Clinical trial • Phase III • Cardiology|Rare Disease
RALINEPAG for Pulmonary arterial hypertension
Phase III trial of RALINEPAG for Pulmonary arterial hypertension. open-label, none/not specified-controlled. 419 participants.
Overview
- Trial Therapeutic Area
- Cardiology|Rare Disease
- Trial Disease
- Pulmonary arterial hypertension
- Trial Stage
- Phase III
- Drug Modality
- Small molecule
- Orphan Drug
- Yes
Key dates
- Initial CTIS Submission Date
- 10-05-2024
- First CTIS Authorization Date
- 19-06-2024
Trial design
open-label, none/not specified-controlled Phase III trial across 47 sites in Spain, Bulgaria, Netherlands and others.
- Open Label
- Yes
- Comparator
- None/Not specified
- Target Sample Size
- 419
- Trial Duration For Participant
- 2190
Eligibility
Recruits 419 The record indicates vulnerable population selection (isVulnerablePopulationSelected = true). Informed consent must be documented as "Evidence of a personally signed and dated Informed Consent Form indicating that the subject has been informed of all pertinent aspects of the study prior to initiation of any study-related procedures." Specific consent materials include Pregnant Partner Consent ICF documents in addition to main ICFs; multiple country/language specific ICFs are provided. No specific assent procedures for minors are described in the provided materials..
- Pregnancy Exclusion
- Female subjects who wish to become pregnant or who have a positive pregnancy test on Day 1 (OLE Entry Visit). Women who are pregnant, lactating, or breastfeeding
- Vulnerable Population
- The record indicates vulnerable population selection (isVulnerablePopulationSelected = true). Informed consent must be documented as "Evidence of a personally signed and dated Informed Consent Form indicating that the subject has been informed of all pertinent aspects of the study prior to initiation of any study-related procedures." Specific consent materials include Pregnant Partner Consent ICF documents in addition to main ICFs; multiple country/language specific ICFs are provided. No specific assent procedures for minors are described in the provided materials.
Inclusion criteria
- {"criterion_text":"- Evidence of a personally signed and dated Informed Consent Form indicating that the subject has been informed of all pertinent aspects of the study prior to initiation of any study-related procedures.\n- Subjects who are willing and able to comply with scheduled clinic visits, treatment plans, laboratory tests, and other study procedures.\n- Completed the protocol-defined Study Drug Termination Visit or End of Study Visit procedures in the preceding ralinepag study.\n- Both male and female subjects agree to use a highly effective method of birth control throughout the entire study period from informed consent through the 30-Day Follow-up Visit, if the possibility of conception exists. Eligible male and female subjects must also agree not to participate in a conception process (ie, actively attempt to become pregnant or to impregnate, in vitro fertilization) during the study and for 30 days after the last dose of ralinepag. Eligible male subjects must agree not to participate in sperm donation for 90 days after the last dose of ralinepag."}
Exclusion criteria
- {"criterion_text":"- Subjects who prematurely discontinued ralinepag due to a drug-related AE/SAE or tolerability issue in the preceding ralinepag study in which they were enrolled, or subjects who did not complete all protocol-defined study procedures at a Study Drug Termination Visit or End of Study Visit in the preceding ralinepag study.\n- Subjects who withdrew consent during participation in another ralinepag study.\n- Female subjects who wish to become pregnant or who have a positive pregnancy test on Day 1 (OLE Entry Visit).