GEPOTIDACIN for Urinary tract infection

Inclusion criteria

• {"criterion_text":"-Participants having ≥2 to <12 years of age at the time of signing the informed consent/assent and have a body weight >=10 kilograms (kg).\n-Participants receiving SoC antibacterial therapy for a confirmed/suspected infection or for prophylaxis AND is able to take a single dose of the powder for oral suspension formulation of gepotidacin after a meal.\n-Participants either hospitalized or in an overnight clinic. Participant is expected to be in hospital/clinic for at least 24 hours post administration of study intervention. Participant has an indwelling venous catheter in place as part of the clinical SoC.\n-Male or female according to their reproductive organs at birth.\n-Pregnancy testing is required as appropriate for the age, sexual activity, and sexual maturity of pediatric participants and as required by local regulations. Investigator should apply clinical judgment.\n-A female participant is eligible to participate if she is a WOCBP who is not pregnant as confirmed by a high sensitivity serum or urine pregnancy test at baseline (Day 1) regardless of current or prior contraception use or abstinence, is not breastfeeding, or is not a WOCBP.\n-Participant LAR(s) who has the ability to understand, agree to, and sign the informed consent form before initiation of any protocol-related procedures; participant has the ability to give documented assent.\n-Participant and participant’s LAR are willing and able to comply with study instructions, study visits, and procedures."}

Exclusion criteria

• {"criterion_text":"-Participants having a BMI-for-age that is less than the 5th percentile or greater than the 95th percentile based on the CDC percentiles. [NCHS Growth Charts].\n-The participant has any surgical or medical condition (active or chronic) that may interfere with drug absorption, distribution, metabolism, or excretion of the study intervention (e.g., ileostomy or malabsorption syndrome).\n-The participant plans to use any of the prohibited medications or nondrug therapies from the Baseline Visit through Follow-up Visit at 7 ±3 days after the single dose of study intervention.\n-The participant has received a prohibited medication within 14 days or 5 half-lives prior to gepotidacin administration, whichever is longer.\n-The participant has been previously enrolled in this study or has previously been treated with gepotidacin.\n-The participant has participated in a clinical trial and has received an investigational product within 30 days or 5 halflives prior to gepotidacin administration, whichever is longer\n-The participant, in the judgment of the investigator, would not be able or willing to comply with the protocol or complete study follow-up.\n-If the child is being breastfed: There is suspicion of current alcohol or substance misuse/abuse in breastfeeding mother; The breastfeeding mother is taking any medication or any substances containing any of the medications included in the prohibited medication list with known or unknown lactation excretion.\n-The participant has severe hepatic organ dysfunction.\n-The participant has an ALT value >2 × ULN.\n-The participant has a total bilirubin >1.5xULN; Participants with Gilbert’s syndrome can be included with total bilirubin >1.5xULN as long as direct bilirubin is </= 1.5xULN.\n-Participants having a clinically significant medical history, including malignancy, significant chromosome abnormality, neurological disorder or history of seizure (excluding simple febrile seizure), chronic immunosuppressive disease, active tuberculosis or acute hepatitis.\n-Cirrhosis or current unstable liver or biliary disease per investigator assessment defined by the presence of ascites, encephalopathy, coagulopathy, hypoalbuminemia, esophageal or gastric varices, persistent jaundice.\n-The participant has congenital long QT syndrome or known prolongation of the QTc interval.\n-The participant has uncompensated heart failure.\n-The participant has severe left ventricular hypertrophy.\n-The participant has a family history of QT prolongation or sudden death or history of sudden infant death in a sibling.\n-Participants with serious disease/condition that could be imminently life-threatening (e.g. is clinically/hemodynamically unstable, is septicemic, has severe sepsis, organ failure, requiring ITU care or has clinical laboratory tests either nonstable or anticipated to be nonstable) or the participant is unlikely to survive for the duration of the study period.\n-The participant has severe renal organ dysfunction or has known anuria, oliguria, or significant impairment of renal function (creatinine clearance <60 mL/min or clinically significant elevated serum creatinine as determined by the investigator).\n-The participant has a history of sensitivity to the study intervention, or components thereof, or a history of a drug or other allergy that, in the opinion of the investigator or medical monitor, contraindicates study participation.\n-The participant is immunocompromised or has altered immune defenses that may predispose the participant to a higher risk of complications (e.g., uncontrolled diabetes in the judgment of the investigator, transplant recipients (with the exception of cornea and autologous BMT), participants with clinically significant persistent granulocytopenia [absolute neutrophil count <1000/μL], and participants receiving immunosuppressive therapy, including corticosteroid therapy [>20 mg/day prednisolone or equivalent for >1 week, 20 mg/day prednisolone or equivalent for >2 weeks, or prednisolone or equivalent ≥10 mg/day for >6 weeks]). Participants with a known CD4 count of <200 cells/mm3 are to not be enrolled.\n-The participant has any of the following medical condition that requires medication that may be impacted by inhibition of acetylcholinesterase, such as: Poorly controlled asthma or obstructive pulmonary disease at baseline and, in the opinion of the investigator, not stable on current therapy; Active peptic ulcer disease; Juvenile Parkinson disease; Juvenile Myasthenia gravis.\n- The participant has a recent history of vasovagal syncope or episodes of symptomatic bradycardia or brady arrhythmia within the last 12 months.\n-The participant is taking QT-prolonging drugs or drugs known to increase the risk of TdP per the ww.crediblemeds.org. “Known Risk of TdP” category at the time of the Baseline Visit, which cannot be safely discontinued from the Baseline Visit (Day 1) through 7 (+3) days after the single dose of study intervention; or the participant is taking a strong CYP3A4 inhibitor.\n-The participant has a mean triplicate QTc >450 msec or a mean triplicate QTc >480 msec for participants with complete bundle branch block.\n-The participant has a documented or recent history of uncorrected hypokalemia within the past 3 months."}

