Clinical trial • Phase III • Immunology
UPADACITINIB for Non-segmental vitiligo
Phase III trial of UPADACITINIB for Non-segmental vitiligo.
Overview
- Trial Therapeutic Area
- Immunology
- Trial Disease
- Non-segmental vitiligo
- Trial Stage
- Phase III
- Drug Modality
- Small molecule
- Paediatric Trial
- Yes
Key dates
- Initial CTIS Submission Date
- 21-11-2023
- First CTIS Authorization Date
- 26-03-2024
Trial design
Randomised, active: upadacitinib 15 mg modified-release tablet, oral; once daily (as stated). comparator arm: upadacitinib placebo (placebo tablet).-controlled Phase III trial in Hungary, Bulgaria, Belgium and others.
- Randomised
- Yes
- Comparator
- Active: Upadacitinib 15 mg modified-release tablet, oral; once daily (as stated). Comparator arm: Upadacitinib Placebo (placebo tablet).
- Target Sample Size
- 381
- Trial Duration For Participant
- 336
Eligibility
Recruits 381 paediatric patients.
- Pregnancy Exclusion
- Pregnancy testing in female subjects of childbearing potential • Females of childbearing potential must not have a positive serum pregnancy test at the Screening Visit and must have a negative urine pregnancy test at Baseline prior to the first dose of study drug (local practices may require serum pregnancy testing at Baseline). • Subjects with a borderline serum pregnancy test at Screening must have absence of clinical suspicion of pregnancy or other pathological causes of borderline results and a serum pregnancy test ≥ 3 days later to document continued lack of a positive result (unless prohibited by local requirements). • Subjects with a urine pregnancy test at Baseline that is borderline or ambiguous must have a serum pregnancy test
- Vulnerable Population
- Vulnerable population considerations: adolescents (≥12 to <18 years) are included. Informed consent must be obtained (adult participants) and assent for minors is required as per applicable regulation; parental or legally authorized guardian consent is required for minors. The protocol requires consent/assent documents approved by an IEC/IRB; country-specific parent/guardian and assent ICFs are provided (multiple languages) and there are provisions for legally authorized representatives where required by local regulations.
Inclusion criteria
- {"criterion_text":"- Subjects or their legally authorized representative (if required per local regulations) must be able to understand and be willing to adhere to all protocol requirements and voluntarily sign and date an informed consent (and assent for minors as required by applicable regulation), approved by an IEC/IRB, prior to the initiation of any screening or study-specific procedures.\n- Adult and adolescent individuals, ≥ 12 years of age at Screening.\n- Body weight must be ≥ 30 kg at Baseline Visit for subjects who are ≥ 12 and < 18 years of age.\n- Documented clinical diagnosis of NSV.\n- At Screening and Baseline Visits, subject must satisfy at least 1 of the following criteria: ·\t≥ 0.5 F-VASI and 5 ≤ T-VASI < 50 AND have failed at least 1 topical corticosteroid and/or at least 1 topical calcineurin inhibitor for vitiligo; or ·\t≥ 0.5 F-VASI and 5 ≤ T-VASI < 50 AND have a sign of actively progressing vitiligo; or ·\t≥ 0.5 F-VASI and 10 ≤ T-VASI < 50.\n- Subject is judged to be in good health as determined by the Principal Investigator, based upon the results of the Screening assessments and medical history.\n- Pregnancy testing in female subjects of childbearing potential • Females of childbearing potential must not have a positive serum pregnancy test at the Screening Visit and must have a negative urine pregnancy test at Baseline prior to the first dose of study drug (local practices may require serum pregnancy testing at Baseline). • Subjects with a borderline serum pregnancy test at Screening must have absence of clinical suspicion of pregnancy or other pathological causes of borderline results and a serum pregnancy test ≥ 3 days later to document continued lack of a positive result (unless prohibited by local requirements). • Subjects with a urine pregnancy test at Baseline that is borderline or ambiguous must have a serum pregnancy test"}
Exclusion criteria
