Clinical trial • Phase III • Oncology

ARLOCABTAGENE AUTOLEUCEL for Relapsed or refractory multiple myeloma

Phase III trial of ARLOCABTAGENE AUTOLEUCEL for Relapsed or refractory multiple myeloma.

Overview

Trial Therapeutic Area
Oncology
Trial Disease
Relapsed or refractory multiple myeloma
Trial Stage
Phase III
Drug Modality
Cell therapy | Monoclonal antibody | Small molecule
Orphan Drug
Yes

Key dates

Initial CTIS Submission Date
22-11-2024
First CTIS Authorization Date
31-03-2025

Trial design

Randomised, open-label, daratumumab + pomalidomide + dexamethasone (dpd); carfilzomib + dexamethasone (kd) — doses and schedules not specified in the ctis record.-controlled Phase III trial in Italy, Romania, Poland and others.

Randomised
Yes
Open Label
Yes
Comparator
Daratumumab + Pomalidomide + Dexamethasone (DPd); Carfilzomib + Dexamethasone (Kd) — doses and schedules not specified in the CTIS record.
Target Sample Size
251

Eligibility

Recruits 251 Vulnerable population not selected; participants must be at least 18 years old. Consent is provided by adult participants. No assent or specific vulnerable-population consent procedures are described in the CTIS record..

Vulnerable Population
Vulnerable population not selected; participants must be at least 18 years old. Consent is provided by adult participants. No assent or specific vulnerable-population consent procedures are described in the CTIS record.

Inclusion criteria

  • {"criterion_text":"- Have RRMM, have received 1-3 prior lines of therapy (LOT) for MM, and with proof that the disease got worse during or after the last treatment and have prior exposure to LEN."}
  • {"criterion_text":"- Have measurable signs of MM as per the study criteria."}
  • {"criterion_text":"- Be at least 18 years old and have adequate organ function and performance status as per study criteria."}

Exclusion criteria

  • {"criterion_text":"- Known or history of central nervous system involvement with MM."}
  • {"criterion_text":"- Solitary plasmacytomas or non-secretory MM and no other measurable signs of MM."}
  • {"criterion_text":"- Need for urgent treatment due to rapidly progressing MM."}
  • {"criterion_text":"- Known or history of central nervous system involvement with MM."}

Endpoints

Primary endpoints

  • {"endpoint_text":"- Progression free survival (PFS): The average time participants are alive without their MM getting worse after starting the study.","definition_or_measurement_approach":"Defined as the average time participants are alive without disease progression after starting the study (time to MM progression or death)."}
  • {"endpoint_text":"- Minimal residual disease (MRD)-negative, complete response (CR): No signs of MM can be found in the participant’s body.","definition_or_measurement_approach":"MRD-negative complete response defined as no detectable signs of multiple myeloma; (protocol translations reference assessment at approximately 9 months ± 3 months after study start)."}

Secondary endpoints

  • {"endpoint_text":"- Overall survival (OS): The average time participants are alive after starting the study.","definition_or_measurement_approach":"Defined as the average time participants are alive after starting the study (time from randomization/start to death from any cause)."}
  • {"endpoint_text":"- Overall response rate (ORR): How many participants show a positive response to treatment.","definition_or_measurement_approach":"Measured as the proportion of participants achieving a predefined positive tumour response to treatment according to study response criteria."}

Recruitment

Planned Sample Size
251
Recruitment Window Months
86
Consent Approach
Informed consent is obtained from adult participants (minimum age 18). Country-specific subject information and informed consent form documents are provided (multiple country/language ICFs present in the application documents). No pediatric assent procedures or other special consent procedures are described in the record.

Geography

Total Number Of Sites
67
Total Number Of Participants
189

Italy

Earliest CTIS Part Ii Submission Date
03-03-2025
Latest Decision Or Authorization Date
24-04-2025
Processing Time Days
52
Number Of Sites
6
Number Of Participants
21

