Clinical trial • Phase II • Gastroenterology

Humanised IgG4 kappa monoclonal antibody against CXCL1, CXCL2, CXCL3, CXCL5, CXCL6, CXCL7 and CXCL8 for Ulcerative colitis

Phase II trial of Humanised IgG4 kappa monoclonal antibody against CXCL1, CXCL2, CXCL3, CXCL5, CXCL6, CXCL7 and CXCL8 for Ulcerative colitis.

Overview

Trial Therapeutic Area
Gastroenterology
Trial Disease
Ulcerative colitis
Trial Stage
Phase II
Drug Modality
Monoclonal antibody

Key dates

Initial CTIS Submission Date
10-10-2024
First CTIS Authorization Date
10-02-2025

Trial design

Randomised, mirikizumab (comparator; solution for injection / solution for infusion) — dose/schedule: not specified; placebo for ly3074828 sc injection, 1ml prefilled syringe — dose/schedule: not specified; 0.9% sodium chloride — dose/schedule: not specified.-controlled, adaptive Phase II trial in Denmark, Belgium, Spain and others.

Randomised
Yes
Comparator
Mirikizumab (comparator; solution for injection / solution for infusion) — dose/schedule: Not specified; Placebo for LY3074828 SC Injection, 1mL Prefilled Syringe — dose/schedule: Not specified; 0.9% sodium chloride — dose/schedule: Not specified.
Adaptive
True, adaptive dose‑ranging design (study described as "An Adaptive, Dose-Ranging, Phase 2 Study" with staged evaluation and dose-ranging elements).
Single Multiple Or Escalation Dose Combined
Yes
Target Sample Size
43

Eligibility

Recruits 43 isVulnerablePopulationSelected is true. Specific subject information and informed consent forms are provided (multiple Main ICF A/B/C and Stage-1 ICFs) as well as dedicated 'Pregnant Partner' ICFs and pharmacogenetic addenda (documents listed for multiple countries). Consent is handled via ICF documents (including country/language-specific ICFs); no paediatric assent process is described in the Part I/II data..

Vulnerable Population
isVulnerablePopulationSelected is true. Specific subject information and informed consent forms are provided (multiple Main ICF A/B/C and Stage-1 ICFs) as well as dedicated 'Pregnant Partner' ICFs and pharmacogenetic addenda (documents listed for multiple countries). Consent is handled via ICF documents (including country/language-specific ICFs); no paediatric assent process is described in the Part I/II data.

Inclusion criteria

  • {"criterion_text":"- 1. Have had an established diagnosis of UC of ≥3 months in duration before baseline."}
  • {"criterion_text":"- 2. Have moderately to severely active UC as assessed by the UC disease activity score."}
  • {"criterion_text":"- 3. Have an inadequate response to, loss of response to, or intolerance to at least one conventional medication (including corticosteroids) or one advanced therapy (including biologics, Janus Kinase (JAK) inhibitors, or sphingosine-1-phosphate (S1P) immunomodulators)."}
  • {"criterion_text":"- 4. Are on a stable dose of certain oral UC medications (including corticosteroids)."}
  • {"criterion_text":"- 5. Must meet contraception requirements."}

Exclusion criteria

  • {"criterion_text":"- 1. Have received anti-IL-23p19 or anti-IL-12p40 antibodies in the past."}
  • {"criterion_text":"- 2. Have experienced a thrombotic event within 24 weeks before baseline."}
  • {"criterion_text":"- 3. Have a current diagnosis of Crohn’s Disease or certain other inflammatory gastrointestinal diseases."}
  • {"criterion_text":"- 4. Have had certain abdominal surgeries within the past 3 months or are likely to require surgery for UC during the study."}
  • {"criterion_text":"- 5. Have a history of certain adenomas, dysplasia’s, or malignancies."}

Endpoints

Primary endpoints

  • {"endpoint_text":"- Proportion of participants who achieve clinical remission at Week 12","definition_or_measurement_approach":"Proportion of participants achieving clinical remission at Week 12, assessed using the UC disease activity score (clinical remission at Week 12)."}

Recruitment

Digital Remote Recruitment
True, includes social media ads, online landing pages, keyword-search campaigns, online pre-screening questionnaires, and telephone pre-consent via Scout Clinical; eConsent/eCOA platforms (Signant Health) are listed as vendors.
Planned Sample Size
43
Recruitment Window Months
39
Consent Approach
Informed consent is obtained from adult participants via country- and language-specific Main ICF documents (Main ICF A/B/C, Stage-1 ICFs). Additional ICFs/addenda available for pharmacogenetic testing and for pregnant partners. Pre-ICF telephone data consent (Scout Clinical) and eConsent/eCOA vendor (Signant Health) are used. ICFs are provided in multiple languages (examples in the documents: English, Spanish, French, German, Italian, Dutch, Polish, Hungarian, Czech, Greek, Croatian, Latvian, Romanian, Danish and localized language versions per country). No assent process for minors is described.

Methods

  • Social media advertising (assets: 1080x1080 and 1200x628 images) — country/language-specific social media materials provided (e.g. ES, DE, PL, LV, FR, IT, CZ, HR, HU, IE etc).
  • Dedicated landing pages / US Landing Page (country-specific versions).
  • Doctor-to-patient letters (country/language-specific).
  • Doctor-to-doctor letters / GP letters (country/language-specific).
  • Patient recruitment brochures and flipcharts (country/language-specific).
  • Keyword-search campaign materials (search advertising).
  • Pre-screening questionnaires (SSPS) and pre-screening materials.
  • Pre-ICF telephone contact and data consent via Scout Clinical (Scout Pre-ICF Telephone Data Consent forms present).
  • Appointment/thank-you cards and site-level recruitment materials.
  • Local site outreach (site-specific materials and doctor/GP letters) and central patient recruitment support via third parties (e.g., Inato listed for patient recruitment).

