Clinical trial • Phase III • Cardiology | Neurology
TENECTEPLASE for Acute ischemic stroke
Phase III trial of TENECTEPLASE for Acute ischemic stroke.
Overview
- Trial Therapeutic Area
- Cardiology | Neurology
- Trial Disease
- Acute ischemic stroke
- Trial Stage
- Phase III
- Drug Modality
- Peptide/protein/enzyme
Key dates
- Initial CTIS Submission Date
- 04-11-2025
- First CTIS Authorization Date
- 11-03-2026
Trial design
Randomised, open-label, standard of care (soc) comparator arm; no specific drug name, dose, or schedule specified for soc in the ctis json-controlled Phase III trial in Bulgaria, Hungary, Spain and others.
- Randomised
- Yes
- Open Label
- Yes
- Comparator
- Standard of care (SOC) comparator arm; no specific drug name, dose, or schedule specified for SOC in the CTIS JSON
- Target Sample Size
- 999
- Trial Duration For Participant
- 90
Eligibility
Recruits 999 Vulnerable population selected (isVulnerablePopulationSelected = true). Inclusion requires a signed and dated written informed consent in accordance with ICH-GCP and local legislation prior to admission; participants must be ≥18 years old (or legal age of consent where higher). No specific assent or proxy-consent wording is provided in the CTIS JSON..
- Vulnerable Population
- Vulnerable population selected (isVulnerablePopulationSelected = true). Inclusion requires a signed and dated written informed consent in accordance with ICH-GCP and local legislation prior to admission; participants must be ≥18 years old (or legal age of consent where higher). No specific assent or proxy-consent wording is provided in the CTIS JSON.
Inclusion criteria
- {"criterion_text":"- Male or female ≥18 years old and at least at the legal age of consent in countries where it is greater than 18 years\n- Signed and dated written informed consent in accordance with ICH-GCP and local legislation prior to admission to the trial. See Section 8.1 for details.\n- Acute ischaemic stroke (including wake-up stroke) affecting the supratentorial circulation, last known well >4.5 h before time of presumed randomisation\n- Pre-stroke mRS ≤1 (to be assessed via medical history)\n- Imaging eligibility by MRI CT"}
Exclusion criteria
- {"criterion_text":"- Intention to proceed to MT at the same site (hospital) of randomisation.\n- Occlusion of the internal carotid artery (ICA)\n- High-risk patients (increased risk of thrombolysis related hemorrhage)\n- Any intracranial hemorrhage detected on NCCT or MRI scans\n- Contra-indication to contrast brain imaging with CT and MRI\n- Severe stroke as assessed clinically (NIHSS > 25)\n- Non-disabling minor stroke symptoms (NIHSS ≤5), or rapidly improving symptoms at the discretion of the investigator\n- Imaging or clinical findings not indicative of acute ischemic stroke or suggesting stroke older than 72 h\n- Patients scheduled to receive i.v. thrombolysis as standard of care\n- Other known history of or identified relevant central nervous system damage (i.e., neoplasm, arterial aneurysm and/or arterial/venous malformation, intracranial or spinal surgery) as well as known arterial aneurysm and/or arterial/venous malformations, and/or neoplasms with increased bleeding risk, located outside of the Central Nervous System.\n- Contra-indications to Tenecteplase"}
Endpoints
Primary endpoints
- {"endpoint_text":"- mRS 0-1 at Day 90","definition_or_measurement_approach":"Modified Rankin Scale (mRS) score of 0-1 at Day 90 (excellent functional outcome)"}
Secondary endpoints
- {"endpoint_text":"- mRS (ordinal) at Day 90","definition_or_measurement_approach":"Ordinal analysis of the modified Rankin Scale at Day 90"}
- {"endpoint_text":"- Early neurological improvement (reduction in acute – 24-hour NIHSS score of ≥8 or value of 0/1)","definition_or_measurement_approach":"Reduction in acute (24-hour) NIHSS score of ≥8 or NIHSS value of 0 or 1 at 24 hours"}
- {"endpoint_text":"- mRS 0-2 at Day 90","definition_or_measurement_approach":"Modified Rankin Scale score of 0-2 at Day 90"}
- {"endpoint_text":"- sICH as defined by SITS-MOST criteria at 36 h","definition_or_measurement_approach":"Symptomatic intracerebral hemorrhage as defined by SITS-MOST criteria assessed at 36 hours"}
- {"endpoint_text":"- sICH as defined by ECASS III criteria at 36 h","definition_or_measurement_approach":"Symptomatic intracerebral hemorrhage as defined by ECASS III criteria assessed at 36 hours"}
- {"endpoint_text":"- Death from any cause within 90 days","definition_or_measurement_approach":"All-cause mortality assessed within 90 days of randomisation"}
Recruitment
- Digital Remote Recruitment
- Yes
- Planned Sample Size
- 999
- Recruitment Window Months
- 17
- Consent Approach
- Signed and dated written informed consent required prior to admission to the trial in accordance with ICH-GCP and local legislation. Participants must be ≥18 years old (or at least the legal age of consent where higher). Informed consent forms and subject information materials are available in multiple languages (documents in English, Bulgarian, Greek, Hungarian, Romanian, Spanish, Norwegian and other local-language versions are listed in the CTIS documents). No detailed proxy-consent or assent procedure text is provided in the CTIS JSON.
