert@ukdd.de
- Contact Person Name
- Stefan Beissert
- Contact Person Email
- Stefan.Beissert@ukdd.de
- Site Name
- ISA Interdisciplinary Study Association GmbH
- Principal Investigator Name
- Margrit Simon
- Principal Investigator Email
- msimon@isa-research.de
- Contact Person Name
- Margrit Simon
- Contact Person Email
- msimon@isa-research.de
- Site Name
- Charite Universitaetsmedizin Berlin KöR
- Department Name
- Campus Charité Mitte (CCM) Klinik mit Schwerpunkt Rheumatologie und klinische Immunologie
- Principal Investigator Name
- David Nils Simon
- Principal Investigator Email
- david.simon@charite.de
- Contact Person Name
- David Nils Simon
- Contact Person Email
- david.simon@charite.de
- Site Name
- Studienzentrum Dr. Schwarz
- Principal Investigator Name
- Beate Schwarz
- Principal Investigator Email
- beate@hautarzt-langenau.de
- Contact Person Name
- Beate Schwarz
- Contact Person Email
- beate@hautarzt-langenau.de
- Site Name
- St. Elisabeth Gruppe GmbH Katholische Kliniken Rhein-Ruhr
- Department Name
- Rheumazentrum Ruhrgebiet
- Principal Investigator Name
- Ioana Andreica
- Principal Investigator Email
- Ioana.Andreica@elisabethgruppe.de
- Contact Person Name
- Ioana Andreica
- Contact Person Email
- Ioana.Andreica@elisabethgruppe.de
- Site Name
- Eberhard Karls Universitaet Tuebingen
- Department Name
- Universitaetsklinikum Tuebingen / Universitaets-Hautklinik Psoriasiszentrum
- Principal Investigator Name
- Matthias Hahn
- Principal Investigator Email
- matthias.hahn@med.uni-tuebingen.de
- Contact Person Name
- Matthias Hahn
- Contact Person Email
- matthias.hahn@med.uni-tuebingen.de
- Site Name
- Thermalsole und Schwefelbad Bentheim GmbH
- Department Name
- Fachklinik Bad Bentheim Abteilung für Rheumatologie
- Principal Investigator Name
- Thomas Rath
- Principal Investigator Email
- t.rath@fk-bentheim.de
- Contact Person Name
- Thomas Rath
- Contact Person Email
- t.rath@fk-bentheim.de
- Site Name
- Medical Center - University Of Freiburg
- Department Name
- Universitaetsklinikum Freiburg Klinik f. Rheumatologie u. Klinische Immunologie
- Principal Investigator Name
- Stephanie Finzel
- Principal Investigator Email
- stephanie.finzel@uniklinik-freiburg.de
- Contact Person Name
- Stephanie Finzel
- Contact Person Email
- stephanie.finzel@uniklinik-freiburg.de
- Site Name
- Johannes Wesling Klinikum Minden
- Department Name
- Klinik für Rheumatologie und klinische Immunologie
- Principal Investigator Name
- Gunter Assmann
- Principal Investigator Email
- gunter.assmann@muehlenkreiskliniken.de
- Contact Person Name
- Gunter Assmann
- Contact Person Email
- gunter.assmann@muehlenkreiskliniken.de
Poland
- Earliest CTIS Part Ii Submission Date
- 10-01-2025
- Latest Decision Or Authorization Date
- 23-03-2026
- Processing Time Days
- 437
- Number Of Sites
- 19
- Number Of Participants
- 179
Sites
- Site Name
- Medicover Integrated Clinical Services Sp. z o.o.
- Department Name
- MICS Centrum Medyczne Torun
- Principal Investigator Name
- Slawomir Jeka
- Principal Investigator Email
- Idalia.Lewandowska@mics.medicover.com
- Contact Person Name
- Slawomir Jeka
- Contact Person Email
- Idalia.Lewandowska@mics.medicover.com
- Site Name
- Malopolskie Badania Kliniczne Sp. z o.o.
- Department Name
- Malopolskie Badania Kliniczne sp. z o.o.
- Principal Investigator Name
- Bogdan Batko
- Principal Investigator Email
- biuro@mbk.clinic
- Contact Person Name
- Bogdan Batko
- Contact Person Email
- biuro@mbk.clinic
- Site Name
- Medicover Integrated Clinical Services Sp. z o.o.
