Clinical trial • Phase III • Respiratory
TEZEPELUMAB for Chronic obstructive pulmonary disease (COPD)
Phase III trial of TEZEPELUMAB for Chronic obstructive pulmonary disease (COPD).
Overview
- Trial Therapeutic Area
- Respiratory
- Trial Disease
- Chronic obstructive pulmonary disease (COPD)
- Trial Stage
- Phase III
- Drug Modality
- Monoclonal antibody
Key dates
- Initial CTIS Submission Date
- 28-01-2025
- First CTIS Authorization Date
- 12-05-2025
Trial design
Randomised, placebo (tezepelumab-placebo) - matching placebo; dose/schedule for placebo not specified in available data.-controlled Phase III trial in Czechia, Germany, Spain and others.
- Randomised
- Yes
- Comparator
- Placebo (Tezepelumab-placebo) - matching placebo; dose/schedule for placebo not specified in available data.
- Target Sample Size
- 803
- Trial Duration For Participant
- 532
Eligibility
Recruits 803 Vulnerable population selected (isVulnerablePopulationSelected = true). The provided data lists ICF and subject information documents for adult participants (including adult, pregnant partner, pregnant participant, genomics and other addenda) and country-specific ICFs, but explicit details on assent/consent handling for vulnerable individuals are not provided in the supplied data..
- Vulnerable Population
- Vulnerable population selected (isVulnerablePopulationSelected = true). The provided data lists ICF and subject information documents for adult participants (including adult, pregnant partner, pregnant participant, genomics and other addenda) and country-specific ICFs, but explicit details on assent/consent handling for vulnerable individuals are not provided in the supplied data.
Inclusion criteria
- {"criterion_text":"- 1. Adult participants 40 to 80 years of age at the time of signing the informed consent."}
- {"criterion_text":"- 2. Documented physician-diagnosed COPD for at least 12 months before Visit 1."}
- {"criterion_text":"- 3. A post-BD FEV1/FVC < 0.70 and a post-BD FEV1 ≥ 20% and ≤70% of the predicted normal value during screening."}
- {"criterion_text":"- 4. Documented regular dose of triple inhaled maintenance therapy (ICS+LABA+LAMA), or dualtherapy (LABA+LAMA, ICS+LABA, ICS+LAMA) if triple therapy is considered not appropriate, for atleast 3 consecutive months before Visit 1."}
- {"criterion_text":"- 5. Documented history ≥2 moderate or ≥1 severe COPD exacerbations within 12 months before Visit 1. At least 1 of the 2 moderate exacerbations must have been treated with SCS. At least one of the previous exacerbations should be confirmed to have occurred while the participant was on triple or dual inhaled maintenance therapy."}
- {"criterion_text":"- 6. EOS ≥ 150 cells/μL during the screening period."}
- {"criterion_text":"- 7. CAT total score ≥ 15 at Visit 1."}
- {"criterion_text":"- 8. Current or former smokers (with smoking cessation ≥ 6 monthsbefore Visit 1) have a history of at least 10 pack-years of tobacco smoking (1 pack year = 20 cigarettes smoked per day for 1 year)."}
Exclusion criteria
- {"criterion_text":"- 1. Clinically important lung disease other than COPD (eg, active lung infection, clinically significant bronchiectasis, pulmonary fibrosis,cystic fibrosis, hypoventilation syndrome associated with obesity,lung cancer, alpha 1 anti-trypsin deficiency and primary ciliary dyskinesia), or another diagnosed pulmonary or systemic disease that is associated with elevated peripheral EOS (eg, allergic bronchopulmonary aspergillosis/mycosis, eosinophilicgranulomatosis with polyangiitis, hypereosinophilic syndrome)."}
- {"criterion_text":"- 10. LTOT with signs and/or symptoms of cor pulmonale and/or rightventricular failure, or LTOT > 4.0 litres/minute (L/min) at rest oran oxyhaemoglobin saturation < 89% despite LTOT."}
- {"criterion_text":"- 11. Use, or need for chronic use, of any non-invasive positive pressure ventilation device. Stable use of non-invasive ventilation for the treatment of Obstructive Sleep Apnoea is permitted."}
- {"criterion_text":"- 12. Maintenance treatment with macrolides or other antibiotics forCOPD if the duration of the treatment is < 6 consecutive months before Visit 1."}
