Clinical trial • Phase III • Oncology
PATRITUMAB DERUXTECAN for Hormone receptor positive HER2-negative breast cancer | Hormone receptor positive breast cancer
Phase III trial of PATRITUMAB DERUXTECAN for Hormone receptor positive HER2-negative breast cancer | Hormone receptor positive breast cancer.
Overview
- Trial Therapeutic Area
- Oncology
- Trial Disease
- Hormone receptor positive HER2-negative breast cancer | Hormone receptor positive breast cancer
- Trial Stage
- Phase III
- Drug Modality
- ADC | Small molecule
Key dates
- Initial CTIS Submission Date
- 10-06-2025
- First CTIS Authorization Date
- 29-09-2025
Trial design
Randomised, open-label, physician’s choice (tpc) comparator options listed in part i: doxorubicin hydrochloride, liposomal (product: doxorubicin hydrochloride, liposomal; route: intravenous infusion; doseuom: mg/m2; maxdailydoseamount: 50), doxorubicin hydrochloride (product: doxorubicin; route: intravenous infusion; doseuom: mg/m2; maxdailydoseamount: 50), capecitabine (product: capecitabine; route: oral use; doseuom: mg/m2; maxdailydoseamount: 2000), trastuzumab deruxtecan (product: trastuzumab deruxtecan; route: intravenous infusion; doseuom: mg/kg; maxdailydoseamount: 5.4), paclitaxel (product: paclitaxel; route: intravenous infusion; doseuom: mg/m2; maxdailydoseamount: 90), paclitaxel albumin-bound (product: paclitaxel albumin-bound; route: intravenous infusion; doseuom: mg/m2; maxdailydoseamount: 100). (no detailed schedule provided in the ctis record.)-controlled Phase III trial in Germany, Greece, Poland and others.
- Randomised
- Yes
- Open Label
- Yes
- Comparator
- Physician’s choice (TPC) comparator options listed in Part I: DOXORUBICIN HYDROCHLORIDE, LIPOSOMAL (product: DOXORUBICIN HYDROCHLORIDE, LIPOSOMAL; route: INTRAVENOUS INFUSION; doseUom: mg/m2; maxDailyDoseAmount: 50), DOXORUBICIN HYDROCHLORIDE (product: DOXORUBICIN; route: INTRAVENOUS INFUSION; doseUom: mg/m2; maxDailyDoseAmount: 50), CAPECITABINE (product: CAPECITABINE; route: ORAL USE; doseUom: mg/m2; maxDailyDoseAmount: 2000), TRASTUZUMAB DERUXTECAN (product: TRASTUZUMAB DERUXTECAN; route: INTRAVENOUS INFUSION; doseUom: mg/kg; maxDailyDoseAmount: 5.4), PACLITAXEL (product: PACLITAXEL; route: INTRAVENOUS INFUSION; doseUom: mg/m2; maxDailyDoseAmount: 90), PACLITAXEL ALBUMIN-BOUND (product: PACLITAXEL ALBUMIN-BOUND; route: INTRAVENOUS INFUSION; doseUom: mg/m2; maxDailyDoseAmount: 100). (No detailed schedule provided in the CTIS record.)
- Target Sample Size
- 771
Eligibility
Recruits 771 No vulnerable population selected (isVulnerablePopulationSelected=false).