Methods
- Site posters (K2_Recruitment Material_Site Poster) - site-based recruitment materials
- Participant brochure (K2_Recruitment Material_Participant Brochure) - participant-facing printed materials
- Clinical Studies Brochure (K2_Clinical Studies Brochure) - informational brochure for sites/participants
- Emergency Letter (K2_Recruitment material_Emergency Letter) - site emergency contact letter
- Recruitment arrangements and informed consent procedure (K1_Recruitment arrangements) - documented recruitment/informed consent workflow
- Animation Video Storyboard (L2_Animation Video Storyboard) - audiovisual storyboard for participant information
- Participant ID Card and Study Guides (L2_Other subject information material_Participant ID Card, Participant Study Guide)
- Talking Points Guide and Site materials (Talking Points Guide) - for site staff engagement
- Surveys and feedback with QR-code/email (multiple L2 survey documents) - participant and caregiver feedback mechanisms
Geography
- Total Number Of Sites
- 54
- Total Number Of Participants
- 326
Bulgaria
- Earliest CTIS Part Ii Submission Date
- 09-02-2026
- Latest Decision Or Authorization Date
- 13-03-2026
- Processing Time Days
- 32
- Number Of Sites
- 15
- Number Of Participants
- 53
Sites
- Site Name
- Multi-profile Hospital for Active Treatment Heart and Brain EAD
- Department Name
- Second Clinic of neurology diseases
- Principal Investigator Name
- Ivan Dimitrov
- Principal Investigator Email
- i.dimitrov.bs@heartandbrain.bg
- Contact Person Name
- Ivan Dimitrov
- Contact Person Email
- i.dimitrov.bs@heartandbrain.bg
- Site Name
- University Hospital St. Anna
- Department Name
- Clinic of neurology diseases
- Principal Investigator Name
- Rosen Kalpachki
- Principal Investigator Email
- neurozona@gmail.com
- Contact Person Name
- Rosen Kalpachki
- Contact Person Email
- neurozona@gmail.com
- Site Name
- Multiprofile Hospital For Active Treatment St. Ivan Rilski Gorna Oriahovitsa EOOD
- Department Name
- Department of neurology diseases
- Principal Investigator Name
- Ivan Ivanov
- Principal Investigator Email
- ivanov@mcmedicaplus.com
- Contact Person Name
- Ivan Ivanov
- Contact Person Email
- ivanov@mcmedicaplus.com
- Site Name
- Multiprofessional Hospital For Active Treatment City Clinic Saint Georgi Ltd
- Department Name
- Department of neurology diseases
- Principal Investigator Name
- Elena Dimitrova
- Principal Investigator Email
- elenadimitrova_md@abv.bg
- Contact Person Name
- Elena Dimitrova
- Contact Person Email
- elenadimitrova_md@abv.bg
- Site Name
- University Multiprofile Hospital For Active Treatment Saint Georgi EAD
- Department Name
- Clinic of neurology diseases
- Principal Investigator Name
- Penka Atanasova
- Principal Investigator Email
- p_a7@abv.bg
- Contact Person Name
- Penka Atanasova
- Contact Person Email
- p_a7@abv.bg
- Site Name
- Mnogoprofilna Bolnitsa Za Aktivno Lechenie Puls AD
- Department Name
- Department of neurology diseases
- Principal Investigator Name
- Sasho Kastrev
- Principal Investigator Email
- kastrev@hotmail.com
- Contact Person Name
- Sasho Kastrev
- Contact Person Email
- kastrev@hotmail.com
- Site Name
- University Multiprofile Hospital For Active Treatment And Emergency Medicine N I Pirogov
- Department Name
- Clinic of neurology diseases
- Principal Investigator Name
- Mariya Dimitrova
- Principal Investigator Email
- dr.m.i.dimitrova@gmail.com
- Contact Person Name
- Mariya Dimitrova
- Contact Person Email
