Clinical trial • Phase III • Neurology
Ocrelizumab for Relapsing-remitting multiple sclerosis
Phase III trial of Ocrelizumab for Relapsing-remitting multiple sclerosis.
Overview
- Trial Therapeutic Area
- Neurology
- Trial Disease
- Relapsing-remitting multiple sclerosis
- Trial Stage
- Phase III
- Drug Modality
- Monoclonal antibody
Key dates
- Initial CTIS Submission Date
- 07-11-2024
- First CTIS Authorization Date
- 18-03-2025
Trial design
Randomised, fda-licensed ocrelizumab and eu-approved ocrelizumab (ocrevus 300 mg concentrate for solution for infusion) — same dose as abp 692 as stated; specific dose amount and dosing schedule not specified in the record.-controlled Phase III trial in Croatia, Slovenia, Bulgaria and others.
- Randomised
- Yes
- Comparator
- FDA-licensed ocrelizumab and EU-approved ocrelizumab (Ocrevus 300 mg concentrate for solution for infusion) — same dose as ABP 692 as stated; specific dose amount and dosing schedule not specified in the record.
- Target Sample Size
- 444
- Trial Duration For Participant
- 336
Eligibility
Recruits 444 No vulnerable populations selected (isVulnerablePopulationSelected: false). Informed consent is from adult subjects (study population 18 to 60 years). Subject information and informed consent form (ICF) documents are provided (multiple country/language versions and PK/main group versions); pregnancy follow-up and partner information documents are available. No assent process for minors is indicated..
- Vulnerable Population
- No vulnerable populations selected (isVulnerablePopulationSelected: false). Informed consent is from adult subjects (study population 18 to 60 years). Subject information and informed consent form (ICF) documents are provided (multiple country/language versions and PK/main group versions); pregnancy follow-up and partner information documents are available. No assent process for minors is indicated.
Inclusion criteria
- {"criterion_text":"- Diagnosis of RRMS in accordance with the revised McDonald Criteria 2017."}
- {"criterion_text":"- Expanded Disability Status Scale score at screening ≥ 0 and ≤ 5.5 inclusive."}
- {"criterion_text":"- Evidence of recent MS activity as defined by the study protocol."}
- {"criterion_text":"- Neurologically stable subject, with no relapse for ≤ 28 days before randomization."}
Exclusion criteria
- {"criterion_text":"- Diagnosis of PPMS according to the 2017 revision of the McDonald diagnostic criteria or with secondary progressive MS (Thompson et al, 2018)."}
- {"criterion_text":"- Multiple sclerosis disease duration of ≥ 10 years in subjects with EDSS score of ≤ 2.5 at screening."}
- {"criterion_text":"- Any contraindications to study procedures or medications as outlined in the study protocol."}
- {"criterion_text":"- Any prohibited medication as defined in the study protocol."}
- {"criterion_text":"- Any significant concomitant disease that may require chronic treatment with systemic corticosteroids and/or systemic immunosuppressants during the study."}
- {"criterion_text":"- Current or history of any medical conditions described in the study protocol."}
- {"criterion_text":"- Any abnormal laboratory blood values as defined in the study protocol."}
- {"criterion_text":"- Any significant concomitant disease that may require chronic treatment with systemic corticosteroids and/or systemic immunosuppressants during the study."}
Endpoints
Primary endpoints
- {"endpoint_text":"- Area under the serum concentration-time curve (AUC) from time 0 to day 15 (AUC0-d15) following infusion 1 of the initial dose","definition_or_measurement_approach":"AUC of serum concentration-time curve from time 0 to day 15 following infusion 1 (measured from blood serum concentrations over time)."}
- {"endpoint_text":"- AUC from time 0 extrapolated to infinity (AUC0-inf) of the entire initial dose","definition_or_measurement_approach":"AUC of serum concentration-time curve from time 0 extrapolated to infinity for the entire initial dose (pharmacokinetic assessment from serum samples, extrapolation to infinity)."}
- {"endpoint_text":"- Total number of new GdE T1-weighted lesions (assessed by brain MRI) over weeks 4, 8, 12, 16, 20, and 24","definition_or_measurement_approach":"Number of new gadolinium-enhancing (GdE) T1-weighted brain MRI lesions counted at scheduled MRI assessments at weeks 4, 8, 12, 16, 20 and 24 (assessed by brain MRI)."}
Recruitment
- Digital Remote Recruitment
- Yes
- Planned Sample Size
- 444
- Recruitment Window Months
- 28
- Consent Approach
- Informed consent obtained from adult subjects (18–60 years). Multiple ICF documents are provided (main group, PK group, pregnancy follow-up, country-specific versions) in multiple languages (examples in the documents: English, Slovenian, Bulgarian, Czech, Slovak, Spanish, French, Polish, Romanian, Dutch, Catalan and others). No assent for minors is indicated.