- {"criterion_text":"- Subject has segmental or localized vitiligo.\n- Subject has been treated with any permanent skin bleaching agents.\n- Subject has a history of active skin disease other than vitiligo that could interfere with the assessment of vitiligo.\n- Subject must not have > 33% leukotrichia in areas of vitiligo on the face or > 33% leukotrichia in areas of vitiligo on the body (including the face).\n- Subject has current or past history of any of the following infections: •Two or more episodes of herpes zoster, or one or more episodes or disseminated herpes zoster; • One or more episodes of disseminated herpes simplex (including eczema herpeticum); • Human immunodeficiency virus infection defined as confirmed positive anti-HIV antibody test; • Active TB or meet TB exclusionary parameters (specific requirements for TB testing will be provided in the Operations Manual [Appendix F]);\n- Subject has evidence of: • HBV • HCV\n- There must be no reason the investigator believes that the subject is an unsuitable candidate to participate in the study, receive study drug, or would be placed at risk by participating in the study.\n- Subject must not have a history of clinically significant (per investigator's judgment) drug or alcohol abuse within the last 6 months.\n- The investigator believes that the subject is an unsuitable candidate to participate in the study, receive study drug, or would be placed at risk by participating in the study.\n- Subject has been treated with any systemic JAK inhibitor."}
Endpoints
Primary endpoints
- {"endpoint_text":"- Achievement of T-VASI 50 (≥ 50% reduction in T-VASI from Baseline) at Week 48","definition_or_measurement_approach":"T-VASI 50 defined as ≥50% reduction in T-VASI from Baseline measured at Week 48."}
- {"endpoint_text":"- Achievement of F-VASI 75 (≥ 75% reduction in F-VASI from Baseline) at Week 48","definition_or_measurement_approach":"F-VASI 75 defined as ≥75% reduction in F-VASI from Baseline measured at Week 48."}
Secondary endpoints
- {"endpoint_text":"- Achievement of F-VASI 50 (≥ 50% reduction in F-VASI from Baseline) at Week 48;","definition_or_measurement_approach":"F-VASI 50: ≥50% reduction in F-VASI from Baseline at Week 48."}
- {"endpoint_text":"- Achievement of F-VASI 75 (≥ 75% reduction in F-VASI from Baseline) at Week 24;","definition_or_measurement_approach":"F-VASI 75 at Week 24: ≥75% reduction in F-VASI from Baseline at Week 24."}
- {"endpoint_text":"- Percent change from Baseline in F-VASI at Week 24;","definition_or_measurement_approach":"Percent change from Baseline in F-VASI measured at Week 24."}
- {"endpoint_text":"- Percent change from Baseline in T-VASI at Week 48;","definition_or_measurement_approach":"Percent change from Baseline in T-VASI measured at Week 48."}
- {"endpoint_text":"- Achievement of F-VASI 90 (≥ 90% reduction in F-VASI from Baseline) at Week 48;","definition_or_measurement_approach":"F-VASI 90: ≥90% reduction in F-VASI from Baseline at Week 48."}
- {"endpoint_text":"- Achievement of VNS score of \"A lot less noticeable (4)\" or \"No longer noticeable (5)\" at Week 48;","definition_or_measurement_approach":"VNS patient/visual noticeability score measured at Week 48; achievement defined as score of 4 or 5."}
- {"endpoint_text":"- Achievement of PaGIC-V of \"Much better (1)\" at Week 48.","definition_or_measurement_approach":"Patient Global Impression of Change for vitiligo (PaGIC-V) measured at Week 48; achievement defined as 'Much better (1)'."}
- {"endpoint_text":"- Achievement of PhGIC-V of \"Much better (1)\" at Week 48;","definition_or_measurement_approach":"Physician Global Impression of Change for vitiligo (PhGIC-V) measured at Week 48; achievement defined as 'Much better (1)'."}
Recruitment
- Digital Remote Recruitment
- Yes
- Planned Sample Size
- 381
- Recruitment Window Months
- 46
- Consent Approach
- Informed consent is required prior to any screening or study procedures; adults provide written informed consent. Adolescents (≥12 to <18 years) provide assent and parent/guardian (or legally authorized representative where required) must provide consent; provision for legally authorized representative consent per local regulations. ICFs, assent forms, and parent/guardian ICFs are prepared and available in multiple languages per country (English, Dutch, French, German, Bulgarian, Polish, Portuguese, Slovak, Hungarian and others as per country-specific documents). All consent/assent documents are IEC/IRB approved.
Methods
- Search Ads — online search advertising (documents titled 'Search Ads') targeting potential participants via internet search channels (country-specific materials available, e.g., DE, BG).
- Digital Ads — online display/digital advertising (documents titled 'Digital Ads' / 'Social Media Script') targeting patients via social media and digital channels (country-specific scripts present).