\n- Women who are pregnant, lactating, or breastfeeding\n- Subjects who have undergone lung or heart/lung transplant or the initiation of long-term (>12 weeks) parenteral (intravenous or subcutaneous infusion) or inhaled therapy with a prostacyclin or oral therapy with another IP receptor agonist during the time since participation in their original ralinepag study.\n- Subjects who had an emergency unblinding procedure in a prior Phase 2 or 3 study.\n- Known hypersensitivity to ralinepag or any of the excipients.\n- Any reason that, in the opinion of the Investigator or Medical Monitor, precludes the subject from participating in the study, eg, noncompliance concerns, any previous or intercurrent medical condition that may increase the risk associated with study participation or that would confound study analysis or impair study participation or cooperation."}
Endpoints
Primary endpoints
- {"endpoint_text":"- Efficacy assessments will include an evaluation of: •\tNT-proBNP •\t6MWD •\tWHO/NYHA FC •\tThe proportion of subjects who achieve all 3 of the following (at specified time points): o\tNT-proBNP level <300 pg/mL o\t6MWD >440 meters o\tWHO/NYHA FC II status or better •\tHRQoL measures (where validated) •\tTime to all-cause hospitalization during the study period •\tTime to all-cause mortality during the study period","definition_or_measurement_approach":"NT-proBNP measured as N-terminal pro-brain natriuretic peptide; 6MWD = 6-Minute Walk Distance measured in meters; WHO/NYHA FC = WHO/New York Heart Association Functional Class; composite proportion defined as achieving NT-proBNP <300 pg/mL AND 6MWD >440 meters AND WHO/NYHA FC II status or better at specified time points; HRQoL by validated health-related quality-of-life instruments; time-to-event endpoints measured as time to all-cause hospitalization and time to all-cause mortality during study period."}
Recruitment
- Planned Sample Size
- 419
- Recruitment Window Months
- 89
- Consent Approach
- Evidence of a personally signed and dated Informed Consent Form indicating that the subject has been informed of all pertinent aspects of the study prior to initiation of any study-related procedures. Subject information and informed consent forms (Main ICF) and Pregnancy/Pregnant Partner consent forms are provided; multiple language versions are available (e.g. English, Bulgarian, French, Spanish, German, Italian, Portuguese, Hungarian, Polish, Dutch, Czech, Greek, Romanian and others as per submitted ICF documents). No assent procedures for minors are specified in the available materials.
Geography
- Total Number Of Sites
- 47
- Total Number Of Participants
- 156
Spain
- Earliest CTIS Part Ii Submission Date
- 23-05-2024
- Latest Decision Or Authorization Date
- 20-06-2024
- Processing Time Days
- 28
- Number Of Sites
- 3
- Number Of Participants
- 13
Sites
- Site Name
- Hospital Clinic De Barcelona
- Department Name
- Pneumology Department
- Principal Investigator Name
- Joan Albert Barberá Mir
- Principal Investigator Email
- jbarbera@clinic.ub.es
- Contact Person Name
- Joan Albert Barberá Mir
- Contact Person Email
- jbarbera@clinic.ub.es
- Site Name
- Hospital Universitario Y Politecnico La Fe
- Department Name
- Pneumology Department
- Principal Investigator Name
- Raquel López Reyes
- Principal Investigator Email
- raquel.lopez@separ.es
- Contact Person Name
- Raquel López Reyes
- Contact Person Email
- raquel.lopez@separ.es
- Site Name
- Hospital Universitario 12 De Octubre
- Department Name
- Cardiology Department
- Principal Investigator Name
- Pilar Escribano Subias
- Principal Investigator Email
- pilar.escribano@telefonica.net
- Contact Person Name
- Pilar Escribano Subias
- Contact Person Email
- pilar.escribano@telefonica.net
Bulgaria
- Earliest CTIS Part Ii Submission Date
- 23-05-2024
- Latest Decision Or Authorization Date
- 02-07-2024
- Processing Time Days
- 40
- Number Of Sites
- 2
- Number Of Participants
- 6
Sites
- Site Name