- Vulnerable Population
- No vulnerable population selected (isVulnerablePopulationSelected=false)
Inclusion criteria
- {"criterion_text":"- Has a diagnosis of hormone receptor positive/human epidermal growth factor receptor 2 negative (HR+/HER2-) invasive breast carcinoma that is either locally advanced disease not amenable to resection with curative intent (herein called unresectable) or metastatic disease not treatable with curative intent"}
- {"criterion_text":"- Has centrally-confirmed HR+ and HER2- results and human epidermal growth factor receptor 3 (HER3) evaluable results from a biopsy obtained from a distant metastatic site or a locally advanced lesion on or after the most recent line of therapy (with certain exceptions)"}
- {"criterion_text":"- Must have had progression or recurrence on prior cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitor + endocrine therapy (ET) with one of the following: a.\tRadiographic disease progression, as assessed by the investigator, on CDK4/6 inhibitor + ET as first line (1L) for treatment of unresectable locally advanced or metastatic HR+/HER2- breast cancer. CDK4/6 inhibitor + ET must be the only line of therapy received in the advanced setting, or b.\tDisease recurrence, either radiographic and/or confirmed histologically via biopsy as assessed by the investigator, while on adjuvant ET in combination with a CDK4/6 inhibitor or within 24 months from the date of last dose of adjuvant CDK4/6 inhibitor"}
- {"criterion_text":"- Is determined by the investigator to be a candidate for at least 1 treatment of physician’s choice (TPC) option"}
- {"criterion_text":"- Has measurable disease per Response Evaluation Criteria in Solid Tumors 1.1 (RECIST 1.1) as assessed by the local site investigator/radiology"}
- {"criterion_text":"- Human immunodeficiency virus (HIV)-infected participants must have well controlled HIV on antiretroviral therapy"}
- {"criterion_text":"- Has an Eastern Cooperative Oncology Group performance status of 0 or 1 assessed within 7 days before randomization"}
Exclusion criteria
- {"criterion_text":"- Has breast cancer amenable to treatment with curative intent"}
- {"criterion_text":"- Has ≥Grade 2 peripheral neuropathy"}
- {"criterion_text":"- Has received prior treatment with an anti-HER3 antibody and/or antibody-drug conjugate that consists of a topoisomerase I inhibitor (e.g., T-DXd) or any other topoisomerase I inhibitor therapy"}
- {"criterion_text":"- Has received prior systemic anticancer therapy within 4 weeks (or 5 half-lives, whichever is shorter) before randomization. Participants previously treated with ET plus a CDK4/6 inhibitor may participate as long as at least 2 weeks have elapsed since the last dose of therapy was administered."}
- {"criterion_text":"- Has received prior radiotherapy for non-central nervous system disease, or required corticosteroids for radiation-related toxicities, within 14 days of the first dose of study intervention"}
- {"criterion_text":"- Has a diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy"}
- {"criterion_text":"- Has known additional malignancy that is progressing or has required active treatment within the past 3 years"}
- {"criterion_text":"- Has severe hypersensitivity (≥Grade 3) to HER3-DXd and/or any of its excipients"}
- {"criterion_text":"- Has severe hypersensitivity (≥Grade 3) to all the available TPC and/or any of their excipients"}
- {"criterion_text":"- Is eligible to receive additional endocrine-based treatment in the advanced setting as determined by the investigator. Patients with alterations/mutations in phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (PI3KCA), phosphatase and tensin homolog (PTEN), alpha-serine/threonine kinase (AKT), or estrogen receptor 1 (ESR1) who are deemed suitable for second line (2L) treatment with ET in combination with targeted therapy, where available, are not eligible"}
- {"criterion_text":"- Has a known germline BReast CAncer gene (BRCA) mutation (deleterious or suspected deleterious) where poly adenosine diphosphate-ribose polymerase (PARP) inhibitor(s) is a potential treatment option (i.e., available and not medically contraindicated)"}