- Social Media Scripts — social media channel messaging/content for patient recruitment (country-specific social media script documents).
- Doctor to Patient Email — emails from physicians to patients to inform about the study (documents titled 'Doctor to Patient Email' per country).
- Recruitment Brochure / Flyer — printable brochures and flyers for distribution at clinics/sites (country-specific brochures/flyers available).
- Landing Page Copy — dedicated study landing page content to capture interested patients (documents titled 'Landing Page Copy').
- Database and Patient Messaging — messaging to patient databases or registries via sites (documents titled 'Database and Patient Messaging').
- Master Screener / Master CC and WS Script — site-level screening scripts and call-center scripts for screening potential participants.
Geography
- Total Number Of Sites
- 60
- Total Number Of Participants
- 381
Hungary
- Earliest CTIS Part Ii Submission Date
- 11-04-2024
- Latest Decision Or Authorization Date
- 06-06-2024
- Processing Time Days
- 56
- Number Of Sites
- 2
- Number Of Participants
- 6
Sites
- Site Name
- Derma-B Kft.
- Contact Person Name
- Emese Heredi
- Contact Person Email
- emeseheredi@gmail.com
- Site Name
- Semmelweis University
- Department Name
- Bor-, Nemikortani es Boronkologiai Klinika
- Contact Person Name
- Peter Hollo
- Contact Person Email
- hollo.peter@med.semmelweis-univ.hu
Bulgaria
- Earliest CTIS Part Ii Submission Date
- 04-12-2023
- Latest Decision Or Authorization Date
- 21-11-2025
- Processing Time Days
- 718
- Number Of Sites
- 5
- Number Of Participants
- 16
Sites
- Site Name
- Medical Center Kordis OOD
- Contact Person Name
- Dimitar Gospodinov
- Contact Person Email
- dkg@abv.bg
- Site Name
- Military Medical Academy
- Department Name
- Department of Dermatology
- Contact Person Name
- Vessel Kantardjiev
- Contact Person Email
- v.kantarjiev@vma.bg
- Site Name
- ASMC IPSMC Skin And Venereal Diseases
- Contact Person Name
- Ivan Botev
- Contact Person Email
- botev2@yahoo.com
- Site Name
- Diagnostic Consultation Center XX-Sofia EOOD
- Contact Person Name
- Toma Tomov
- Contact Person Email
- toma_tomov2015@abv.bg
- Site Name
- Dkc Fokus-5 Lzip OOD
- Contact Person Name
- Grisha Mateev
- Contact Person Email
- grisha_mateev@yahoo.com
Belgium
- Earliest CTIS Part Ii Submission Date
- 28-02-2024
- Latest Decision Or Authorization Date
- 24-11-2025
- Processing Time Days
- 635
- Number Of Sites
- 4
- Number Of Participants
- 18
Sites
- Site Name
- Grand Hopital De Charleroi
- Department Name
- Dermatology
- Contact Person Name
- Pierre Paul Roquet-Gravy
- Contact Person Email
- pierre-paul.roquet-gravy@ghdc.be
- Site Name
- CHU De Liege
- Department Name
- Dermatology
- Contact Person Name
- Arjen Nikkels
- Contact Person Email
- af.nikkels@chuliege.be
- Site Name
- Cliniques Universitaires Saint-Luc
- Department Name
- Dermatology
- Contact Person Name
- Pierre Dominique Ghislain
- Contact Person Email
- pierre-dominique.ghislain@saintluc.uclouvain.be
- Site Name
- Universitair Ziekenhuis Gent
- Department Name
- Dermatology
- Contact Person Name
- Reinhart Speeckaert
- Contact Person Email
- reinhart.speeckaert@uzgent.be
Portugal
- Earliest CTIS Part Ii Submission Date
- 05-02-2024
- Latest Decision Or Authorization Date
- 18-11-2025
- Processing Time Days
- 592
- Number Of Sites
- 4
- Number Of Participants
- 18
Sites
- Site Name
- Centro Hospitalar E Universitario De Coimbra E.P.E.
- Department Name
- Dermatology
- Contact Person Name
- Leonor Ramos
- Contact Person Email
- leonoricr@gmail.com
- Site Name
- Centro Hospitalar Universitario De Santo Antonio E.P.E.