- MHAT National Heart Hospital EAD
- Department Name
- Clinic of Cardiology
- Principal Investigator Name
- Borislav Georgiev
- Principal Investigator Email
- b.georgiev@abv.bg
- Contact Person Name
- Borislav Georgiev
- Contact Person Email
- b.georgiev@abv.bg
- Site Name
- University Hospital St. Anna
- Department Name
- Clinic of Cardiology
- Principal Investigator Name
- Vasil Velchev
- Principal Investigator Email
- velchevvasil@gmail.com
- Contact Person Name
- Vasil Velchev
- Contact Person Email
- velchevvasil@gmail.com
Netherlands
- Earliest CTIS Part Ii Submission Date
- 23-05-2024
- Latest Decision Or Authorization Date
- 19-06-2024
- Processing Time Days
- 27
- Number Of Sites
- 1
- Number Of Participants
- 5
Sites
- Site Name
- VUmc Stichting
- Department Name
- Department of Pulmonary Medicine
- Principal Investigator Name
- Antonie Vonk Noordegraaf
- Principal Investigator Email
- a.vonk@vumc.nl
- Contact Person Name
- Antonie Vonk Noordegraaf
- Contact Person Email
- a.vonk@vumc.nl
France
- Earliest CTIS Part Ii Submission Date
- 23-05-2024
- Latest Decision Or Authorization Date
- 24-06-2024
- Processing Time Days
- 32
- Number Of Sites
- 5
- Number Of Participants
- 17
Sites
- Site Name
- Hospices Civils De Lyon
- Department Name
- Pneumology
- Principal Investigator Name
- Vincent COTTIN
- Principal Investigator Email
- vincent.cottin@chu-lyon.fr
- Contact Person Name
- Vincent COTTIN
- Contact Person Email
- vincent.cottin@chu-lyon.fr
- Site Name
- Les Hopitaux Universitaires De Strasbourg
- Department Name
- Pneumology
- Principal Investigator Name
- Matthieu CANUET
- Principal Investigator Email
- matthieu.canuet@chru-strasbourg.fr
- Contact Person Name
- Matthieu CANUET
- Contact Person Email
- matthieu.canuet@chru-strasbourg.fr
- Site Name
- Centre Hospitalier Regional Et Universitaire De Brest
- Department Name
- Internal medicine and pulmonology department
- Principal Investigator Name
- Francis COUTURAUD
- Principal Investigator Email
- francis.couturaud@chu-brest.fr
- Contact Person Name
- Francis COUTURAUD
- Contact Person Email
- francis.couturaud@chu-brest.fr
- Site Name
- CHRU De Nancy
- Department Name
- Pneumology
- Principal Investigator Name
- Ari CHAOUAT
- Principal Investigator Email
- a.chaouat@chru-nancy.fr
- Contact Person Name
- Ari CHAOUAT
- Contact Person Email
- a.chaouat@chru-nancy.fr
- Site Name
- CHU De Rouen
- Department Name
- Pneumology, Thoracic Oncology and Respiratory Intensive Care Department
- Principal Investigator Name
- Elise ARTAUD-MACARI
- Principal Investigator Email
- elise.artaud-macari@chu-rouen.fr
- Contact Person Name
- Elise ARTAUD-MACARI
- Contact Person Email
- elise.artaud-macari@chu-rouen.fr
Poland
- Earliest CTIS Part Ii Submission Date
- 23-05-2024
- Latest Decision Or Authorization Date
- 22-07-2024
- Processing Time Days
- 60
- Number Of Sites
- 3
- Number Of Participants
- 13
Sites
- Site Name
- Uniwersytecki Szpital Kliniczny W Poznaniu
- Department Name
- Oddział Kardiologii
- Principal Investigator Name
- Tatiana Mularek-Kubzdela
- Principal Investigator Email
- tatianamularek@wp.pl
- Contact Person Name
- Tatiana Mularek-Kubzdela
- Contact Person Email
- tatianamularek@wp.pl
- Site Name
- Uniwersytecki Szpital Kliniczny W Bialymstoku
- Department Name
- Klinika Kardiologii z O. Intensywnego Nadzoru
- Principal Investigator Name
- Karol Kamiński
- Principal Investigator Email
- fizklin@wp.pl
- Contact Person Name
- Karol Kamiński
- Contact Person Email
- fizklin@wp.pl
- Site Name
- Premium Clinic Wrocław CM
- Principal Investigator Name
- Ewa Mroczek
- Principal Investigator Email
- mroczeke@wp.pl
- Contact Person Name
- Ewa Mroczek
- Contact Person Email
- mroczeke@wp.pl
Italy
- Earliest CTIS Part Ii Submission Date
- 23-05-2024
- Latest Decision Or Authorization Date
- 24-06-2024
- Processing Time Days
- 32
- Number Of Sites
- 4
