Clinical trial • Phase III • Psychiatry
SELTOREXANT for Major depressive disorder | Insomnia
Phase III trial of SELTOREXANT for Major depressive disorder | Insomnia.
Overview
- Trial Therapeutic Area
- Psychiatry
- Trial Disease
- Major depressive disorder | Insomnia
- Trial Stage
- Phase III
- Drug Modality
- Small molecule
Key dates
- Initial CTIS Submission Date
- 29-10-2024
- First CTIS Authorization Date
- 03-03-2025
Trial design
Randomised, open-label, placebo film-coated tablet (matching placebo) versus jnj-42847922 (seltorexant) 20 mg (as adjunctive therapy to an ssri/snri). dose stated as 20 mg for seltorexant; comparator is placebo film-coated tablet. detailed schedule/frequency not specified in the ctis record.-controlled Phase III trial across 75 sites in Slovakia, Bulgaria, Spain and others.
- Randomised
- Yes
- Open Label
- Yes
- Comparator
- Placebo Film-coated tablet (matching placebo) versus JNJ-42847922 (seltorexant) 20 mg (as adjunctive therapy to an SSRI/SNRI). Dose stated as 20 mg for seltorexant; comparator is placebo film-coated tablet. Detailed schedule/frequency not specified in the CTIS record.
- Target Sample Size
- 522
- Trial Duration For Participant
- 126
Eligibility
Recruits 522 Vulnerable population flag selected. Trial population is adults (aged 18–74) including elderly. Subject information sheets and informed consent forms (SIS and ICF) are provided (country-specific versions available) for obtaining informed consent from participants; no assent procedures for minors are specified in the available CTIS Part II materials..
- Vulnerable Population
- Vulnerable population flag selected. Trial population is adults (aged 18–74) including elderly. Subject information sheets and informed consent forms (SIS and ICF) are provided (country-specific versions available) for obtaining informed consent from participants; no assent procedures for minors are specified in the available CTIS Part II materials.
Inclusion criteria
- {"criterion_text":"- Participants in Part 1 and Direct Enrollers to Part 2: Participants aged 18 to 74 years (inclusive).\n- Participants must be medically stable based on the following performed at screening: physical examination, vital signs, and 12-lead ECG performed at screening and baseline\n- Meet DSM-5 diagnostic criteria for MDD, without psychotic features.\n- Have had an inadequate response to at least 1 but no more than 2 antidepressants, administered at an adequate dose and duration started in the current episode of depression. An adequate trial is defined as an antidepressant treatment for at least 6 weeks on a stable dose at or above the minimum therapeutic dose specified in the MGH-ATRQ\n- Is receiving and tolerating well any one of the following SSRI or SNRI for depressive symptoms at screening, in any formulation and approved in the participating country: citalopram, duloxetine, escitalopram, fluvoxamine, fluoxetine, milnacipran, levomilnacipran, paroxetine, sertraline, venlafaxine, desvenlafaxine, vilazodone, or vortioxetine at a stable dose (at therapeutic dose level) for at least 6 weeks\n- Having a major depressive episode of at least moderate severity, as assessed with SIGH-D in a blinded manner at screening and must not demonstrate a clinically significant improvement from the beginning to end of screening\n- Body mass index (BMI) between 18 and 40 kg/m2.\n- Participants Entering After Completing Part 1 (ie, Rollover Participants) must meet the following criteria: Must have completed Part 1 DB treatment phase\n- Can consistently tolerate study drug"}
Exclusion criteria
- {"criterion_text":"- Participants in Part 1 and Part 2 Direct Enrollers: Has a current or recent history of homicidal ideation or clinically significant suicidal ideation within the past 3 months, or a history of suicidal behavior within the past 6 months.\n- Has a history of treatment-resistant MDD, defined as a lack of response to 2 or more adequate antidepressant treatments in the current episode\n- Current active DSM-5 diagnosis of obsessive-compulsive disorder, posttraumatic stress disorder, anorexia nervosa, bulimia nervosa or fibromyalgia. All of these disorders need to be in remission for at least 1 year for the participant to be enrolled.\n- Has history or current diagnosis of a psychotic disorder, bipolar disorder, intellectual disability, autism spectrum disorder, borderline personality disorder, or somatoform disorders.\n- Has any significant sleep disorder, including but not limited to untreated/uncontrolled obstructive sleep apnea, restless leg syndrome, or parasomnias. Participants with insomnia disorder or well controlled obstructive sleep apnea are allowed\n- Has a history of moderate to severe substance use disorder including alcohol use disorder according to DSM-5 criteria within 6 months before screening."}
