Clinical trial • Phase II • Haematology
1-4-{[6-AMINO-5-(4-PHENOXY-PHENYL)-PYRIMIDIN-4-YLAMINO]-METHYL}-4-FLUORO-PIPERIDIN-1-YL)-PROPENONE for Myelofibrosis | Indolent systemic mastocytosis | Monoclonal mast cell activation syndrome | Non-monoclonal mast cell activation syndrome
Phase II trial of 1-4-{[6-AMINO-5-(4-PHENOXY-PHENYL)-PYRIMIDIN-4-YLAMINO]-METHYL}-4-FLUORO-PIPERIDIN-1-YL)-PROPENONE for Myelofibrosis | Indolent systemic…
Overview
- Trial Therapeutic Area
- Haematology
- Trial Disease
- Myelofibrosis | Indolent systemic mastocytosis | Monoclonal mast cell activation syndrome | Non-monoclonal mast cell activation syndrome
- Trial Stage
- Phase II
- Drug Modality
- Small molecule
Key dates
- Initial CTIS Submission Date
- 13-06-2024
- First CTIS Authorization Date
- 11-07-2024
Trial design
Randomised, open-label, tl-895 matching placebo is used as a placebo comparator (cohort 5 part c compares tl-895 vs placebo). dose and schedule details are not specified in the ctis json.-controlled, adaptive Phase II trial across 38 sites in Belgium, Bulgaria, France and others.
- Randomised
- Yes
- Open Label
- Yes
- Comparator
- TL-895 matching placebo is used as a placebo comparator (Cohort 5 Part C compares TL-895 vs placebo). Dose and schedule details are not specified in the CTIS JSON.
- Adaptive
- True, Part A is a dose-finding/adaptive component to determine recommended phase 2 and phase 3 doses and schedules (cohort-based dose determination/escalation). Specific dose-escalation rules or interim decision rules are not provided in the CTIS JSON.
- Single Multiple Or Escalation Dose Combined
- Yes
- Target Sample Size
- 120
- Trial Duration For Participant
- 168
Eligibility
Recruits 120 Vulnerable population selected. The trial enrols adults (≥18 years). Informed consent is managed via subject information and informed consent forms (multiple country- and language-specific versions are listed in the CTIS documents, including dedicated 'Pregnant Partner' and 'Genetic Sample' consent materials), indicating consent is sought using ICFs; no child assent details are provided in the CTIS record..
- Vulnerable Population
- Vulnerable population selected. The trial enrols adults (≥18 years). Informed consent is managed via subject information and informed consent forms (multiple country- and language-specific versions are listed in the CTIS documents, including dedicated 'Pregnant Partner' and 'Genetic Sample' consent materials), indicating consent is sought using ICFs; no child assent details are provided in the CTIS record.
Inclusion criteria
- {"criterion_text":"- Cohorts 1-6: Adults ≥18 years of age\n- Cohort 4 only: Ineligibility for JAKi treatment with a platelet count of ≥ 15 and < 25x10^9/L\n- Cohort 6: Moderate-to-severe chronic MCAS symptoms\n- Cohort 6: Subject must have failed to achieve symptom control for one or more baseline chronic symptoms\n- Cohort 6: The subject’s symptomatic MCAS therapies must be stable\n- Cohorts 1-4: Confirmed diagnosis of PMF, post-PV MF, or post-ET MF, as assessed by treating physician according to the World Health Organization (WHO) criteria\n- Cohorts 1-4: High-risk, intermediate-2 risk, or intermediate-1 risk, defined by DIPSS\n- Cohorts 1-6: Adequate hematologic, hepatic, and renal functions\n- Cohorts 1-4: MF symptoms as defined by having at least 2 symptoms with an average baseline (Day -7 to Day -1) score of at least 1 for each of the 2 symptoms per MFSAF v4.0\n- Cohort 3 only: Ineligibility for JAKi treatment with a platelet count of ≥ 25 and < 50 x 10^9/L\n- Cohort 5: Confirmed diagnosis of ISM as defined by WHO diagnostic criteria based on review of bone marrow biopsy pathology report results\n- Cohort 5: Subject must have moderate-to-severe symptoms\n- Cohort 6: Confirmed diagnosis of MCAS as defined by Working Group diagnostic criteria"}
