Clinical trial • Phase IV • Haematology
zanubrutinib for Waldenström macroglobulinemia
Phase IV trial of zanubrutinib for Waldenström macroglobulinemia. open-label, none/not specified-controlled. 102 participants.
Overview
- Trial Therapeutic Area
- Haematology
- Trial Disease
- Waldenström macroglobulinemia
- Trial Stage
- Phase IV
- Drug Modality
- Small molecule
Key dates
- Initial CTIS Submission Date
- 14-03-2024
- First CTIS Authorization Date
- 27-06-2024
Trial design
open-label, none/not specified-controlled Phase IV trial across 40 sites in France.
- Open Label
- Yes
- Comparator
- None/Not specified
- Target Sample Size
- 102
Eligibility
Recruits 102 Vulnerable population not selected; no specific consent or assent arrangements provided..
- Vulnerable Population
- Vulnerable population not selected; no specific consent or assent arrangements provided.
Recruitment
- Planned Sample Size
- 102
- Recruitment Window Months
- 78
Geography
- Total Number Of Sites
- 40
- Total Number Of Participants
- 102
France
- Earliest CTIS Part Ii Submission Date
- 18-06-2024
- Latest Decision Or Authorization Date
- 04-03-2026
- Processing Time Days
- 624
- Number Of Sites
- 40
- Number Of Participants
- 102
Sites
- Site Name
- Les Hopitaux Universitaires De Strasbourg
- Department Name
- Onco-hématologie
- Contact Person Name
- Elise Tousaint
- Contact Person Email
- elise.toussaint@chru-strasbourg.fr
- Site Name
- L'Hopital Prive Du Confluent
- Department Name
- Hématologie
- Contact Person Name
- Katell LE DU
- Contact Person Email
- kledu@vivalto-sante.com
- Site Name
- Centre Hospitalier Et Universitaire De Limoges
- Department Name
- Hématologie et thérapie cellulaire
- Contact Person Name
- Nataliya Dmytruk
- Contact Person Email
- nataliya.dmytruk@chu-limoges.fr
- Site Name
- Institut Gustave Roussy
- Department Name
- Service d'Hématologie
- Contact Person Name
- David Ghez
- Contact Person Email
- david.ghez@gustaveroussy.fr
- Site Name
- Assistance Publique Hopitaux De Paris
- Department Name
- Service d'Hématologie
- Contact Person Name
- Damien Roos-Weil
- Contact Person Email
- damien.roosweil@aphp.fr
- Site Name
- Centre Hospitalier De Versailles
- Department Name
- Service d'hématologie-oncologie
- Contact Person Name
- Fatiha Merabet
- Contact Person Email
- fmerabet@ght78sud.fr
- Site Name
- Groupe Hospitalier De La Region De Mulhouse Et Sud Alsace
- Department Name
- Service d'Hématologie
- Contact Person Name
- Bernard Drenou
- Contact Person Email
- drenoub@ghrmsa.fr
- Site Name
- Centre Leon Berard
- Department Name
- Oncologie Médicale
- Contact Person Name
- Mohammed Bendouda
- Contact Person Email
- mohammed.bendouda@lyon.unicancer.fr
- Site Name
- Centre Hospitalier Le Mans
- Department Name
- Centre de Cancérologie de la Sarthe
- Contact Person Name
- Kamel Laribi
- Contact Person Email
- klaribi@ch-lemans.fr
- Site Name
- Centre Hospitalier Universitaire De Nantes
- Department Name
- Service d'Hématologie
- Contact Person Name
- Anne Lok
- Contact Person Email
- anne.lok@chu-nantes.fr
- Site Name
- Centre Hospitalier Universitaire De Bordeaux
- Department Name
- Service d'Hématologie
- Contact Person Name
- Raphaëlle Aubrais
- Contact Person Email
- raphaelle.aubrais@chu-bordeaux.fr
- Site Name
- Centre Hospitalier Universitaire De Toulouse
- Department Name
- Service d'Hématologie
- Contact Person Name
- Loic Ysebaert
- Contact Person Email
- ysebaert.loic@iuct-oncopole.fr
- Site Name
- CHU Henri Mondor
- Department Name
- Unité Hémopathies Lymphoïdes
- Contact Person Name
- Jehan Dupuis
- Contact Person Email
- jehan.dupuis@aphp.fr
- Site Name
- Hospices Civils De Lyon
- Department Name
- Hématologie Clinique - Pavillon 1 F Marcel Berard - 3ème et.