Endpoints
Primary endpoints
- {"endpoint_text":"- Part 1 (Efficacy): Change from baseline to Day 43 in the MADRS total score.","definition_or_measurement_approach":"Change from baseline to Day 43 in the Montgomery-Åsberg Depression Rating Scale (MADRS) total score; measured by blinded MADRS assessments at baseline and Day 43."}
- {"endpoint_text":"- Part 2 Time from randomization to the first relapse during the double-blind (DB) Maintenance Phase in participants who achieve a stable response at the end of open-label (OL) seltorexant treatment","definition_or_measurement_approach":"Time-to-event endpoint: time (days) from randomization to first relapse during the double-blind maintenance phase in participants who achieved a stable response after open-label seltorexant; analyzed as time from randomization to relapse."}
Recruitment
- Digital Remote Recruitment
- True, recruitment uses digital/remote methods including Link2Trials online platform, social media content, banner/online ads, websites, call center scripts and email outreach (country-specific digital materials provided).
- Planned Sample Size
- 522
- Recruitment Window Months
- 21
- Consent Approach
- Informed consent is obtained from adult participants via Subject Information Sheet (SIS) and Informed Consent Form (ICF) documents. Country-specific ICF/SIS documents are provided (multiple languages/country versions listed, e.g., English, Spanish, Bulgarian, Polish, Czech, Italian, Portuguese, Slovak, Swedish). Consent is provided by the participant (no assent from minors is specified). Additional ICF materials for pregnancy/pregnant partners and privacy appendices are included in the document set.
Methods
- Link2Trials / vendor-mediated online recruitment (country-specific Link2Trials materials and call center indicated for multiple countries, e.g., IT, SE, CZ, PT) — online platform targeting potential participants in participating countries.
- Social media content and online advertising (banner ads, online ads) — country-specific social media and banner ad materials listed (e.g., ES, PL, PT, SE, CZ).
- Website-based recruitment (Link2Trials and local websites) — patient-facing websites and online one-pagers described in recruitment materials.
- Call centre outreach (Link2Trials call center scripts) — vendor call center scripts and procedures for contacting interested participants.
- Printed materials and local outreach: flyers, posters, brochures, patient leaflets and posters (country-specific patient flyer and poster materials for Part 1 and Part 2).
- Physician-to-patient communications / email to patients (country-specific templates) — recruitment material includes 'Email doctor to patient' in some countries.
- Local clinic/center recruitment through participating hospitals and psychiatric clinics (site-based recruitment using local patient-facing materials).
Geography
- Total Number Of Sites
- 75
- Total Number Of Participants
- 230
Slovakia
- Earliest CTIS Part Ii Submission Date
- 28-02-2025
- Latest Decision Or Authorization Date
- 10-11-2025
- Processing Time Days
- 255
- Number Of Sites
- 6
- Number Of Participants
- 14
Sites
- Site Name
- Univerzitna nemocnica L. Pasteura Kosice
- Department Name
- Psychiatricke oddelenie
- Contact Person Name
- Slavka Dubinska
- Contact Person Email
- slavka.dubinska@unlp.sk
- Site Name
- Mentum s.r.o.
- Department Name
- Psychiatricka ambulancia
- Contact Person Name
- Peter Molcan
- Contact Person Email
- molcan@mentum.sk
- Site Name
- Centrum Zdravia R.B.K. s.r.o.
- Department Name
- Psychiatricka ambulancia
- Contact Person Name
- Rastislav Korba
- Contact Person Email
- rastislav.korba@gmail.com
- Site Name
- Crystal Comfort s.r.o.