- {"criterion_text":"- 2. Radiological findings suggestive of a respiratory disease other than COPD that is significantly contributing to the participant’s respiratory symptoms. Radiological findings of pulmonary nodulessuspicious for lung cancer, as per applicable guidance, (eg, ACRLung-RADS v2022, (Christensen et al 2024)) without appropriatefollow up before Visit 2."}
- {"criterion_text":"- 3. Radiological findings suggestive of acute respiratory infection, if confirmed clinically."}
- {"criterion_text":"- 4. Current physician diagnosed asthma according to the Global Initiative for Asthma (GINA 2024 and onwards versions) guidelines or other accepted guidelines, past physician diagnosed asthma including paediatric asthma, or asthma-COPD overlap syndrome."}
- {"criterion_text":"- 5. Any unstable disorder, including, but not limited to, cardiovascular,gastrointestinal, hepatic, renal, neurological, musculoskeletal,infectious, endocrine, metabolic, haematological, immune,psychiatric, or major physical/or cognitive impairment that is not stable in the opinion of the investigator or the sponsor and/orcould: − Affect the safety of the participant throughout the study − Influence the findings of the study or their interpretation − Impede the participant’s ability to complete the entire durationof the study and/or comply with the study visit schedule and procedures"}
- {"criterion_text":"- 6. Unstable cardiovascular disorder (including but not limited toischemic heart disease, arrhythmia, cardiomyopathy, severe right and/or left heart failure (NYHA class IV)), renal failure,uncontrolled hypertension, as defined by the Investigator, or anyother relevant cardiovascular disorder or ECG abnormality that in the Investigator’s judgment may put the participant at risk or negatively affect the outcome of the study."}
- {"criterion_text":"- 7. Tuberculosis requiring treatment in the last 12 months before Visit 2. Local guidelines for diagnosis and treatment should be followed."}
- {"criterion_text":"- 8. Malignancy, current or past (within 5 years before Visit 1), except for basal cell carcinoma, localised squamous cell carcinoma of thes kin, or in situ carcinoma of the cervix provided when a curative therapy was completed at least 12 months before Visit 1."}
- {"criterion_text":"- 9. Treatment with systemic immunosuppressive/immunomodulatingmedications including maintenance use of SCS within the last 12 weeks or 5 half-lives before Visit 1 or during the screening for other reasons than COPD exacerbation. Expected need for chronicuse during the study for any reason."}
Endpoints
Primary endpoints
- {"endpoint_text":"- Annualised rate of moderate or severe COPD exacerbations up to 76 weeks","definition_or_measurement_approach":"Annualised rate calculated up to 76 weeks (no further measurement detail provided in the available data)."}
Secondary endpoints
- {"endpoint_text":"- 1. Change from baseline in pre-BD FEV1 at Week 52","definition_or_measurement_approach":"Change from baseline in pre-bronchodilator FEV1 measured at Week 52 versus baseline."}
- {"endpoint_text":"- 3. Change from baseline in the SGRQ total score over 52 weeks","definition_or_measurement_approach":"Change from baseline in St. George's Respiratory Questionnaire (SGRQ) total score over 52 weeks."}
- {"endpoint_text":"- 4. Annualised rate of moderate or severe COPD exacerbations up to 76 weeks among participants with screening EOS ≥ 300 cells/μL.","definition_or_measurement_approach":"Annualised exacerbation rate up to 76 weeks in the subgroup with screening blood eosinophils ≥300 cells/μL."}
- {"endpoint_text":"- 5. Annualised rate of severe COPD exacerbations requiring ER visits and/or hospitalisations up to 76 weeks.","definition_or_measurement_approach":"Annualised rate of severe exacerbations (those requiring ER visit and/or hospitalisation) up to 76 weeks."}
- {"endpoint_text":"- 6. Participants achieving a clinically meaningful improvement from baseline in SGRQ total score (4-point score decrease) over 52 weeks.","definition_or_measurement_approach":"Proportion of participants with a ≥4-point decrease in SGRQ total score over 52 weeks compared with baseline."}