Sites

Site Name
Azienda Sanitaria Universitaria Friuli Centrale
Department Name
SOC Clinica Ematologica
Principal Investigator Name
Francesca Patriarca
Principal Investigator Email
francesca.patriarca@asufc.sanita.fvg.it
Contact Person Name
Francesca Patriarca
Site Name
Azienda Ospedaliero-Universitaria Di Bologna IRCCS Istituto Di Ricerca E Di Cura A Carattere Scientifico
Department Name
Dipartimento Malattia Oncologiche ed Ematologiche
Principal Investigator Name
Elena Zamagni
Principal Investigator Email
e.zamagni@unibo.it
Contact Person Name
Elena Zamagni
Contact Person Email
e.zamagni@unibo.it
Site Name
IRCCS Ospedale Policlinico San Martino
Department Name
Hematology and Cell Therapy
Principal Investigator Name
Emanuele Angelucci
Principal Investigator Email
emanuele.angelucci@hsanmartino.it
Contact Person Name
Emanuele Angelucci
Site Name
Humanitas Mirasole S.p.A.
Department Name
Cellular therapy and transplant unit
Principal Investigator Name
Stefania Bramanti
Contact Person Name
Stefania Bramanti
Site Name
Fondazione IRCCS Istituto Nazionale Dei Tumori
Department Name
Dipartimento di Oncologia ed Emato-Oncologia
Principal Investigator Name
Paolo Corradini
Principal Investigator Email
paolo.corradini@unimi.it
Contact Person Name
Paolo Corradini
Contact Person Email
paolo.corradini@unimi.it
Site Name
Azienda Ospedaliera Universitaria Citta Della Salute E Della Scienza Di Torino
Department Name
Hematology U division/SSD Clinical Trial in Oncohematology and Multiple Myeloma
Principal Investigator Name
Francesca Gay
Principal Investigator Email
francesca.gay@unito.it
Contact Person Name
Francesca Gay
Contact Person Email
francesca.gay@unito.it

Romania

Earliest CTIS Part Ii Submission Date
28-02-2025
Latest Decision Or Authorization Date
07-04-2025
Processing Time Days
38
Number Of Sites
3
Number Of Participants
11

Sites

Site Name
Institutul Clinic Fundeni
Department Name
Hematology
Principal Investigator Name
Alina Tanase
Principal Investigator Email
hematologie1@icfundeni.ro
Contact Person Name
Alina Tanase
Contact Person Email
hematologie1@icfundeni.ro
Site Name
Spitalul Universitar De Urgenta Bucuresti
Department Name
Hematology
Principal Investigator Name
Horia Bumbea
Principal Investigator Email
secretariat@suub.ro
Contact Person Name
Horia Bumbea
Contact Person Email
secretariat@suub.ro
Site Name
Institutul Regional De Oncologie Iasi
Department Name
Hematology
Principal Investigator Name
Angela Dascalescu
Principal Investigator Email
onco@iroiasi.ro
Contact Person Name
Angela Dascalescu
Contact Person Email
onco@iroiasi.ro

Poland

Earliest CTIS Part Ii Submission Date
27-02-2025
Latest Decision Or Authorization Date
06-04-2025
Processing Time Days
38
Number Of Sites
3
Number Of Participants
12

Sites

Site Name
Centrum Onkologii Ziemi Lubelskiej Im. Sw. Jana Z Dukli
Department Name
Oddział Hematologii i Transplantacji Szpiku
Principal Investigator Name
Wojciech Legieć
Principal Investigator Email
wlegiec@cozl.pl
Contact Person Name
Wojciech Legieć
Contact Person Email
wlegiec@cozl.pl
Site Name
Uniwersyteckie Centrum Kliniczne
Department Name
Katedra i Klinika Hematologi i Transplantologii
Principal Investigator Name
Jan Zaucha
Principal Investigator Email
info@uck.gda.pl
Contact Person Name
Jan Zaucha
Contact Person Email
info@uck.gda.pl
Site Name
Wojewodzkie Wielospecjalistyczne Centrum Onkologii I Traumatologii Im M.Kopernika W Lodzi
Department Name
Oddział Hematologii i Transplantologii- Klinika Hematologii
Principal Investigator Name
Agnieszka Wierzbowska
Principal Investigator Email
badania.kliniczne@kopernik.lodz.pl
Contact Person Name
Agnieszka Wierzbowska

Austria

Earliest CTIS Part Ii Submission Date
21-03-2025
Latest Decision Or Authorization Date
07-04-2025
Processing Time Days
17
Number Of Sites
2
Number Of Participants
8