Exclusion criteria
- {"criterion_text":"- Cohorts 1-4: Prior treatment with JAKi within 28 days prior to first study treatment\n- Cohorts 1-4: Prior splenectomy or splenic irradiation within 24 weeks prior to first dose of study treatment\n- Cohort 5: Diagnosis with another myeloid disorder\n- Cohort 6: A current diagnosis of cutaneous or systemic mastocytosis as defined by WHO criteria"}
Endpoints
Primary endpoints
- {"endpoint_text":"- Cohorts 1-4: Part A: Determine the RP2D of TL-895","definition_or_measurement_approach":"Determine the recommended phase 2 dose (RP2D) and schedule of TL-895 in each cohort based on safety, tolerability, and other data collected in Part A (dose-finding/cohort escalation)."}
- {"endpoint_text":"- Cohorts 1-4: Part B: The proportion of subjects achieving ≥ 50% reduction in TSS at Week 24 by MFSAF v4.0","definition_or_measurement_approach":"Proportion of subjects with ≥50% reduction in Total Symptom Score (TSS) at Week 24 assessed using the MFSAF v4.0 instrument."}
- {"endpoint_text":"- Cohort 5: Part A: The recommended TL-895 dosing regimen(s) will be determined based on safety, efficacy, and tolerability data","definition_or_measurement_approach":"Selection of recommended dosing regimen(s) for TL-895 in Cohort 5 based on integrated assessment of safety, efficacy and tolerability from Part A (dose-finding evaluation)."}
- {"endpoint_text":"- Cohort 5: Part B Mean change in ISM-TSAF TSS from Baseline to Week 24","definition_or_measurement_approach":"Mean change from baseline to Week 24 in ISM-TSAF Total Symptom Score (TSS) for Cohort 5."}
- {"endpoint_text":"- Cohort 6: Part A: The recommended phase 3 dose will be determined based on safety, efficacy, and tolerability data","definition_or_measurement_approach":"Determine recommended phase 3 dose (RP3D) for TL-895 in Cohort 6 based on safety, efficacy and tolerability data from Part A (dose-finding)."}
Secondary endpoints
- {"endpoint_text":"- Cohorts 1-4: Part A: The proportion of subjects achieving ≥ 35% SVR at Week 24 by magnetic resonance imaging (MRI) or computed tomography (CT) scan (central review)","definition_or_measurement_approach":"Proportion of subjects achieving ≥35% spleen volume reduction (SVR) at Week 24 measured by MRI or CT with central review."}
- {"endpoint_text":"- Cohorts 1-4: Part B: The proportion of subjects achieving a platelet response defined as per International Working Group – Myeloproliferative Neoplasms Research and Treatment (IWG-MRT 2006) criteria specified in the study protocol","definition_or_measurement_approach":"Proportion achieving platelet response as defined by IWG-MRT 2006 criteria (as specified in protocol)."}
- {"endpoint_text":"- Cohort 5: Part B: Changes in patient reported symptoms","definition_or_measurement_approach":"Changes in patient-reported symptoms (e.g., ISM-specific symptom assessments such as ISM-TSAF TSS), as captured by patient questionnaires per protocol."}
Recruitment
- Planned Sample Size
- 120
- Recruitment Window Months
- 110
- Consent Approach
- Informed consent is obtained via subject information and informed consent forms; multiple country- and language-specific ICFs are listed in the CTIS documents (EN, BG, FR, DU/NL, IT, ES, PL, DE, NO as applicable). Participants are adults (≥18) who provide their own consent. There are also dedicated ICFs for pregnant partners and for genetic sample consent where applicable.