- {"endpoint_text":"- 7. Change from baseline in the CAT total score over 52 weeks","definition_or_measurement_approach":"Change from baseline in COPD Assessment Test (CAT) total score over 52 weeks."}
- {"endpoint_text":"- 8. Participants achieving a clinically meaningful improvement frombaseline in CAT total score (2-point score decrease) over 52 weeks.","definition_or_measurement_approach":"Proportion of participants with a ≥2-point decrease in CAT total score over 52 weeks versus baseline."}
- {"endpoint_text":"- 9. Time to first moderate to severe COPD exacerbation up to 76 weeks","definition_or_measurement_approach":"Time (days) from randomisation to first moderate or severe COPD exacerbation, up to 76 weeks."}
- {"endpoint_text":"- 10. Time to first severe COPD exacerbation up to 76 weeks","definition_or_measurement_approach":"Time (days) from randomisation to first severe COPD exacerbation, up to 76 weeks."}
- {"endpoint_text":"- 11. PK: Serum trough concentrations","definition_or_measurement_approach":"Pharmacokinetics endpoint measuring serum trough concentrations of tezepelumab."}
- {"endpoint_text":"- 12. Immunogenicity: Incidence of anti-drug antibodies and neutralising antibodies","definition_or_measurement_approach":"Incidence and characterization of anti-drug antibodies and neutralising antibodies to tezepelumab."}
- {"endpoint_text":"- 2. Change from baseline in post-BD FEV1 at Week 52.","definition_or_measurement_approach":"Change from baseline in post-bronchodilator FEV1 measured at Week 52."}
Recruitment
- Digital Remote Recruitment
- Yes
- Planned Sample Size
- 803
- Recruitment Window Months
- 31
- Consent Approach
- Informed consent is obtained from adult participants (study enrolment restricted to adults aged 40–80). Subject information and ICF documents are provided (documents listed for adult participants, pregnant participant/partner, genomics addenda and country-specific ICFs). Protocol and synopsis translations and ICF documents are available for multiple languages/countries (English and country-specific documents/translations such as Spanish, Polish, Slovak, Italian indicated in the materials). Specific details on assent (not applicable as only adults enrolled) or additional vulnerable-consent procedures are not provided in the available data.
Methods
- Posters: country-specific recruitment posters listed in recruitment materials (documents titled 'K2_Recruitment material Poster' and similar).
- Leaflets/Text leaflets: text leaflets and online text materials referenced (e.g., 'K2_Recruitment material_Text Leaflet', 'K2_Recruitment material_Text Online_PRATIA SA').
- Website/Online information: Website information and online recruitment text (e.g., 'K2_Recruitment material_Website Information_PRATIA SA').
- General advertisement materials: general advertisement packages (document 'K2_Recruitment material general advertisment').
- Country-specific recruitment arrangements: K1 recruitment arrangements documents exist for multiple countries (Germany, Spain, Italy, Poland, Slovakia, Denmark, Czechia) indicating tailored, country-specific recruitment materials.
Geography
- Total Number Of Sites
- 56
- Total Number Of Participants
- 187
Czechia
- Earliest CTIS Part Ii Submission Date
- 29-04-2025
- Latest Decision Or Authorization Date
- 02-12-2025
- Processing Time Days
- 217
- Number Of Sites
- 11
- Number Of Participants
- 20
Sites
- Site Name
- MediTrial s.r.o.
- Principal Investigator Name
- Petr Kopecky
- Principal Investigator Email
- kopir@post.cz
- Contact Person Name
- Petr Kopecky
- Contact Person Email
- kopir@post.cz
- Site Name
- Plicni centrum s.r.o.
- Principal Investigator Name
- Pavel Spas
- Principal Investigator Email
- spaspavel@seznam.cz
- Contact Person Name
- Pavel Spas
- Contact Person Email
- spaspavel@seznam.cz
- Site Name
- Fakultni Nemocnice Brno
- Department Name
- Klinika nemoci plicnich a tuberkulozy
- Principal Investigator Name
- Milan Sova
- Principal Investigator Email
- sova.milan@fnbrno.cz
- Contact Person Name
- Milan Sova
- Contact Person Email
- sova.milan@fnbrno.cz
- Site Name
- Cefispiro s.r.o.