Methods
- Site-based recruitment using study-site materials (site brochures, flyers, posters, site biosimilar infographics) as listed in recruitment documents.
- Patient-facing materials: patient brochures, patient letters, patient leaflets and study brochures (country-specific language versions available).
- Recruitment advertising statements and recruitment arrangements documents intended for publication (country-specific).
- In-clinic engagement including GP letters and subject cards provided to potential participants.
- ICF flipbooks and informed consent materials delivered at sites (paper/print materials) and country-specific ICFs.
Geography
- Total Number Of Sites
- 83
- Total Number Of Participants
- 375
Croatia
- Earliest CTIS Part Ii Submission Date
- 14-02-2025
- Latest Decision Or Authorization Date
- 08-09-2025
- Processing Time Days
- 206
- Number Of Sites
- 2
- Number Of Participants
- 11
Sites
- Site Name
- University Hospital Centre Zagreb
- Department Name
- Neurology Department
- Contact Person Name
- Mario Habek
- Contact Person Email
- mhabek@mef.hr
- Site Name
- Klinicki bolnicki centar Sestre milosrdnice
- Department Name
- Neurology Department
- Contact Person Name
- Lidija Dezmalj Grbelja
- Contact Person Email
- lidija.dezmalj@kbcsm.hr
Slovenia
- Earliest CTIS Part Ii Submission Date
- 11-09-2025
- Latest Decision Or Authorization Date
- 13-11-2025
- Processing Time Days
- 63
- Number Of Sites
- 2
- Number Of Participants
- 6
Sites
- Site Name
- UNIVERZITETNI KLINICNI CENTER MARIBOR
- Department Name
- Department of neurology
- Contact Person Name
- Jožef Magdič
- Contact Person Email
- jozef.magdic@ukc-mb.si
- Site Name
- University Medical Center Ljubljana
- Department Name
- Department of neurology
- Contact Person Name
- Gregor Brecl Jakob
- Contact Person Email
- gregor.brecljakob@kclj.si
Bulgaria
- Earliest CTIS Part Ii Submission Date
- 18-02-2025
- Latest Decision Or Authorization Date
- 18-11-2025
- Processing Time Days
- 273
- Number Of Sites
- 6
- Number Of Participants
- 14
Sites
- Site Name
- University Multiprofile Hospital For Active Treatment Dr. Georgi Stranski EAD
- Department Name
- Neurological Clinic
- Contact Person Name
- Maya Danovska-Mladenova
- Contact Person Email
- mdanovska@yahoo.com
- Site Name
- Diagnostics And Consultation Center Convex Ltd.