- Department Name
- Dermatology
- Contact Person Name
- Tiago Torres
- Contact Person Email
- torres.tiago@outlook.com
- Site Name
- Centro Hospitalar De Leiria E.P.E.
- Department Name
- Dermatology
- Contact Person Name
- Tiago Gomes
- Contact Person Email
- tiago.gomes@chleiria.min-saude.pt
- Site Name
- Hospital Cuf Descobertas S.A.
- Department Name
- Dermatology
- Contact Person Name
- Pedro Mendes-Bastos
- Contact Person Email
- pmendesbastos@gmail.com
Netherlands
- Earliest CTIS Part Ii Submission Date
- 28-02-2024
- Latest Decision Or Authorization Date
- 20-11-2025
- Processing Time Days
- 631
- Number Of Sites
- 3
- Number Of Participants
- 8
Sites
- Site Name
- Amsterdam UMC
- Department Name
- Dermatology
- Contact Person Name
- Albert Wolkerstorfer
- Contact Person Email
- a.wolkerstorfer@amsterdamumc.nl
- Site Name
- Bravis Ziekenhuis
- Department Name
- Dermatology
- Contact Person Name
- Milan Tjioe
- Contact Person Email
- m.tjioe@bravis.nl
- Site Name
- Amphia Hospital
- Department Name
- Dermatology
- Contact Person Name
- Bas Prens
- Contact Person Email
- BPrens@amphia.nl
Slovakia
- Earliest CTIS Part Ii Submission Date
- 16-02-2024
- Latest Decision Or Authorization Date
- 18-11-2025
- Processing Time Days
- 641
- Number Of Sites
- 3
- Number Of Participants
- 7
Sites
- Site Name
- Fakultna Nemocnica Trnava
- Department Name
- dermatologia
- Contact Person Name
- Peter Kozub
- Contact Person Email
- peter.kozub.derm@gmail.com
- Site Name
- Fakultna Nemocnica S Poliklinikou J. A. Reimana Presov
- Department Name
- dermatologia
- Contact Person Name
- Silvia Petrova
- Contact Person Email
- petrovasilvia11@gmail.com
- Site Name
- Derma therapy spol. s r.o.
- Department Name
- Derma therapy, spol. s r.o.
- Contact Person Name
- Michaela Dubcekova
- Contact Person Email
- mdubcekova@gmail.com
Germany
- Earliest CTIS Part Ii Submission Date
- 16-02-2024
- Latest Decision Or Authorization Date
- 18-11-2025
- Processing Time Days
- 641
- Number Of Sites
- 11
- Number Of Participants
- 53
Sites
- Site Name
- Technische Universitat Dresden
- Department Name
- Klinik und Poliklinik für Dermatologie
- Principal Investigator Name
- Roland Aschoff
- Principal Investigator Email
- dermastudien@ukdd.de
- Contact Person Name
- Roland Aschoff
- Contact Person Email
- dermastudien@ukdd.de
- Site Name
- Charite Universitaetsmedizin Berlin KöR
- Principal Investigator Name
- Kamran Ghoreschi
- Principal Investigator Email
- kamran.ghoreschi@charite.de
- Contact Person Name
- Kamran Ghoreschi
- Contact Person Email
- kamran.ghoreschi@charite.de
- Site Name
- Universitaetsklinikum Erlangen AöR
- Department Name
- Hautklinik
- Principal Investigator Name
- Michael Sticherling
- Principal Investigator Email
- studien.de@uk-erlangen.de
- Contact Person Name
- Michael Sticherling
- Contact Person Email
- studien.de@uk-erlangen.de
- Site Name
- Klinikum rechts der Isar der TU Muenchen AöR
- Department Name
- Klinik und Poliklinik für Dermatologie und Allergologie am Biederstein
- Principal Investigator Name
- Bernadette Eberlein
- Principal Investigator Email
- studienambulanz.de@mri.tum.de
- Contact Person Name
- Bernadette Eberlein
- Contact Person Email
- studienambulanz.de@mri.tum.de
- Site Name
- Universitaet Muenster
- Department Name
- Klinik für Hautkrankheiten, Zentrale Studienkoordination für innovative Dermatologie (ZID)
- Principal Investigator Name
- Nina Magnolo
- Principal Investigator Email
- Nina.Magnolo@ukmuenster.der