Geography
- Total Number Of Sites
- 38
- Total Number Of Participants
- 188
Belgium
- Earliest CTIS Part Ii Submission Date
- 25-06-2024
- Latest Decision Or Authorization Date
- 28-04-2026
- Processing Time Days
- 672
- Number Of Sites
- 3
- Number Of Participants
- 24
Sites
- Site Name
- Cliniques Universitaires Saint-Luc
- Department Name
- Hematologie voor volwassenen
- Principal Investigator Name
- Marie-Christiane Vekemans
- Principal Investigator Email
- marie-christiane.vekemans@uclouvain.be
- Contact Person Name
- Marie-Christiane Vekemans
- Contact Person Email
- marie-christiane.vekemans@uclouvain.be
- Site Name
- Antwerp University Hospital
- Department Name
- Immunologie, allergologie en reumatologie
- Principal Investigator Name
- Vito Sabato
- Principal Investigator Email
- vito.sabato@uza.be
- Contact Person Name
- Vito Sabato
- Contact Person Email
- vito.sabato@uza.be
- Site Name
- Centre hospitalier universitaire de Liege
- Department Name
- Hematologie clinique
- Principal Investigator Name
- Aurélie Jaspers
- Principal Investigator Email
- aurelie.jaspers@chuliege.be
- Contact Person Name
- Aurélie Jaspers
- Contact Person Email
- aurelie.jaspers@chuliege.be
Bulgaria
- Earliest CTIS Part Ii Submission Date
- 25-06-2024
- Latest Decision Or Authorization Date
- 13-02-2025
- Processing Time Days
- 233
- Number Of Sites
- 1
- Number Of Participants
- 13
Sites
- Site Name
- Military Medical Academy
- Department Name
- Hematology Clinic
- Principal Investigator Name
- Viktoria Varbanova
- Principal Investigator Email
- viktoriia1982@abv.bg
- Contact Person Name
- Viktoria Varbanova
- Contact Person Email
- viktoriia1982@abv.bg
France
- Earliest CTIS Part Ii Submission Date
- 25-06-2024
- Latest Decision Or Authorization Date
- 17-02-2025
- Processing Time Days
- 237
- Number Of Sites
- 2
- Number Of Participants
- 13
Sites
- Site Name
- Centre Hospitalier Le Mans
- Department Name
- onco-hematology
- Principal Investigator Name
- Kamel Laribi
- Principal Investigator Email
- klaribi@ch-lemans.fr
- Contact Person Name
- Kamel Laribi
- Contact Person Email
- klaribi@ch-lemans.fr
- Site Name
- Centre Hospitalier Universitaire De Nice
- Department Name
- hematology
- Principal Investigator Name
- Michael Loschi
- Principal Investigator Email
- loschi.m@chu-nice.fr
- Contact Person Name
- Michael Loschi
- Contact Person Email
- loschi.m@chu-nice.fr
Germany
- Earliest CTIS Part Ii Submission Date
- 25-06-2024
- Latest Decision Or Authorization Date
- 28-04-2026
- Processing Time Days
- 672
- Number Of Sites
- 8
- Number Of Participants
- 24
Sites
- Site Name
- Charite Universitaetsmedizin Berlin KöR
- Department Name
- Campus Benjamin Franklin, Institute of Allergology
- Principal Investigator Name
- Frank Siebenhaar
- Principal Investigator Email
- frank.siebenhaar@charite.de
- Contact Person Name
- Frank Siebenhaar
- Contact Person Email
- frank.siebenhaar@charite.de
- Site Name
- Universitaetsklinikum Halle (Saale) AöR
- Department Name
- Klinik für Innere Medizin IV- Hämatologie/Onkologie
- Principal Investigator Name
- Haifa Kathrin Al-Ali
- Principal Investigator Email
- haifa.al-ali@uk-halle.de
- Contact Person Name
- Haifa Kathrin Al-Ali
- Contact Person Email
- haifa.al-ali@uk-halle.de
- Site Name
- Universitaetsklinikum Mannheim GmbH
- Department Name
- (Internal Medicine, Haematology, Oncology
- Principal Investigator Name
- Andreas Reiter