- Department Name
- Psychiatricka ambulancia
- Contact Person Name
- Dagmar Breznoscakova
- Contact Person Email
- dbreznoscakova@gmail.com
- Site Name
- PsychoLine s.r.o.
- Department Name
- Psychiatricka ambulancia
- Contact Person Name
- Abdul Shinwari
- Contact Person Email
- psycholinesro@gmail.com
- Site Name
- Liptovska Nemocnica S Poliklinikou Mudr. Ivana Stodolu Liptovsky Mikulas
- Department Name
- Psychiatricke oddelenie
- Contact Person Name
- Zuzana Janikova
- Contact Person Email
- janikova@nsplm.sk
Bulgaria
- Earliest CTIS Part Ii Submission Date
- 10-02-2025
- Latest Decision Or Authorization Date
- 17-10-2025
- Processing Time Days
- 249
- Number Of Sites
- 7
- Number Of Participants
- 24
Sites
- Site Name
- Center For Mental Health Prof. N. Shipkovenski EOOD
- Department Name
- Admission-Diagnostic Unit and Day Care Unit
- Contact Person Name
- Ana Popova
- Contact Person Email
- dr.anapopova@gmail.com
- Site Name
- Medical Center Saint Naum EOOD
- Contact Person Name
- Assen Karadaliev
- Contact Person Email
- karadaliev@hotmail.com
- Site Name
- Center For Mental Health Prof. Dr. Ivan Temkov Burgas EOOD
- Department Name
- Department for Treatment of Emergency Psychiatric Conditions
- Contact Person Name
- Veselin Palazov
- Contact Person Email
- vpalazov@abv.bg
- Site Name
- University Multiprofile Hospital For Active Treatment Saint Georgi EAD
- Department Name
- Psychiatry Clinic
- Contact Person Name
- Andriana Kakanakova
- Contact Person Email
- andriana_kakanakova@hotmail.com
- Site Name
- Diagnostic And Consultation Centre St.Vrach And St.St. Kuzma And Damian OOD
- Contact Person Name
- Petya Dimitrova
- Contact Person Email
- drdimitrova@abv.bg
- Site Name
- Diagnostics-Consultancy Center Mladost M Varna OOD
- Contact Person Name
- Hristo Kozhuharov
- Contact Person Email
- christokojuharov@abv.bg
- Site Name
- Medical Center Zara-Med EOOD
- Contact Person Name
- Detelina Komsiyska
- Contact Person Email
- detelinakomsiiska@abv.bg
Spain
- Earliest CTIS Part Ii Submission Date
- 11-02-2025
- Latest Decision Or Authorization Date
- 15-10-2025
- Processing Time Days
- 246
- Number Of Sites
- 10
- Number Of Participants
- 22
Sites
- Site Name
- Hospital Universitario Central De Asturias
- Department Name
- Servicio de Psiquiatria
- Contact Person Name
- Pilar Saiz
- Contact Person Email
- Frank@uniovi.es
- Site Name
- Hestia Palau S.L.