- Contact Person Name
- Emmanuelle Ferrant
- Contact Person Email
- emmanuelle.ferrant2@chu-lyon.fr
- Site Name
- Centre Hospitalier Victor Dupouy Argenteuil
- Department Name
- Service d'Hématologie
- Contact Person Name
- Mariem Romdhani
- Contact Person Email
- mariem.romdhani@ch-argenteuil.fr
- Site Name
- Centre Hospitalier Bretagne Atlantique
- Department Name
- Hématologie et thérapie cellulaire
- Contact Person Name
- Guillaume Aussedat
- Contact Person Email
- guillaume.aussedat@ch-bretagne-atlantique.fr
- Site Name
- Centre Hospitalier De Perpignan
- Department Name
- Service d'Hématologie clinique
- Contact Person Name
- Sara Burcheri
- Contact Person Email
- sara.burcheri@ch-perpignan.fr
- Site Name
- Centre Hospitalier Universitaire De Montpellier
- Department Name
- Service d'Hématologie clinique
- Contact Person Name
- Charles Herbaux
- Contact Person Email
- c-herbaux@chu-montpellier.fr
- Site Name
- Centre Hospital Region Metz Thionville
- Department Name
- Hématologie
- Contact Person Name
- Philippe Carassou
- Contact Person Email
- philippe.carassou@chr-metz-thionville.fr
- Site Name
- Centre Hospitalier Universitaire De Caen Normandie
- Department Name
- Service d'Hématologie clinique
- Contact Person Name
- Ghandi-Laurent Damaj
- Contact Person Email
- damaj-gl@chu-caen.fr
- Site Name
- Centre Hospitalier Universitaire D Orleans
- Department Name
- Service d'Hématologie
- Contact Person Name
- Marlène Ochmann
- Contact Person Email
- marlene.ochmann@chu-orleans.fr
- Site Name
- Centre Hospitalier Departemental Vendee
- Department Name
- Département Onco-Hématologie
- Contact Person Name
- Jessie Bourcier
- Contact Person Email
- jessie.bourcier@ght85.fr
- Site Name
- Centre Hospitalier Universitaire Amiens Picardie
- Department Name
- Hématologie clinique
- Contact Person Name
- Lydia Montes
- Contact Person Email
- montes.lydia@chu-amiens.fr
- Site Name
- Centre Hospitalier Universitaire De Lille
- Department Name
- service Maladies du Sang
- Contact Person Name
- Morgane Nudel
- Contact Person Email
- morgane.nudel@chu-lille.fr
- Site Name
- Assistance Publique Hopitaux De Paris
- Department Name
- Hématologie
- Contact Person Name
- Lise Willems
- Contact Person Email
- lise.willems@aphp.fr
- Site Name
- Besancon University Hospital Center
- Department Name
- Service d'Hématologie
- Contact Person Name
- Adrien Caillet
- Contact Person Email
- acaillet@chu-besancon.fr
- Site Name
- Institut Paoli Calmettes
- Department Name
- Service d'Hématologie
- Contact Person Name
- Anne Calleja
- Contact Person Email
- callejaa@ipc.unicancer.fr
- Site Name
- Centre Hospitalier Regional Universitaire De Tours
- Department Name
- Hématologie et thérapie cellulaire
- Contact Person Name
- Caroline Dartigeas
- Contact Person Email
- c.dartigeas@chu-tours.fr
- Site Name
- Centre Hospitalier Universitaire Grenoble Alpes
- Department Name
- Service d'Hématologie
- Contact Person Name
- Lucile Bussot
- Contact Person Email
- lbussot@chu-grenoble.fr
- Site Name
- Groupement Des Hopitaux De L'Institut Catholique De Lille
- Department Name
- Onco-Hématologie
- Contact Person Name
- Bénédicte Hivert
- Contact Person Email
- hivert.benedicte@ghicl.net
- Site Name
- Institut Bergonie
- Department Name
- Service d'Hématologie
- Contact Person Name
- Fontanet Bijou
- Contact Person Email
- f.bijou@bordeaux.unicancer.fr
- Site Name
- Centre Henri Becquerel
- Department Name
- Service d'Hématologie
- Contact Person Name
- Stéphane Lepretre
- Contact Person Email
- stephane.lepretre@chb.unicancer.fr
- Site Name
- Centre Hospitalier Universitaire De Dijon
- Department Name
- Service d'Hématologie clinique
- Contact Person Name
- Amandine Durand
- Contact Person Email
- amandine.durand@chu-dijon.fr
- Site Name
- Centre Hospitalier Universitaire Reims
- Department Name
- Service d'Hématologie
- Contact Person Name
- Eric Durot
- Contact Person Email
- edurot@chu-reims.fr
- Site Name
- Centre Hospitalier Universitaire De Poitiers
- Department Name
- Service d'Hématologie
- Contact Person Name
- Cécile Tomowiak
- Contact Person Email
- cecile.tomowiak@chu-poitiers.fr
- Site Name
- CHRU De Nancy
- Department Name
- Service d'Hématologie
- Contact Person Name
- Pierre Feugier
- Contact Person Email
- p.feugier@chru-nancy.fr
- Site Name
- Centre Hospitalier Annecy Genevois
- Department Name
- Service d'Hématologie
- Contact Person Name
- Stéphanie Tardy
- Contact Person Email
- stardy@ch-annecygenevois.fr
Sponsor
Primary sponsor
- Full Name
- French Innovative Leukemia Organization
- Organisation Type
- Laboratory/Research/Testing facility
- Country Of Registered Address
- France
Investigational products
- Investigational Product Name
- zanubrutinib
- Active Substance
- zanubrutinib
- Modality
- Small molecule
- Investigational Product Name
- BGB-11417
- Active Substance
- BGB-11417
- Modality
- Small molecule
- Combination Treatment
- Yes
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