- Contact Person Name
- Nina Magnolo
- Contact Person Email
- Nina.Magnolo@ukmuenster.der
- Site Name
- Praxis Dr. med. Abdou Zarzour
- Principal Investigator Name
- Abdou Zarzour
- Principal Investigator Email
- Zarzour@gmx.de
- Contact Person Name
- Abdou Zarzour
- Contact Person Email
- Zarzour@gmx.de
- Site Name
- MVZ Dermatologisches Zentrum Bonn GmbH
- Principal Investigator Name
- Uwe Reinhold
- Principal Investigator Email
- info@derma-bonn.de
- Contact Person Name
- Uwe Reinhold
- Contact Person Email
- info@derma-bonn.de
- Site Name
- Goethe University Frankfurt
- Department Name
- Klinik für Dermatologie, Venerologie und Allergologie, Klinische Forschung
- Principal Investigator Name
- Andreas Pinter
- Principal Investigator Email
- decker-klifo-ffm@gmx.de
- Contact Person Name
- Andreas Pinter
- Contact Person Email
- decker-klifo-ffm@gmx.de
- Site Name
- Fachaerztliche Gemeinschaftspraxis fuer Dermatologie Und Venerologie Allergologie Umweltmedizin Lasermedizin GbR
- Principal Investigator Name
- Michael Sebastian
- Principal Investigator Email
- kontakt@derma-mahlow.de
- Contact Person Name
- Michael Sebastian
- Contact Person Email
- kontakt@derma-mahlow.de
- Site Name
- Thermalsole und Schwefelbad Bentheim GmbH
- Department Name
- Klinisches Studienzentrum
- Principal Investigator Name
- Athanasios Tsianakas
- Principal Investigator Email
- studien-dermatologie@fk-bentheim.de
- Contact Person Name
- Athanasios Tsianakas
- Contact Person Email
- studien-dermatologie@fk-bentheim.de
- Site Name
- Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz KöR
- Department Name
- Dermatologie / Clinical Research Center
- Principal Investigator Name
- Petra Staubach-Renz
- Principal Investigator Email
- crc-hautklinik@unimedizin-mainz.de
- Contact Person Name
- Petra Staubach-Renz
- Contact Person Email
- crc-hautklinik@unimedizin-mainz.de
Poland
- Earliest CTIS Part Ii Submission Date
- 04-12-2023
- Latest Decision Or Authorization Date
- 21-11-2025
- Processing Time Days
- 718
- Number Of Sites
- 11
- Number Of Participants
- 56
Sites
- Site Name
- Futuremeds Sp. z o.o.
- Contact Person Name
- Agnieszka Synarska-Drygalska
- Contact Person Email
- agnieszka.snarska@futuremeds.com
- Site Name
- Osteo Medic s.c. Artur Racewicz Jerzy Supronik
- Contact Person Name
- Małgorzata Janczyło-Jankowska
- Contact Person Email
- jjgosia@gmail.com
- Site Name
- Klinika Osipowicz & Turkowski Sp. z o.o.
- Contact Person Name
- Katarzyna Osipowicz
- Contact Person Email
- osipowicz.kasia@gmail.com
- Site Name
- Specjalistyczny Gabinet Dermatologiczny Aplikacyjno Badawczy Marek Brzewski Paweł Brzewski s.c.
- Contact Person Name
- Paweł Brzewski
- Contact Person Email
- brzewski@sgd-polska.com
- Site Name
- DermoDent Centrum Medyczne Aldona Czajkowska Rafal Czajkowski s.c
- Contact Person Name
- Rafał Czajkowski
- Contact Person Email
- r.czajkowski@dermodent.pl
- Site Name
- ROYALDERM AGNIESZKA NAWROCKA
- Contact Person Name
- Witold Owczarek
- Contact Person Email
- kontakt@royalderm.pl
- Site Name
- Klinika Ambroziak Sp. z o.o.
- Contact Person Name
- Monika Kałowska
- Contact Person Email
- principalkalowska@klinikaambroziak.pl
- Site Name
- Twoja Przychodnia Szczecinskie Centrum Medyczne Sp. z o.o.
- Contact Person Name
- Tadeusz Dębniak
- Contact Person Email
- debniak@twojaprzychodnia.com
- Site Name
- Malopolskie Centrum Kliniczne
- Contact Person Name
- Teresa Kusiba-Wodniak
- Contact Person Email
- tkwodniak@mck-krakow.pl
- Site Name
- Provita Sp. z o.o.