- {"criterion_text":"- Has current visceral crisis or is at risk for impending visceral crisis that has or may cause imminent organ compromise and/or other life-threatening complications"}
- {"criterion_text":"- Has any of the following: a pulse oximeter reading <92% at rest, or requires intermittent supplemental oxygen, or requires chronic supplemental oxygen"}
- {"criterion_text":"- Has uncontrolled, significant cardiovascular disease or cerebrovascular disease"}
- {"criterion_text":"- Has clinically significant corneal disease"}
- {"criterion_text":"- Has received prior chemotherapy for unresectable locally advanced or metastatic breast cancer"}
- {"criterion_text":"- Has history of (noninfectious) pneumonitis/interstitial lung disease (ILD) that required steroids, has current pneumonitis/interstitial lung disease, or has suspected ILD/pneumonitis"}
Endpoints
Primary endpoints
- {"endpoint_text":"- Progression Free Survival (PFS)","definition_or_measurement_approach":"PFS per RECIST 1.1 as assessed by BICR (as stated in trial objectives)"}
- {"endpoint_text":"- Overall Survival (OS)","definition_or_measurement_approach":"Compare HER3-DXd to TPC with respect to OS in all participants (as stated in trial objectives)"}
Secondary endpoints
- {"endpoint_text":"- Objective Response Rate (ORR)","definition_or_measurement_approach":"ORR per RECIST 1.1 as assessed by BICR (stated in secondary objectives)"}
- {"endpoint_text":"- Duration of Response (DOR)","definition_or_measurement_approach":"DOR per RECIST 1.1 as assessed by BICR (stated in secondary objectives)"}
- {"endpoint_text":"- Change from Baseline in European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30) Global Health Status-Quality of Life Score","definition_or_measurement_approach":"Change from baseline in EORTC QLQ-C30 GHS/QoL score (instrument specified)"}
- {"endpoint_text":"- Change from Baseline in EORTC QLQ-C30 Physical Functioning Score","definition_or_measurement_approach":"Change from baseline in EORTC QLQ-C30 physical functioning score"}
- {"endpoint_text":"- Change from Baseline in EORTC QLQ-C30 Emotional Functioning Score","definition_or_measurement_approach":"Change from baseline in EORTC QLQ-C30 emotional functioning score"}
- {"endpoint_text":"- Change from Baseline in EORTC QLQ-C30 Pain Score","definition_or_measurement_approach":"Change from baseline in EORTC QLQ-C30 pain score"}
- {"endpoint_text":"- Time to First Deterioration (TTD) in EORTC QLQ-C30 Global Health Status-Quality of Life Score","definition_or_measurement_approach":"TTD in EORTC QLQ-C30 GHS/QoL score"}
- {"endpoint_text":"- TTD in EORTC QLQ-C30 Physical Functioning Score","definition_or_measurement_approach":"TTD in EORTC QLQ-C30 physical functioning score"}
- {"endpoint_text":"- TTD in EORTC QLQ-C30 Emotional Functioning Score","definition_or_measurement_approach":"TTD in EORTC QLQ-C30 emotional functioning score"}
- {"endpoint_text":"- TTD in EORTC QLQ-C30 Pain Score","definition_or_measurement_approach":"TTD in EORTC QLQ-C30 pain score"}
- {"endpoint_text":"- Number of Participants Who Experience an Adverse Event (AE)","definition_or_measurement_approach":"Count of participants experiencing any AE"}
- {"endpoint_text":"- Number of Participants Who Discontinue Study Treatment Due to an AE","definition_or_measurement_approach":"Count of participants who discontinue study treatment due to an AE"}
Recruitment
- Digital Remote Recruitment
- True, digital/remote methods explicitly referenced in documents: Website (Poland - Recruitment Doc Website_POL_PL), Patient Banner Ad (Germany) and Greenphire/eCOA reference (Greece: L1_ICF_Optional_Greenphire adults_GRC_EL_IN_for pub).
- Planned Sample Size
- 771
- Recruitment Window Months
- 93
- Consent Approach
- Informed consent obtained using country-specific adult main consent forms. Subject information and informed consent forms available in multiple country versions (documents list includes main consent forms in DEU, GRC/EL, POL/PL, FRA/FR, ESP/ES, ITA/IT, HUN/HU and English versions). Optional consents listed include limited screening consent, optional pregnancy follow-up, pregnant partner consent, genetic consent and data privacy addenda where applicable. No assent/children consent documents are indicated in the CTIS record.