- Contact Person Name
- Krasimir Genov
- Contact Person Email
- Kr_genov@abv.bg
- Site Name
- Medical Center Hera EOOD
- Contact Person Name
- Plamen Antimov
- Contact Person Email
- Plamen.antimov@gmail
- Site Name
- University Multiprofile Hospital For Active Treatment And Emergency Medicine N I Pirogov
- Department Name
- Clinic of Neurology
- Contact Person Name
- Mariya Dimitrova
- Contact Person Email
- dr.m.i.dimitrova@gmail.com
- Site Name
- University Multiprofile Hospital For Active Treatment St. Ivan Rilski EAD
- Department Name
- Neurology
- Contact Person Name
- Penko Shotekov
- Contact Person Email
- shotekov@abv.bg
- Site Name
- Multiprofile Hospital For Active Treatment In Neurology And Psychiatry St. Naum EAD
- Department Name
- Neurology
- Contact Person Name
- Ivan Milanov
- Contact Person Email
- milanovivan54@gmail.com
Belgium
- Earliest CTIS Part Ii Submission Date
- 14-02-2025
- Latest Decision Or Authorization Date
- 20-04-2026
- Processing Time Days
- 430
- Number Of Sites
- 3
- Number Of Participants
- 23
Sites
- Site Name
- Noorderhart
- Department Name
- Neurology
- Contact Person Name
- Cornelia Rogojan
- Contact Person Email
- cornelia.rogojan@noorderhart.be
- Site Name
- Algemeen Ziekenhuis Delta
- Department Name
- Neurology
- Contact Person Name
- Maarten Buyle
- Contact Person Email
- maarten.buyle@azdelta.be
- Site Name
- Universitair Ziekenhuis Antwerpen
- Department Name
- Neurology
- Contact Person Name
- Barbara Willekens
- Contact Person Email
- barbara.willekens@uza.be
Sweden
- Earliest CTIS Part Ii Submission Date
- 19-02-2025
- Latest Decision Or Authorization Date
- 22-04-2026
- Processing Time Days
- 427
- Number Of Sites
- 2
- Number Of Participants
- 9
Sites
- Site Name
- Sahlgrenska University Hospital-Vaestra Goetalandsregionen
- Department Name
- MS Centrum Forskningsenhet
- Contact Person Name
- Lenka Nováková Nyrén
- Contact Person Email
- forskningsenheten.mscentrum.sinnen.ostra.su@vgregion.se
- Site Name
- Karolinska University Hospital
- Department Name
- ME Neurologi
- Contact Person Name
- Katharina Fink
- Contact Person Email
- Katharina.fink@regionstockholm.se
Czechia
- Earliest CTIS Part Ii Submission Date
- 28-02-2025
- Latest Decision Or Authorization Date
- 07-05-2026
- Processing Time Days
- 433
- Number Of Sites
- 5
- Number Of Participants
- 16
Sites
- Site Name
- Fakultni Nemocnice U Sv Anny V Brne
- Department Name
- I. neurologicka klinika
- Contact Person Name
- Michal Dufek
- Contact Person Email
- michal.dufek@fnusa.cz
- Site Name
- Fakultni Nemocnice Hradec Kralove
- Department Name
- Neurologicka klinika
- Contact Person Name
- Zbyšek Pavelek
- Contact Person Email
- zbysek.pavelek@fnhk.cz
- Site Name
- Krajska zdravotni a.s.
- Department Name
- MS centrum pri neurologickem oddeleni
- Contact Person Name
- Marta Vachová
- Contact Person Email
- marta.vachova@kzcr.eu
- Site Name
- Neurologie Rs Centrum s.r.o.