- Department Name
- MICS Centrum Medyczne Warszawa
- Principal Investigator Name
- Malgorzata Gryka-Marton
- Principal Investigator Email
- kontakt@medycynakliniczna.pl
- Contact Person Name
- Malgorzata Gryka-Marton
- Contact Person Email
- kontakt@medycynakliniczna.pl
- Site Name
- Specderm Poznanska Sp. j.
- Department Name
- SPECDERM Poznanska sp.j
- Principal Investigator Name
- Magdalena Bagrowska
- Principal Investigator Email
- badania@specderm.pl
- Contact Person Name
- Magdalena Bagrowska
- Contact Person Email
- badania@specderm.pl
- Site Name
- Reumed Sp. z o.o.
- Department Name
- Zespol Poradni Specjalistycznych REUMED Filia nr 1
- Principal Investigator Name
- Marcin Mazurek
- Principal Investigator Email
- reumedlublinpl@gmail.com
- Contact Person Name
- Marcin Mazurek
- Contact Person Email
- reumedlublinpl@gmail.com
- Site Name
- Dermed Centrum Medyczne Sp. z o.o.
- Department Name
- „DERMED” Centrum Medyczne Sp. zo.o
- Principal Investigator Name
- Andrzej Kaszuba
- Principal Investigator Email
- gabinety@dermed.com.pl
- Contact Person Name
- Andrzej Kaszuba
- Contact Person Email
- gabinety@dermed.com.pl
- Site Name
- Centrum Medyczne All-Med Badania Kliniczne
- Department Name
- Centrum Medyczne "All-med" Badania Kliniczne
- Principal Investigator Name
- Grazyna Pulka
- Principal Investigator Email
- allmed.recepcja@gmail.com
- Contact Person Name
- Grazyna Pulka
- Contact Person Email
- allmed.recepcja@gmail.com
- Site Name
- Ambulatorium Sp. z o.o.
- Department Name
- Ambulatorium Sp.zo.o
- Principal Investigator Name
- Anna Bazela-Ostromecka
- Principal Investigator Email
- ambulatorium@ambulatorium.pl
- Contact Person Name
- Anna Bazela-Ostromecka
- Contact Person Email
- ambulatorium@ambulatorium.pl
- Site Name
- Szpital Uniwersytecki Nr 2 Im Dr Jana Biziela W Bydgoszczy
- Department Name
- Klinika Reumatologii i Ukladowych Chorob Tkanki laczne
- Principal Investigator Name
- Rafal Wojciechowski
- Principal Investigator Email
- reumatologia@biziel.pl
- Contact Person Name
- Rafal Wojciechowski
- Contact Person Email
- reumatologia@biziel.pl
- Site Name
- NZOZ Lecznica Mak Med s.c.
- Department Name
- NZOZ Lecznica MAK-MED. S.C.
- Principal Investigator Name
- Marek Krogulec
- Principal Investigator Email
- marekkrogulec@wp.pl
- Contact Person Name
- Marek Krogulec
- Contact Person Email
- marekkrogulec@wp.pl
- Site Name
- Centrum Medyczne Oporow
- Department Name
- Centrum Medyczne Oporow
- Principal Investigator Name
- Maria Misterska-Skora
- Principal Investigator Email
- badania@cmoporow.com
- Contact Person Name
- Maria Misterska-Skora
- Contact Person Email
- badania@cmoporow.com
- Site Name
- Pratia S.A.
- Department Name
- Centrum Medyczne Pratia Gdynia
- Principal Investigator Name
- Anna Sylwestrzak
- Principal Investigator Email
- kontakt@pratia.com
- Contact Person Name
- Anna Sylwestrzak
- Contact Person Email
- kontakt@pratia.com
- Site Name
- Clinicmed Daniluk Nowak Sp. k.
- Department Name
- ClinicMed Daniluk, Nowak Sp.k.
- Principal Investigator Name
- Stefan Daniluk
- Principal Investigator Email
- rejestracja@clinicmed.pl
- Contact Person Name
- Stefan Daniluk
- Contact Person Email
- rejestracja@clinicmed.pl
- Site Name
- Osteo Medic s.c. Artur Racewicz Jerzy Supronik
- Department Name
- „Osteo-Medic” spolka cywilna Artur Racewicz, Jerzy Supronik
- Principal Investigator Name
- Artur Racewicz
- Principal Investigator Email
- sekretariat@osteo-medic.pl
- Contact Person Name
- Artur Racewicz
- Contact Person Email
- sekretariat@osteo-medic.pl
- Site Name
- Centrum Kliniczno-Badawcze J.Brzezicki B.Gornikiewicz-Brzezicka Lekarze sp.p.