Methods
- Germany: Recruitment materials indicated (document titles) Patient Banner Ad; Patient Brochure; Posters (documents listed under Germany K1/K2 materials) — channel: printed/online patient-facing materials; target: patients
- Greece: Recruitment materials indicated Patient Brochure; Poster; Master Tissue Brochure (documents under Greece K1/K2) — channel: printed/online patient-facing materials; target: patients
- Poland: Recruitment materials indicated Website and Patient Brochure (documents include Website_POL_PL) — channel: website; target: patients
- France: Recruitment materials indicated Poster and Patient Brochure (documents under FRA_FR) — channel: printed/online patient-facing materials; target: patients
- Spain: Recruitment materials indicated patient-facing consent and brochures (ESP_ES documents) — channel: printed/online materials; target: patients
- Italy: Recruitment arrangements document present (ITA_EN) — channel: country recruitment document; target: patients
- Hungary: Recruitment materials and patient brochure indicated (HUN documents) — channel: printed/online materials; target: patients
Geography
- Total Number Of Sites
- 48
- Total Number Of Participants
- 211
Germany
- Earliest CTIS Part Ii Submission Date
- 07-08-2025
- Latest Decision Or Authorization Date
- 30-09-2025
- Processing Time Days
- 54
- Number Of Sites
- 14
- Number Of Participants
- 50
Sites
- Site Name
- Universitaet Des Saarlandes
- Department Name
- Klinik für Gynäkologie, Geburtshilfe und Reproduktionsmedizi
- Contact Person Name
- Julia Radosa
- Contact Person Email
- Julia.Radosa@uks.eu
- Site Name
- Klinikum Chemnitz gGmbH
- Department Name
- Klinik für Frauenheilkunde und Geburtshilfe
- Contact Person Name
- Paul Gaß
- Contact Person Email
- paul.gass@skc.de
- Site Name
- Universitaetsklinikum Erlangen AöR
- Department Name
- Frauenklinik
- Contact Person Name
- Peter Fasching
- Contact Person Email
- peter.fasching.studien@uk-erlangen.de
- Site Name
- Klinikum Mutterhaus der Borromaeerinnen gGmbH
- Department Name
- Gynäkologischen Krebszentrums
- Contact Person Name
- Sebastian Jud
- Contact Person Email
- Sebastian.Jud@mutterhaus.de
- Site Name
- Klinikum Dortmund gGmbH
- Department Name
- Frauenklinik
- Contact Person Name
- Claudia Biehl
- Contact Person Email
- Claudia.Biehl@klinikumdo.de
- Site Name
- Diakonie in Suedwestfalen gGmbH
- Department Name
- Allgemeine Gynäkologie und Gynäkologische Onkologie
- Contact Person Name
- Katharina Gillen
- Contact Person Email
- Katharina.Gillen@diakonie-sw.de
- Site Name
- Universitaetsklinikum Schleswig-Holstein AöR
- Department Name
- Klinik für Gynäkologie und Geburtshilfe
- Contact Person Name
- Marion Von Mackelenbergh
- Contact Person Email
- MarionTina.vanMackelenbergh@uksh.de
- Site Name
- Agaplesion Frankfurter Diakonie Kliniken gGmbH
- Department Name
- Department of Gynaecology and Obstetrics
- Contact Person Name
- Marc Thill
- Contact Person Email
- madeleine.modrow@agaplesion.de
- Site Name
- Universitaetsklinikum Magdeburg AöR
- Department Name
- Universitätsklinik für Frauenheilkunde, Geburtshilfe und Reproduktionsmedizin
- Contact Person Name
- Atanas Ignatov
- Contact Person Email
- atanas.ignatov@med.ovgu.de
- Site Name
- Charite Universitaetsmedizin Berlin KöR
- Department Name
- Klinik für Gynäkologie mit Zentrum für onkologische Chirurgie Charité
- Contact Person Name
- Verena Kiver
- Contact Person Email
- verena.kiver@charite.de
- Site Name
- Universitaetsklinikum Ulm AöR
- Department Name
- Klinik für Frauenheilkunde und Geburtshilfe
- Contact Person Name
- Sabine Heublein
- Contact Person Email
- sabine.heublein@med.uni-heidelberg.de
- Site Name
- Medizinische Hochschule Hannover
- Department Name
- Klinik für Frauenheilkunde und Geburtshilfe
- Contact Person Name
- Tjoung-Won Park-Simon
- Contact Person Email
- frauenklinik.studien@mh-hannover.de
- Site Name
- Luisenkrankenhaus GmbH & Co. KG
- Department Name
- Zentrum für Gynäkologische Onkologie Düsseldorf
- Contact Person Name
- Athina Kostara
- Contact Person Email
- athina.kostara@luisenkrankenhaus.de
- Site Name
- Klinikum Lippe GmbH
- Department Name
- Universitätsklinik für Frauenheilkunde und Geburtshilfe
- Contact Person Name
- Beyhan Ataseven
- Contact Person Email
- beyhan.ataseven@klinikum-lippe.de
Greece
- Earliest CTIS Part Ii Submission Date
- 26-06-2025
- Latest Decision Or Authorization Date
- 03-10-2025
- Processing Time Days
- 99
- Number Of Sites
- 4
- Number Of Participants
- 20
Sites
- Site Name
- Athens Medical Center S.A.