Sites

Site Name
Hanusch Krankenhaus Der Wiener Gebietskrankenkasse
Department Name
Department of Hematology and Oncology
Principal Investigator Name
Felix Keil
Principal Investigator Email
felix.keil@oegk.at
Contact Person Name
Felix Keil
Contact Person Email
felix.keil@oegk.at
Site Name
Ordensklinikum Linz GmbH
Department Name
Department of Hematology and Oncology
Principal Investigator Name
Irene Strassl
Principal Investigator Email
irene.strassl@ordensklinikum.at
Contact Person Name
Irene Strassl

France

Earliest CTIS Part Ii Submission Date
27-03-2025
Latest Decision Or Authorization Date
07-04-2025
Processing Time Days
11
Number Of Sites
5
Number Of Participants
6

Sites

Site Name
CHU Nantes
Department Name
Service d'Hématologie
Principal Investigator Name
Cyrille TOUZEAU
Principal Investigator Email
cyrille.touzeau@chu-nantes.fr
Contact Person Name
Cyrille TOUZEAU
Contact Person Email
cyrille.touzeau@chu-nantes.fr
Site Name
CHU Henri Mondor
Department Name
Unité Hématopathies Lymphoïdes
Principal Investigator Name
Karim BELHADJ-MERZOUG
Principal Investigator Email
romain.gounot@aphp.fr
Contact Person Name
Karim BELHADJ-MERZOUG
Contact Person Email
romain.gounot@aphp.fr
Site Name
Assistance Publique Hopitaux De Paris
Department Name
Service clinique d'Immuno-Hématologie
Principal Investigator Name
Bertrand ARNULF
Principal Investigator Email
bertrand.arnulf@sls.aphp.fr
Contact Person Name
Bertrand ARNULF
Contact Person Email
bertrand.arnulf@sls.aphp.fr
Site Name
Hospices Civils De Lyon
Department Name
Département d'hématologie
Principal Investigator Name
Lionel KARLIN
Principal Investigator Email
lionel.karlin@chu-lyon.fr
Contact Person Name
Lionel KARLIN
Contact Person Email
lionel.karlin@chu-lyon.fr
Site Name
Centre Hospitalier Universitaire De Lille
Department Name
Service des Maladies du Sang
Principal Investigator Name
Salomon MANIER
Principal Investigator Email
salomon.manier@chru-lille.fr
Contact Person Name
Salomon MANIER
Contact Person Email
salomon.manier@chru-lille.fr

Germany

Earliest CTIS Part Ii Submission Date
16-01-2025
Latest Decision Or Authorization Date
04-04-2025
Processing Time Days
78
Number Of Sites
11
Number Of Participants
22

Sites

Site Name
Charite Universitaetsmedizin Berlin KöR
Department Name
Hematology and Oncology
Principal Investigator Name
Olaf Penack
Principal Investigator Email
olaf.penack@charite.de
Contact Person Name
Olaf Penack
Contact Person Email
olaf.penack@charite.de
Site Name
University Medical Center Hamburg-Eppendorf
Department Name
II. Medizinische Klinik und Poliklinik
Principal Investigator Name
Katja Weisel
Principal Investigator Email
k.weisel@uke.de
Contact Person Name
Katja Weisel
Contact Person Email
k.weisel@uke.de
Site Name
Universitaetsklinikum Wuerzburg AöR
Department Name
Medizinische Klinik und Poliklinik II
Principal Investigator Name
Martin Kortüm
Principal Investigator Email
kortuem_m@ukw.de
Contact Person Name
Martin Kortüm
Contact Person Email
kortuem_m@ukw.de
Site Name
Otto Von Guericke Universitaet Magdeburg
Department Name
Hematology and Oncology
Principal Investigator Name
Dimitrios Mougiakakos
Principal Investigator Email
dimitrios.mougiakakos@med.ovgu.de
Contact Person Name
Dimitrios Mougiakakos
Site Name
Medizinische Hochschule Hannover
Department Name
Klinik für Hämatologie, Hämostaseologie, Onkologie und Stammzelltransplantation
Principal Investigator Name
Annamaria Brioli
Principal Investigator Email
brioli.annamaria@mh-hannover.de
Contact Person Name
Annamaria Brioli
Site Name
Klinikum Chemnitz gGmbH
Department Name
Hematology and Oncology
Principal Investigator Name
Mathias Haenel
Principal Investigator Email
m.haenel@skc.de
Contact Person Name
Mathias Haenel
Contact Person Email
m.haenel@skc.de
Site Name
Universitaetsklinikum Heidelberg AöR
Department Name
Klinik für Hämatologie, Onkologie, Rheumatologie
Principal Investigator Name
Marc-Steffen Raab
Principal Investigator Email
marc.raab@med.uni-heidelberg.de
Contact Person Name
Marc-Steffen Raab
Site Name
Universitaetsklinikum Schleswig-Holstein AöR
Department Name
Klinik für innere Medizin II
Principal Investigator Name
Natalie Schub
Principal Investigator Email
Natalie.Schub@uksh.de
Contact Person Name
Natalie Schub
Contact Person Email
Natalie.Schub@uksh.de
Site Name
Klinikum Nuernberg
Department Name
Medizinische Klinik 5
Principal Investigator Name
Stefan Knop
Principal Investigator Email
stefan.knop@klinikum-nuernberg.de
Contact Person Name
Stefan Knop
Site Name
Klinikum der Technischen Universitaet Muenchen (TUM Klinikum)
Department Name
Klinik und Poliklinik für Innere Medizin III
Principal Investigator Name
Judith Hecker
Principal Investigator Email
judith.hecker@mri.tum.de
Contact Person Name
Judith Hecker
Contact Person Email
judith.hecker@mri.tum.de
Site Name
Universitaet Leipzig
Department Name
Klinik und Poliklinik für Hämatologie, Zelltherapie und Hämostaseologie
Principal Investigator Name
Vladan Vucinic
Principal Investigator Email
vladan.vucinic@medizin.uni-leipzig.de
Contact Person Name
Vladan Vucinic