- Principal Investigator Email
- andreas.reiter@medma.uni-heidelberg.de
- Contact Person Name
- Andreas Reiter
- Contact Person Email
- andreas.reiter@medma.uni-heidelberg.de
- Site Name
- University Medical Center Hamburg-Eppendorf
- Department Name
- Department II
- Principal Investigator Name
- Philippe Schafhausen
- Principal Investigator Email
- schafhausen@uke.de
- Contact Person Name
- Philippe Schafhausen
- Contact Person Email
- schafhausen@uke.de
- Site Name
- Azienda Unita Sanitaria Locale Della Romagna
- Department Name
- Hämatologie und Onkologie
- Principal Investigator Name
- Nikolaus von Bubnoff
- Principal Investigator Email
- nikolausChristianCornelius.vonBubnoff@uksh.de
- Contact Person Name
- Nikolaus von Bubnoff
- Contact Person Email
- nikolausChristianCornelius.vonBubnoff@uksh.de
- Site Name
- Universitaetsklinikum Jena KöR
- Department Name
- Klinik für Innere Medizin II- Hämatologie und Internistische Onkologie
- Principal Investigator Name
- Carl Crodel
- Principal Investigator Email
- carl.crodel@med.uni-jena.de
- Contact Person Name
- Carl Crodel
- Contact Person Email
- carl.crodel@med.uni-jena.de
- Site Name
- Universitaetsklinikum Schleswig-Holstein AöR
- Department Name
- Hämatologie, Oncology
- Principal Investigator Name
- Jens Panse
- Principal Investigator Email
- jpanse@ukaachen.de
- Contact Person Name
- Jens Panse
- Contact Person Email
- jpanse@ukaachen.de
- Site Name
- Universitaetsklinikum Carl Gustav Carus Dresden an der Technischen Universitaet Dresden AöR
- Department Name
- Medizinische Klinik und Poliklinik 1, Bereich Hämatologie
- Principal Investigator Name
- Katja Sockel
- Principal Investigator Email
- katja.sockel@uniklinikum-dresden.de
- Contact Person Name
- Katja Sockel
- Contact Person Email
- katja.sockel@uniklinikum-dresden.de
Italy
- Earliest CTIS Part Ii Submission Date
- 25-06-2024
- Latest Decision Or Authorization Date
- 28-04-2026
- Processing Time Days
- 672
- Number Of Sites
- 11
- Number Of Participants
- 34
Sites
- Site Name
- Azienda Ospedaliero-Universitaria Policlinico G. Rodolico-San Marco Di Catania
- Department Name
- UO di Ematologia con T.M.O.
- Principal Investigator Name
- Giuseppe Palumbo
- Principal Investigator Email
- studiclinicimpn.unict@gmail.com
- Contact Person Name
- Giuseppe Palumbo
- Contact Person Email
- studiclinicimpn.unict@gmail.com
- Site Name
- Azienda Ospedaliero-Universitaria Maggiore Della Carita
- Department Name
- Dipartimento medico specialistico e oncologico
- Principal Investigator Name
- Andrea Patriarca
- Principal Investigator Email
- andrea.patriarca@uniupo.it
- Contact Person Name
- Andrea Patriarca
- Contact Person Email
- andrea.patriarca@uniupo.it
- Site Name
- Fondazione IRCCS Policlinico San Matteo
- Department Name
- SC ematologia I
- Principal Investigator Name
- Chiara Elena
- Principal Investigator Email
- c.elena@smatteo.pv.it
- Contact Person Name
- Chiara Elena
- Contact Person Email
- c.elena@smatteo.pv.it
- Site Name
- Grande Ospedale Metropolitano Bianchi Melacrino Morelli
- Department Name
- Divisione di Ematologia
- Principal Investigator Name
- Maria Bruna Greve
- Principal Investigator Email
- mariabruna.greve@ospedalerc.it
- Contact Person Name
- Maria Bruna Greve
- Contact Person Email
- mariabruna.greve@ospedalerc.it
- Site Name
- Azienda Ospedaliero-Universitaria Policlinico Umberto I
- Department Name