- Department Name
- International Oncology Center- Oncology Department
- Contact Person Name
- Sofia Baka
- Contact Person Email
- bakasofia@hotmail.com
- Site Name
- Areteio Hospital
- Department Name
- B' Surgery Clinic, Oncology Unit, National and Kapodistrian University of Athens
- Contact Person Name
- Flora Zagouri
- Contact Person Email
- florazagouri@yahoo.co.uk
- Site Name
- University General Hospital Of Heraklion
- Department Name
- Internal Medicine-Department of Medical Oncology, Clinical Trials Office
- Contact Person Name
- Dimitrios Mavroudis
- Contact Person Email
- medoncsec@med.uoc.gr
- Site Name
- Laiko General Hospital Of Athens
- Department Name
- University of Athens, Oncology Department
- Contact Person Name
- Helen Gogas
- Contact Person Email
- helgogas@gmail.com
Poland
- Earliest CTIS Part Ii Submission Date
- 29-08-2025
- Latest Decision Or Authorization Date
- 06-10-2025
- Processing Time Days
- 38
- Number Of Sites
- 8
- Number Of Participants
- 42
Sites
- Site Name
- Salve Medica Sp. z o.o. S.K.
- Contact Person Name
- Monika Kukulska
- Contact Person Email
- badaniakliniczne@salvemedica.pl
- Site Name
- Narodowy Instytut Onkologii Im. Marii Sklodowskiej-Curie Panstwowy Instytut Badawczy
- Department Name
- Klinika Nowotworów Piersi i Chirurgii Rekonstrukcyjnej
- Contact Person Name
- Zbigniew Nowecki
- Contact Person Email
- nowotworypiersi@nio.gov.pl
- Site Name
- Wojewodzki Szpital Specjalistyczny Im. Janusza Korczaka W Slupsku Sp. z o.o.
- Department Name
- Oddział Onkologii Klinicznej, Chemioterapii
- Contact Person Name
- Wojciech Rogowski
- Contact Person Email
- kopec.em@gmail.com
- Site Name
- Szpital Wojewodzki Im. Mikolaja Kopernika W Koszalinie
- Department Name
- Oddział Dzienny Chemioterapii
- Contact Person Name
- Mariusz Kwiatkowski
- Contact Person Email
- sekretariat.odch@swk.med.pl
- Site Name
- Szpital Kliniczny Ministerstwa Spraw Wewnetrznych I Administracji Z Warminsko-Mazurskim Centrum Onkologii W Olsztynie
- Department Name
- Klinika Onkologii i Immunologii z Oddziałem Dziennym Terapii Onkologicznej
- Contact Person Name
- Monika Kotyla
- Contact Person Email
- clinicaltrialsoffice@poliklinika.net
- Site Name
- Centrum Onkologii Im. Prof. Franciszka Lukaszczyka W Bydgoszczy
- Department Name
- Oddział Kliniczny Onkologii
- Contact Person Name
- Adrianna Makarewicz
- Contact Person Email
- makarewicza@co.bydgoszcz.pl
- Site Name
- Bialostockie Centrum Onkologii Im. Marii Sklodowskiej-Curie W Bialymstoku
- Department Name
- Oddział Onkologii Klinicznej im. dr E. Pileckiej z pododdziałem Chemioterapii Dziennej
- Contact Person Name
- Kinga Hermanowicz-Szamatowicz
- Contact Person Email
- bco@onkologia.bialystok.pl
- Site Name
- Wojewodzki Szpital Specjalistyczny Im. Janusza Korczaka W Slupsku Sp. z o.o.