- Contact Person Name
- Anita Lewartowska-Białek
- Contact Person Email
- a.bialek@angelius.org
- Site Name
- additional listed Polish site(s)
Italy
- Earliest CTIS Part Ii Submission Date
- 01-03-2024
- Latest Decision Or Authorization Date
- 19-11-2025
- Processing Time Days
- 628
- Number Of Sites
- 4
- Number Of Participants
- 4
Sites
- Site Name
- Ospedale San Raffaele S.r.l.
- Department Name
- Unit of Dermatology and Cosmetology
- Principal Investigator Name
- Santo Raffaele Mercuri
- Principal Investigator Email
- mercuri.santoraffaele@hsr.it
- Contact Person Name
- Santo Raffaele Mercuri
- Contact Person Email
- mercuri.santoraffaele@hsr.it
- Site Name
- Azienda Ospedaliero Universitaria Di Modena
- Department Name
- Complex structure of Dermatology
- Principal Investigator Name
- Cristina Magnoni
- Principal Investigator Email
- cristina.magnoni@unimore.it
- Contact Person Name
- Cristina Magnoni
- Contact Person Email
- cristina.magnoni@unimore.it
- Site Name
- Azienda Socio Sanitaria Territoriale Degli Spedali Civili Di Brescia
- Department Name
- U.O. Dermatology
- Principal Investigator Name
- Mariachiara Arisi
- Principal Investigator Email
- mariachiara.arisi@gmail.com
- Contact Person Name
- Mariachiara Arisi
- Contact Person Email
- mariachiara.arisi@gmail.com
- Site Name
- I.F.O. Istituti Fisioterapici Ospitalieri
- Department Name
- Complex Operative Unit of Clinic dermatology
- Principal Investigator Name
- Paolo Iacovelli
- Principal Investigator Email
- paolo.iacovelli@ifo.it
- Contact Person Name
- Paolo Iacovelli
- Contact Person Email
- paolo.iacovelli@ifo.it
France
- Earliest CTIS Part Ii Submission Date
- 06-03-2024
- Latest Decision Or Authorization Date
- 01-12-2025
- Processing Time Days
- 635
- Number Of Sites
- 5
- Number Of Participants
- 27
Sites
- Site Name
- Hospital Edouard Herriot
- Department Name
- SERVICE DE DERMATOLOGIE
- Principal Investigator Name
- Cécile LESORT
- Principal Investigator Email
- Cecile.lesort@chu-lyon.fr
- Contact Person Name
- Cécile LESORT
- Contact Person Email
- Cecile.lesort@chu-lyon.fr
- Site Name
- Centre Hospitalier Universitaire De Nice
- Department Name
- SERVICE DE DERMATOLOGIE
- Principal Investigator Name
- Thierry PASSERON
- Principal Investigator Email
- passeron.t@chu-nice.fr
- Contact Person Name
- Thierry PASSERON
- Contact Person Email
- passeron.t@chu-nice.fr
- Site Name
- Centre Hospitalier Universitaire De Bordeaux
- Department Name
- SERVICE DE DERMATOLOGIE ADULTE ET PEDIATRIQUE
- Principal Investigator Name
- Julien SENESCHAL
- Principal Investigator Email
- julien.seneschal@chu-bordeaux.fr
- Contact Person Name
- Julien SENESCHAL
- Contact Person Email
- julien.seneschal@chu-bordeaux.fr
- Site Name
- Assistance Publique Hopitaux De Paris
- Department Name
- SERVICE DE DERMATOLOGIE
- Principal Investigator Name
- Khaled EZZEDINE
- Principal Investigator Email
- khaled.ezzedine@aphp.fr
- Contact Person Name
- Khaled EZZEDINE
- Contact Person Email
- khaled.ezzedine@aphp.fr
- Site Name
- Centre Hospitalier Universitaire De Toulouse
- Department Name
- CENTRE DES MALADIE RARES DE LA PEAU - SERVICE DE DERMATOLOGIE
- Principal Investigator Name
- Juliette MAZEREEUW-HAUTIER
- Principal Investigator Email
- mazereeuw-hautier.j@chu-toulouse.fr
- Contact Person Name
- Juliette MAZEREEUW-HAUTIER
- Contact Person Email
- mazereeuw-hautier.j@chu-toulouse.fr
Spain
- Earliest CTIS Part Ii Submission Date
- 27-02-2024
- Latest Decision Or Authorization Date
- 11-02-2026
- Processing Time Days
- 715
- Number Of Sites
- 8
- Number Of Participants
- 26
Sites
- Site Name
- Hospital General Universitario De Valencia