- Department Name
- Nestatni zdravotnicke zarizeni, Privatni ordinace neurologie
- Contact Person Name
- Radomír Taláb
- Contact Person Email
- radomir.talab@gmail.com
- Site Name
- Nemocnice Jihlava prispevkova organizace
- Department Name
- Neurologicke oddeleni
- Contact Person Name
- Radek Ampapa
- Contact Person Email
- ampapar@gmail.com
Spain
- Earliest CTIS Part Ii Submission Date
- 20-02-2025
- Latest Decision Or Authorization Date
- 22-04-2026
- Processing Time Days
- 426
- Number Of Sites
- 13
- Number Of Participants
- 32
Sites
- Site Name
- Hospital Universitario Dr Peset Aleixandre
- Department Name
- Neurology
- Contact Person Name
- Lamberto Landete Pascual
- Contact Person Email
- landete.investigacion@gmail.com
- Site Name
- Hospital General Universitario Gregorio Maranon
- Department Name
- Neurology
- Contact Person Name
- Maria Luisa Martinez Gines
- Contact Person Email
- marisamgines@hotmail.com
- Site Name
- Hospital Universitario De Torrejon
- Department Name
- Neurology
- Contact Person Name
- Luis Ignacio Casanova Peño
- Contact Person Email
- licasanova@torrejonsalud.com
- Site Name
- Hospital Universitario Y Politecnico La Fe
- Department Name
- Neurology
- Contact Person Name
- Francisco Carlos Perez Miralles
- Contact Person Email
- perez_fca@gva.es
- Site Name
- Hospital Santa Caterina Ias
- Department Name
- Neurology
- Contact Person Name
- Gary Álvarez Bravo
- Contact Person Email
- galvarez@idibgi.org
- Site Name
- Hospital Alvaro Cunqueiro
- Department Name
- Neurology
- Contact Person Name
- Ines Gonzalez-Suarez
- Contact Person Email
- igonsua@gmail.com
- Site Name
- Hospital Vithas Parque San Antonio
- Department Name
- Neurology
- Contact Person Name
- Nicolas Lundahi Ciano Petersen
- Contact Person Email
- nico.edss.neuro@gmail.com
- Site Name
- Hospital De Denia
- Department Name
- Servicio de Neurología
- Contact Person Name
- Alexandre Garcia Escriva
- Contact Person Email
- agarescriva@gmail.com
- Site Name
- Hospital Universitario Virgen De La Macarena
- Department Name
- Neurology
- Contact Person Name
- Sara Eichau Maueno
- Contact Person Email
- saraeichau@hotmail.com
- Site Name
- Hospital Clinic De Barcelona
- Department Name
- Neurology
- Contact Person Name
- Yolanda Blanco Morgado
- Contact Person Email
- yblanco@clinic.cat
- Site Name
- Hospital Universitario Regional De Malaga
- Department Name
- Neurology
- Contact Person Name
- Ana Alonso Torres
- Contact Person Email
- a.alonso.eecc@gmail.com
- Site Name
- Hospital Universitario Fundacion Alcorcon
- Department Name
- Neurology
- Contact Person Name
- Laura Borrega Canelo
- Contact Person Email
- laura.borrega@salud.madrid.org
- Site Name
- Hospital Nisa Sevilla Aljarafe
- Department Name
- Neurology
- Contact Person Name
- Maria Dolores Paramo Camino
- Contact Person Email
- draparamo@gmail.com
Poland
- Earliest CTIS Part Ii Submission Date
- 05-03-2025
- Latest Decision Or Authorization Date
- 24-04-2026
- Processing Time Days
- 415
- Number Of Sites
- 14
- Number Of Participants
- 150
Sites
- Site Name
- Neuro-Medic Sp. z o.o.
- Department Name
- Neuro-Medic Poradnia Wielospecjalistyczna
- Contact Person Name
- Janusz Zbrojkiewicz
- Contact Person Email
- neuromedic@op.pl
- Site Name
- Krakowska Akademia Neurologii Sp. z o.o.
- Department Name
- Centrum Neurologii Klinicznej
- Contact Person Name
- Andrzej Szczudlik
- Contact Person Email
- karolina.tomala@neurologia.org.pl
- Site Name
- Vitamed Galaj I Cichomski Sp. j.
- Department Name
- NA/ND
- Contact Person Name
- Paweł Lisewski
- Contact Person Email
- r.cichomski@wp.pl
- Site Name
- Ilkowski I Partnerzy sp.p. Lekarzy
- Department Name
- NZOZ NEURO-KARD Ilkowski i Partnerzy Spolka Partnerska Lekarzy
- Contact Person Name
- Jan Ilkowski
- Contact Person Email
- biuro@neurokard.pl
- Site Name
- Niepubliczny Zaklad Opieki Zdrowotnej Neuromed M. I M. Nastaj. sp.p.