- Dipartimento di Ematologia, Oncologia e Dermatologia
- Principal Investigator Name
- Massimo Breccia
- Principal Investigator Email
- massimo.breccia@uniroma1.it
- Contact Person Name
- Massimo Breccia
- Contact Person Email
- massimo.breccia@uniroma1.it
- Site Name
- Azienda Ospedaliero-Universitaria Di Bologna IRCCS Istituto Di Ricerca E Di Cura A Carattere Scientifico
- Department Name
- DIPARTIMENTO MALATTIE ONCOLOGICHE ED EMATOLOGICHE
- Principal Investigator Name
- Francesca Palandri
- Principal Investigator Email
- francesca.palandri@unibo.it
- Contact Person Name
- Francesca Palandri
- Contact Person Email
- francesca.palandri@unibo.it
- Site Name
- Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico
- Department Name
- UO di Ematologia
- Principal Investigator Name
- Mariarita Sciumè
- Principal Investigator Email
- mariarita.sciume@policlinico.mi.it
- Contact Person Name
- Mariarita Sciumè
- Contact Person Email
- mariarita.sciume@policlinico.mi.it
- Site Name
- Azienda Ospedaliera di Padova
- Department Name
- UOSD Allergologia
- Principal Investigator Name
- Riccardo Senter
- Principal Investigator Email
- riccardo.senter@aopd.veneto.it
- Contact Person Name
- Riccardo Senter
- Contact Person Email
- riccardo.senter@aopd.veneto.it
- Site Name
- ASST Grande Ospedale Metropolitano Niguarda
- Department Name
- Divisione di Ematologia
- Principal Investigator Name
- Marianna Caramella
- Principal Investigator Email
- marianna.caramella@ospedaleniguarda.it
- Contact Person Name
- Marianna Caramella
- Contact Person Email
- marianna.caramella@ospedaleniguarda.it
- Site Name
- Azienda Ospedaliero Universitaria Careggi
- Department Name
- SOD Ematologia
- Principal Investigator Name
- Francesco Mannelli
- Principal Investigator Email
- francesco.mannelli@unifi.it
- Contact Person Name
- Francesco Mannelli
- Contact Person Email
- francesco.mannelli@unifi.it
- Site Name
- Azienda Unita Sanitaria Locale Della Romagna (Ravenna)
- Department Name
- Dipartimento Di Onco-Ematologia
- Principal Investigator Name
- Michela Rondoni
- Principal Investigator Email
- michela.rondoni@auslromagna.it
- Contact Person Name
- Michela Rondoni
- Contact Person Email
- michela.rondoni@auslromagna.it
Netherlands
- Earliest CTIS Part Ii Submission Date
- 17-02-2026
- Latest Decision Or Authorization Date
- 28-04-2026
- Processing Time Days
- 70
- Number Of Sites
- 1
- Number Of Participants
- 14
Sites
- Site Name
- Erasmus Universitair Medisch Centrum Rotterdam (Erasmus MC)
- Department Name
- Internal Medicine
- Principal Investigator Name
- Paul van Daele
- Principal Investigator Email
- p.l.a.vandaele@erasmusmc.nl
- Contact Person Name
- Paul van Daele
- Contact Person Email
- p.l.a.vandaele@erasmusmc.nl
Norway
- Earliest CTIS Part Ii Submission Date
- 27-03-2026
- Latest Decision Or Authorization Date
- 28-04-2026
- Processing Time Days
- 32
- Number Of Sites
- 1
- Number Of Participants
- 24
Sites
- Site Name
- Oslo Universitetssykehus HF
- Department Name
- Department of Hematology
- Principal Investigator Name
- Ingunn Dybedal
- Principal Investigator Email
- idybedal@ous-hf.no
- Contact Person Name
- Ingunn Dybedal
- Contact Person Email
- idybedal@ous-hf.no
Poland
- Earliest CTIS Part Ii Submission Date
- 25-06-2024
- Latest Decision Or Authorization Date
- 28-04-2026
- Processing Time Days
- 672
- Number Of Sites
- 4
- Number Of Participants
- 18
Sites
- Site Name