Belgium

Earliest CTIS Part Ii Submission Date
14-03-2025
Latest Decision Or Authorization Date
31-03-2025
Processing Time Days
17
Number Of Sites
4
Number Of Participants
8

Sites

Site Name
Universitair Ziekenhuis Gent
Department Name
Hematology
Principal Investigator Name
Nicolas Kint
Principal Investigator Email
Nicolas.Kint@uzgent.be
Contact Person Name
Nicolas Kint
Contact Person Email
Nicolas.Kint@uzgent.be
Site Name
Cliniques Universitaires Saint-Luc
Department Name
Hematology
Principal Investigator Name
Marie-Christiane Vekemans
Contact Person Name
Marie-Christiane Vekemans
Site Name
Universitair Ziekenhuis Antwerpen
Department Name
Hematology
Principal Investigator Name
Sebastien Anguille
Principal Investigator Email
sebastien.anguille@uza.be
Contact Person Name
Sebastien Anguille
Contact Person Email
sebastien.anguille@uza.be
Site Name
Centre Hospitalier Universitaire Dinant Godinne Sainte-Elisabeth-UCL-Namur
Department Name
Hematology
Principal Investigator Name
Gilles Crochet
Principal Investigator Email
Gilles.crochet@chuuclnamur.uclouvain.be
Contact Person Name
Gilles Crochet

Sweden

Earliest CTIS Part Ii Submission Date
06-03-2025
Latest Decision Or Authorization Date
24-04-2025
Processing Time Days
49
Number Of Sites
3
Number Of Participants
4

Sites

Site Name
Sahlgrenska University Hospital-Vaestra Goetalandsregionen
Department Name
Department of Hematology Bruna Stråket 5 413 45 Göteborg
Principal Investigator Name
Markus Hansson
Principal Investigator Email
markus.hansson.2@gu.se
Contact Person Name
Markus Hansson
Contact Person Email
markus.hansson.2@gu.se
Site Name
Region Skane Skanes Universitetssjukhus
Department Name
VO Hematologi, Onkologi & Strålningsfysik
Principal Investigator Name
Stina Wichert
Principal Investigator Email
stina.wichert@skane.se
Contact Person Name
Stina Wichert
Contact Person Email
stina.wichert@skane.se
Site Name
Karolinska University Hospital
Department Name
ME CAST (Medicinska enheten för Cellterapi och Allogen StamcellsTransplantation)
Principal Investigator Name
Johan Torlen
Principal Investigator Email
johan.karlsson-torlen@regionstockholm.se
Contact Person Name
Johan Torlen

Norway

Earliest CTIS Part Ii Submission Date
04-03-2025
Latest Decision Or Authorization Date
24-04-2025
Processing Time Days
51
Number Of Sites
1
Number Of Participants
11