- Department Name
- Centrum Kliniczno-Badawcze J.Brzezicki B.Gornikiewicz-Brzezicka Lekarze spolka partnerska
- Principal Investigator Name
- Jan Brzezicki
- Principal Investigator Email
- kontakt@ckb.elblag.pl
- Contact Person Name
- Jan Brzezicki
- Contact Person Email
- kontakt@ckb.elblag.pl
- Site Name
- Dermmedica Sp. z o.o.
- Department Name
- Centrum Columbus
- Principal Investigator Name
- Jolanta Weglowska
- Principal Investigator Email
- office@dermmedica.pl
- Contact Person Name
- Jolanta Weglowska
- Contact Person Email
- office@dermmedica.pl
- Site Name
- Specjalistyczny Gabinet Dermatologiczny Aplikacyjno Badawczy Marek Brzewski Paweł Brzewski s.c.
- Department Name
- Specjalistyczny Gabinet Dermatologiczny Aplikacyjno-Badawczy Marek Brzewski Pawel Brzewski s. c.
- Principal Investigator Name
- Pawel Brzewski
- Principal Investigator Email
- info@dermatolog-brzewski.com
- Contact Person Name
- Pawel Brzewski
- Contact Person Email
- info@dermatolog-brzewski.com
- Site Name
- Klinika Reuma Park Sp. z o.o. S.K.
- Department Name
- Centrum Medyczne Reuma Park
- Principal Investigator Name
- Ewa Matyska-Piekarska
- Principal Investigator Email
- info@reumatika.pl
- Contact Person Name
- Ewa Matyska-Piekarska
- Contact Person Email
- info@reumatika.pl
Spain
- Earliest CTIS Part Ii Submission Date
- 11-03-2025
- Latest Decision Or Authorization Date
- 27-03-2026
- Processing Time Days
- 381
- Number Of Sites
- 12
- Number Of Participants
- 22
Sites
- Site Name
- Complexo Hospitalario Universitario A Coruna
- Department Name
- Rheumatology
- Principal Investigator Name
- Francisco Javier Blanco Garcia
- Principal Investigator Email
- fblagar@sergas.es
- Contact Person Name
- Francisco Javier Blanco Garcia
- Contact Person Email
- fblagar@sergas.es
- Site Name
- Hospital Clinic De Barcelona
- Department Name
- Rheumatology
- Principal Investigator Name
- Julio Ramirez Garcia
- Principal Investigator Email
- julramga@gmail.com
- Contact Person Name
- Julio Ramirez Garcia
- Contact Person Email
- julramga@gmail.com
- Site Name
- University Hospital Virgen Del Rocio S.L.
- Department Name
- Rheumatology
- Principal Investigator Name
- Elena Alonso Blanco-Morales
- Principal Investigator Email
- elenaabm@hotmail.com
- Contact Person Name
- Elena Alonso Blanco-Morales
- Contact Person Email
- elenaabm@hotmail.com
- Site Name
- Hospital Universitario Regional De Malaga
- Department Name
- Rheumatology
- Principal Investigator Name
- Antonio Fernandez Nebro
- Principal Investigator Email
- afnebro@gmail.com
- Contact Person Name
- Antonio Fernandez Nebro
- Contact Person Email
- afnebro@gmail.com
- Site Name
- Hospital Universitario Virgen De La Macarena
- Department Name
- Rheumatology
- Principal Investigator Name
- Jose Javier Perez Venegas
- Principal Investigator Email
- perez.venegas@gmail.com
- Contact Person Name
- Jose Javier Perez Venegas
- Contact Person Email
- perez.venegas@gmail.com
- Site Name
- Hospital Universitario 12 De Octubre
- Department Name
- Rheumatology
- Principal Investigator Name
- Beatriz Joven Ibañez
- Principal Investigator Email
- beatrizjoven@hotmail.com
- Contact Person Name
- Beatriz Joven Ibañez
- Contact Person Email
- beatrizjoven@hotmail.com
- Site Name
- Hospital Universitario Marques De Valdecilla
- Department Name
- Rheumatology
- Principal Investigator Name
- Ricardo Blanco Alonso
- Principal Investigator Email
- rblancovela@gmail.com