Primary endpoints

• {"endpoint_text":"-AUC from time zero to the time of the last quantifiable concentration (AUC[0-t]) of gepotidacin.","definition_or_measurement_approach":"Pharmacokinetic parameter calculated from plasma concentration-time data (AUC[0-t])."}
• {"endpoint_text":"-Area under the concentration-time curve from time zero extrapolated to infinite time (AUC[0-inf]) of gepotidacin.","definition_or_measurement_approach":"Pharmacokinetic parameter extrapolated from plasma concentration-time data (AUC[0-inf])."}
• {"endpoint_text":"-Maximum observed plasma concentration (Cmax) of gepotidacin.","definition_or_measurement_approach":"Peak plasma concentration measured from plasma concentration-time profile."}
• {"endpoint_text":"-Apparent oral clearance (CL/F) of gepotidacin.","definition_or_measurement_approach":"PK parameter calculated from dose and plasma concentration-time data."}
• {"endpoint_text":"-Apparent volume of distribution (Vz/F) of gepotidacin.","definition_or_measurement_approach":"PK parameter derived from plasma concentration-time data."}
• {"endpoint_text":"-Terminal phase half-life (t1/2) of gepotidacin.","definition_or_measurement_approach":"Elimination half-life determined from terminal phase of plasma concentration-time curve."}

Secondary endpoints

• {"endpoint_text":"-Number of participants with Adverse events (AEs), Adverse Events of Special Interest (AESI) and Serious Adverse Events (SAEs);","definition_or_measurement_approach":"Safety reporting of AEs, AESIs and SAEs collected during study period."}
• {"endpoint_text":"-Change from baseline in vital signs: Temperature;","definition_or_measurement_approach":"Difference between baseline and post-dose temperature measurements."}
• {"endpoint_text":"-Change from baseline in vital signs: Blood Pressure;","definition_or_measurement_approach":"Difference between baseline and post-dose blood pressure measurements."}
• {"endpoint_text":"-Change from baseline in vital signs: Pulse Rate;","definition_or_measurement_approach":"Difference between baseline and post-dose pulse rate measurements."}
• {"endpoint_text":"-Change from baseline in Electrocardiogram (ECG).","definition_or_measurement_approach":"Comparison of baseline and post-dose ECG parameters (e.g., QTc)."}

Poland

Earliest CTIS Part Ii Submission Date

09-03-2026

Latest Decision Or Authorization Date

09-04-2026

Processing Time Days

31

Number Of Sites

2

Number Of Participants

2

Spain

Earliest CTIS Part Ii Submission Date

12-03-2026

Latest Decision Or Authorization Date

09-04-2026

Processing Time Days

28

Number Of Sites

3

Number Of Participants

3

Primary sponsor

Full Name

Glaxosmithkline Research & Development Limited

Organisation Type

Pharmaceutical company

Country Of Registered Address

United Kingdom

Contract research organisations

Name

Eresearchtechnology Inc.

Responsibilities

ECG Central Reading

Name

Quipment

Responsibilities

Supply of dosing cups and lids

Name

Scout Clinical

Responsibilities

Management of Patient Stipends

Name

PPD Global Limited

Name

Ppd Inc.

Third parties

• {"country":"France","full_name":"Quipment","duties_or_roles":"Supply of dosing cups and lids","organisation_type":"Non-Pharmaceutical company"}
• {"country":"United States","full_name":"Eresearchtechnology Inc.","duties_or_roles":"ECG Central Reading","organisation_type":"Pharmaceutical company"}
• {"country":"United States","full_name":"Scout Clinical","duties_or_roles":"Management of Patient Stipends","organisation_type":"Hospital/Clinic/Other health care facility"}
• {"country":"United Kingdom","full_name":"PPD Global Limited","duties_or_roles":"","organisation_type":"Pharmaceutical company"}
• {"country":"United States","full_name":"Ppd Inc.","duties_or_roles":"","organisation_type":"Pharmaceutical company"}