- Principal Investigator Name
- Petra Filipova
- Principal Investigator Email
- pphilip@seznam.cz
- Contact Person Name
- Petra Filipova
- Contact Person Email
- pphilip@seznam.cz
- Site Name
- Pneumologie Varnsdorf s.r.o.
- Principal Investigator Name
- Milan Sklenar
- Principal Investigator Email
- milansklenar@seznam.cz
- Contact Person Name
- Milan Sklenar
- Contact Person Email
- milansklenar@seznam.cz
- Site Name
- Fakultni Nemocnice Plzen
- Department Name
- Klinika pneumologie a ftizeologie
- Principal Investigator Name
- Ondrej Fibigr
- Principal Investigator Email
- fibigro@fnplzen.cz
- Contact Person Name
- Ondrej Fibigr
- Contact Person Email
- fibigro@fnplzen.cz
- Site Name
- Plicni alergo s.r.o.
- Principal Investigator Name
- Radka Mokosova
- Principal Investigator Email
- radka.mokosova@seznam.cz
- Contact Person Name
- Radka Mokosova
- Contact Person Email
- radka.mokosova@seznam.cz
- Site Name
- Plicni Stredisko Teplice s.r.o.
- Principal Investigator Name
- Stanislav Holub
- Principal Investigator Email
- stanislavholub@seznam.cz
- Contact Person Name
- Stanislav Holub
- Contact Person Email
- stanislavholub@seznam.cz
- Site Name
- MUDr. I. Cierna Peterova s.r.o.
- Principal Investigator Name
- Ivana Cierna Peterova
- Principal Investigator Email
- trnbrnl@gmail.com
- Contact Person Name
- Ivana Cierna Peterova
- Contact Person Email
- trnbrnl@gmail.com
- Site Name
- Ordinace chorob plicnich s.r.o.
- Principal Investigator Name
- Zuzana Kovarikova
- Principal Investigator Email
- kovarikova@plicnipraha.cz
- Contact Person Name
- Zuzana Kovarikova
- Contact Person Email
- kovarikova@plicnipraha.cz
- Site Name
- MUDr. I. Cierna Peterova s.r.o.
- Principal Investigator Name
- Ivana Cierna Peterova
- Principal Investigator Email
- trnbrnl@gmail.com
- Contact Person Name
- Ivana Cierna Peterova
- Contact Person Email
- trnbrnl@gmail.com
Germany
- Earliest CTIS Part Ii Submission Date
- 08-04-2025
- Latest Decision Or Authorization Date
- 03-12-2025
- Processing Time Days
- 239
- Number Of Sites
- 7
- Number Of Participants
- 22
Sites
- Site Name
- Lungenfacharztzentrum an den Quellen
- Principal Investigator Name
- Peter Fried
- Principal Investigator Email
- peter-fried@web.de
- Contact Person Name
- Peter Fried
- Contact Person Email
- peter-fried@web.de
- Site Name
- KPPK GmbH
- Principal Investigator Name
- Olaf Schmidt
- Principal Investigator Email
- schmidt@kppk-gmbh.de
- Contact Person Name
- Olaf Schmidt
- Contact Person Email
- schmidt@kppk-gmbh.de
- Site Name
- Velocity Clinical Research Germany GmbH
- Principal Investigator Name
- Isabelle Schenkenberger
- Principal Investigator Email
- ischenkenberger@velocityclinical.com
- Contact Person Name
- Isabelle Schenkenberger
- Contact Person Email
- ischenkenberger@velocityclinical.com
- Site Name
- Romed Klinikum Rosenheim
- Department Name
- Lungenfacharztpraxis / Pneumologische Ambulanz
- Principal Investigator Name
- Stephan Budweiser
- Principal Investigator Email
- Stephan.budweiser@ro-med.de
- Contact Person Name
- Stephan Budweiser
- Contact Person Email
- Stephan.budweiser@ro-med.de
- Site Name
- Pneumologicum im Suedstadtforum Dr. Alexander Schulz Dr. Martin Hoffmann Dr. Henning Geldmacher PD Dr. Hendrik Suhling Fachaerzte fuer Innere Medizin Pneumologie Partnerschaftsgesellschaft