Geography

Total Number Of Sites
112
Total Number Of Participants
605

Denmark

Earliest CTIS Part Ii Submission Date
16-01-2025
Latest Decision Or Authorization Date
13-02-2025
Processing Time Days
28
Number Of Sites
2
Number Of Participants
12

Sites

Site Name
Region Hovedstaden
Department Name
Gastroenterologisk afdeling
Principal Investigator Name
Jakob Wium Bjerrum
Principal Investigator Email
jacob.wium.bjerrum@regionh.dk
Contact Person Name
Jakob Wium Bjerrum
Contact Person Email
jacob.wium.bjerrum@regionh.dk
Site Name
Region Hovedstaden
Department Name
Digestive Disease Center
Principal Investigator Name
Martin Eefsen
Principal Investigator Email
Martin.eefsen@regionh.dk
Contact Person Name
Martin Eefsen
Contact Person Email
Martin.eefsen@regionh.dk

Belgium

Earliest CTIS Part Ii Submission Date
17-01-2025
Latest Decision Or Authorization Date
13-02-2025
Processing Time Days
27
Number Of Sites
2
Number Of Participants
8

Sites

Site Name
Centre hospitalier universitaire de Tivoli Institut medical des Mutualites socialistes
Department Name
Gastro-enterelogy
Principal Investigator Name
Gaël Englebert
Principal Investigator Email
genglebe@chu-tivoli.be
Contact Person Name
Gaël Englebert
Contact Person Email
genglebe@chu-tivoli.be
Site Name
Centre Hospitalier Universitaire Dinant Godinne Sainte-Elisabeth-UCL-Namur
Department Name
Gastro-enterelogy
Principal Investigator Name
Jean-François Rahier
Contact Person Name
Jean-François Rahier

Spain

Earliest CTIS Part Ii Submission Date
20-11-2024
Latest Decision Or Authorization Date
11-02-2025
Processing Time Days
83
Number Of Sites
9
Number Of Participants
50

Sites

Site Name
Centro Medico Teknon-Grupo Quironsalud
Department Name
Gastroenterology
Principal Investigator Name
Miquel Sans Cuffi
Principal Investigator Email
miqul.sans@quironsalud.es
Contact Person Name
Miquel Sans Cuffi
Contact Person Email
miqul.sans@quironsalud.es
Site Name
Hospital Universitario Y Politecnico La Fe
Department Name
Gastroenterology
Principal Investigator Name
Marisa Iborra Colomino
Principal Investigator Email
marisaiborra@hotmail.com
Contact Person Name
Marisa Iborra Colomino
Contact Person Email
marisaiborra@hotmail.com
Site Name
El Hospital Universitario De Gran Canaria Dr. Negrin
Department Name
Gastroenterology
Principal Investigator Name
Daniel Ceballos Santos
Principal Investigator Email
dcebsan@gobiernodecanarias.org
Contact Person Name
Daniel Ceballos Santos
Contact Person Email
dcebsan@gobiernodecanarias.org
Site Name
Hospital General De Tomelloso
Department Name
Gastroenterology
Principal Investigator Name
Alfredo Lucendo Villarin
Principal Investigator Email
ajlucendo@hotmail.com
Contact Person Name
Alfredo Lucendo Villarin
Contact Person Email
ajlucendo@hotmail.com
Site Name
Hospital Universitario Virgen De La Macarena
Department Name
Gastroenterology
Principal Investigator Name
Federico Argüelles-Arias
Principal Investigator Email
farguelles@telefonica.net
Contact Person Name
Federico Argüelles-Arias
Contact Person Email
farguelles@telefonica.net
Site Name
Hospital Universitario La Paz
Department Name
Gastroenterology
Principal Investigator Name
Maria Dolores Martín Arranz
Principal Investigator Email
mmartinarranz@salud.madrid.org
Contact Person Name
Maria Dolores Martín Arranz
Contact Person Email
mmartinarranz@salud.madrid.org
Site Name
Hospital Universitario Reina Sofia
Department Name
Digestive
Principal Investigator Name
Eva Maria Iglesias Flores
Principal Investigator Email
evaiflores@gmail.com
Contact Person Name
Eva Maria Iglesias Flores
Contact Person Email
evaiflores@gmail.com
Site Name
Hospital Universitario Juan Ramon Jimenez
Department Name
Digestivo
Principal Investigator Name
Hector Pallares
Principal Investigator Email
hpallaresmanrique@gmail.com
Contact Person Name
Hector Pallares
Contact Person Email
hpallaresmanrique@gmail.com
Site Name
Complexo Hospitalario Universitario De Santiago
Department Name
Gastroenterology
Principal Investigator Name
Manuel Francisco Barreiro De Acosta
Principal Investigator Email
manuel.barreiro.de.acosta@sergas.es
Contact Person Name
Manuel Francisco Barreiro De Acosta

Czechia

Earliest CTIS Part Ii Submission Date
17-01-2025
Latest Decision Or Authorization Date
11-02-2025
Processing Time Days
25
Number Of Sites
4
Number Of Participants
30

Sites

Site Name
SurGal Clinic s.r.o.
Department Name
Endoskopické centrum
Principal Investigator Name
Jan Ulbrych
Principal Investigator Email
Ulbrych.jan@surgalclinic.cz
Contact Person Name
Jan Ulbrych
Contact Person Email
Ulbrych.jan@surgalclinic.cz
Site Name
Krajska Nemocnice T Bati a.s.
Department Name
Interní klinika
Principal Investigator Name
Vladimír Kojecký
Principal Investigator Email
kojecky@bnzlin.cz
Contact Person Name
Vladimír Kojecký
Contact Person Email
kojecky@bnzlin.cz
Site Name
Nemocnice Slany
Department Name
Interní klinika Gastroenterologie
Principal Investigator Name
Martin Peterka
Principal Investigator Email
peterka.studie@seznam.cz
Contact Person Name
Martin Peterka
Contact Person Email
peterka.studie@seznam.cz
Site Name
Vojenska Nemocnice Brno
Department Name
Interní oddělení
Principal Investigator Name
David Štěpek
Principal Investigator Email
dstepek@vnbrno.cz
Contact Person Name
David Štěpek
Contact Person Email
dstepek@vnbrno.cz