- Department Name
- NA/ND
- Contact Person Name
- Marcin Nastaj
- Contact Person Email
- marcinnastaj@gmail.com
- Site Name
- Mtz Clinical Research Powered By Pratia
- Department Name
- NA/ND
- Contact Person Name
- Małgorzata Zajda
- Contact Person Email
- info@pratia.com
- Site Name
- Neurocentrum Bydgoszcz Sp. z o.o.
- Department Name
- NA / ND
- Contact Person Name
- Robert Bonek
- Contact Person Email
- r.bonek@ncbydgoszcz.pl
- Site Name
- Neurologiczny NZOZ Centrum Leczenia SM Osrodek Badan Klinicznych im. dr n. med. Hanki Hertmanowskiej
- Department Name
- NA/ND
- Contact Person Name
- Adriana Chelminiak
- Contact Person Email
- neurologiczny.nzoz@gmail.com
- Site Name
- Centrum Neurologii Krzysztof Selmaj
- Department Name
- NA/ND
- Contact Person Name
- Krzysztof Selmaj
- Contact Person Email
- centrum.neurologii.k.selmaj@gmail.com
- Site Name
- Centrum Medyczne Neuroprotect
- Department Name
- NA/ND
- Contact Person Name
- Anna Karlinska
- Contact Person Email
- marta.biel@neuroprotect.pl
- Site Name
- Samodzielny Publiczny Zaklad Opieki Zdrowotnej Szpital Uniwersytecki W Krakowie
- Department Name
- SU w Krakowie, Zespol Poradni Specjalistycznych - Botaniczna 3, Poradnia Neurologiczna
- Contact Person Name
- Agnieszka Slowik
- Contact Person Email
- neurologiabk@su.krakow.pl
- Site Name
- Neuro-Care Sp. z o.o. sp.k.
- Department Name
- NA/ND
- Contact Person Name
- Gabriela Klodowska
- Contact Person Email
- neuro-care@neuro-care.pl
- Site Name
- Resmedica Sp. z o.o.
- Department Name
- Resmedica
- Contact Person Name
- Elzbieta Jasinska
- Contact Person Email
- ejasinska6@gmail.com
- Site Name
- Ma-Lek Clinical Sp. z o.o.
- Department Name
- Centrum Terapii SM
- Contact Person Name
- Maciej Maciejowski
- Contact Person Email
- m.m@ctsm.pl
Slovakia
- Earliest CTIS Part Ii Submission Date
- 29-01-2025
- Latest Decision Or Authorization Date
- 20-04-2026
- Processing Time Days
- 446
- Number Of Sites
- 3
- Number Of Participants
- 9
Sites
- Site Name
- University Hospital Bratislava
- Department Name
- Neurologická klinika SZU Nemocnica Ružinov Ružinovská 6 826 06 Bratislava
- Contact Person Name
- Viera Hančinová
- Contact Person Email
- hancinova@pobox.sk
- Site Name
- EMPATHY s. r. o.
- Department Name
- Neurologická ambulancia EMPATHY s. r. o. Švabinského 17 85101 Bratislava
- Contact Person Name
- Soňa Feketová
- Contact Person Email
- empathy@gmail.com
- Site Name
- Fakultna Nemocnica Trnava
- Department Name
- Neurologická klinika
- Contact Person Name
- Georgi Krastev
- Contact Person Email
- georgi.krastev@fntt.sk
Denmark
- Earliest CTIS Part Ii Submission Date
- 17-02-2025
- Latest Decision Or Authorization Date
- 20-04-2026
- Processing Time Days
- 427
- Number Of Sites
- 3
- Number Of Participants
- 11
Sites
- Site Name
- Esbjerg Og Grindsted Sygehus
- Department Name
- Danish Multiple Sclerosis Center
- Contact Person Name
- Tobias Sejbaek
- Contact Person Email
- tobias.sejbaek@rsyd.dk
- Site Name
- Aarhus University Hospital
- Department Name
- Department of Neurology
- Contact Person Name
- Kristina Svendsen
- Contact Person Email
- krissven@rm.dk
- Site Name
- Rigshospitalet
- Department Name
- Danish Multiple Sclerosis Center
- Contact Person Name
- Finn Sellebjerg
- Contact Person Email
- finn.sellebjerg@regionh.dk
Romania
- Earliest CTIS Part Ii Submission Date
- 06-01-2026
- Latest Decision Or Authorization Date
- 27-04-2026
- Processing Time Days
- 111
- Number Of Sites
- 4
- Number Of Participants
- 5
Sites
- Site Name
- Spitalul Clinic Judetean De Urgenta Cluj
- Department Name
- Neurologie
- Contact Person Name
- Vitalie Vacaras
- Contact Person Email
- Vitalie.vacaras.ext@arensia-em.com
- Site Name
- Arensia Clinics S.R.L.