- dr.m.i.dimitrova@gmail.com
- Site Name
- Multiprofile Hospital For Active Treatment In Neurology And Psychiatry St. Naum EAD
- Department Name
- Clinic for intensive treatment of neurology diseases
- Principal Investigator Name
- Milena Milanova
- Principal Investigator Email
- milanova_m@dir.bg
- Contact Person Name
- Milena Milanova
- Contact Person Email
- milanova_m@dir.bg
- Site Name
- Multiprofile Hospital For Active Treatment Hadji Dimitar OOD
- Department Name
- Department of neurology diseases
- Principal Investigator Name
- Tanya Beleva
- Principal Investigator Email
- tbb.n@abv.bg
- Contact Person Name
- Tanya Beleva
- Contact Person Email
- tbb.n@abv.bg
- Site Name
- University Multiprofile Hospital For Active Treatment Kaspela EOOD
- Department Name
- Department of neurology diseases
- Principal Investigator Name
- Valcho Naydenov
- Principal Investigator Email
- val.nay@mail.bg
- Contact Person Name
- Valcho Naydenov
- Contact Person Email
- val.nay@mail.bg
- Site Name
- Multi-profile Hospital for Active Treatment Heart and Brain EAD
- Department Name
- Clinic of neurology diseases
- Principal Investigator Name
- Plamen Bozhinov
- Principal Investigator Email
- psbozhinov@yahoo.com
- Contact Person Name
- Plamen Bozhinov
- Contact Person Email
- psbozhinov@yahoo.com
- Site Name
- University Multiprofile Hospital For Active Treatment Dr. Georgi Stranski EAD
- Department Name
- Neurology Clinic
- Principal Investigator Name
- Danovska-Mladenova Maya
- Principal Investigator Email
- mdanovska@yahoo.com
- Contact Person Name
- Danovska-Mladenova Maya
- Contact Person Email
- mdanovska@yahoo.com
- Site Name
- University First multiprofile hospital for active treatment Sofia St. Joan Krastitel EAD
- Department Name
- Clinic of neurology diseases
- Principal Investigator Name
- Dimitar Maslarov
- Principal Investigator Email
- maslarovdb@abv.bg
- Contact Person Name
- Dimitar Maslarov
- Contact Person Email
- maslarovdb@abv.bg
- Site Name
- Universitetska Mnogoprofilna Bolnitsa Za Aktivno Lechenie Medika Ruse OOD
- Department Name
- Department of neurology diseases
- Principal Investigator Name
- Rositsa Krasteva
- Principal Investigator Email
- rosikrasteva@abv.bg
- Contact Person Name
- Rositsa Krasteva
- Contact Person Email
- rosikrasteva@abv.bg
- Site Name
- Acibadem City Clinic Tokuda University Hospital EAD
- Department Name
- Clinic of Neurology and Sleep Medicine
- Principal Investigator Name
- Ivan Staikov
- Principal Investigator Email
- ivanstaikov@hotmail.com
- Contact Person Name
- Ivan Staikov
- Contact Person Email
- ivanstaikov@hotmail.com
Hungary
- Earliest CTIS Part Ii Submission Date
- 21-01-2026
- Latest Decision Or Authorization Date
- 12-03-2026
- Processing Time Days
- 50
- Number Of Sites
- 8
- Number Of Participants
- 41
Sites
- Site Name
- University Of Pecs
- Department Name
- Neurológiai Klinika
- Principal Investigator Name
- László Szapáry
- Principal Investigator Email
- szapary.laszlo@pte.hu
- Contact Person Name
- László Szapáry
- Contact Person Email
- szapary.laszlo@pte.hu
- Site Name
- Budapesti Uzsoki Utcai Korhaz
- Department Name
- Neurológiai osztály
- Principal Investigator Name
- Géza Szilágyi
- Principal Investigator Email
- szilagyi.geza@uzsoki.hu
- Contact Person Name
- Géza Szilágyi
- Contact Person Email
- szilagyi.geza@uzsoki.hu
- Site Name
- Fejer Varmegyei Szent Gyoergy Egyetemi Oktato Korhaz
- Department Name
- Neurológia
- Principal Investigator Name
- Levente Kerényi
- Principal Investigator Email