Croatia

Earliest CTIS Part Ii Submission Date
27-01-2025
Latest Decision Or Authorization Date
17-02-2025
Processing Time Days
21
Number Of Sites
6
Number Of Participants
28

Sites

Site Name
Specijalna Bolnica Medico
Principal Investigator Name
Boris Brozovic
Principal Investigator Email
borizbrozovic@yahoo.com
Contact Person Name
Boris Brozovic
Contact Person Email
borizbrozovic@yahoo.com
Site Name
University Hospital Centre Zagreb
Department Name
Gastroenterology and Hepatology
Principal Investigator Name
Zeljko Krznaric
Principal Investigator Email
Zeljko.krznaric1@zg.t-com.hr
Contact Person Name
Zeljko Krznaric
Contact Person Email
Zeljko.krznaric1@zg.t-com.hr
Site Name
Poliklinika Solmed d.o.o.
Department Name
Gastroenterology
Principal Investigator Name
Dominik Kralj
Principal Investigator Email
info@solmed-clinic.com
Contact Person Name
Dominik Kralj
Contact Person Email
info@solmed-clinic.com
Site Name
Poliklinika Borzan d.o.o.
Department Name
Gastroenterology
Principal Investigator Name
Vladimir Borzan
Principal Investigator Email
Info@poliklinika-borzan.hr
Contact Person Name
Vladimir Borzan
Contact Person Email
Info@poliklinika-borzan.hr
Site Name
Opca Bolnica Dr. Andelko Visic Bjelovar
Department Name
Gastroenterology and Pulmology
Principal Investigator Name
Marinko Lukic
Principal Investigator Email
interna@obbj.hr
Contact Person Name
Marinko Lukic
Contact Person Email
interna@obbj.hr
Site Name
General Hospital Dr. Josip Bencevic
Department Name
Internal Medicine
Principal Investigator Name
Blazenka Miskic
Principal Investigator Email
interna@bolnicasb.hr
Contact Person Name
Blazenka Miskic
Contact Person Email
interna@bolnicasb.hr

Latvia

Earliest CTIS Part Ii Submission Date
07-02-2025
Latest Decision Or Authorization Date
12-02-2025
Processing Time Days
5
Number Of Sites
3
Number Of Participants
10

Sites

Site Name
Veselibas Centrs 4 SIA
Principal Investigator Name
Alda Bumbure
Principal Investigator Email
aldabumbure@inbox.lv
Contact Person Name
Alda Bumbure
Contact Person Email
aldabumbure@inbox.lv
Site Name
Liepajas Regionala Slimnica SIA
Principal Investigator Name
Linda Erne
Principal Investigator Email
liepaajaa@inbox.lv
Contact Person Name
Linda Erne
Contact Person Email
liepaajaa@inbox.lv
Site Name
Pauls Stradins Clinical University Hospital
Principal Investigator Name
Aldis Pukitis
Principal Investigator Email
pukitis@latnet.lv
Contact Person Name
Aldis Pukitis
Contact Person Email
pukitis@latnet.lv

Greece

Earliest CTIS Part Ii Submission Date
29-10-2024
Latest Decision Or Authorization Date
11-02-2025
Processing Time Days
105
Number Of Sites
7
Number Of Participants
36

Sites

Site Name
Hippokration Hospital
Department Name
Hepatogastroenterology Unit
Principal Investigator Name
Spilios Manolakopoulos
Principal Investigator Email
smanolak@med.uoa.gr
Contact Person Name
Spilios Manolakopoulos
Contact Person Email
smanolak@med.uoa.gr
Site Name
Evangelismos S.A.
Department Name
Gastroenterology Department
Principal Investigator Name
Nikolaos Viazis
Principal Investigator Email
nikos.viazis@gmail.com
Contact Person Name
Nikolaos Viazis
Contact Person Email
nikos.viazis@gmail.com
Site Name
Thoracic General Hospital Of Athens I Sotiria
Department Name
3rd Academic Department of Internal Medicine, Gastroenterology Unit
Principal Investigator Name
Georgios (Giorgos) Bamias
Principal Investigator Email
gbamias@gmail.com
Contact Person Name
Georgios (Giorgos) Bamias
Contact Person Email
gbamias@gmail.com
Site Name
General Oncological Hospital Of Kifissia Agioi Anargyroi
Department Name
Endoscopy Unit
Principal Investigator Name
Athanasia Tasovasili
Principal Investigator Email
atasovasili@hotmail.com
Contact Person Name
Athanasia Tasovasili
Contact Person Email
atasovasili@hotmail.com
Site Name
University General Hospital Of Ioannina
Department Name
Gastroenterology clinic and endoscopic unit
Principal Investigator Name
Dimitrios Christodoulou
Principal Investigator Email
dchristodoulou@gmail.com
Contact Person Name
Dimitrios Christodoulou
Contact Person Email
dchristodoulou@gmail.com
Site Name
University General Hospital Of Heraklion
Department Name
Gastroenterology Department
Principal Investigator Name
Ioannis Koutroubakis
Principal Investigator Email
researchprot@pagni.gr
Contact Person Name
Ioannis Koutroubakis
Contact Person Email
researchprot@pagni.gr
Site Name
Alexandra Hospital
Department Name
Hepato-Gastroenterology Department
Principal Investigator Name
Spyridon Michopoulos
Principal Investigator Email
michosp5@gmail.com
Contact Person Name
Spyridon Michopoulos
Contact Person Email
michosp5@gmail.com

Poland

Earliest CTIS Part Ii Submission Date
27-11-2024
Latest Decision Or Authorization Date
17-02-2025
Processing Time Days
82
Number Of Sites
27
Number Of Participants
93