- Department Name
- Psychiatry
- Contact Person Name
- Elena Ros
- Contact Person Email
- e.ros@bcnneuroscience.com
- Site Name
- Hospital Universitario Basurto
- Department Name
- Psychiatry
- Contact Person Name
- Ana Catalán
- Contact Person Email
- ana.catalanalcantara@gmail.com
- Site Name
- Hospital Universitario Ramon Y Cajal
- Department Name
- Psychiatry
- Contact Person Name
- Ángela Ibáñez
- Contact Person Email
- aibanez.hrc@gmail.com
- Site Name
- Hospital Clinic De Barcelona
- Department Name
- Psychiatry
- Contact Person Name
- Eduard Vieta
- Contact Person Email
- evieta@clinic.cat
- Site Name
- Hospital Universitario De Torrevieja
- Department Name
- Psychiatry
- Contact Person Name
- Jesús Enrique Mesones
- Contact Person Email
- mesones_jes@gva.es
- Site Name
- Hospital Universitario La Paz
- Department Name
- Servicio de Psiquiatria
- Contact Person Name
- Rosa Villanueva
- Contact Person Email
- rosa.villanueva@salud.madrid.org
- Site Name
- Hospital Universitari Vall D Hebron
- Department Name
- Psychiatry
- Contact Person Name
- Amanda Rodríguez
- Contact Person Email
- amanda.rodriguez@vallhebron.cat
- Site Name
- Hospital Universitario General De Villalba
- Department Name
- Psychiatry
- Contact Person Name
- Enrique Baca
- Contact Person Email
- EBaca@quironsalud.es
- Site Name
- Hospital Universitario Infanta Leonor
- Department Name
- Psychiatry
- Contact Person Name
- Francisco Javier Quintero
- Contact Person Email
- fjquinterog@yahoo.es
Romania
- Earliest CTIS Part Ii Submission Date
- 19-11-2024
- Latest Decision Or Authorization Date
- 20-10-2025
- Processing Time Days
- 335
- Number Of Sites
- 12
- Number Of Participants
- 37
Sites
- Site Name
- Spitalul Clinic De Psihiatrie Prof.Dr.Alexandru Obregia
- Department Name
- Sectia Clinica II
- Contact Person Name
- Valentin Petre Matei
- Contact Person Email
- valipmatei@yahoo.com
- Site Name
- Spitalul Clinic Judetean De Urgenta Bihor
- Department Name
- Psihiatrie I
- Contact Person Name
- Adrian Bumbu
- Contact Person Email
- dradibumbu@gmail.com
- Site Name
- Spitalul Clinic De Psihiatrie Dr. Gheorghe Preda Sibiu
- Department Name
- Centrul de Sanatate Mintala Adulti
- Contact Person Name
- Ana-Ioana Secelean
- Contact Person Email
- Dr.secelean@psihiatrieonline.ro
- Site Name
- Spitalul Clinic De Psihiatrie Prof.Dr.Alexandru Obregia
- Department Name
- Sectia Clinica IX Psihiatrie
- Contact Person Name
- Adela Magdalena Ciobanu
- Contact Person Email
- adela.ciobanu@gmail.com
- Site Name
- Spitalul Clinic De Psihiatrie Dr. Gheorghe Preda Sibiu
- Department Name
- Sectia III
- Contact Person Name
- Ciprian Bacila
- Contact Person Email
- bacila_c@yahoo.com
- Site Name
- Institutul De Psihiatrie Socola Iasi
- Department Name
- Sectia II
- Contact Person Name
- Raluca-Ioana Modoranu
- Contact Person Email
- raluca.prepelita@yahoo.com
- Site Name
- Spitalul Clinic De Psihiatrie Si Neurologie Brasov
- Department Name
- Psihiatrie
- Contact Person Name
- Petru-Iulian Ifteni
- Contact Person Email
- petru_ifteni@yahoo.com
- Site Name
- Institutul De Psihiatrie Socola Iasi
- Department Name
- Sectia V
- Contact Person Name
- Cristinel Stefanescu
- Contact Person Email
- cristinel.stefanescu@gmail.com
- Site Name
- Spitalul Clinic De Psihiatrie Prof.Dr.Alexandru Obregia
- Department Name
- Sectia XIV
- Contact Person Name
- Paul-Sorinel Pletea
- Contact Person Email
- dr.sorinpletea@gmail.com
- Site Name
- Institutul De Psihiatrie Socola Iasi
- Department Name
- Sectia Clinica Psihiatrie III Acuti
- Contact Person Name
- Ovidiu Alexinschi
- Contact Person Email
- secretariat@socola.eu
- Site Name
- Institutul Privat de Cercetare Melchisedec pentru Boli Autoimune, Ereditare si Rare
- Department Name
- Psihiatrie
- Contact Person Name
- Victor Gheorman
- Contact Person Email
- gheormanv@gmail.com
- Site Name
- Spitalul Clinic Judetean De Urgenta Cluj
- Department Name
- Psihiatrie I
- Contact Person Name
- Catalina Crisan
- Contact Person Email
- ccrisan2004@yahoo.com
Czechia
- Earliest CTIS Part Ii Submission Date
- 10-02-2025
- Latest Decision Or Authorization Date
- 26-02-2026
- Processing Time Days
- 381
- Number Of Sites
- 6
- Number Of Participants
- 23
Sites
- Site Name
- Clintrial s.r.o.