- lkerenyi@mail.fmkorhaz.hu
- Contact Person Name
- Levente Kerényi
- Contact Person Email
- lkerenyi@mail.fmkorhaz.hu
- Site Name
- Szabolcs-Szatmar-Bereg Varmegyei Oktatokorhaz
- Department Name
- Neurológia - Stroke osztály
- Principal Investigator Name
- Lajos Varannai
- Principal Investigator Email
- dr.varannai.lajos@szszbmk.hu
- Contact Person Name
- Lajos Varannai
- Contact Person Email
- dr.varannai.lajos@szszbmk.hu
- Site Name
- Borsod-Abauj-Zemplen Varmegyei Koezponti Korhaz Es Egyetemi Oktatokorhaz
- Department Name
- Stroke,Vascularis és Altalános Neurológiai és Toxikológiai Osztály
- Principal Investigator Name
- Attila Valikovics
- Principal Investigator Email
- valikovics.idegtox@bazmkorhaz.hu
- Contact Person Name
- Attila Valikovics
- Contact Person Email
- valikovics.idegtox@bazmkorhaz.hu
- Site Name
- University Of Szeged
- Department Name
- Neurológiai Klinika
- Principal Investigator Name
- Péter Klivényi
- Principal Investigator Email
- klivenyi.peter@med.u-szeged.hu
- Contact Person Name
- Péter Klivényi
- Contact Person Email
- klivenyi.peter@med.u-szeged.hu
- Site Name
- Semmelweis University
- Department Name
- Neurológiai Klinika
- Principal Investigator Name
- Dániel Bereczki
- Principal Investigator Email
- bereczki.daniel@semmelweis.hu
- Contact Person Name
- Dániel Bereczki
- Contact Person Email
- bereczki.daniel@semmelweis.hu
- Site Name
- Kistarcsai Flor Ferenc Korhaz
- Department Name
- Neurologia és Stroke Osztály
- Principal Investigator Name
- Gyula Pánczél
- Principal Investigator Email
- panczel.gyula@florhosp.hu
- Contact Person Name
- Gyula Pánczél
- Contact Person Email
- panczel.gyula@florhosp.hu
Spain
- Earliest CTIS Part Ii Submission Date
- 06-02-2026
- Latest Decision Or Authorization Date
- 11-03-2026
- Processing Time Days
- 33
- Number Of Sites
- 16
- Number Of Participants
- 89
Sites
- Site Name
- Hospital General Universitario Dr. Balmis
- Department Name
- Neurology
- Principal Investigator Name
- Nicolás López Hernández
- Principal Investigator Email
- lopez_nic@gva.es
- Contact Person Name
- Nicolás López Hernández
- Contact Person Email
- lopez_nic@gva.es
- Site Name
- Hospital Universitari De Girona Doctor Josep Trueta
- Department Name
- Neurology
- Principal Investigator Name
- Yolanda Silva Blas
- Principal Investigator Email
- ysilva.girona.ics@gencat.cat
- Contact Person Name
- Yolanda Silva Blas
- Contact Person Email
- ysilva.girona.ics@gencat.cat
- Site Name
- Hospital Germans Trias I Pujol
- Department Name
- Neurology
- Principal Investigator Name
- Meritxell Gomis Cortina
- Principal Investigator Email
- mgomis.germanstrias@gencat.cat
- Contact Person Name
- Meritxell Gomis Cortina
- Contact Person Email
- mgomis.germanstrias@gencat.cat
- Site Name
- Fundacio Assistencial De Mutua De Terrassa Fpc
- Department Name
- Neurology
- Principal Investigator Name
- Jerzy Krupinski
- Principal Investigator Email
- jkrupinski@mutuaterrassa.es
- Contact Person Name
- Jerzy Krupinski
- Contact Person Email
- jkrupinski@mutuaterrassa.es
- Site Name
- Hospital Universitario De Cruces
- Department Name
- Neurology
- Principal Investigator Name
- María del Mar Freijo Guerrero
- Principal Investigator Email
- mariadelmar.freijoguerrero@osakidetza.eus
- Contact Person Name
- María del Mar Freijo Guerrero
- Contact Person Email
- mariadelmar.freijoguerrero@osakidetza.eus
- Site Name
- Hospital Clinico San Carlos
- Department Name
- Neurology
- Principal Investigator Name