- Contact Person Name
- Ricardo Blanco Alonso
- Contact Person Email
- rblancovela@gmail.com
- Site Name
- Hospital Universitari Vall D Hebron
- Department Name
- Rheumatology
- Principal Investigator Name
- Alba Erra Duran
- Principal Investigator Email
- alba.erra@vallhebron.cat
- Contact Person Name
- Alba Erra Duran
- Contact Person Email
- alba.erra@vallhebron.cat
- Site Name
- Parc Tauli Hospital Universitari
- Department Name
- Rheumatology
- Principal Investigator Name
- Mireia Moreno Martinez-Losa
- Principal Investigator Email
- Moreno.parctauli@gmail.com
- Contact Person Name
- Mireia Moreno Martinez-Losa
- Contact Person Email
- Moreno.parctauli@gmail.com
- Site Name
- Hospital Quironsalud Infanta Luisa
- Department Name
- Rheumatology
- Principal Investigator Name
- Nadia Abdel-Kader Martin
- Principal Investigator Email
- abdelmartin@hotmail.com
- Contact Person Name
- Nadia Abdel-Kader Martin
- Contact Person Email
- abdelmartin@hotmail.com
- Site Name
- Hospital Quironsalud Sagrado Corazon
- Department Name
- Rheumatology
- Principal Investigator Name
- Paula Cejas
- Principal Investigator Email
- pcejashil@gmail.com
- Contact Person Name
- Paula Cejas
- Contact Person Email
- pcejashil@gmail.com
- Site Name
- Hospital Universitario Reina Sofia
- Department Name
- Rheumatology
- Principal Investigator Name
- Clementina López Medina
- Principal Investigator Email
- clementinalopezmedina@gmail.com
- Contact Person Name
- Clementina López Medina
- Contact Person Email
- clementinalopezmedina@gmail.com
Hungary
- Earliest CTIS Part Ii Submission Date
- 11-02-2025
- Latest Decision Or Authorization Date
- 06-05-2026
- Processing Time Days
- 449
- Number Of Sites
- 11
- Number Of Participants
- 22
Sites
- Site Name
- Vital-Medicina Kft.
- Principal Investigator Name
- Edit Drescher
- Principal Investigator Email
- dr.dreschere@gmail.com
- Contact Person Name
- Edit Drescher
- Contact Person Email
- dr.dreschere@gmail.com
- Site Name
- Betegapolo Irgalmasrend Budai Irgalmasrendi Korhaz
- Department Name
- Department of Rheumatology
- Principal Investigator Name
- Bernadette Rojkovich
- Principal Investigator Email
- rojkovich.b@irgalmas.hu
- Contact Person Name
- Bernadette Rojkovich
- Contact Person Email
- rojkovich.b@irgalmas.hu
- Site Name
- Fejer Varmegyei Szent Gyoergy Egyetemi Oktato Korhaz
- Department Name
- Department of Rheumatology
- Principal Investigator Name
- Judit Pulai
- Principal Investigator Email
- juditpulai@yahoo.com
- Contact Person Name
- Judit Pulai
- Contact Person Email
- juditpulai@yahoo.com
- Site Name
- Obudai Egeszseguegyi Centrum Kft.
- Principal Investigator Name
- Viktoria Csonka
- Principal Investigator Email
- viktoria.csonka@oec.hu
- Contact Person Name
- Viktoria Csonka
- Contact Person Email
- viktoria.csonka@oec.hu
- Site Name
- University Of Debrecen
- Department Name
- Department of Internal Medicine, Rheumatology
- Principal Investigator Name
- Nora Bodnar
- Principal Investigator Email
- drbodnarnora@gmail.com
- Contact Person Name
- Nora Bodnar
- Contact Person Email
- drbodnarnora@gmail.com
- Site Name
- Szolnoki Mav Korhaz Es Rendelointezet
- Department Name
- Department of Clinical Pharmacology
- Principal Investigator Name
- Laszlo Samson
- Principal Investigator Email
- samsonlaszlo59@gmail.com
- Contact Person Name
- Laszlo Samson
- Contact Person Email
- samsonlaszlo59@gmail.com
- Site Name
- Obudai Egeszseguegyi Centrum Kft.