Sites

Site Name
Pro Life Medica Sp. z o.o.
Department Name
ETG Zamość
Principal Investigator Name
Katarzyna Wójcik
Principal Investigator Email
k.wojcik@etg-network.com
Contact Person Name
Katarzyna Wójcik
Contact Person Email
k.wojcik@etg-network.com
Site Name
M2M Med. Sp. z o.o. Sp. j.
Principal Investigator Name
Magdalena Włoch-Targońska
Principal Investigator Email
m.wloch-targonska@m2m-badania.pl
Contact Person Name
Magdalena Włoch-Targońska
Site Name
EMC Instytut Medyczny S.A.
Department Name
EuroMediCare Przychodnia Specjalistyczna we Wrocławiu
Principal Investigator Name
Patryk Smoliński
Principal Investigator Email
psmolinski@poczta.onet.pl
Contact Person Name
Patryk Smoliński
Contact Person Email
psmolinski@poczta.onet.pl
Site Name
Eb Group Sp. z o.o.
Department Name
Centrum Zdrowia MDM
Principal Investigator Name
Marek Woynarowski
Principal Investigator Email
marek.woynarowski@czmdm.pl
Contact Person Name
Marek Woynarowski
Contact Person Email
marek.woynarowski@czmdm.pl
Site Name
Medical Concierge Centrum Medyczne
Principal Investigator Name
Jarosław Witkowski
Principal Investigator Email
pradziszewski@medicalconcierge.pl
Contact Person Name
Jarosław Witkowski
Site Name
Vitamed Galaj I Cichomski Sp. j.
Principal Investigator Name
Piotr Sikorski
Principal Investigator Email
p.sikorski@vitamed.info
Contact Person Name
Piotr Sikorski
Contact Person Email
p.sikorski@vitamed.info
Site Name
Amicare Sp. z o.o. S.K.
Principal Investigator Name
Rafał Drozda
Principal Investigator Email
r.drozda@amicare.pl
Contact Person Name
Rafał Drozda
Contact Person Email
r.drozda@amicare.pl
Site Name
Melita Medical Sp. z o.o.
Department Name
Centrum Medyczne Melita Medical
Principal Investigator Name
Jarosław Leszczyszyn
Principal Investigator Email
j.leszczyszyn@melitamedical.pl
Contact Person Name
Jarosław Leszczyszyn
Contact Person Email
j.leszczyszyn@melitamedical.pl
Site Name
Twoja Przychodnia Szczecinskie Centrum Medyczne Sp. z o.o.
Department Name
Twoja Przychodnia SCM
Principal Investigator Name
Beata Gawdis-Wojnarska
Principal Investigator Email
scm@twojaprzychodnia.com
Contact Person Name
Beata Gawdis-Wojnarska
Contact Person Email
scm@twojaprzychodnia.com
Site Name
H-T.Centrum Medyczne Sp. z o.o. sp.k.
Department Name
H-T. Centrum Medyczne - Endoterapia
Principal Investigator Name
Tomasz Romańczyk
Principal Investigator Email
romanczyk@htcentrum.pl
Contact Person Name
Tomasz Romańczyk
Contact Person Email
romanczyk@htcentrum.pl
Site Name
Centrum Medyczne Med-Gastr Sp. z o.o.
Principal Investigator Name
Arkadiusz Mamos
Principal Investigator Email
arkadiusz.mamos@medgastr.pl
Contact Person Name
Arkadiusz Mamos
Contact Person Email
arkadiusz.mamos@medgastr.pl
Site Name
Endoskopia Sp. z o.o.
Principal Investigator Name
Marek Horyński
Principal Investigator Email
homar@mp.pl
Contact Person Name
Marek Horyński
Contact Person Email
homar@mp.pl
Site Name
Medical Network Sp. z o.o.
Department Name
WIP Warsaw IBD Point Profesor Kierkuś
Principal Investigator Name
Jaroslaw Kierkuś
Principal Investigator Email
j.kierkus@med-net.pl
Contact Person Name
Jaroslaw Kierkuś
Contact Person Email
j.kierkus@med-net.pl
Site Name
Centrum Medyczne Kermed Renata Bijata-Bronisz I Ewa Kowalinska Sp. j.
Department Name
Centrum Medyczne KERmed
Principal Investigator Name
Patryk Korga
Principal Investigator Email
patryk.korga@kermed.pl
Contact Person Name
Patryk Korga
Contact Person Email
patryk.korga@kermed.pl
Site Name
VISTAMED
Principal Investigator Name
Bernardeta Fryśna
Principal Investigator Email
b.frysna@vistamed.pl
Contact Person Name
Bernardeta Fryśna
Contact Person Email
b.frysna@vistamed.pl
Site Name
Manermed Sp. z o.o.
Department Name
Centrum Medyczne Medis
Principal Investigator Name
Maria Kłopocka
Principal Investigator Email
mariaklopocka@wp.pl
Contact Person Name
Maria Kłopocka
Contact Person Email
mariaklopocka@wp.pl
Site Name
Twoja Przychodnia Opolskie Centrum Medyczne
Principal Investigator Name
Marzena Kwinto
Principal Investigator Email
mkwinto@opolemed.com
Contact Person Name
Marzena Kwinto
Contact Person Email
mkwinto@opolemed.com
Site Name
Medrise Sp. z o.o.
Principal Investigator Name
Wit Danilkiewicz
Principal Investigator Email
wdanilk@gmail.com
Contact Person Name
Wit Danilkiewicz
Contact Person Email
wdanilk@gmail.com
Site Name
Centrum Medyczne Plejady Magdalena Celinska Loewenhoff Michal Zolnowski sp.k.
Principal Investigator Name
Monika Augustyn
Principal Investigator Email
amonika@interia.pl
Contact Person Name
Monika Augustyn
Contact Person Email
amonika@interia.pl
Site Name
Centrum Medyczne Oporow
Principal Investigator Name
Radoslaw Kempiński
Principal Investigator Email
radoslaw.kempinski@cmoporow.com
Contact Person Name
Radoslaw Kempiński
Site Name
Ip Clinic Sp. z o.o.
Principal Investigator Name
Cezary Rudnicki
Principal Investigator Email
cezary.rudnicki@ipclinic.pl
Contact Person Name
Cezary Rudnicki
Contact Person Email
cezary.rudnicki@ipclinic.pl
Site Name
Topolowa Medicenter Ryszawa & Wspolnicy Sp. j.
Principal Investigator Name
Zbigniew Wylegała
Principal Investigator Email
zbigniew.wylegala@tmedicenter.com
Contact Person Name
Zbigniew Wylegała
Site Name
MIGRE Polskie Centrum Leczenia Migreny Anna Gryglas-Dworak
Principal Investigator Name
Dorota Waśko-Czopnik
Principal Investigator Email
dorota.czopnik@migre.pl
Contact Person Name
Dorota Waśko-Czopnik
Contact Person Email
dorota.czopnik@migre.pl
Site Name
Pratia S.A.
Department Name
Pratia Poznań
Principal Investigator Name
Magdalena Andrzejewska
Principal Investigator Email
magdalena.andrzejewska@pratia.com
Contact Person Name
Magdalena Andrzejewska