- Principal Investigator Name
- Martin Hoffmann
- Principal Investigator Email
- hoffmann@pneumologicum.de
- Contact Person Name
- Martin Hoffmann
- Contact Person Email
- hoffmann@pneumologicum.de
- Site Name
- Lungenfachklinik Immenhausen
- Principal Investigator Name
- Peter Hammerl
- Principal Investigator Email
- hammerl@lungenfachklinik-immenhausen.de
- Contact Person Name
- Peter Hammerl
- Contact Person Email
- hammerl@lungenfachklinik-immenhausen.de
- Site Name
- Zentrum Fuer Ambulante Pneumologische Forschung Marburg GbR
- Principal Investigator Name
- Lukas Jerrentrup
- Principal Investigator Email
- jerrentrup@studienzentrum-marburg.de
- Contact Person Name
- Lukas Jerrentrup
- Contact Person Email
- jerrentrup@studienzentrum-marburg.de
Spain
- Earliest CTIS Part Ii Submission Date
- 09-04-2025
- Latest Decision Or Authorization Date
- 02-12-2025
- Processing Time Days
- 237
- Number Of Sites
- 10
- Number Of Participants
- 38
Sites
- Site Name
- Hospital Clinico Universitario De Valencia
- Department Name
- Servicio Neumologia
- Principal Investigator Name
- Jaime Signes-Costa
- Principal Investigator Email
- jaimesignescosta@gmail.com
- Contact Person Name
- Jaime Signes-Costa
- Contact Person Email
- jaimesignescosta@gmail.com
- Site Name
- University Hospital Son Espases
- Department Name
- Servicio Neumologia
- Principal Investigator Name
- Francisco Borja Garcia-Cosio Piqueras
- Principal Investigator Email
- borja.cosio@ssib.es
- Contact Person Name
- Francisco Borja Garcia-Cosio Piqueras
- Contact Person Email
- borja.cosio@ssib.es
- Site Name
- Hospital Universitario Virgen De La Victoria
- Department Name
- Servicio Neumologia
- Principal Investigator Name
- Jose Luis Velasco Garrido
- Principal Investigator Email
- jlvelascogarrido@hotmail.com
- Contact Person Name
- Jose Luis Velasco Garrido
- Contact Person Email
- jlvelascogarrido@hotmail.com
- Site Name
- Hospital General Universitario Gregorio Maranon
- Department Name
- Servicio Neumologia
- Principal Investigator Name
- Luis Puente Maestu
- Principal Investigator Email
- luis.puente@salud.madrid.org
- Contact Person Name
- Luis Puente Maestu
- Contact Person Email
- luis.puente@salud.madrid.org
- Site Name
- Hospital Universitario De Cruces
- Department Name
- Servicio Neumologia
- Principal Investigator Name
- Patricia Sobradillo Ecenarro
- Principal Investigator Email
- psobradillo@separ.es
- Contact Person Name
- Patricia Sobradillo Ecenarro
- Contact Person Email
- psobradillo@separ.es
- Site Name
- Hospital Universitario Virgen De Las Nieves
- Department Name
- Servicio Neumologia
- Principal Investigator Name
- Bernardino Alcazar Navarrete
- Principal Investigator Email
- balcazarnavarrete@gmail.com
- Contact Person Name
- Bernardino Alcazar Navarrete
- Contact Person Email
- balcazarnavarrete@gmail.com
- Site Name
- Hospital Clinic De Barcelona
- Department Name
- Servicio Neumologia
- Principal Investigator Name
- Nestor Soler Porcar
- Principal Investigator Email
- nsoler@clinic.cat
- Contact Person Name
- Nestor Soler Porcar
- Contact Person Email
- nsoler@clinic.cat
- Site Name
- University Hospital Virgen Del Rocio S.L.