- Department Name
- Neurologie
- Contact Person Name
- Adina Maria Roceanu
- Contact Person Email
- adina.roceanu@arensia-em.com
- Site Name
- Spitalul Clinic Cai Ferate Constanta
- Department Name
- Neurologie
- Contact Person Name
- Ana Maria Ionescu
- Contact Person Email
- spunivcf_cta@yahoo.com
- Site Name
- Brainaxy Clinic S.R.L.
- Department Name
- Neurologie
- Contact Person Name
- Any Axelerad
- Contact Person Email
- brainaxy_neurofeedback@yahoo.com
Italy
- Earliest CTIS Part Ii Submission Date
- 14-02-2025
- Latest Decision Or Authorization Date
- 20-04-2026
- Processing Time Days
- 430
- Number Of Sites
- 9
- Number Of Participants
- 28
Sites
- Site Name
- Careggi University Hospital
- Department Name
- SOD Neurologia II
- Contact Person Name
- Alice Mariottini
- Contact Person Email
- alice.mariottini@unifi.it
- Site Name
- Azienda Ospedaliera Universitaria Senese
- Department Name
- UOC Clinica Neurologica e Malattie Neurometaboliche
- Contact Person Name
- Nicola De Stefano
- Contact Person Email
- destefano@unisi.it
- Site Name
- Azienda Ospedaliera Universitaria Universita' Degli Studi Della Campania Luigi Vanvitelli
- Department Name
- Clinica Neurologica,Dip.to Scienze Mediche e Chirurgiche Avanzate
- Contact Person Name
- Antonio Gallo
- Contact Person Email
- antonio.gallo@unicampania.it
- Site Name
- Fondazione Istituto G. Giglio Di Cafalu
- Department Name
- Division of Neurology
- Contact Person Name
- Luigi Maria Grimaldi
- Contact Person Email
- luigi.grimaldi@hsrgiglio.it
- Site Name
- Azienda Ospedaliera Policlinico Universitario Tor Vergata
- Department Name
- UOSD Multiple Sclerosis Clinical and Research Center
- Contact Person Name
- Girolama Alessandra Marfia
- Contact Person Email
- marfia@uniroma2.it
- Site Name
- Azienda Unita Sanitaria Locale Di Bologna
- Department Name
- UO Riabilitazione Sclerosi Multipla
- Contact Person Name
- Francesco Ventruto
- Contact Person Email
- francesco.ventruto@ausl.bologna.it
- Site Name
- Azienda Ospedaliero-Universitaria Sant Andre
- Department Name
- Neurologia Azienda Ospedaliero-Universitaria Sant Andrea
- Contact Person Name
- Marco Salvetti
- Contact Person Email
- marco.salvetti@uniroma1.it
- Site Name
- Azienda Ospedaliero-Universitaria Policlinico G. Rodolico-San Marco Di Catania
- Department Name
- Centro Sclerosi Multipla – Ambulatorio di Neuroriabilitazione
- Contact Person Name
- Francesco Patti
- Contact Person Email
- patti@unict.it
- Site Name
- Casa Di Cura Igea S.p.A.