- José Antonio Egido Herrero
- Principal Investigator Email
- jegidoh@yahoo.com
- Contact Person Name
- José Antonio Egido Herrero
- Contact Person Email
- jegidoh@yahoo.com
- Site Name
- Hospital Del Mar
- Department Name
- Neurology
- Principal Investigator Name
- Ana Rodríguez Campello
- Principal Investigator Email
- arodriguezc@parcdesalutmar.cat
- Contact Person Name
- Ana Rodríguez Campello
- Contact Person Email
- arodriguezc@parcdesalutmar.cat
- Site Name
- Hospital De La Santa Creu I Sant Pau
- Department Name
- Neurology
- Principal Investigator Name
- Pol Camps Renom
- Principal Investigator Email
- pcamps@santpau.cat
- Contact Person Name
- Pol Camps Renom
- Contact Person Email
- pcamps@santpau.cat
- Site Name
- Hospital Universitario 12 De Octubre
- Department Name
- Neurology
- Principal Investigator Name
- Patricia Calleja Castaño
- Principal Investigator Email
- patricia.calleja@salud.madrid.org
- Contact Person Name
- Patricia Calleja Castaño
- Contact Person Email
- patricia.calleja@salud.madrid.org
- Site Name
- Hospital Universitario Virgen De La Macarena
- Department Name
- Neurology
- Principal Investigator Name
- Miguel Ángel Gamero García
- Principal Investigator Email
- gamero.ma@gmail.com
- Contact Person Name
- Miguel Ángel Gamero García
- Contact Person Email
- gamero.ma@gmail.com
- Site Name
- Hospital Ruber Juan Bravo
- Department Name
- Neurology
- Principal Investigator Name
- Rafael Arroyo González
- Principal Investigator Email
- rafaelarroyo09@gmail.com
- Contact Person Name
- Rafael Arroyo González
- Contact Person Email
- rafaelarroyo09@gmail.com
- Site Name
- Hospital Clinico Universitario De Valencia
- Department Name
- Neurology
- Principal Investigator Name
- Alejandro Ponz de Tienda
- Principal Investigator Email
- ponz_ale@gva.es
- Contact Person Name
- Alejandro Ponz de Tienda
- Contact Person Email
- ponz_ale@gva.es
- Site Name
- Hospital Universitari Vall D Hebron
- Department Name
- Neurology
- Principal Investigator Name
- Carlos Molina Cateriano
- Principal Investigator Email
- carlosav.molina@vallhebron.cat
- Contact Person Name
- Carlos Molina Cateriano
- Contact Person Email
- carlosav.molina@vallhebron.cat
- Site Name
- Hospital General Universitario Gregorio Maranon
- Department Name
- Neurology
- Principal Investigator Name
- Andrés García Pastor
- Principal Investigator Email
- agpastor@salud.madrid.org
- Contact Person Name
- Andrés García Pastor
- Contact Person Email
- agpastor@salud.madrid.org
- Site Name
- Complexo Hospitalario Universitario A Coruna
- Department Name
- Neurology
- Principal Investigator Name
- María del Mar Castellanos Rodrigo
- Principal Investigator Email
- maria.del.mar.castellanos.rodrigo@sergas.es
- Contact Person Name
- María del Mar Castellanos Rodrigo
- Contact Person Email
- maria.del.mar.castellanos.rodrigo@sergas.es
- Site Name
- Bellvitge University Hospital
- Department Name
- Neurology
- Principal Investigator Name
- Pedro Cardona Portela
- Principal Investigator Email
- pcardonap@bellvitgehospital.cat
- Contact Person Name
- Pedro Cardona Portela
- Contact Person Email
- pcardonap@bellvitgehospital.cat
Norway
- Earliest CTIS Part Ii Submission Date
- 11-02-2026
- Latest Decision Or Authorization Date
- 16-03-2026
- Processing Time Days
- 33
- Number Of Sites
- 2
- Number Of Participants
- 20
Sites
- Site Name
- Sykehuset Ostfold HF
- Department Name
- Department of Neurology
- Principal Investigator Name
- Monika Mochol
- Principal Investigator Email