Hungary

Earliest CTIS Part Ii Submission Date
27-11-2024
Latest Decision Or Authorization Date
13-02-2025
Processing Time Days
78
Number Of Sites
6
Number Of Participants
40

Sites

Site Name
University Of Szeged
Department Name
Belgyógyászati Klinika
Principal Investigator Name
Klaudia FARKAS
Principal Investigator Email
farkas.klaudia@gmail.com
Contact Person Name
Klaudia FARKAS
Contact Person Email
farkas.klaudia@gmail.com
Site Name
Fejer Varmegyei Szent Gyoergy Egyetemi Oktato Korhaz
Department Name
I.Sz. Belgyógyászati Osztály
Principal Investigator Name
Roland FEJES
Principal Investigator Email
rfejes@mail.fmkorhaz.hu
Contact Person Name
Roland FEJES
Contact Person Email
rfejes@mail.fmkorhaz.hu
Site Name
Clinexpert Kft.
Principal Investigator Name
Gábor TÓTH
Principal Investigator Email
medicatorbt@gmail.com
Contact Person Name
Gábor TÓTH
Contact Person Email
medicatorbt@gmail.com
Site Name
Obudai Egeszseguegyi Centrum Kft.
Principal Investigator Name
Róbert SIKE
Principal Investigator Email
sike.endoexpert@gmail.com
Contact Person Name
Róbert SIKE
Contact Person Email
sike.endoexpert@gmail.com
Site Name
Clinexpert Gyoengyoes Kft.
Principal Investigator Name
Gyula HORVÁT
Principal Investigator Email
horvatgyula@gmail.com
Contact Person Name
Gyula HORVÁT
Contact Person Email
horvatgyula@gmail.com
Site Name
Semmelweis Egyetem
Department Name
II.Sz. Belgyógyászati Klinika
Principal Investigator Name
Zsolt TULASSAY
Principal Investigator Email
tulassay.zsolt@semelweis.hu
Contact Person Name
Zsolt TULASSAY
Contact Person Email
tulassay.zsolt@semelweis.hu

Germany

Earliest CTIS Part Ii Submission Date
16-01-2025
Latest Decision Or Authorization Date
14-02-2025
Processing Time Days
29
Number Of Sites
13
Number Of Participants
86

Sites

Site Name
Magen-Darm-Zentrum Remscheid
Principal Investigator Name
Eric Jörgensen
Principal Investigator Email
ericjoergensen@me.com
Contact Person Name
Eric Jörgensen
Contact Person Email
ericjoergensen@me.com
Site Name
Studiengesellschaft BSF UG (haftungsbeschraenkt)
Principal Investigator Name
Lars Fechner
Principal Investigator Email
larsfechner1@icloud.com
Contact Person Name
Lars Fechner
Contact Person Email
larsfechner1@icloud.com
Site Name
Hamburgisches Forschungsinstitut fuer chronisch entzuendliche Darmerkrankungen HaFCED e.K.
Principal Investigator Name
Stefanie Howaldt
Principal Investigator Email
howaldt@hafced.de
Contact Person Name
Stefanie Howaldt
Contact Person Email
howaldt@hafced.de
Site Name
Charite Universitaetsmedizin Berlin KöR
Department Name
Medizinische Klinik mit Schwerpunkt Hepatologie und Gastroenterologie
Principal Investigator Name
Michael Sigal
Principal Investigator Email
michael.sigal@charite.de
Contact Person Name
Michael Sigal
Contact Person Email
michael.sigal@charite.de
Site Name
Klinikum rechts der Isar der TU Muenchen AöR
Department Name
Klinik und Poliklinik für Innere Medizin II
Principal Investigator Name
Matthias Treiber
Principal Investigator Email
Matthias.Treiber@mri.tum.de
Contact Person Name
Matthias Treiber
Contact Person Email
Matthias.Treiber@mri.tum.de
Site Name
Universitaetsklinikum Augsburg
Department Name
III. Medizinische Klinik
Principal Investigator Name
Elisabeth Schnoy
Principal Investigator Email
elisabeth.schnoy@uk-augsburg.de
Contact Person Name
Elisabeth Schnoy
Site Name
Universitaetsklinikum Brandenburg an der Havel GmbH
Department Name
Zentrum für Innere Medizin II Klinik für Gastroenterologie, Hepatologie, Diabetologie und Endoskopie
Principal Investigator Name
Stefan Lüth
Principal Investigator Email
s.lueth@klinikum-brandenburg.de
Contact Person Name
Stefan Lüth
Site Name
Goethe University Frankfurt
Department Name
Medizinische Klinik 1
Principal Investigator Name
Irina Blumenstein
Principal Investigator Email
Blumenstein@em.uni-frankfurt.de
Contact Person Name
Irina Blumenstein
Site Name
Medizinische Hochschule Hannover
Department Name
Klinik für Gastroenterologie, Hepatologie, Infektiologie und Endokrinologie
Principal Investigator Name
Ursula Seidler
Principal Investigator Email
seidler.ursula@mh-hannover.de
Contact Person Name
Ursula Seidler
Contact Person Email
seidler.ursula@mh-hannover.de
Site Name
Universitaetsklinikum Ulm AöR
Department Name
Klinik für Innere Medizin I
Principal Investigator Name
Jochen Klaus
Principal Investigator Email
jochen.klaus@uniklinik-ulm.de
Contact Person Name
Jochen Klaus
Contact Person Email
jochen.klaus@uniklinik-ulm.de
Site Name
Universitaetsklinikum Schleswig-Holstein AöR
Department Name
Klinik für Allgemeine Innere Medizin I Medizinische Klinik
Principal Investigator Name
Stefan Schreiber
Principal Investigator Email
s.schreiber@mucosa.de
Contact Person Name
Stefan Schreiber
Contact Person Email
s.schreiber@mucosa.de
Site Name
CED Studien UG (haftungsbeschraenkt)
Department Name
Interdisziplinäres Crohn Colitis Centrum Rhein-Main
Principal Investigator Name
Jürgen Stein
Principal Investigator Email
j.stein@em.uni-frankfurt.de
Contact Person Name
Jürgen Stein
Contact Person Email
j.stein@em.uni-frankfurt.de
Site Name
Medizinisches Versorgungszentrum fuer spezialaerztliche Versorgung Professor Dr. Friedrichs GmbH
Department Name
MVZ für spezialärztliche Versorgung Dr. Friedrichs GmbH
Principal Investigator Name
Wolfgang Nitz
Principal Investigator Email
wolfgang.nitz@sana.de
Contact Person Name
Wolfgang Nitz
Contact Person Email
wolfgang.nitz@sana.de