- Department Name
- Dipartimento di Riabilitazione Igea
- Contact Person Name
- Annunziata Maria Letizia Leocani
- Contact Person Email
- l.leocani@casadicuraigea.it
Germany
- Earliest CTIS Part Ii Submission Date
- 26-02-2025
- Latest Decision Or Authorization Date
- 21-04-2026
- Processing Time Days
- 419
- Number Of Sites
- 13
- Number Of Participants
- 41
Sites
- Site Name
- Universitaetsklinikum Heidelberg AöR
- Department Name
- Department of Neurology
- Contact Person Name
- Klemens Ruprecht
- Contact Person Email
- klemens.ruprecht@med.uni-heidelberg.de
- Site Name
- Gemeinschaftpraxis Dres. Med Blersch/Redelstein
- Department Name
- Centre for Neurology
- Contact Person Name
- Wendelin Blersch
- Contact Person Email
- praxis@neuroamdom.de
- Site Name
- MultipEL Studies
- Department Name
- Institut für klinische Studien GbR
- Contact Person Name
- Birte Elias-Hamp
- Contact Person Email
- birte.eliashamp@neuropraxis-elias.de
- Site Name
- Klinische Forschung Hamburg GmbH
- Department Name
- Center for Neurology
- Contact Person Name
- Christian Deckert
- Contact Person Email
- christian.deckert@pratia.com
- Site Name
- Universitaetsklinikum Giessen und Marburg GmbH
- Department Name
- Neurology
- Contact Person Name
- Steffen Pfeuffer
- Contact Person Email
- Steffen.Pfeuffer@neuro.med.uni-giessen.de
- Site Name
- Universitaetsklinikum Essen AöR
- Department Name
- Clinic for Neurology
- Contact Person Name
- Refik Pul
- Contact Person Email
- refik.pul@uk-essen.de
- Site Name
- Universitaetsklinikum Carl Gustav Carus Dresden an der Technischen Universitaet Dresden AöR
- Department Name
- Department of Neurology MS Center
- Contact Person Name
- Tjalf Ziemssen
- Contact Person Email
- tjalf.ziemssen@uniklinikum-dresden.de
- Site Name
- ZNS GmbH Zentrum fuer Neuro-Psychiatrische Studien Gutachten und medizinische Fortbildung Siegen
- Department Name
- Department of Neurology
- Contact Person Name
- Eugen Schlegel
- Contact Person Email
- schlegel@zns-siegen.de
- Site Name
- Neuropraxis Muenchen Sued
- Department Name
- Department of Neurology
- Contact Person Name
- Klaus Lehmann-Horn
- Contact Person Email
- lehmann-horn@neuropraxis-muenchen.de
- Site Name
- Universitaetsklinikum Leipzig AöR
- Department Name
- Department of Neurology
- Contact Person Name
- Florian Then Bergh
- Contact Person Email
- florian.thenbergh@medizin.uni-leipzig.de
- Site Name
- Studienzentrum Dr. Bischof GmbH
- Department Name
- Department of Neurology
- Contact Person Name
- Felix Bischof
- Contact Person Email
- felix.bischof@me.com
- Site Name
- Zentrum fuer klinische Forschung Dr. I. Schoell GmbH
- Department Name
- Centre for Neurology
- Contact Person Name
- Elvira Steidl
- Contact Person Email
- info@forschung-badhomburg.de
- Site Name
- curiositas ad sanum Studien und Beratungs GmbH
- Department Name
- Centre for Neurology
- Contact Person Name
- Johannes Schwarz
- Contact Person Email
- j.schwarz@curiositas-ad-sanum.de
Lithuania
- Earliest CTIS Part Ii Submission Date
- 17-02-2025
- Latest Decision Or Authorization Date
- 21-04-2026
- Processing Time Days
- 428
- Number Of Sites
- 2
- Number Of Participants
- 11
Sites
- Site Name
- Klaipedos universiteto ligonine VšĮ
- Department Name
- Neurology center
- Contact Person Name
- Lina Malciene
- Contact Person Email
- lina.malciene@kulig.lt
- Site Name
- Lietuvos sveikatos mokslu universiteto ligonine Kauno klinikos
- Department Name
- Neurology department
- Contact Person Name
- Renata Balnyte
- Contact Person Email
- renata.balnyte@lsmu.lt
France
- Earliest CTIS Part Ii Submission Date
- 03-03-2025
- Latest Decision Or Authorization Date
- 23-04-2026
- Processing Time Days
- 416
- Number Of Sites
- 2
- Number Of Participants
- 9
Sites
- Site Name
- Centre Hospitalier Universitaire Reims
- Department Name
- Service de Neurologie
- Contact Person Name
- Maximilien MOULIN
- Contact Person Email
- mmoulin@chu-reims.fr
- Site Name
- Centre Hospitalier Universitaire De Nimes
- Department Name
- Service Neurologie
- Contact Person Name
- Eric Thouvenot
- Contact Person Email
- eric.thouvenot@chu-nimes.fr
Sponsor
Primary sponsor
- Full Name
- Amgen Inc.