- Department Name
- Oddział Onkologii Klinicznej, Chemioterapii
France
- Earliest CTIS Part Ii Submission Date
- 29-08-2025
- Latest Decision Or Authorization Date
- 13-11-2025
- Processing Time Days
- 76
- Number Of Sites
- 4
- Number Of Participants
- 31
Sites
- Site Name
- Centre Hospitalier Regional Et Universitaire De Brest
- Department Name
- Oncologie
- Contact Person Name
- Laura Deiana
- Contact Person Email
- laura.deiana@chu-brest.fr
- Site Name
- Centre Henri Becquerel
- Department Name
- Oncologie
- Contact Person Name
- Julien Hoba
- Contact Person Email
- julien.hoba@chb.unicancer.fr
- Site Name
- Centre Leon Berard
- Department Name
- Oncologie
- Contact Person Name
- Thomas Bachelot
- Contact Person Email
- thomas.bachelot@lyon.unicancer.fr
- Site Name
- Institut Gustave Roussy
- Department Name
- Oncologie
- Contact Person Name
- Barbara Pistilli
- Contact Person Email
- barbara.pistilli@gustaveroussy.fr
Spain
- Earliest CTIS Part Ii Submission Date
- 21-08-2025
- Latest Decision Or Authorization Date
- 02-10-2025
- Processing Time Days
- 42
- Number Of Sites
- 8
- Number Of Participants
- 28
Sites
- Site Name
- Hospital Clinic De Barcelona
- Department Name
- Oncología médica
- Contact Person Name
- Milana Bergamino Silven
- Contact Person Email
- bergamino@clinic.cat
- Site Name
- Complexo Hospitalario Universitario A Coruna
- Department Name
- Oncología médica
- Contact Person Name
- Cristina Reboredo Rendo
- Contact Person Email
- cristina.reboredo.rendo@sergas.es
- Site Name
- Hospital Universitario Virgen De Valme
- Department Name
- Oncología médica
- Contact Person Name
- Maria Rodriguez de la Borbolla
- Contact Person Email
- maria.rodriguezborb.sspa@juntadeandalucia.es
- Site Name
- Institut Catala D'oncologia
- Department Name
- Oncología médica
- Contact Person Name
- Gaston Zatta Cobos
- Contact Person Email
- uicico_badalona@iconcologia.net
- Site Name
- Hospital Universitario Marques De Valdecilla
- Department Name
- Oncología médica
- Contact Person Name
- Carmen Hinojo Gonzalez
- Contact Person Email
- carmen.hinojo@scsalud.es
- Site Name
- Hospital Universitario Ramon Y Cajal
- Department Name
- Oncología médica
- Contact Person Name
- Maria Fernandez Abad
- Contact Person Email
- mariafernandezabad@hotmail.com
- Site Name
- Hospital Clinico San Carlos
- Department Name
- Oncología médica
- Contact Person Name
- Jose Angel Garcia Saenz
- Contact Person Email
- jgsaenz@salud.madrid.com
- Site Name
- Hospital Universitario Virgen De Valme
- Department Name
- Oncología médica
Italy
- Earliest CTIS Part Ii Submission Date
- 12-09-2025
- Latest Decision Or Authorization Date
- 02-10-2025
- Processing Time Days
- 20
- Number Of Sites
- 6
- Number Of Participants
- 20
Sites
- Site Name
- Azienda Socio Sanitaria Territoriale Papa Giovanni Xxiii
- Department Name
- Oncologia
- Contact Person Name
- Alberto Zambelli
- Contact Person Email
- azambelli@asst-pg23.it
- Site Name
- IRCCS Istituto Nazionale Tumori Fondazione Pascale
- Department Name
- S.C. Oncologia Clinica Sperimentale di Senologia – Senologia
- Contact Person Name
- Michelino De Laurentiis
- Contact Person Email
- m.delaurentiis@istitutotumori.na.it
- Site Name
- Fondazione IRCCS Istituto Nazionale Dei Tumori
- Department Name
- Struttura Complessa di Oncologia Medica 1
- Contact Person Name
- Claudio Vernieri
- Contact Person Email
- claudio.vernieri@istitutotumori.mi.it
- Site Name
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
- Department Name
- UOSD Medicina di Precisione in Senologia
- Contact Person Name
- Alessandra Fabi
- Contact Person Email
- alessandra.fabi@policlinicogemelli.it
- Site Name
- Ospedale San Raffaele S.r.l.
- Department Name
- Dipartimento di Oncologia Medica
- Contact Person Name
- Giampaolo Bianchini
- Contact Person Email
- bianchini.giampaolo@hsr.it
- Site Name
- Istituto Europeo Di Oncologia S.r.l.