- Department Name
- Psychiatrická ambulance
- Contact Person Name
- Zdeněk Šolle
- Contact Person Email
- zdenek.solle@clintrial.cz
- Site Name
- Neuropsychiatrie Petrska s.r.o.
- Department Name
- Psychiatrická ambulance
- Contact Person Name
- Aleš Urban
- Contact Person Email
- ordinace@psychiatrie-urban.cz
- Site Name
- A-Shine s.r.o.
- Department Name
- Psychiatrická ambulance
- Contact Person Name
- Luboš Janů
- Contact Person Email
- lubos.janu@seznam.cz
- Site Name
- Pragtis s.r.o.
- Department Name
- psychiatrická ambulance
- Contact Person Name
- Martin Anders
- Contact Person Email
- martin.anders@pragtis.cz
- Site Name
- Medical Services Prague s.r.o.
- Department Name
- Psychiatrická ambulance
- Contact Person Name
- Erik Herman
- Contact Person Email
- erik.herman@seznam.cz
- Site Name
- Medipa s.r.o.
- Department Name
- Psychiatrická ambulance
- Contact Person Name
- Marta Lendlová
- Contact Person Email
- lendlova.m@gmail.com
Poland
- Earliest CTIS Part Ii Submission Date
- 03-02-2025
- Latest Decision Or Authorization Date
- 17-10-2025
- Processing Time Days
- 256
- Number Of Sites
- 11
- Number Of Participants
- 42
Sites
- Site Name
- Specjalistyczna Praktyka Lekarska Piotr Zalitacz
- Department Name
- Psychiatry
- Contact Person Name
- Piotr Zalitacz
- Contact Person Email
- pzalitacz@gmail.com
- Site Name
- Centrum Zdrowia Alcea
- Department Name
- Psychiatry
- Contact Person Name
- Jakub Grabowski
- Contact Person Email
- jakub.grabowski@gumed.edu.pl
- Site Name
- Clinic BBP Bozena Pawelczyk
- Department Name
- Psychiatry
- Contact Person Name
- Bozena Pawelczyk
- Contact Person Email
- bozena.pawelczyk@clinicbbp.com
- Site Name
- Przychodnie Grudziadz Sp. z o.o.
- Department Name
- Psychiatry
- Contact Person Name
- Barbara Janczewska
- Contact Person Email
- basiajanczewska@tlen.pl
- Site Name
- Praktyka Lekarska dr n med Malgorzata Wojtanowska Bogacka
- Department Name
- Psychiatry
- Contact Person Name
- Sylwia Szymkowiak
- Contact Person Email
- szymkowiaksylwia@gmail.com
- Site Name
- Ośrodek Badań Klinicznych CLINSANTE S.C.
- Contact Person Name
- Agnieszka Bijakowska
- Contact Person Email
- bijak2@wp.pl
- Site Name
- Mtz Clinical Research Powered By Pratia
- Department Name
- Psychiatry
- Contact Person Name
- Bozena Cichosz
- Contact Person Email
- bcichosz@esculap.pl
- Site Name
- Centrum Medyczne Intercor Sp. z o.o.
- Department Name
- Psychiatry
- Contact Person Name
- Daria Kosinska-Kwasna
- Contact Person Email
- dariakosinskakwasna.bydgoszcz@gmail.com
- Site Name
- Samodzielny Wojewodzki Zespol Publicznych Zakladow Psychiatrycznej Opieki Zdrowotnej W Warszawie
- Department Name
- Szpital Nowowiejski Osrodek Badan Klinicznych
- Contact Person Name
- Anna Zofia Antosik-Wojcinska
- Contact Person Email
- antosikwojcinska@gmail.com
- Site Name
- Niepubliczny Zaklad Opieki Psychiatrycznej Mentis
- Department Name
- Psychiatry
- Contact Person Name
- Mariusz Perucki
- Contact Person Email
- mariperu@wp.pl
- Site Name
- Promente Sp. z o.o.