- Department Name
- Servicio Neumologia
- Principal Investigator Name
- Francisco Ortega-Ruiz
- Principal Investigator Email
- francisco.ortega.sspa@juntadeandalucia.es
- Contact Person Name
- Francisco Ortega-Ruiz
- Contact Person Email
- francisco.ortega.sspa@juntadeandalucia.es
- Site Name
- Hospital Universitario De Navarra
- Department Name
- Servicio Neumologia
- Principal Investigator Name
- Pablo Antonio Sanchez Salcedo
- Principal Investigator Email
- pa.sanchez.salcedo@navarra.es
- Contact Person Name
- Pablo Antonio Sanchez Salcedo
- Contact Person Email
- pa.sanchez.salcedo@navarra.es
- Site Name
- Hospital Universitario De Granada / Hospital Universitario Virgen De Las Nieves (entry duplication possible)
- Department Name
- Servicio Neumologia
- Principal Investigator Name
- Bernardino Alcazar Navarrete
- Principal Investigator Email
- balcazarnavarrete@gmail.com
- Contact Person Name
- Bernardino Alcazar Navarrete
- Contact Person Email
- balcazarnavarrete@gmail.com
Slovakia
- Earliest CTIS Part Ii Submission Date
- 14-04-2025
- Latest Decision Or Authorization Date
- 01-12-2025
- Processing Time Days
- 231
- Number Of Sites
- 4
- Number Of Participants
- 8
Sites
- Site Name
- Meditrez s.r.o.
- Department Name
- Pneumology Outpacient Care
- Principal Investigator Name
- Antónia Marinčáková
- Principal Investigator Email
- antoniamarincakova@gmail.com
- Contact Person Name
- Antónia Marinčáková
- Contact Person Email
- antoniamarincakova@gmail.com
- Site Name
- Fakultna Nemocnica Trnava
- Department Name
- Pneumology and Phtiseology Department
- Principal Investigator Name
- Miroslava Čulagová
- Principal Investigator Email
- miroslava.culagova@fntt.sk
- Contact Person Name
- Miroslava Čulagová
- Contact Person Email
- miroslava.culagova@fntt.sk
- Site Name
- Zapa Jj s.r.o.
- Department Name
- Pneumology Outpacient Care
- Principal Investigator Name
- Ján Plutinský
- Principal Investigator Email
- plutinskyjan@gmail.com
- Contact Person Name
- Ján Plutinský
- Contact Person Email
- plutinskyjan@gmail.com
- Site Name
- Inspiro s.r.o.
- Department Name
- Pneumology Outpacient Care
- Principal Investigator Name
- Alexander Golubov
- Principal Investigator Email
- agolubov0904@gmail.com
- Contact Person Name
- Alexander Golubov
- Contact Person Email
- agolubov0904@gmail.com
Denmark
- Earliest CTIS Part Ii Submission Date
- 02-05-2025
- Latest Decision Or Authorization Date
- 03-02-2026
- Processing Time Days
- 277
- Number Of Sites
- 1
- Number Of Participants
- 2
Sites
- Site Name
- Region Hovedstaden
- Department Name
- Lungmedicinsk Forskningsenhed
- Principal Investigator Name
- Asger Sverrild
- Principal Investigator Email
- asger.sverrild@regionh.dk
- Contact Person Name
- Asger Sverrild
- Contact Person Email
- asger.sverrild@regionh.dk
Italy
- Earliest CTIS Part Ii Submission Date
- 27-03-2025
- Latest Decision Or Authorization Date
- 20-04-2026
- Processing Time Days
- 389
- Number Of Sites
- 9
- Number Of Participants
- 35
Sites
- Site Name
- University Hospital Of Ferrara
- Department Name
- Respiratory Unit
- Principal Investigator Name
- Alberto Papi
- Principal Investigator Email
- ppa@unife.it
- Contact Person Name
- Alberto Papi
- Contact Person Email
- ppa@unife.it
- Site Name
- Azienda Ospedaliero Universitaria Careggi
- Department Name
- Respiratory and Critical Care Unit
- Principal Investigator Name
- Federico Lavorini
- Principal Investigator Email
- Federico.lavorini@unifi.it
- Contact Person Name
- Federico Lavorini
- Contact Person Email
- Federico.lavorini@unifi.it
- Site Name
- Azienda Unita' Locale Socio Sanitaria N. 2 Marca Trevigiana
- Department Name
- Pneumology Unit
- Principal Investigator Name
- Francesco Menzella
- Principal Investigator Email
- francesco.menzella@aulss2.veneto.it
- Contact Person Name
- Francesco Menzella
- Contact Person Email
- francesco.menzella@aulss2.veneto.it
- Site Name
- Fondazione IRCCS Policlinico San Matteo
- Department Name
- S.C. Pneumologia
- Principal Investigator Name
- Angelo Guido Corsico
- Principal Investigator Email
- corsico@unipv.it
- Contact Person Name
- Angelo Guido Corsico
- Contact Person Email
- corsico@unipv.it
- Site Name
- Fondazione Policlinico Universitario Campus Bio-medico
- Department Name
- Unit of Internal Medicine
- Principal Investigator Name
- Panaiotis Finamore
- Principal Investigator Email
- p.finamore@policlinicocampus.it
- Contact Person Name
- Panaiotis Finamore
- Contact Person Email
- p.finamore@policlinicocampus.it
- Site Name
- Istituti Clinici Scientifici Maugeri S.p.A.