- Number Of Participants
- 10
Sites
- Site Name
- Fondazione IRCCS Policlinico San Matteo
- Department Name
- Cardiology
- Principal Investigator Name
- Stefano Ghio
- Principal Investigator Email
- s.ghio@smatteo.pv.it
- Contact Person Name
- Stefano Ghio
- Contact Person Email
- s.ghio@smatteo.pv.it
- Site Name
- IRCCS Ospedale Policlinico San Martino
- Department Name
- Cardiology
- Principal Investigator Name
- Pietro Ameri
- Principal Investigator Email
- pietroameri@unige.it
- Contact Person Name
- Pietro Ameri
- Contact Person Email
- pietroameri@unige.it
- Site Name
- Istituto Mediterraneo Per I Trapianti E Terapie Ad Alta Specializzazione S.r.l. I.S.M.E.T.T. S.r.L
- Department Name
- Cardiology
- Principal Investigator Name
- Patrizio Vitulo
- Principal Investigator Email
- pvitulo@ismett.edu
- Contact Person Name
- Patrizio Vitulo
- Contact Person Email
- pvitulo@ismett.edu
- Site Name
- Azienda Ospedaliero-Universitaria Policlinico Umberto I
- Department Name
- Cardiology
- Principal Investigator Name
- Roberto Badagliacca
- Principal Investigator Email
- robero.badagliacca@uniroma1.it
- Contact Person Name
- Roberto Badagliacca
- Contact Person Email
- robero.badagliacca@uniroma1.it
Czechia
- Earliest CTIS Part Ii Submission Date
- 23-05-2024
- Latest Decision Or Authorization Date
- 20-06-2024
- Processing Time Days
- 28
- Number Of Sites
- 1
- Number Of Participants
- 3
Sites
- Site Name
- Vseobecna Fakultni Nemocnice V Praze
- Department Name
- II. interní klinika kardiologie a angiologie VFN a 1.LF UK, Centrum pro plicní hypertenzi
- Principal Investigator Name
- Pavel Jansa
- Principal Investigator Email
- pavel.jansa@vfn.cz
- Contact Person Name
- Pavel Jansa
- Contact Person Email
- pavel.jansa@vfn.cz
Romania
- Earliest CTIS Part Ii Submission Date
- 23-05-2024
- Latest Decision Or Authorization Date
- 25-06-2024
- Processing Time Days
- 33
- Number Of Sites
- 4
- Number Of Participants
- 12
Sites
- Site Name
- Clinical Hospital Of Infectious Diseases And Pneumophysiology Dr.Victor Babes Timisoara
- Department Name
- Sectia 2 Pneumologie
- Principal Investigator Name
- Ovidiu Fira-Mladinescu
- Principal Investigator Email
- mladinescu@umft.ro
- Contact Person Name
- Ovidiu Fira-Mladinescu
- Contact Person Email
- mladinescu@umft.ro
- Site Name
- Institutul Inimii De Urgenta Pentru Boli Cardiovasculare Niculae Stancioiu
- Department Name
- Sectia Cardiologie I
- Principal Investigator Name
- Stefan Dan Cezar Mot
- Principal Investigator Email
- motstefan@gmail.com
- Contact Person Name
- Stefan Dan Cezar Mot
- Contact Person Email
- motstefan@gmail.com
- Site Name
- Institutul De Urgenta Pentru Boli Cardiovasculare Prof. Dr. C. C. Iliescu
- Department Name
- Sectia Cardiologie II
- Principal Investigator Name
- Ioan Mircea Coman
- Principal Investigator Email
- iocoman@yahoo.com
- Contact Person Name
- Ioan Mircea Coman
- Contact Person Email
- iocoman@yahoo.com
- Site Name
- Institutul De Pneumoftiziologie Marius Nasta
- Department Name
- Sectia 4 Pneumologie
- Principal Investigator Name
- Claudia Lucia Toma
- Principal Investigator Email
- claudiatoma@yahoo.co.uk
- Contact Person Name
- Claudia Lucia Toma
- Contact Person Email
- claudiatoma@yahoo.co.uk
Hungary
- Earliest CTIS Part Ii Submission Date
- 23-05-2024
- Latest Decision Or Authorization Date
- 19-06-2024
- Processing Time Days
- 27
- Number Of Sites
- 3
- Number Of Participants
- 7
Sites
- Site Name
- University Of Szeged
- Department Name
- Családorvosi Intézet és Rendelő
- Principal Investigator Name
- Albert Varga
- Principal Investigator Email
- varga.albert@med.u-szeged.hu
- Contact Person Name
- Albert Varga
- Contact Person Email
- varga.albert@med.u-szeged.hu
- Site Name
- Gottsegen National Cardiovascular Center
- Department Name
- -
- Principal Investigator Name
- Olga Hajnalka Bálint
- Principal Investigator Email
- titkarsag@kardio.hu