- Department Name
- Divisione di Sviluppo di Nuovi Farmaci per Terapie Innovative
- Contact Person Name
- Giuseppe Curigliano
- Contact Person Email
- giuseppe.curigliano@ieo.it
Hungary
- Earliest CTIS Part Ii Submission Date
- 01-08-2025
- Latest Decision Or Authorization Date
- 03-10-2025
- Processing Time Days
- 63
- Number Of Sites
- 4
- Number Of Participants
- 20
Sites
- Site Name
- Szabolcs-Szatmar-Bereg Varmegyei Oktatokorhaz
- Department Name
- Onkoradiológia
- Contact Person Name
- Ágnes Wéber
- Contact Person Email
- agneswebermd@gmail.com
- Site Name
- Orszagos Onkologiai Intezet
- Department Name
- B-Belgyógyászati Onkológiai Osztály
- Contact Person Name
- Gábor Rubovszky
- Contact Person Email
- rubovszky.gabor@oncol.hu
- Site Name
- Bacs-Kiskun Varmegyei Oktatokorhaz
- Department Name
- Onkoradiológiai Központ
- Contact Person Name
- Zsolt Horváth
- Contact Person Email
- horvathzso.study@kmk.hu
- Site Name
- Semmelweis University
- Department Name
- Belgyógyászati és Hematológiai Klinika
- Contact Person Name
- Júlia Lohinszky
- Contact Person Email
- lohinszky.julia@mail.semmelweis-univ.hu
Sponsor
Primary sponsor
- Full Name
- Merck Sharp & Dohme LLC
- Organisation Type
- Pharmaceutical company
- Country Of Registered Address
- United States
Contract research organisations
- Name
- Parexel International Corp.
- Responsibilities
- EUB services (call center and medical services)
- Name
- PPDBioA
- Responsibilities
- sponsorDuties code 4 (role code list present in CTIS record)
- Name
- Clario
- Responsibilities
- sponsorDuties code 13 (role code list present in CTIS record)
- Name
- Almac Clinical Services LLC
- Responsibilities
- sponsorDuties code 3 (role code list present in CTIS record)
- Name
- Signant Health Global LLC
- Responsibilities
- Electronic Patient Reported Outcomes
- Name
- Labcorp Central Laboratory Services SARL
- Responsibilities
- central laboratory services (sponsorDuties code 4)
- Name
- Median Technologies
- Responsibilities
- Imaging
- Name
- Infinity Biologix LLC
- Responsibilities
- sponsorDuties code 4
- Name
- Roche Diagnostics GmbH
- Responsibilities
- sponsorDuties code 4
Third parties
- {"country":"Germany","full_name":"Roche Diagnostics GmbH","duties_or_roles":"sponsorDuties codes: [4]","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Clario","duties_or_roles":"sponsorDuties codes: [13]","organisation_type":"Health care"}
- {"country":"United States","full_name":"PPDBioA","duties_or_roles":"sponsorDuties codes: [4]","organisation_type":"Industry"}
- {"country":"United States","full_name":"Parexel International Corp.","duties_or_roles":"EUB services (call center and medical services) (sponsorDuties code 15)","organisation_type":"Pharmaceutical company"}
- {"country":"Switzerland","full_name":"Labcorp Central Laboratory Services SARL","duties_or_roles":"sponsorDuties codes: [4]","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Signant Health Global LLC","duties_or_roles":"Electronic Patient Reported Outcomes (sponsorDuties code 15)","organisation_type":"Pharmaceutical company"}
- {"country":"France","full_name":"Median Technologies","duties_or_roles":"Imaging (sponsorDuties code 15)","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Infinity Biologix LLC","duties_or_roles":"sponsorDuties codes: [4]","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Almac Clinical Services LLC","duties_or_roles":"sponsorDuties codes: [3]","organisation_type":"Pharmaceutical company"}
Investigational products
- Investigational Product Name
- MK-1022
- Active Substance
- PATRITUMAB DERUXTECAN
- Modality
- ADC
- Routes Of Administration
- INTRAVENOUS INFUSION
- Route
- INTRAVENOUS INFUSION
- Authorisation Status
- prodAuthStatus: 1
- Maximum Dose
- maxTotalDoseAmount: 106.4 mg/Kg (maxDailyDoseAmount: 5.6 mg/kg)
Related trials
Other published trials that may interest you.
- GDC-9545 for Locally advanced or metastatic estrogen receptor-positive breast cancer
- Abemaciclib for Stage IV lung cancer | Breast cancer
- BGB-43395 for Advanced or metastatic solid tumors | Hormone receptor positive HER2 negative breast cancer
- AZD9833 for Estrogen receptor-positive HER2-negative advanced breast cancer
- Pembrolizumab for Classical Hodgkin lymphoma | Melanoma | Solid tumours (MSI-H/dMMR) | Solid tumours (TMB-H)