- Department Name
- Psychiatry
- Contact Person Name
- Katarzyna Lachut
- Contact Person Email
- k.lachut@pro-mente.pl
Italy
- Earliest CTIS Part Ii Submission Date
- 24-01-2025
- Latest Decision Or Authorization Date
- 29-10-2025
- Processing Time Days
- 278
- Number Of Sites
- 11
- Number Of Participants
- 23
Sites
- Site Name
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
- Department Name
- UOC di psichiatria clinica e d'urgenza
- Contact Person Name
- Marco Di Nicola
- Contact Person Email
- marco.dinicola@policlinicogemelli.it
- Site Name
- Azienda Ospedaliero-Universitaria Sant Andre
- Department Name
- U.O.C. Psichiatria
- Contact Person Name
- Maurizio Pompili
- Contact Person Email
- maurizio.pompili@uniroma1.it
- Site Name
- Azienda Sanitaria Locale 2 Lanciano Vasto Chieti
- Department Name
- UOC Clinica Psichiatrica Uni. Dip. di Neuroscienze, Imaging e Scienze Cliniche PO SS Annunziata
- Contact Person Name
- Giovanni Martinotti
- Contact Person Email
- giovanni.martinotti@gmail.com
- Site Name
- Azienda Sanitaria Locale Di Salerno
- Department Name
- PO San Francesco d'Assisi di Oliveto Citra – Dip. di Salute mentale, UOSM 5
- Contact Person Name
- Antonio Mautone
- Contact Person Email
- a.mautone@aslsalerno.it
- Site Name
- Azienda Socio Sanitaria Territoriale Degli Spedali Civili Di Brescia
- Department Name
- U.O. Psichiatria
- Contact Person Name
- Antonio Vita
- Contact Person Email
- antonio.vita@unibs.it
- Site Name
- Azienda Ospedaliera Universitaria Senese
- Department Name
- UOC PSICHIATRIA
- Contact Person Name
- Andrea Fagiolini
- Contact Person Email
- andreafagiolini@gmail.com
- Site Name
- IRCCS Ospedale Policlinico San Martino
- Department Name
- UO Clinica Psichiatrica
- Contact Person Name
- Gianluca Serafini
- Contact Person Email
- gianluca.serafini@unige.it
- Site Name
- Fondazione IRCCS San Gerardo Dei Tintori
- Department Name
- Dipartimento di Salute Mentale e Dipendenze
- Contact Person Name
- Giuseppe Carrà
- Contact Person Email
- giuseppe.carra@unimib.it
- Site Name
- Azienda Ospedaliera di Padova
- Department Name
- U.O.C. Psichiatria
- Contact Person Name
- Giorgio Pigato
- Contact Person Email
- giorgio.pigato@aopd.veneto.it
- Site Name
- Azienda Ospedaliero Universitaria Pisana
- Department Name
- Unità Operativa di Psichiatria
- Contact Person Name
- Giulio Perugi
- Contact Person Email
- giulio.perugi@gmail.com
- Site Name
- Azienda Ospedaliero Universitaria Policlinico G Rodolico San Marco Di Catania
- Department Name
- U.O.C. Clinica Psichiatrica
- Contact Person Name
- Antonino Petralia
- Contact Person Email
- petralia@unict.it
Portugal
- Earliest CTIS Part Ii Submission Date
- 07-02-2025
- Latest Decision Or Authorization Date
- 15-12-2025
- Processing Time Days
- 311
- Number Of Sites
- 8
- Number Of Participants
- 23
Sites
- Site Name
- Champalimaud Clinical Centre
- Department Name
- Neuropsychiatry
- Contact Person Name
- Albino Maia
- Contact Person Email
- albino.maia@neuro.fchampalimaud.org
- Site Name
- Unidade Local De Saude Da Regiao De Leiria E.P.E.