- Contact Person Name
- Olga Hajnalka Bálint
- Contact Person Email
- titkarsag@kardio.hu
- Site Name
- University Of Pecs
- Department Name
- Szívgyógyászati Klinika
- Principal Investigator Name
- András Komócsi
- Principal Investigator Email
- andras.komocsi@aok.pte.hu
- Contact Person Name
- András Komócsi
- Contact Person Email
- andras.komocsi@aok.pte.hu
Germany
- Earliest CTIS Part Ii Submission Date
- 23-05-2024
- Latest Decision Or Authorization Date
- 20-06-2024
- Processing Time Days
- 28
- Number Of Sites
- 7
- Number Of Participants
- 21
Sites
- Site Name
- Thoraxklinik Heidelberg gGmbH
- Department Name
- Zentrum für Pulmolare Hypertonie
- Principal Investigator Name
- Ekkehard Gruenig
- Principal Investigator Email
- ekkehard.gruenig@med.uni-heidelberg.de
- Contact Person Name
- Ekkehard Gruenig
- Contact Person Email
- ekkehard.gruenig@med.uni-heidelberg.de
- Site Name
- Technische Universitaet Dresden
- Department Name
- Medizinische Klinik I
- Principal Investigator Name
- Michael Halank
- Principal Investigator Email
- michael.halank@uniklinikum-dresden.de
- Contact Person Name
- Michael Halank
- Contact Person Email
- michael.halank@uniklinikum-dresden.de
- Site Name
- Universitaetsklinikum des Saarlandes AöR
- Department Name
- Innere Medizin V
- Principal Investigator Name
- Heinrike Wilkens
- Principal Investigator Email
- heinrike.wilkens@uks.eu
- Contact Person Name
- Heinrike Wilkens
- Contact Person Email
- heinrike.wilkens@uks.eu
- Site Name
- Universitaetsmedizin Greifswald KöR
- Department Name
- Klinik und Poliklinik für Innere Medizin B
- Principal Investigator Name
- Ralf Ewert
- Principal Investigator Email
- ralf.ewert@med.uni-greifswald.de
- Contact Person Name
- Ralf Ewert
- Contact Person Email
- ralf.ewert@med.uni-greifswald.de
- Site Name
- Universitaet Leipzig
- Department Name
- Medizinische Klinik II
- Principal Investigator Name
- Hubert Wirtz
- Principal Investigator Email
- hubert.wirtz@medizin.uni-leipzig.de
- Contact Person Name
- Hubert Wirtz
- Contact Person Email
- hubert.wirtz@medizin.uni-leipzig.de
- Site Name
- University Medical Center Hamburg-Eppendorf
- Department Name
- II. Medizinische Klinik und Poliklinik
- Principal Investigator Name
- Hans F. E. Klose
- Principal Investigator Email
- klose@uke.de
- Contact Person Name
- Hans F. E. Klose
- Contact Person Email
- klose@uke.de
- Site Name
- Schwarzwald-Baar Klinikum Villingen-Schwenningen GmbH
- Department Name
- Lungenzentrum
- Principal Investigator Name
- Hinrich-Cordt Bremer
- Principal Investigator Email
- hinrich.bremer@sbk-vs.de
- Contact Person Name
- Hinrich-Cordt Bremer
- Contact Person Email
- hinrich.bremer@sbk-vs.de
Portugal
- Earliest CTIS Part Ii Submission Date
- 23-05-2024
- Latest Decision Or Authorization Date
- 02-07-2024
- Processing Time Days
- 40
- Number Of Sites
- 4
- Number Of Participants
- 17
Sites
- Site Name
- Unidade Local De Saude De Almada-Seixal E.P.E.
- Department Name
- Cardiology
- Principal Investigator Name
- Filipa Ferreira
- Principal Investigator Email
- filipa.ferreira@hgo.min-saude.pt
- Contact Person Name
- Filipa Ferreira
- Contact Person Email
- filipa.ferreira@hgo.min-saude.pt
- Site Name
- Unidade Local De Saude De Coimbra E.P.E.
- Department Name
- Cardiology
- Principal Investigator Name
- Maria da Graça Castro
- Principal Investigator Email
- castro2406@gmail.com
- Contact Person Name
- Maria da Graça Castro
- Contact Person Email
- castro2406@gmail.com
- Site Name
- Centro Hospitalar Universitario De Santo Antonio E.P.E.
- Department Name
- Cardiology
- Principal Investigator Name
- Fabienne Gonçalves
- Principal Investigator Email
- geral.investigacao.defi@chporto.min-saude.pt
- Contact Person Name
- Fabienne Gonçalves
- Contact Person Email
- geral.investigacao.defi@chporto.min-saude.pt
- Site Name
- Unidade Local De Saude De Santa Maria E.P.E.