- Department Name
- Servicio de Dermatología
- Principal Investigator Name
- Jorge Magdaleno Tapial
- Principal Investigator Email
- jormagta@gmail.com
- Contact Person Name
- Jorge Magdaleno Tapial
- Contact Person Email
- jormagta@gmail.com
- Site Name
- Hospital Universitario Quironsalud Madrid
- Department Name
- Servicio de Dermatología
- Principal Investigator Name
- Javier Pedraz Muñoz
- Principal Investigator Email
- javierpedraz78@gmail.com
- Contact Person Name
- Javier Pedraz Muñoz
- Contact Person Email
- javierpedraz78@gmail.com
- Site Name
- Hospital Universitario Clinico San Cecilio
- Department Name
- Servicio de Dermatología
- Principal Investigator Name
- Jose Carlos Ruiz Carrascosa
- Principal Investigator Email
- ruizcarrascosa@movistar.es
- Contact Person Name
- Jose Carlos Ruiz Carrascosa
- Contact Person Email
- ruizcarrascosa@movistar.es
- Site Name
- Hospital Universitario De Getafe
- Department Name
- Servicio de Dermatología
- Principal Investigator Name
- Héctor Muñoz González
- Principal Investigator Email
- hector.munoz@salud.madrid.org
- Contact Person Name
- Héctor Muñoz González
- Contact Person Email
- hector.munoz@salud.madrid.org
- Site Name
- Hospital Germans Trias I Pujol
- Department Name
- Servicio de Dermatología
- Principal Investigator Name
- Ane jaka Moreno
- Principal Investigator Email
- ajaka.germanstrias@gencat.cat
- Contact Person Name
- Ane jaka Moreno
- Contact Person Email
- ajaka.germanstrias@gencat.cat
- Site Name
- Hospital Clinico Universitario Lozano Blesa
- Department Name
- Servicio de Dermatología
- Principal Investigator Name
- Mariano Ara Martin
- Principal Investigator Email
- mariano_ara@yahoo.es
- Contact Person Name
- Mariano Ara Martin
- Contact Person Email
- mariano_ara@yahoo.es
- Site Name
- Icr Medical S.L.
- Department Name
- Servicio de Dermatología (Grupo Pedro Jaen)
- Principal Investigator Name
- Gonzalo Segurado Miravalles
- Principal Investigator Email
- j.villanueva@pjaen.com
- Contact Person Name
- Gonzalo Segurado Miravalles
- Contact Person Email
- j.villanueva@pjaen.com
- Site Name
- additional listed Spanish site(s)
Sponsor
Primary sponsor
- Full Name
- AbbVie Deutschland GmbH & Co. KG
- Organisation Type
- Pharmaceutical company
- Country Of Registered Address
- Germany
Contract research organisations
- Name
- Advarra Inc.
- Responsibilities
- code: 3
- Name
- WCG Clinical Inc.
- Responsibilities
- Training, Cardiac and GI Adjudication
Third parties
- {"country":"United States","full_name":"Labcorp Central Laboratory Services LP","duties_or_roles":"code: 4","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Canfield Scientific Inc.","duties_or_roles":"Imaging","organisation_type":"Pharmaceutical company"}
- {"country":"United Kingdom","full_name":"Cherry Pharma Limited","duties_or_roles":"Imaging","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Advarra Inc.","duties_or_roles":"code: 3","organisation_type":"Non-Pharmaceutical company"}
- {"country":"United States","full_name":"WCG Clinical Inc.","duties_or_roles":"Training, Cardiac and GI Adjudication","organisation_type":"Pharmaceutical company"}
Investigational products
- Investigational Product Name
- Upadacitinib
- Active Substance
- UPADACITINIB
- Modality
- Small molecule
- Routes Of Administration
- Oral
- Route
- Oral
- Authorisation Status
- Authorised
- Starting Dose
- 15 mg
- Dose Levels
- 15 mg
- Frequency
- Once daily
- Maximum Dose
- 15 mg (max daily dose amount listed as 15 mg)
- Investigational Product Name
- Upadacitinib Placebo
- Modality
- Other
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