Ireland

Earliest CTIS Part Ii Submission Date
06-02-2025
Latest Decision Or Authorization Date
14-02-2025
Processing Time Days
8
Number Of Sites
1
Number Of Participants
16

Sites

Site Name
Beaumont Hospital
Department Name
Gastroenterology
Principal Investigator Name
Aoibhlinn Mary O’Toole
Principal Investigator Email
aoibhlinnmaryotoole@beaumont.ie
Contact Person Name
Aoibhlinn Mary O’Toole

Romania

Earliest CTIS Part Ii Submission Date
29-10-2024
Latest Decision Or Authorization Date
14-02-2025
Processing Time Days
108
Number Of Sites
7
Number Of Participants
34

Sites

Site Name
Monza-Ares S.R.L.
Department Name
Gastroenterolgy Department
Principal Investigator Name
Theodor-Alexandru Voiosu
Principal Investigator Email
theodor.voiosu@gmail.com
Contact Person Name
Theodor-Alexandru Voiosu
Contact Person Email
theodor.voiosu@gmail.com
Site Name
Centrul De Gastroenterologie Dr. Goldis S.R.L.
Department Name
Gastroenterolgy
Principal Investigator Name
Eugen-Adrian Goldis
Principal Investigator Email
goldisadi@yahoo.com
Contact Person Name
Eugen-Adrian Goldis
Contact Person Email
goldisadi@yahoo.com
Site Name
Valahia Medical S.R.L.
Department Name
Gastroenterology
Principal Investigator Name
George Stancu
Principal Investigator Email
stancu.george@valahiamedical.ro
Contact Person Name
George Stancu
Site Name
Spitalul Universitar De Urgenta Militar Central Dr. Carol Davila
Department Name
Sectia Clinica Gastroenterologie
Principal Investigator Name
Sandica-Nicoleta Bucurica
Principal Investigator Email
bucuricasandy@yahoo.co
Contact Person Name
Sandica-Nicoleta Bucurica
Contact Person Email
bucuricasandy@yahoo.co
Site Name
Spitalul Clinic Colentina Bucuresti
Department Name
Gastroenterology
Principal Investigator Name
Radu-Bogdan Mateescu
Principal Investigator Email
gastrostudii@gmail.com
Contact Person Name
Radu-Bogdan Mateescu
Contact Person Email
gastrostudii@gmail.com
Site Name
Spitalul Universitar De Urgenta Bucuresti
Department Name
Gastroenterology
Principal Investigator Name
Lucian Negreanu
Principal Investigator Email
negreanu_99@yahoo.com
Contact Person Name
Lucian Negreanu
Contact Person Email
negreanu_99@yahoo.com
Site Name
Institutul Regional De Gastroenterologie Hepatologie Prof. Dr. Octavian Fodor Cluj
Department Name
Gastroenterology
Principal Investigator Name
Cristina Pojoga
Principal Investigator Email
cristina.pojoga@yahoo.com
Contact Person Name
Cristina Pojoga
Contact Person Email
cristina.pojoga@yahoo.com

France

Earliest CTIS Part Ii Submission Date
29-01-2025
Latest Decision Or Authorization Date
10-02-2025
Processing Time Days
12
Number Of Sites
6
Number Of Participants
38

Sites

Site Name
Centre Hospitalier Universitaire De Nice
Department Name
Gastroenterology Department
Principal Investigator Name
Adrien Nicolau
Principal Investigator Email
nicolau.a@chu-nice.fr
Contact Person Name
Adrien Nicolau
Contact Person Email
nicolau.a@chu-nice.fr
Site Name
Assistance Publique Hopitaux De Paris
Department Name
Gastroenterology Department
Principal Investigator Name
Mathieu UZZAN
Principal Investigator Email
mathieu.uzzan@aphp.fr
Contact Person Name
Mathieu UZZAN
Contact Person Email
mathieu.uzzan@aphp.fr
Site Name
Centre Hospitalier Universitaire Rouen
Department Name
Hepato-Gastroenterology Department
Principal Investigator Name
Guillaume Savoye
Principal Investigator Email
guillaume.savoye@chu-rouen.fr
Contact Person Name
Guillaume Savoye
Contact Person Email
guillaume.savoye@chu-rouen.fr
Site Name
Centre Hospitalier Universitaire Grenoble Alpes
Department Name
Hepato-Gastroenterology Department
Principal Investigator Name
Clémence LOMBOIS
Principal Investigator Email
CLombois@chu-grenoble.fr
Contact Person Name
Clémence LOMBOIS
Contact Person Email
CLombois@chu-grenoble.fr
Site Name
Centre Hospitalier Departemental Vendee
Department Name
Hepato-Gastroenterology Department
Principal Investigator Name
Morgane Amil
Principal Investigator Email
morgane.amil@ght85.fr
Contact Person Name
Morgane Amil
Contact Person Email
morgane.amil@ght85.fr
Site Name
Hospices Civils De Lyon
Department Name
Gastroenterology Department
Principal Investigator Name
Stéphane Nancey
Principal Investigator Email
stephane.nancey@chu-lyon.fr
Contact Person Name
Stéphane Nancey
Contact Person Email
stephane.nancey@chu-lyon.fr