- Department Name
- Cardiology
- Principal Investigator Name
- Rui Plácido
- Principal Investigator Email
- placidorui@gmail.com
- Contact Person Name
- Rui Plácido
- Contact Person Email
- placidorui@gmail.com
Greece
- Earliest CTIS Part Ii Submission Date
- 23-05-2024
- Latest Decision Or Authorization Date
- 22-07-2024
- Processing Time Days
- 60
- Number Of Sites
- 3
- Number Of Participants
- 10
Sites
- Site Name
- University General Hospital Of Thessaloniki Ahepa
- Department Name
- A' Cardiology Clinic
- Principal Investigator Name
- George Giannakoulas
- Principal Investigator Email
- g.giannakoulas@gmail.com
- Contact Person Name
- George Giannakoulas
- Contact Person Email
- g.giannakoulas@gmail.com
- Site Name
- Onassis Cardiac Surgery Center
- Department Name
- Hemodynamic Research and Interventional Cardiology
- Principal Investigator Name
- Vassilios Voudris
- Principal Investigator Email
- vvoudris@otenet.gr
- Contact Person Name
- Vassilios Voudris
- Contact Person Email
- vvoudris@otenet.gr
- Site Name
- University General Hospital Of Alexandroupoli
- Department Name
- University Cardiology Clinic
- Principal Investigator Name
- Stavros Konstantinides
- Principal Investigator Email
- skonst@med.duth.gr
- Contact Person Name
- Stavros Konstantinides
- Contact Person Email
- skonst@med.duth.gr
Denmark
- Earliest CTIS Part Ii Submission Date
- 23-05-2024
- Latest Decision Or Authorization Date
- 19-06-2024
- Processing Time Days
- 27
- Number Of Sites
- 2
- Number Of Participants
- 13
Sites
- Site Name
- Aarhus Universitetshospital
- Department Name
- Department of Cardiology
- Principal Investigator Name
- Søren Mellemkjær
- Principal Investigator Email
- soren.mellemkjaer@rm.dk
- Contact Person Name
- Søren Mellemkjær
- Contact Person Email
- soren.mellemkjaer@rm.dk
- Site Name
- Rigshospitalet
- Department Name
- Department of Cardiology
- Principal Investigator Name
- Jørn Carlsen
- Principal Investigator Email
- joern.carlsen@regionh.dk
- Contact Person Name
- Jørn Carlsen
- Contact Person Email
- joern.carlsen@regionh.dk
Austria
- Earliest CTIS Part Ii Submission Date
- 23-05-2024
- Latest Decision Or Authorization Date
- 24-06-2024
- Processing Time Days
- 32
- Number Of Sites
- 3
- Number Of Participants
- 4
Sites
- Site Name
- Medizinische Universitaet Innsbruck
- Department Name
- Division of Internal Medicine II
- Principal Investigator Name
- Judith Loeffler-Ragg
- Principal Investigator Email
- judith.loeffler@i-med.ac.at
- Contact Person Name
- Judith Loeffler-Ragg
- Contact Person Email
- judith.loeffler@i-med.ac.at
- Site Name
- Ordensklinikum Linz GmbH
- Department Name
- Ordensklinikum Linz Elisabethinen, Internal II - Cardiology, Angiology & Intensive Care Medicine
- Principal Investigator Name
- Regina Steringer-Mascherbauer
- Principal Investigator Email
- regina.steringer-mascherbauer@ordensklinikum.at
- Contact Person Name
- Regina Steringer-Mascherbauer
- Contact Person Email
- regina.steringer-mascherbauer@ordensklinikum.at
- Site Name
- Medical University Of Vienna
- Department Name
- Division of Internal Medicine II, Dept. of
- Principal Investigator Name
- Irene Marthe Lang
- Principal Investigator Email
- irene.lang@meduniwien.ac.at
- Contact Person Name
- Irene Marthe Lang
- Contact Person Email
- irene.lang@meduniwien.ac.at
Belgium
- Earliest CTIS Part Ii Submission Date
- 23-05-2024
- Latest Decision Or Authorization Date
- 21-06-2024
- Processing Time Days
- 29
- Number Of Sites
- 2
- Number Of Participants
- 5
Sites
- Site Name
- Hopital Erasme
- Department Name
- Pneumology
- Principal Investigator Name
- Jean-Luc Vachiery
- Principal Investigator Email
- jeanluc.vachiery@erasme.ulb.ac.be
- Contact Person Name
- Jean-Luc Vachiery
- Contact Person Email
- jeanluc.vachiery@erasme.ulb.ac.be
- Site Name
- UZ Leuven
- Department Name
- Pneumology
- Principal Investigator Name
- Marion Delcroix
- Principal Investigator Email
- marion.delcroix@uzleuven.be
- Contact Person Name
- Marion Delcroix
- Contact Person Email
- marion.delcroix@uzleuven.be
Sponsor
Primary sponsor
- Full Name
- United Therapeutics Corp.