- Department Name
- Respiratory Pathophysiology Service
- Principal Investigator Name
- Dina Visca
- Principal Investigator Email
- dina.visca@icsmaugeri.it
- Contact Person Name
- Dina Visca
- Contact Person Email
- dina.visca@icsmaugeri.it
- Site Name
- Azienda Ospedaliero Universitaria Di Sassari
- Department Name
- Pneumologia Clinica e Interventistica
- Principal Investigator Name
- Pietro Pirina
- Principal Investigator Email
- pietro.pirina@aouss.it
- Contact Person Name
- Pietro Pirina
- Contact Person Email
- pietro.pirina@aouss.it
- Site Name
- Azienda Ospedaliera Dei Colli
- Department Name
- U.O.C. Clinica Pneumologica
- Principal Investigator Name
- Andrea Bianco
- Principal Investigator Email
- Andrea.bianco@unicampania.it
- Contact Person Name
- Andrea Bianco
- Contact Person Email
- Andrea.bianco@unicampania.it
- Site Name
- Istituti Clinici Scientifici Maugeri S.p.A. (Telese Terme location)
- Department Name
- Pulmonary Rehabilitation Department
- Principal Investigator Name
- Mauro Maniscalco
- Principal Investigator Email
- Mauro.maniscalco@icsmaugeri.it
- Contact Person Name
- Mauro Maniscalco
- Contact Person Email
- Mauro.maniscalco@icsmaugeri.it
Poland
- Earliest CTIS Part Ii Submission Date
- 22-04-2025
- Latest Decision Or Authorization Date
- 29-04-2026
- Processing Time Days
- 372
- Number Of Sites
- 14
- Number Of Participants
- 62
Sites
- Site Name
- Promed P.Lach R.Glowacki Sp. j.
- Department Name
- Centrum Medyczne Promed
- Principal Investigator Name
- Bozena Zurowicz
- Principal Investigator Email
- bzurowicz@cmpromed.pl
- Contact Person Name
- Bozena Zurowicz
- Contact Person Email
- bzurowicz@cmpromed.pl
- Site Name
- Cbk Med Clinic Sp. z o.o.
- Department Name
- CBK Centrum Badan
- Principal Investigator Name
- Maria Wozniak
- Principal Investigator Email
- maria.wozniak@cbkmedclinic.pl
- Contact Person Name
- Maria Wozniak
- Contact Person Email
- maria.wozniak@cbkmedclinic.pl
- Site Name
- Centrum Medycyny Oddechowej Mroz Sp. j.
- Department Name
- Centrum Medycyny Oddechowej Mroz-Ambulatorium
- Principal Investigator Name
- Robert Mroz
- Principal Investigator Email
- robmmroz@gmail.com
- Contact Person Name
- Robert Mroz
- Contact Person Email
- robmmroz@gmail.com
- Site Name
- Centrum Medyczne Kermed Renata Bijata-Bronisz I Ewa Kowalinska Sp. j.
- Department Name
- NZOZ Centrum Medyczne KERmed
- Principal Investigator Name
- Renata Bijata-Bronisz
- Principal Investigator Email
- renata.bijata-bronisz@kermed.pl
- Contact Person Name
- Renata Bijata-Bronisz
- Contact Person Email
- renata.bijata-bronisz@kermed.pl
- Site Name
- Mcbk s.c. Iwona Czajkowska Anna Podrazka Szczepaniak
- Department Name
- MCBK
- Principal Investigator Name
- Anna Podrazka-Szczepaniak
- Principal Investigator Email
- annaps@mcbk.pl
- Contact Person Name
- Anna Podrazka-Szczepaniak
- Contact Person Email
- annaps@mcbk.pl
- Site Name
- B&R Clinical Sp. z o.o.