- monika.mochol@so-hf.no
- Contact Person Name
- Monika Mochol
- Contact Person Email
- monika.mochol@so-hf.no
- Site Name
- Helse Stavanger HF
- Department Name
- Department of Neurology
- Principal Investigator Name
- Martin Kurz
- Principal Investigator Email
- martin.kurz@sus.no
- Contact Person Name
- Martin Kurz
- Contact Person Email
- martin.kurz@sus.no
Romania
- Earliest CTIS Part Ii Submission Date
- 18-11-2025
- Latest Decision Or Authorization Date
- 17-03-2026
- Processing Time Days
- 119
- Number Of Sites
- 6
- Number Of Participants
- 68
Sites
- Site Name
- Spitalul Judetean De Urgenta Sfantul Ioan Cel Nou Suceava
- Department Name
- Sectia Neurologie
- Principal Investigator Name
- Daniela Beatrice Neagu
- Principal Investigator Email
- neagudaniela@ymail.com
- Contact Person Name
- Daniela Beatrice Neagu
- Contact Person Email
- neagudaniela@ymail.com
- Site Name
- Spitalul Clinic Judetean De Urgenta Sfantul Apostol Andrei Constanta
- Department Name
- Sectia Clinica Neurologie
- Principal Investigator Name
- Any Axelerad
- Principal Investigator Email
- docuaxi@yahoo.com
- Contact Person Name
- Any Axelerad
- Contact Person Email
- docuaxi@yahoo.com
- Site Name
- Spitalul Clinic Judetean De Urgenta Targu Mures
- Department Name
- Sectia Clinica Neurologie I
- Principal Investigator Name
- Rodica Ioana Balasa
- Principal Investigator Email
- rodica.balasa@umfst.ro
- Contact Person Name
- Rodica Ioana Balasa
- Contact Person Email
- rodica.balasa@umfst.ro
- Site Name
- Spitalului Judetean De Urgenta Piatra Neamt
- Department Name
- Sectia Neurologie
- Principal Investigator Name
- Rodica Gurau
- Principal Investigator Email
- rgurau@gmail.com
- Contact Person Name
- Rodica Gurau
- Contact Person Email
- rgurau@gmail.com
- Site Name
- Spitalul Clinic Judetean De Urgenta Brasov
- Department Name
- Sectia Clinica Neurologie
- Principal Investigator Name
- Cristian Falup-Pecurariu
- Principal Investigator Email
- crisfp100@yahoo.co.uk
- Contact Person Name
- Cristian Falup-Pecurariu
- Contact Person Email
- crisfp100@yahoo.co.uk
- Site Name
- Spitalul Clinic Județean De Urgența Arad
- Department Name
- Sectia Neurologie
- Principal Investigator Name
- Catalin Hreniuc
- Principal Investigator Email
- secretariat@scjarad.ro
- Contact Person Name
- Catalin Hreniuc
- Contact Person Email
- secretariat@scjarad.ro
Greece
- Earliest CTIS Part Ii Submission Date
- 15-12-2025
- Latest Decision Or Authorization Date
- 11-03-2026
- Processing Time Days
- 86
- Number Of Sites
- 7
- Number Of Participants
- 55
Sites
- Site Name
- General Hospital Of Thessaloniki Papageorgiou
- Department Name
- Neurology Clinic
- Principal Investigator Name
- Rudolf Jobst
- Principal Investigator Email
- jobstrudolf@hotmail.com
- Contact Person Name
- Rudolf Jobst
- Contact Person Email
- jobstrudolf@hotmail.com
- Site Name
- Eginitio Hospital
- Department Name
- 1st Department of Neurology
- Principal Investigator Name
- Sofia Vassilopoulou
- Principal Investigator Email
- svassilopoulou@gmail.com
- Contact Person Name
- Sofia Vassilopoulou
- Contact Person Email
- svassilopoulou@gmail.com
- Site Name
- University General Hospital Of Thessaloniki Ahepa
- Department Name
- 2nd Department of Neurology
- Principal Investigator Name
- Theodoros Karapanayiotides
- Principal Investigator Email
- tkarapanayiotides@yahoo.gr
- Contact Person Name
- Theodoros Karapanayiotides
- Contact Person Email
- tkarapanayiotides@yahoo.gr
- Site Name
- Athens Euroclinic S.A.