- Organisation Type
- Pharmaceutical company
- Country Of Registered Address
- United States
Contract research organisations
- Name
- ICON Clinical Research Limited
- Name
- ICON Clinical Research Limited Ireland Filial
- Responsibilities
- On site monitoring for Denmark only
- Name
- Icon Development Solutions LLC
Third parties
- {"country":"United States","full_name":"Azenta US Inc.","duties_or_roles":"Sample Storage for back-up samples","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Bioagilytix Labs LLC","duties_or_roles":"assay of ADA samples","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Advarra Inc.","duties_or_roles":"Central IRB (US/Canada)","organisation_type":"Non-Pharmaceutical company"}
- {"country":"United States","full_name":"Almac Clinical Services LLC","duties_or_roles":"Investigational product packaging, labeling and distribution","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Meeting Protocol Worldwide LP","duties_or_roles":"Patient Stipend","organisation_type":"Pharmaceutical company"}
- {"country":"Sweden","full_name":"ICON Clinical Research Limited Ireland Filial","duties_or_roles":"On site monitoring for Denmark only","organisation_type":"Pharmaceutical company"}
- {"country":"Ireland","full_name":"Icon Clinical Research Limited","duties_or_roles":"","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Icon Development Solutions LLC","duties_or_roles":"","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Trulab Inc.","duties_or_roles":"Sample management and Tracking","organisation_type":"Pharmaceutical company"}
- {"country":"Ireland","full_name":"Accellacare Limited","duties_or_roles":"In-home healthcare services to collect PK and ADA samples","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Medidata Solutions Inc.","duties_or_roles":"","organisation_type":"Non-Pharmaceutical company"}
- {"country":"United States","full_name":"Arup Laboratories Inc.","duties_or_roles":"Teriflunomide test laboratory","organisation_type":"Laboratory/Research/Testing facility"}
- {"country":"Germany","full_name":"CSI Clinical Services International GmbH","duties_or_roles":"","organisation_type":"Pharmaceutical company"}
Investigational products
- Investigational Product Name
- ABP 692
- Active Substance
- Ocrelizumab
- Modality
- Monoclonal antibody
- Routes Of Administration
- Intravenous infusion
- Route
- Intravenous infusion
- Authorisation Status
- Not authorised (investigational product; prodAuthStatus: 1)
- Investigational Product Name
- Ocrevus 300 mg concentrate for solution for infusion
- Active Substance
- Ocrelizumab
- Modality
- Monoclonal antibody
- Routes Of Administration
- Intravenous infusion
- Route
- Intravenous infusion
- Authorisation Status
- Authorised (marketing authorisation present; prodAuthStatus: 2)
- Starting Dose
- 300 mg (product name indicates 300 mg concentrate for solution for infusion)
Related trials
Other published trials that may interest you.