- Principal Investigator Name
- Gyongyi Tatar
- Principal Investigator Email
- reuma@hotmail.hu
- Contact Person Name
- Gyongyi Tatar
- Contact Person Email
- reuma@hotmail.hu
- Site Name
- Revita Kft.
- Principal Investigator Name
- Marta Megyaszai
- Principal Investigator Email
- m.megyaszai@gmail.com
- Contact Person Name
- Marta Megyaszai
- Contact Person Email
- m.megyaszai@gmail.com
- Site Name
- Bekes Varmegyei Koezponti Korhaz
- Department Name
- Department of Rheumatology
- Principal Investigator Name
- Peter Keszthelyi
- Principal Investigator Email
- keszthelyi.peter@bmkk.eu
- Contact Person Name
- Peter Keszthelyi
- Contact Person Email
- keszthelyi.peter@bmkk.eu
- Site Name
- Uno Medical Trials Kft.
- Principal Investigator Name
- Eva Apostol
- Principal Investigator Email
- broadway21@freemail.hu
- Contact Person Name
- Eva Apostol
- Contact Person Email
- broadway21@freemail.hu
- Site Name
- University Of Szeged
- Department Name
- Rheumatology Clinic
- Principal Investigator Name
- Attila Balog
- Principal Investigator Email
- balog.attila@med.u-szeged.hu
- Contact Person Name
- Attila Balog
- Contact Person Email
- balog.attila@med.u-szeged.hu
Sponsor
Primary sponsor
- Full Name
- Janssen Cilag International
- Organisation Type
- Pharmaceutical company
- Country Of Registered Address
- Belgium
Contract research organisations
- Name
- Eresearchtechnology Inc.
- Responsibilities
- codes: 6, 7
- Name
- 4g Clinical LLC
- Responsibilities
- code: 3
Third parties
- {"country":"United States","full_name":"Eresearchtechnology Inc.","duties_or_roles":"codes: 6, 7","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"4g Clinical LLC","duties_or_roles":"code: 3","organisation_type":"Non-Pharmaceutical company"}
- {"country":"United States","full_name":"Labcorp Central Laboratory Services LP","duties_or_roles":"codes: 15 (Kit production), 4, 5, 6, 8","organisation_type":"Pharmaceutical company"}
Investigational products
- Investigational Product Name
- JNJ-77242113
- Active Substance
- JNJ-77242113
- Modality
- Peptide/protein/enzyme
- Routes Of Administration
- ORAL USE
- Route
- Oral
- Authorisation Status
- prodAuthStatus: 1 (recorded in CTIS productDictionaryInfo)
- Starting Dose
- 200 mg
- Dose Levels
- 200 mg; 400 mg
- Investigational Product Name
- STELARA 45 mg solution for injection
- Active Substance
- USTEKINUMAB
- Modality
- Monoclonal antibody
- Routes Of Administration
- SUBCUTANEOUS USE
- Route
- Subcutaneous
- Authorisation Status
- authorised (marketingAuthNumber EU/1/08/494/001)
- Starting Dose
- 45 mg
- Dose Levels
- 45 mg
- Maximum Dose
- 225 mg (max total dose amount listed)
- Investigational Product Name
- STELARA 90 mg solution for injection in pre-filled syringe
- Active Substance
- USTEKINUMAB
- Modality
- Monoclonal antibody
- Routes Of Administration
- SUBCUTANEOUS USE
- Route
- Subcutaneous
- Authorisation Status
- authorised (marketingAuthNumber EU/1/08/494/004)
- Starting Dose
- 90 mg
- Dose Levels
- 90 mg
- Maximum Dose
- 450 mg (max total dose amount listed)
- Investigational Product Name
- JNJ-77242113-AAC Placebo tablet
- Modality
- Other
- Routes Of Administration
- ORAL USE (placebo)
- Route
- Oral (placebo)
- Investigational Product Name
- Solution for injection in pre-filled syringe without Ustekinumab 45
- Modality
- Other (placebo for injection)
- Routes Of Administration
- SUBCUTANEOUS USE (placebo)
- Route
- Subcutaneous (placebo)
- Investigational Product Name
- Solution for injection in pre-filled syringe without Ustekinumab 90
- Modality
- Other (placebo for injection)
- Routes Of Administration
- SUBCUTANEOUS USE (placebo)
- Route
- Subcutaneous (placebo)
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