Sites

Site Name
Oslo University Hospital HF
Department Name
Department of Haematology
Principal Investigator Name
Ingerid Weum Abrahamsen
Principal Investigator Email
inabra@ous-hf.no
Contact Person Name
Ingerid Weum Abrahamsen
Contact Person Email
inabra@ous-hf.no

Finland

Earliest CTIS Part Ii Submission Date
03-03-2025
Latest Decision Or Authorization Date
08-04-2025
Processing Time Days
36
Number Of Sites
3
Number Of Participants
3

Sites

Site Name
HUS-Yhtymae
Department Name
Comprehensive cancer center, Clinical Trial Unit
Principal Investigator Name
Mikko Keränen
Principal Investigator Email
mikko.keranen@hus.fi
Contact Person Name
Mikko Keränen
Contact Person Email
mikko.keranen@hus.fi
Site Name
Oulu University Hospital
Department Name
Clinical Hematology
Principal Investigator Name
Marjaana Säily
Principal Investigator Email
marjaana.saily@pohde.fi
Contact Person Name
Marjaana Säily
Contact Person Email
marjaana.saily@pohde.fi
Site Name
Turku University Hospital
Department Name
Hematology
Principal Investigator Name
Juha Ranti
Principal Investigator Email
juha.ranti@varha.fi
Contact Person Name
Juha Ranti
Contact Person Email
juha.ranti@varha.fi

Portugal

Earliest CTIS Part Ii Submission Date
24-02-2025
Latest Decision Or Authorization Date
24-04-2025
Processing Time Days
59
Number Of Sites
1
Number Of Participants
5

Sites

Site Name
Instituto Portugues De Oncologia Do Porto Francisco Gentil E.P.E.
Department Name
Hematology and Bone Marrow Transplant Department
Principal Investigator Name
José Mário Mariz
Principal Investigator Email
mariz@ipoporto.min-saude.pt
Contact Person Name
José Mário Mariz
Contact Person Email
mariz@ipoporto.min-saude.pt

Spain

Earliest CTIS Part Ii Submission Date
11-02-2025
Latest Decision Or Authorization Date
02-04-2025
Processing Time Days
50
Number Of Sites
8
Number Of Participants
15

Sites

Site Name
University Hospital Son Espases
Department Name
Hematology
Principal Investigator Name
Antonia Sampol
Principal Investigator Email
antonia.sampolm@ssib.es
Contact Person Name
Antonia Sampol
Contact Person Email
antonia.sampolm@ssib.es
Site Name
Clinica Universidad De Navarra
Department Name
Hematology
Principal Investigator Name
Paula Rodriguez Otero
Principal Investigator Email
paurodriguez@unav.es
Contact Person Name
Paula Rodriguez Otero
Contact Person Email
paurodriguez@unav.es
Site Name
Hospital Universitario De Salamanca
Department Name
Hematology
Principal Investigator Name
Maria Victoria Mateos Manteca
Principal Investigator Email
mvmateos@usal.es
Contact Person Name
Maria Victoria Mateos Manteca
Contact Person Email
mvmateos@usal.es
Site Name
Hospital Universitario Virgen De Las Nieves
Department Name
Hematology
Principal Investigator Name
Maria Esther Clavero
Principal Investigator Email
mariae.clavero@juntadeandalucia.es
Contact Person Name
Maria Esther Clavero
Site Name
Institut Catala D'oncologia
Department Name
Hematolgy
Principal Investigator Name
Laura Abril
Principal Investigator Email
labril@iconcologia.net
Contact Person Name
Laura Abril
Contact Person Email
labril@iconcologia.net
Site Name
Clinica Universidad De Navarra (Madrid site)
Department Name
Hematology
Principal Investigator Name
Paula Rodriguez Otero
Principal Investigator Email
paurodriguez@unav.es
Contact Person Name
Paula Rodriguez Otero
Contact Person Email
paurodriguez@unav.es
Site Name
Complexo Hospitalario Universitario De Santiago
Department Name
Hematology
Principal Investigator Name
Marta Sonia Gonzalez Perez
Principal Investigator Email
marta.sonia.gonzalez.perez@sergas.es
Contact Person Name
Marta Sonia Gonzalez Perez
Site Name
University Hospital Son Espases (additional site listed)
Department Name
Hematology
Principal Investigator Name
Antonia Sampol
Principal Investigator Email
antonia.sampolm@ssib.es
Contact Person Name
Antonia Sampol
Contact Person Email
antonia.sampolm@ssib.es