- Department Name
- Centrum Medyczne B & R Clinical
- Principal Investigator Name
- Oskar Solarski
- Principal Investigator Email
- oskar.solarski@brclinical.pl
- Contact Person Name
- Oskar Solarski
- Contact Person Email
- oskar.solarski@brclinical.pl
- Site Name
- Pro Familia Altera Sp. z o.o.
- Department Name
- Pro Familia Altera Poradnia Wielospecjalistyczna
- Principal Investigator Name
- Danuta Wronska
- Principal Investigator Email
- dwronska@profamilia.katowice.pl
- Contact Person Name
- Danuta Wronska
- Contact Person Email
- dwronska@profamilia.katowice.pl
- Site Name
- Alergologia Plus Sp. z o.o.
- Department Name
- Ośrodek Alergologia Plus
- Principal Investigator Name
- Michał Springer
- Principal Investigator Email
- michal.springer.pl@gmail.com
- Contact Person Name
- Michał Springer
- Contact Person Email
- michal.springer.pl@gmail.com
- Site Name
- Pratia S.A.
- Department Name
- Centrum Medyczne Pratia Bydgoszcz
- Principal Investigator Name
- Jacek Duleba
- Principal Investigator Email
- jduleba@pratia.pl
- Contact Person Name
- Jacek Duleba
- Contact Person Email
- jduleba@pratia.pl
- Site Name
- Centrum Innowacyjnych Terapii Sp. z o.o.
- Department Name
- Centrum Innowacyjnych Terapii Sp.z o.o Oddzial Piaseczno
- Principal Investigator Name
- Luiza Jonczak
- Principal Investigator Email
- luiza.jonczak@citrials.pl
- Contact Person Name
- Luiza Jonczak
- Contact Person Email
- luiza.jonczak@citrials.pl
- Site Name
- Szpital Powiatowy W Chrzanowie
- Department Name
- Oddzial Chorob Pluc
- Principal Investigator Name
- Rafal Harat
- Principal Investigator Email
- haratb@interia.pl
- Contact Person Name
- Rafal Harat
- Contact Person Email
- haratb@interia.pl
- Site Name
- Zbigniew Zegota Specjalistyczny Osrodek Leczniczo Badawczy
- Principal Investigator Name
- Joanna Piskorz-Wapinska
- Principal Investigator Email
- jpiskorzwapinska@gmail.com
- Contact Person Name
- Joanna Piskorz-Wapinska
- Contact Person Email
- jpiskorzwapinska@gmail.com
- Site Name
- Endo-Med Sp. z o.o.
- Department Name
- ENDO-MED Centrum Medyczne
- Principal Investigator Name
- Stefan Gruszka
- Principal Investigator Email
- sg.badania@endo-med.pl
- Contact Person Name
- Stefan Gruszka
- Contact Person Email
- sg.badania@endo-med.pl
- Site Name
- Clinical Best Solutions Sp. z o.o. S.K.
- Department Name
- Gabinet Lekarski
- Principal Investigator Name
- Barbara Rybacka-Chabros
- Principal Investigator Email
- b.rybacka.chabros@gmail.com
- Contact Person Name
- Barbara Rybacka-Chabros
- Contact Person Email
- b.rybacka.chabros@gmail.com
Sponsor
Primary sponsor
- Full Name
- AstraZeneca AB
- Organisation Type
- Pharmaceutical company
- Country Of Registered Address
- Sweden
Investigational products
- Investigational Product Name
- Tezspire 210 mg solution for injection in pre-filled syringe
- Active Substance
- TEZEPELUMAB
- Modality
- Monoclonal antibody
- Routes Of Administration
- SUBCUTANEOUS INJECTION
- Route
- Subcutaneous injection
- Authorisation Status
- Marketing authorisation EU/1/22/1677/001
- Starting Dose
- 210 mg
- Dose Levels
- 210 mg
- Investigational Product Name
- Tezepelumab-placebo
- Modality
- Other
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