- Department Name
- Neurology Department
- Principal Investigator Name
- Vaso Zisimopoulou
- Principal Investigator Email
- vzisimopoulou@gmail.com
- Contact Person Name
- Vaso Zisimopoulou
- Contact Person Email
- vzisimopoulou@gmail.com
- Site Name
- Athens Naval Hospital
- Department Name
- Neurology Department
- Principal Investigator Name
- Michail Ioakeimidis
- Principal Investigator Email
- michael_ioakeimidis@hotmail.com
- Contact Person Name
- Michail Ioakeimidis
- Contact Person Email
- michael_ioakeimidis@hotmail.com
- Site Name
- University General Hospital Attikon General Hospital Of West Attica H Agia Varvara
- Department Name
- Second Department of Neurology
- Principal Investigator Name
- Georgios Tsivgoulis
- Principal Investigator Email
- tsivgoulisgiorg@yahoo.gr
- Contact Person Name
- Georgios Tsivgoulis
- Contact Person Email
- tsivgoulisgiorg@yahoo.gr
- Site Name
- General University Hospital Of Patras
- Department Name
- Neurology Clinic
- Principal Investigator Name
- John Ellul
- Principal Investigator Email
- ellul@upatras.gr
- Contact Person Name
- John Ellul
- Contact Person Email
- ellul@upatras.gr
Sponsor
Primary sponsor
- Full Name
- Boehringer Ingelheim International GmbH
- Organisation Type
- Pharmaceutical company
- Country Of Registered Address
- Germany
Contract research organisations
- Name
- IQVIA Limited
- Responsibilities
- sponsorDuties codes: 1,11,12,13,14,2,5,8
- Name
- Cronos Clinical Consulting Services, Inc.
- Responsibilities
- Scale Management, Rater Services, Translations
- Name
- Perceptive Informatics Inc.
- Responsibilities
- sponsorDuties code: 3
- Name
- Clario
- Responsibilities
- MRI,CTs
- Name
- Almac Clinical Services Limited
- Responsibilities
- sponsorDuties code: 14
- Name
- Veeva Systems Inc.
- Responsibilities
- sponsorDuties code: 7
- Name
- IQVIA RDS Hellas Single Member S.A.
- Responsibilities
- sponsorDuties codes: 1,12,2,8
Third parties
- {"country":"United Kingdom","full_name":"IQVIA Limited","duties_or_roles":"sponsorDuties codes: 1,11,12,13,14,2,5,8","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Cronos Clinical Consulting Services, Inc.","duties_or_roles":"Scale Management, Rater Services, Translations","organisation_type":"Industry"}
- {"country":"United States","full_name":"Perceptive Informatics Inc.","duties_or_roles":"sponsorDuties code: 3","organisation_type":"Pharmaceutical company"}
- {"country":"Germany","full_name":"Clario","duties_or_roles":"MRI,CTs","organisation_type":"Health care"}
- {"country":"United Kingdom (Northern Ireland)","full_name":"Almac Clinical Services Limited","duties_or_roles":"sponsorDuties code: 14","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Veeva Systems Inc.","duties_or_roles":"sponsorDuties code: 7","organisation_type":"Non-Pharmaceutical company"}
- {"country":"Greece","full_name":"IQVIA RDS Hellas Single Member S.A.","duties_or_roles":"sponsorDuties codes: 1,12,2,8","organisation_type":"Pharmaceutical company"}
Investigational products
- Investigational Product Name
- Metalyse 5 000 units (25 mg) powder for solution for injection
- Active Substance
- TENECTEPLASE
- Modality
- Peptide/protein/enzyme
- Routes Of Administration
- Intravenous bolus
- Route
- Intravenous bolus
- Authorisation Status
- Authorised (marketing authorisation EU/1/00/169/007)
- Starting Dose
- 0.25 mg/kg (maximum 25 mg)
- Dose Levels
- 0.25 mg/kg (maximum 25 mg)
- Frequency
- Single administration (one-time intravenous bolus)
- Maximum Dose
- 25 mg
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