Netherlands

Earliest CTIS Part Ii Submission Date
24-03-2025
Latest Decision Or Authorization Date
03-04-2025
Processing Time Days
10
Number Of Sites
4
Number Of Participants
22

Sites

Site Name
Universitair Medisch Centrum Utrecht
Department Name
Hematalogy
Principal Investigator Name
Rimke Oostvogels
Principal Investigator Email
hemat-research@umcutrecht.nl
Contact Person Name
Rimke Oostvogels
Contact Person Email
hemat-research@umcutrecht.nl
Site Name
Radboud universitair medisch centrum Stichting
Department Name
Hematalogy
Principal Investigator Name
Elizabeth de Kort
Principal Investigator Email
studies.hemat@radboudumc.nl
Contact Person Name
Elizabeth de Kort
Contact Person Email
studies.hemat@radboudumc.nl
Site Name
Academisch Ziekenhuis Maastricht
Department Name
Hematalogy
Principal Investigator Name
Janine van Elssen
Principal Investigator Email
poli.oncologie@mumc.nl
Contact Person Name
Janine van Elssen
Contact Person Email
poli.oncologie@mumc.nl
Site Name
Amsterdam UMC Stichting
Department Name
Hematalogy
Principal Investigator Name
Sonja Zweegman
Principal Investigator Email
ctis@amsterdamumc.nl
Contact Person Name
Sonja Zweegman
Contact Person Email
ctis@amsterdamumc.nl

Denmark

Earliest CTIS Part Ii Submission Date
05-03-2025
Latest Decision Or Authorization Date
31-03-2025
Processing Time Days
26
Number Of Sites
4
Number Of Participants
12

Sites

Site Name
Region Sjaelland
Department Name
Department of Hematology
Principal Investigator Name
Nicolai Grønne Jørgensen
Principal Investigator Email
ngje@regsj.dk
Contact Person Name
Nicolai Grønne Jørgensen
Contact Person Email
ngje@regsj.dk
Site Name
Region Midtjylland
Department Name
Department of Hematology
Principal Investigator Name
Maja Vase
Principal Investigator Email
majavase@rm.dk
Contact Person Name
Maja Vase
Contact Person Email
majavase@rm.dk
Site Name
Rigshospitalet
Department Name
Department of Hematology
Principal Investigator Name
Anne Kærsgaard Mylin
Principal Investigator Email
anne.kaersgaard.mylin@regionh.dk
Contact Person Name
Anne Kærsgaard Mylin
Site Name
Odense University Hospital
Department Name
Department of Hematology
Principal Investigator Name
Ida Bruun Kristensen
Principal Investigator Email
ida.bruun.kristensen@rsyd.dk
Contact Person Name
Ida Bruun Kristensen
Contact Person Email
ida.bruun.kristensen@rsyd.dk

Hungary

Earliest CTIS Part Ii Submission Date
03-02-2025
Latest Decision Or Authorization Date
04-04-2025
Processing Time Days
60
Number Of Sites
2
Number Of Participants
8

Sites

Site Name
Del-Pesti Centrumkorhaz Orszagos Hematologiai Es Infektologiai Intezet
Department Name
Haematology & Stem Cell Transplantation
Principal Investigator Name
Laszlo Zsolt Gopcsa
Principal Investigator Email
dpckorhaz@dpckorhaz.hu
Contact Person Name
Laszlo Zsolt Gopcsa
Contact Person Email
dpckorhaz@dpckorhaz.hu
Site Name
University Of Debrecen
Department Name
Department of Hematology
Principal Investigator Name
Arpad Illes
Principal Investigator Email
illes.arpad@med.unideb.hu
Contact Person Name
Arpad Illes
Contact Person Email
illes.arpad@med.unideb.hu

Greece

Earliest CTIS Part Ii Submission Date
04-12-2024
Latest Decision Or Authorization Date
31-03-2025
Processing Time Days
117
Number Of Sites
3
Number Of Participants
12