- Organisation Type
- Pharmaceutical company
- Country Of Registered Address
- United States
Contract research organisations
- Name
- Syneos Health Netherlands B.V.
- Responsibilities
- Expedited and periodic safety reporting (for Spain only expediated reporting); code: 8
- Name
- IQVIA Limited
- Responsibilities
- Roles including regulatory and safety activities (codes: 1,12,13,15 with periodic safety reporting for Spain; codes 5,8)
- Name
- IQVIA RDS Hellas Single Member S.A.
- Responsibilities
- Regulatory Applications in Greece; other sponsor duties (codes: 1,8,15)
- Name
- Eresearchtechnology Inc.
- Responsibilities
- ECG analysis/ review (code:15)
- Name
- Q Squared Solutions Limited
- Responsibilities
- Sponsor duty code: 4
- Name
- Labcorp Early Development Laboratories Inc.
- Responsibilities
- Sponsor duty code: 4
Third parties
- {"country":"Netherlands","full_name":"Syneos Health Netherlands B.V.","duties_or_roles":"Expedited and periodic safety reporting (for Spain only expediated reporting); code: 8","organisation_type":"Pharmaceutical company"}
- {"country":"United Kingdom","full_name":"IQVIA Limited","duties_or_roles":"Codes: 1, 12, 13, 15 (Periodic safety reporting for Spain), 5, 8","organisation_type":"Pharmaceutical company"}
- {"country":"Greece","full_name":"IQVIA RDS Hellas Single Member S.A.","duties_or_roles":"Codes: 1, 15 (Regulatory Applications in Greece), 8","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Eresearchtechnology Inc.","duties_or_roles":"15 (ECG analysis/ review)","organisation_type":"Pharmaceutical company"}
- {"country":"United Kingdom","full_name":"Q Squared Solutions Limited","duties_or_roles":"4","organisation_type":"Non-Pharmaceutical company"}
- {"country":"United States","full_name":"Labcorp Early Development Laboratories Inc.","duties_or_roles":"4","organisation_type":"Pharmaceutical company"}
Investigational products
- Investigational Product Name
- Ralinepag
- Active Substance
- RALINEPAG
- Modality
- Small molecule
- Routes Of Administration
- ORAL USE
- Route
- ORAL USE
- Authorisation Status
- Authorised
- Orphan Designation
- Yes
- Maximum Dose
- 9000 µg per day
- Investigational Product Name
- Ralinepag
- Active Substance
- RALINEPAG
- Modality
- Small molecule
- Routes Of Administration
- ORAL USE
- Route
- ORAL USE
- Authorisation Status
- Authorised
- Orphan Designation
- Yes
- Maximum Dose
- 9000 µg per day
- Investigational Product Name
- Ralinepag
- Active Substance
- RALINEPAG
- Modality
- Small molecule
- Routes Of Administration
- ORAL USE
- Route
- ORAL USE
- Authorisation Status
- Authorised
- Orphan Designation
- Yes
- Maximum Dose
- 9000 µg per day
- Investigational Product Name
- Ralinepag
- Active Substance
- RALINEPAG
- Modality
- Small molecule
- Routes Of Administration
- ORAL USE
- Route
- ORAL USE
- Authorisation Status
- Authorised
- Orphan Designation
- Yes
- Maximum Dose
- 9000 µg per day
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- PF-07868489 for Pulmonary arterial hypertension
- (S)-2,2',2''-(10-(2-(4-(3-((4-(2-(2-CYANO-4,4-DIFLUOROPYRROLIDIN-1-YL)-2-OXOETHYLCARBAMOYL)-QUINOLIN-6-YL)(METHYL)AMINO)-PROPYL)PIPERAZIN-1-YL)-2-OXOETHYL)-68GA-[1,4,7,10]-TETRAAZACYCLODODECANE-1,4,7-TRIYL)TRIACETATE for Pulmonary arterial hypertension