- Department Name
- Psychiatry
- Contact Person Name
- Sofia Marques
- Contact Person Email
- sofia.marques@ulsrl.min-saude.pt
- Site Name
- Unidade Local De Saude Lisboa Ocidental E.P.E.
- Department Name
- Psychiatry of adults
- Contact Person Name
- António Talina
- Contact Person Email
- atalina@chlo.min-saude.pt
- Site Name
- Unidade Local De Saude De Loures-Odivelas EPE
- Department Name
- Psychiatry
- Contact Person Name
- Miguel Constante
- Contact Person Email
- miguel.constante@ulslod.min-saude.pt
- Site Name
- Unidade Local De Saude De Santa Maria E.P.E.
- Department Name
- Psychiatry and Mental Health
- Contact Person Name
- Paulo Martins
- Contact Person Email
- martintpaulo@gmail.com
- Site Name
- CCAB Centro Clinico Academico Braga Associacao
- Department Name
- Psychiatry
- Contact Person Name
- João Bessa
- Contact Person Email
- joaobessa@med.uminho.pt
- Site Name
- Hospital Divino Espirito Santo De Ponta Delgada EPER
- Department Name
- Psychiatry
- Contact Person Name
- André Ponte
- Contact Person Email
- andredbponte@gmail.com
- Site Name
- Hospital CUF Porto S.A.
- Department Name
- Neuropsychiatry
- Contact Person Name
- Susana Almeida
- Contact Person Email
- s.sousa.almeida@gmail.com
Sweden
- Earliest CTIS Part Ii Submission Date
- 06-02-2025
- Latest Decision Or Authorization Date
- 02-12-2025
- Processing Time Days
- 299
- Number Of Sites
- 4
- Number Of Participants
- 22
Sites
- Site Name
- ProbarE i Stockholm AB
- Department Name
- ProbarE i Stockholm AB
- Contact Person Name
- Peter Bosson
- Contact Person Email
- peter.bosson@probare.se
- Site Name
- ProbarE i Lund AB
- Department Name
- ProbarE i Lund AB
- Contact Person Name
- Anders Luts
- Contact Person Email
- anders.luts@probare.se
- Site Name
- CTC Clinical Trial Consultants AB (Uppsala)
- Department Name
- CTC Uppsala
- Contact Person Name
- Sonia Jonsson
- Contact Person Email
- sonia.jonsson@ctc-ab.se
- Site Name
- CTC Clinical Trial Consultants AB (Moelndal)
- Department Name
- CTC GoCO Molndal
- Contact Person Name
- Kaj Stenlof
- Contact Person Email
- Kaj.stenlof@ctc-ab.se
Sponsor
Primary sponsor
- Full Name
- Janssen Cilag International
- Organisation Type
- Pharmaceutical company
- Country Of Registered Address
- Belgium
Contract research organisations
- Name
- Iqvia Inc.
- Responsibilities
- Central Vendor
- Name
- 4g Clinical LLC
Third parties
- {"country":"Switzerland","full_name":"Labcorp Central Laboratory Services SARL","duties_or_roles":"","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Labcorp Central Laboratory Services LP","duties_or_roles":"","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Iqvia Inc.","duties_or_roles":"Central Vendor","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Massachusetts General Hospital - Clinical Trials Network and Institute","duties_or_roles":"Central Vendor","organisation_type":"Health care"}
- {"country":"United States","full_name":"4g Clinical LLC","duties_or_roles":"","organisation_type":"Non-Pharmaceutical company"}
- {"country":"United States","full_name":"Eresearchtechnology Inc.","duties_or_roles":"Central ECG","organisation_type":"Pharmaceutical company"}
Investigational products
- Investigational Product Name
- JNJ-42847922
- Active Substance
- SELTOREXANT
- Modality
- Small molecule
- Routes Of Administration
- ORAL USE
- Route
- Oral
- Authorisation Status
- Investigational medicinal product (used in clinical trial)
- Starting Dose
- 20 mg
- Dose Levels
- 20 mg
- Investigational Product Name
- Placebo Film-coated tablet
- Modality
- Other
- Authorisation Status
- Placebo comparator (not an active medicinal product)
- Combination Treatment
- Yes
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