Sites

Site Name
Evaggelismos Hospital
Department Name
Hematology Clinic, Bοne Marrow Tranplanation Unit
Principal Investigator Name
Ioannis Baltadakis
Principal Investigator Email
ibaltadakis@icloud.com
Contact Person Name
Ioannis Baltadakis
Contact Person Email
ibaltadakis@icloud.com
Site Name
General University Hospital Of Patras
Department Name
Bone Marrow Transplantation Unit
Principal Investigator Name
Alexandros Spyridonidis
Principal Investigator Email
spyridonidis@upatras.gr
Contact Person Name
Alexandros Spyridonidis
Contact Person Email
spyridonidis@upatras.gr
Site Name
University General Hospital Attikon
Department Name
2nd Dept of Internal Medicine Division of Hematology
Principal Investigator Name
Evangelos Terpos
Principal Investigator Email
eterpos@hotmail.com
Contact Person Name
Evangelos Terpos
Contact Person Email
eterpos@hotmail.com

Czechia

Earliest CTIS Part Ii Submission Date
03-03-2025
Latest Decision Or Authorization Date
01-04-2025
Processing Time Days
29
Number Of Sites
4
Number Of Participants
9

Sites

Site Name
Fakultni Nemocnice Hradec Kralove
Department Name
IV. interni hematologicka klinika FN Hradec Kralove
Principal Investigator Name
Jakub Radocha
Principal Investigator Email
jakub.radocha@fnhk.cz
Contact Person Name
Jakub Radocha
Contact Person Email
jakub.radocha@fnhk.cz
Site Name
Vseobecna Fakultni Nemocnice V Praze
Department Name
I. interni klinika - klinika hematologie 1.LF a VFN
Principal Investigator Name
Jan Straub
Principal Investigator Email
jan.straub@vfn.cz
Contact Person Name
Jan Straub
Contact Person Email
jan.straub@vfn.cz
Site Name
Fakultni Nemocnice Ostrava
Department Name
Klinika hematoonkologie
Principal Investigator Name
Jana Mihalyova
Principal Investigator Email
jana.mihalyova@fno.cz
Contact Person Name
Jana Mihalyova
Contact Person Email
jana.mihalyova@fno.cz
Site Name
Fakultni Nemocnice Brno
Department Name
Interni hematologicka a onkologicka klinika FN Brno
Principal Investigator Name
Ludek Pour
Principal Investigator Email
pour.ludek@fnbrno.cz
Contact Person Name
Ludek Pour
Contact Person Email
pour.ludek@fnbrno.cz

Sponsor

Primary sponsor

Full Name
Celgene Corp.
Organisation Type
Pharmaceutical company
Country Of Registered Address
United States

Contract research organisations

Name
IQVIA Inc.
Responsibilities
Site
Name
Medidata Solutions Inc.
Responsibilities
6
Name
Signant Health Global LLC
Responsibilities
eCOA
Name
Clincierge
Responsibilities
Patient Reimbursement