Italy

Earliest CTIS Part Ii Submission Date
10-12-2024
Latest Decision Or Authorization Date
14-02-2025
Processing Time Days
66
Number Of Sites
19
Number Of Participants
124

Sites

Site Name
IRCCS Azienda Ospedaliero-Universitaria di Bologna - Policlinico di Sant'Orsola
Department Name
SSD Malattie Infiammatorie Croniche Intestinali - Centro di Riferimento per le MICI
Principal Investigator Name
Fernando Rizzello
Principal Investigator Email
fernando.rizzello@unibo.it
Contact Person Name
Fernando Rizzello
Contact Person Email
fernando.rizzello@unibo.it
Site Name
Azienda Ospedaliera Universitaria Gaetano Martino Messina
Department Name
UOC Gastroenterologia e malattie infiammatorie croniche intestinali
Principal Investigator Name
Walter Fries
Principal Investigator Email
fwalter@unime.it
Contact Person Name
Walter Fries
Contact Person Email
fwalter@unime.it
Site Name
Fondazione IRCCS Policlinico San Matteo
Department Name
UOC Gastroenterologia Dipartimento di Medicina Interna e Terapia Medica
Principal Investigator Name
Antonio Di Sabatino
Principal Investigator Email
a.disabatino@smatteo.pv.it
Contact Person Name
Antonio Di Sabatino
Contact Person Email
a.disabatino@smatteo.pv.it
Site Name
Ospedale San Raffaele S.r.l.
Department Name
Gastroenterologia ed Endoscopia digestiva
Principal Investigator Name
Silvio Danese
Principal Investigator Email
ibd.trials@hsr.it
Contact Person Name
Silvio Danese
Contact Person Email
ibd.trials@hsr.it
Site Name
Azienda Ospedaliera di Padova
Department Name
UOC Gastroenterologia
Principal Investigator Name
Edoardo Savarino
Principal Investigator Email
edoardo.savarino@unipd.it
Contact Person Name
Edoardo Savarino
Contact Person Email
edoardo.savarino@unipd.it
Site Name
Azienda Ospedaliera Universitaria Citta Della Salute E Della Scienza Di Torino
Department Name
S.C. Gastroenterology U.
Principal Investigator Name
Davide Giuseppe Ribaldone
Principal Investigator Email
avidegiuseppe.ribaldone@unito.it
Contact Person Name
Davide Giuseppe Ribaldone
Site Name
Azienda Ospedaliero-Universitaria Di Cagliari
Department Name
Unità di Gastroenterologia Dipartimento di Scienze Mediche e Salute Pubblica
Principal Investigator Name
Massimo Claudio Fantini
Principal Investigator Email
massimoc.fantini@unica.it
Contact Person Name
Massimo Claudio Fantini
Contact Person Email
massimoc.fantini@unica.it
Site Name
Azienda Ospedaliera Policlinico Universitario Tor Vergata
Department Name
U.O.C. Gastroenterologia
Principal Investigator Name
Giovanni Monteleone
Principal Investigator Email
gi.monteleone@med.uniroma2.it
Contact Person Name
Giovanni Monteleone
Contact Person Email
gi.monteleone@med.uniroma2.it
Site Name
Azienda Socio Sanitaria Territoriale Santi Paolo E Carlo
Department Name
S.C. Medicina ad indirizzo Epatologico e Gastroenterologico
Principal Investigator Name
Luca Pastorelli
Principal Investigator Email
luca.pastorelli@unimi.it
Contact Person Name
Luca Pastorelli
Contact Person Email
luca.pastorelli@unimi.it
Site Name
Fondazione Poliambulanza
Department Name
Gastroenterology and Digestive Endoscopy Unit
Principal Investigator Name
Paola Cesaro
Principal Investigator Email
paola.cesaro@poliambulanza.it
Contact Person Name
Paola Cesaro
Contact Person Email
paola.cesaro@poliambulanza.it
Site Name
Humanitas Mirasole S.p.A.
Department Name
Chronic Infiammatory Bowel Diseases Unit
Principal Investigator Name
Alessandro Armuzzi
Principal Investigator Email
alessandro.armuzzi@hunimed.eu
Contact Person Name
Alessandro Armuzzi
Contact Person Email
alessandro.armuzzi@hunimed.eu
Site Name
Policlinico San Donato S.p.A.
Department Name
Unità di Gastroenterologia ed Endoscopia Digestiva
Principal Investigator Name
Vito Annese
Principal Investigator Email
Vito.Annese@grupposandonato.it
Contact Person Name
Vito Annese
Contact Person Email
Vito.Annese@grupposandonato.it
Site Name
Azienda Ospedaliera Universitaria Di Modena
Department Name
Struttura Complessa di Gastroenterologia ed Endoscopia Digestiva
Principal Investigator Name
Antonio Colecchia
Principal Investigator Email
antonio.colecchia@unimore.it
Contact Person Name
Antonio Colecchia
Contact Person Email
antonio.colecchia@unimore.it
Site Name
Casa Sollievo Della Sofferenza
Department Name
UOC di Gastroenterologia ed Endoscopia Digestiva
Principal Investigator Name
Fabrizio Bossa
Principal Investigator Email
f.bossa@operapadrepio.it
Contact Person Name
Fabrizio Bossa
Contact Person Email
f.bossa@operapadrepio.it
Site Name
Azienda Ospedaliero Universitaria Careggi
Department Name
SOD Gastroenterology
Principal Investigator Name
Francesca Rogai
Principal Investigator Email
rogaif@aou-careggi.toscana.it
Contact Person Name
Francesca Rogai
Contact Person Email
rogaif@aou-careggi.toscana.it
Site Name
Azienda Sanitaria Territoriale Di Pesaro E Urbino
Department Name
UOC Gastroenterologia e Endoscopia Digestiva
Principal Investigator Name
Antonella Scarcelli
Principal Investigator Email
antonella.scarcelli@ospedalimarchenord.it
Contact Person Name
Antonella Scarcelli
Site Name
Fondazione Policlinico Universitario Campus Bio-medico
Department Name
UOC Gastroenterologia
Principal Investigator Name
Michele Cicala
Principal Investigator Email
m.cicala@policlinicocampus.it
Contact Person Name
Michele Cicala
Contact Person Email
m.cicala@policlinicocampus.it
Site Name
Azienda Ospedaliera S Giovanni Addolorata
Department Name
UOC Gastroenterologia Endoscopia Digestiva
Principal Investigator Name
Maria Giovanna Graziani
Principal Investigator Email
mg.graziani@virgilio.it
Contact Person Name
Maria Giovanna Graziani
Contact Person Email
mg.graziani@virgilio.it