- Uniwersyteckie Centrum Kliniczne (Gdansk)
- Department Name
- Klinika Alergologii
- Principal Investigator Name
- Marek Niedoszytko
- Principal Investigator Email
- marek.niedoszytko@gumed.edu.pl
- Contact Person Name
- Marek Niedoszytko
- Contact Person Email
- marek.niedoszytko@gumed.edu.pl
- Site Name
- Uniwersytecki Szpital Kliniczny Im. Jana Mikulicza-Radeckiego We Wroclawiu
- Department Name
- Klinika Hematologii, Nowotworow Krwii i Transplantacji Szpiku
- Principal Investigator Name
- Tomasz Wrobel
- Principal Investigator Email
- tomasz_wrobel@wp.pl
- Contact Person Name
- Tomasz Wrobel
- Contact Person Email
- tomasz_wrobel@wp.pl
- Site Name
- Samodzielny Publiczny Zaklad Opieki Zdrowotnej Szpital Uniwersytecki W Krakowie
- Department Name
- Oddzial Kliniczny Hematologii
- Principal Investigator Name
- Tomasz Sacha
- Principal Investigator Email
- sachatom@gmail.com
- Contact Person Name
- Tomasz Sacha
- Contact Person Email
- sachatom@gmail.com
- Site Name
- Szpital Uniwersytecki Nr 2 Im Dr Jana Biziela W Bydgoszczy
- Department Name
- Klinika Hematologii
- Principal Investigator Name
- Marta Sobas
- Principal Investigator Email
- marta.sobas@gmail.com
- Contact Person Name
- Marta Sobas
- Contact Person Email
- marta.sobas@gmail.com
Spain
- Earliest CTIS Part Ii Submission Date
- 25-06-2024
- Latest Decision Or Authorization Date
- 28-04-2026
- Processing Time Days
- 672
- Number Of Sites
- 7
- Number Of Participants
- 24
Sites
- Site Name
- Hospital Germans Trias I Pujol
- Department Name
- Hematology
- Principal Investigator Name
- Blanca Xicoy Cirici
- Principal Investigator Email
- bxicoy@iconcologia.net
- Contact Person Name
- Blanca Xicoy Cirici
- Contact Person Email
- bxicoy@iconcologia.net
- Site Name
- Hospital Universitario Ramon Y Cajal
- Department Name
- Hematology
- Principal Investigator Name
- Miguel Piris Villaespesa
- Principal Investigator Email
- mpirisv@gmail.com
- Contact Person Name
- Miguel Piris Villaespesa
- Contact Person Email
- mpirisv@gmail.com
- Site Name
- Hospital Virgen Del Valle
- Department Name
- Hematology
- Principal Investigator Name
- Ivan Alvarez-Twose
- Principal Investigator Email
- ivana@sescam.jccm.es
- Contact Person Name
- Ivan Alvarez-Twose
- Contact Person Email
- ivana@sescam.jccm.es
- Site Name
- Institut Catala D'oncologia
- Department Name
- Hematology
- Principal Investigator Name
- Helena Pomares Marin
- Principal Investigator Email
- hpomares@iconcologia.net
- Contact Person Name
- Helena Pomares Marin
- Contact Person Email
- hpomares@iconcologia.net
- Site Name
- Hospital Del Mar
- Department Name
- Hematology
- Principal Investigator Name
- Alicia Senin Magan
- Principal Investigator Email
- msenin@hmar.cat
- Contact Person Name
- Alicia Senin Magan
- Contact Person Email
- msenin@hmar.cat
- Site Name
- Hospital Universitario 12 De Octubre
- Department Name
- Hematology
- Principal Investigator Name
- Rosa Ayala Diaz
- Principal Investigator Email
- rosam.ayala@salud.madrid.org
- Contact Person Name
- Rosa Ayala Diaz
- Contact Person Email
- rosam.ayala@salud.madrid.org
- Site Name
- Hospital Quironsalud Zaragoza
- Department Name
- Hematology
- Principal Investigator Name
- Pilar Giraldo
- Principal Investigator Email
- giraldocastellano@gmail.com
- Contact Person Name
- Pilar Giraldo
- Contact Person Email
- giraldocastellano@gmail.com
Sponsor
Primary sponsor
- Full Name
- Telios Pharma Inc.