Third parties

  • {"country":"United States","full_name":"Clincierge","duties_or_roles":"Patient Reimbursement","organisation_type":"Industry"}
  • {"country":"United States","full_name":"Signant Health Global LLC","duties_or_roles":"eCOA","organisation_type":"Pharmaceutical company"}
  • {"country":"India","full_name":"Accenture Solutions Private Limited","duties_or_roles":"Embarc operations","organisation_type":"Pharmaceutical company"}
  • {"country":"United States","full_name":"Cellcarta Fremont LLC","duties_or_roles":"Myeloid Derived Suppressor Cells (MDSCs) analysi","organisation_type":"Pharmaceutical company"}
  • {"country":"United States","full_name":"Medidata Solutions Inc.","duties_or_roles":"6","organisation_type":"Non-Pharmaceutical company"}
  • {"country":"Sweden","full_name":"Olink Proteomics AB","duties_or_roles":"Specialty Biomarker Lab; Proteomic Analysis","organisation_type":"Pharmaceutical company"}
  • {"country":"Germany","full_name":"ProtaGene CGT GmbH","duties_or_roles":"RCL","organisation_type":"Pharmaceutical company"}
  • {"country":"United States","full_name":"Q2 Solutions","duties_or_roles":"Routine clinical pathology testing, Clinical chemistry, Clinical haematology, Clinical microbiology, Flow cytometry, BioA, Smpl mgmt, Kit building, Storage-distrib of smpl to other vendors for analysis","organisation_type":"Health care"}
  • {"country":"United States","full_name":"Mosaic Laboratories LLC","duties_or_roles":"Speciality Biomarker Laboratory, IHC Biomarker expression analysis (PD-L1)","organisation_type":"Pharmaceutical company"}
  • {"country":"United States","full_name":"Neogenomics Laboratories Inc.","duties_or_roles":"Genomic Analysis","organisation_type":"Laboratory/Research/Testing facility"}
  • {"country":"Australia","full_name":"Cellcarta Pty Limited","duties_or_roles":"Routine clinical pathology testing, Clinical chemistry, Clinical haematology, Histopatholog, Analytical chemistry","organisation_type":"Pharmaceutical company"}
  • {"country":"United States","full_name":"Cellcarta Naperville LLC","duties_or_roles":"Histopathology","organisation_type":"Pharmaceutical company"}
  • {"country":"United States","full_name":"Iqvia Inc.","duties_or_roles":"Site","organisation_type":"Pharmaceutical company"}
  • {"country":"India","full_name":"Accenture Services Pvt. Ltd.","duties_or_roles":"Pharmacovigilance duties: Medical review and Cases Data Entry","organisation_type":"SME"}
  • {"country":"United Kingdom","full_name":"Q2 Solutions (UK address)","duties_or_roles":"Routine clin.pathology testing,Clin.chemistry,Clin.haematology,Clin.microbiology,Histopath,Serology/endocrinology,Analytical chem,ECG analysis/review,Flow cytometry,Smpl mgmt,Kit building,Storage and distrib. of smpls to other vendors for analysis","organisation_type":"Health care"}
  • {"country":"United States","full_name":"Omnitrace Corp.","duties_or_roles":"Patient Location","organisation_type":"Non-Pharmaceutical company"}
  • {"country":"United States","full_name":"Q2 Solutions LLC","duties_or_roles":"Bioanalytical","organisation_type":"Laboratory/Research/Testing facility"}
  • {"country":"United States","full_name":"Q2 Solutions, 2 Squared Solutions LLC","duties_or_roles":"Routine clin pathology testing, Clin chemistry, Clin haematology, Clin microbiology, Histopathology, Serology/endocrinology, Analytical chemistry, Flow cytometry, Sample mgmt, Kit building, Storage and distribution of samples to other vendors for analysis","organisation_type":"Industry"}
  • {"country":"United States","full_name":"Adaptive","duties_or_roles":"Genomics","organisation_type":"Industry"}

Investigational products

Investigational Product Name
GPRC5D-TARGETED CAR T
Active Substance
ARLOCABTAGENE AUTOLEUCEL
Modality
Cell therapy
Routes Of Administration
INTRAVENIOUS INFUSION
Route
Intravenous infusion
Investigational Product Name
DARATUMUMAB
Active Substance
DARATUMUMAB
Modality
Monoclonal antibody
Routes Of Administration
SUBCUTANEOUS
Route
Subcutaneous
Orphan Designation
Yes
Investigational Product Name
POMALIDOMIDE
Active Substance
POMALIDOMIDE
Modality
Small molecule
Routes Of Administration
ORAL
Route
Oral
Investigational Product Name
CARFILZOMIB
Active Substance
CARFILZOMIB
Modality
Small molecule
Routes Of Administration
INTRAVENOUS
Route
Intravenous
Orphan Designation
Yes
Investigational Product Name
DEXAMETHASONE
Active Substance
DEXAMETHASONE
Modality
Small molecule
Routes Of Administration
INTRAVENOUS | ORAL
Route
Intravenous or Oral
Investigational Product Name
CYCLOPHOSPHAMIDE
Active Substance
CYCLOPHOSPHAMIDE
Modality
Small molecule
Routes Of Administration
INTRAVENOUS INJECTION
Route
Intravenous injection
Investigational Product Name
FLUDARABINE PHOSPHATE
Active Substance
FLUDARABINE PHOSPHATE
Modality
Small molecule
Routes Of Administration
INTRAVENOUS
Route
Intravenous
Investigational Product Name
TOCILIZUMAB
Active Substance
TOCILIZUMAB
Modality
Monoclonal antibody
Routes Of Administration
INTRAVENOUS INFUSION
Route
Intravenous infusion
Combination Treatment
Yes

Related trials

Other published trials that may interest you.