Sponsor

Primary sponsor

Full Name
Eli Lilly & Co.
Organisation Type
Pharmaceutical company
Country Of Registered Address
United States

Contract research organisations

Name
Pharmaceutical Product Development LLC (PPD)
Responsibilities
Testing, reporting, and sample management (i.e., receipt, storage, and shipment)
Name
PPD Global Central Labs / PPD Global Ltd. / PPD Development LP
Responsibilities
Central lab services, testing, sample management and various operational roles (multiple codes listed)
Name
Icon Development Solutions LLC
Responsibilities
PK Mirikizumab
Name
Pra International
Responsibilities
Reporting, and sample management (i.e., receipt, storage, and shipment)

Third parties

  • {"country":"France","full_name":"Inato","duties_or_roles":"Patient Recruitment","organisation_type":"Pharmaceutical company"}
  • {"country":"United States","full_name":"Veeva Systems Inc.","duties_or_roles":"","organisation_type":"Non-Pharmaceutical company"}
  • {"country":"United States","full_name":"Pharmaceutical Product Development LLC","duties_or_roles":"Testing, reporting, and sample management(i.e., receipt, storage, and shipment)","organisation_type":"Pharmaceutical company"}
  • {"country":"Canada","full_name":"Charles River Laboratories Montreal ULC","duties_or_roles":"Lab sciences assay for quantification of human plasma by Elisa","organisation_type":"Pharmaceutical company"}
  • {"country":"United States","full_name":"RWS Life Sciences Inc.","duties_or_roles":"eCOA licensing and translation","organisation_type":"Pharmaceutical company"}
  • {"country":"United States","full_name":"Scout Clinical","duties_or_roles":"Itinerary Management; Expense Reimbursement Management; Patient Payment Management","organisation_type":"Hospital/Clinic/Other health care facility"}
  • {"country":"United States","full_name":"Bioagilytix Labs LLC","duties_or_roles":"Mirikizumab ADA","organisation_type":"Pharmaceutical company"}
  • {"country":"United States","full_name":"Eurofins Pharma Bioanalytics Services US Inc.","duties_or_roles":"IL-8 testing, Eltrekibart ADA","organisation_type":"Pharmaceutical company"}
  • {"country":"United States","full_name":"Signant Health Global LLC","duties_or_roles":"ECoA and eConsent vendor","organisation_type":"Non-Pharmaceutical company"}
  • {"country":"Belgium","full_name":"PPD Global Central Labs","duties_or_roles":"Testing, reporting, and sample management(i.e., receipt, storage, and shipment)","organisation_type":"Pharmaceutical company"}
  • {"country":"United States","full_name":"Acelabio (US) Inc.","duties_or_roles":"","organisation_type":"Pharmaceutical company"}
  • {"country":"Greece","full_name":"PPD Global Ltd.","duties_or_roles":"","organisation_type":"Pharmaceutical company"}
  • {"country":"United States","full_name":"Jumo Health USA Inc.","duties_or_roles":"patient education and engagement materials","organisation_type":"Hospital/Clinic/Other health care facility"}
  • {"country":"United States","full_name":"Icon Development Solutions LLC","duties_or_roles":"PK Mirikizumab","organisation_type":"Pharmaceutical company"}
  • {"country":"United States","full_name":"WCG Clinical Inc.","duties_or_roles":"Investigator meeting","organisation_type":"Pharmaceutical company"}
  • {"country":"United States","full_name":"PPD Development LP","duties_or_roles":"Multiple operational duties (codes 1,12,5 etc) as listed","organisation_type":"Pharmaceutical company"}
  • {"country":"United States","full_name":"Pra International","duties_or_roles":"Reporting, and sample management(i.e., receipt, storage, and shipment)","organisation_type":"Pharmaceutical company"}
  • {"country":"Netherlands","full_name":"Alimentiv B.V.","duties_or_roles":"Central Image Management","organisation_type":"Pharmaceutical company"}

Investigational products

Investigational Product Name
Eltrekibart
Active Substance
Humanised IgG4 kappa monoclonal antibody against CXCL1, CXCL2, CXCL3, CXCL5, CXCL6, CXCL7 and CXCL8
Modality
Monoclonal antibody
Routes Of Administration
Infusion
Route
Infusion
Authorisation Status
Authorised (prodAuthStatus: 1)
Investigational Product Name
Mirikizumab
Active Substance
Mirikizumab
Modality
Monoclonal antibody
Routes Of Administration
Solution for injection (pre-filled syringe) and solution for infusion
Route
Injection / Infusion
Authorisation Status
Authorised (prodAuthStatus: 1)
Investigational Product Name
Placebo for LY3074828 SC Injection, 1mL Prefilled Syringe
Modality
Other
Routes Of Administration
SC injection (placebo)
Route
SC injection (placebo)
Investigational Product Name
0.9% sodium chloride
Modality
Other
Routes Of Administration
Infusion (placebo for infusion)
Route
Infusion (placebo)
Combination Treatment
Yes

Related trials

Other published trials that may interest you.