- Organisation Type
- Pharmaceutical company
- Country Of Registered Address
- United States
Contract research organisations
- Name
- Medpace Inc.
- Responsibilities
- sponsorDuties codes: 1,12,2,5 (as listed in CTIS record)
- Name
- Ppd Inc.
- Responsibilities
- sponsorDuties code: 4 (as listed in CTIS record)
- Name
- Suvoda LLC
- Responsibilities
- sponsorDuties code: 3 (as listed in CTIS record)
Third parties
- {"country":"United States","full_name":"Medidata Solutions Inc.","duties_or_roles":"central ultrasound vendor, ePRO (sponsorDuties entries include code 15 with value 'central ultrasound vendor, ePRO'; additional duty codes present without textual value).","organisation_type":"Non-Pharmaceutical company"}
- {"country":"Germany","full_name":"LabConnect GmbH","duties_or_roles":"","organisation_type":"Laboratory/Research/Testing facility"}
- {"country":"United States","full_name":"Telios Pharma Inc.","duties_or_roles":"","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Aperio Clinical Outcomes LLC","duties_or_roles":"","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"EPL Pathology Archives LLC","duties_or_roles":"","organisation_type":"Laboratory/Research/Testing facility"}
- {"country":"United States","full_name":"Arup Laboratories Inc.","duties_or_roles":"","organisation_type":"Laboratory/Research/Testing facility"}
- {"country":"France","full_name":"KCAS Bio","duties_or_roles":"","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Greenphire LLC","duties_or_roles":"Patient travel reimbursement","organisation_type":"Non-Pharmaceutical company"}
- {"country":"United States","full_name":"Ppd Inc.","duties_or_roles":"","organisation_type":"Pharmaceutical company"}
- {"country":"Canada","full_name":"Unity Health St. Michael’s Hospital","duties_or_roles":"","organisation_type":"Health care"}
- {"country":"United States","full_name":"Suvoda LLC","duties_or_roles":"","organisation_type":"Non-Pharmaceutical company"}
- {"country":"United States","full_name":"Medpace Inc.","duties_or_roles":"","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Labconnect LLC","duties_or_roles":"","organisation_type":"Laboratory/Research/Testing facility"}
- {"country":"United Kingdom","full_name":"Primevigilance Limited","duties_or_roles":"","organisation_type":"Pharmaceutical company"}
- {"country":"Australia","full_name":"Crux Biolabs Pty Limited","duties_or_roles":"","organisation_type":"Pharmaceutical company"}
- {"country":"Germany","full_name":"Fisher Clinical Services GmbH","duties_or_roles":"","organisation_type":"Pharmaceutical company"}
Investigational products
- Investigational Product Name
- TL-895
- Active Substance
- 1-4-{[6-AMINO-5-(4-PHENOXY-PHENYL)-PYRIMIDIN-4-YLAMINO]-METHYL}-4-FLUORO-PIPERIDIN-1-YL)-PROPENONE
- Modality
- Small molecule
- Routes Of Administration
- ORAL USE
- Route
- ORAL
- Authorisation Status
- Authorised
- Maximum Dose
- 300 mg/Kg (maxDailyDoseAmount as listed)
- Investigational Product Name
- TL-895 matching placebo
- Modality
- Other
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