Clinical trial • Phase III • Neurology
OCRELIZUMAB for Primary progressive multiple sclerosis
Phase III trial of OCRELIZUMAB for Primary progressive multiple sclerosis.
Overview
- Trial Therapeutic Area
- Neurology
- Trial Disease
- Primary progressive multiple sclerosis
- Trial Stage
- Phase III
- Drug Modality
- Monoclonal antibody
Key dates
- Initial CTIS Submission Date
- 18-12-2023
- First CTIS Authorization Date
- 08-02-2024
Trial design
Randomised, placebo ocrelizumab (placebo) and approved dose of ocrelizumab (ocrevus 300 mg concentrate for solution for infusion); investigational arm is a higher dose of ocrelizumab. specific dosing and schedule not specified in provided data.-controlled Phase III trial in Greece, Hungary, Italy and others.
- Randomised
- Yes
- Comparator
- Placebo Ocrelizumab (placebo) and approved dose of ocrelizumab (Ocrevus 300 mg concentrate for solution for infusion); investigational arm is a higher dose of ocrelizumab. Specific dosing and schedule not specified in provided data.
- Target Sample Size
- 459
- Trial Duration For Participant
- 1344
Eligibility
Recruits 459 adults.
Inclusion criteria
- {"criterion_text":"- 1. Ages 18-55 years at time of screening"}
- {"criterion_text":"- 2. Diagnosis of PPMS, in accordance with the revised McDonald criteria 2017"}
- {"criterion_text":"- 3. Expanded disability status scale (EDSS) score at screening and baseline 3- 6.5, inclusive"}
- {"criterion_text":"- 4. Score of ≥ 2.0 on the Functional Systems (FS) scale for the pyramidal system that was due to lower extremity findings at screening and baseline"}
- {"criterion_text":"- 5. Documented MRI of brain with abnormalities consistent with MS"}
- {"criterion_text":"- 6. Patients must be neurologically stable for at least 30 days prior to randomization and baseline assessments"}
Exclusion criteria
- {"criterion_text":"- 1. History of relapsing remitting or secondary progressive MS at screening"}
- {"criterion_text":"- 2. Any known or suspected active infection at screening or baseline, or any major episode of infection requiring hospitalization or treatment with IV anti microbials within 8 weeks prior to and during screening or treatment with oral anti microbials within 2 weeks prior to and during screening"}
- {"criterion_text":"- 3. History of cancer, including hematologic malignancy and solid tumors, within 10 years of screening"}
- {"criterion_text":"- 4. Immunocompromised state"}
- {"criterion_text":"- 5. Known presence of other neurologic disorders that could interfere with the diagnosis of MS or assessments of efficacy and/or safety during the study"}
- {"criterion_text":"- 6. History of confirmed or suspected progressive multifocal leukoencephalopathy (PML)"}
Endpoints
Primary endpoints
- {"endpoint_text":"- 1. Time to onset of cCDP sustained for at least 12 weeks. Time to onset of cCDP is defined as the first occurrence of a predefined confirmed progression event measured by EDSS, T25FWT or 9-HPT","definition_or_measurement_approach":"Time to onset of cCDP sustained for at least 12 weeks; defined as the first occurrence of a predefined confirmed progression event measured by EDSS, T25FWT or 9-HPT"}
Secondary endpoints
- {"endpoint_text":"- 1. Time to onset of 24 week cCDP (cCDP24)","definition_or_measurement_approach":""}
- {"endpoint_text":"- 2. Time to onset of cCDP12 independent of protocol-defined relapses (PDR), also termed progression independent of relapse activity (PIRA) as per Kappos et al.2020","definition_or_measurement_approach":""}
- {"endpoint_text":"- 3. Time to onset of 12-week CDP (CDP12)","definition_or_measurement_approach":""}
- {"endpoint_text":"- 4. Time to ≥ 20% increase in 12 week confirmed T25FWT","definition_or_measurement_approach":""}
- {"endpoint_text":"- 5. Annual rate of percent change from baseline in total brain volume","definition_or_measurement_approach":""}
- {"endpoint_text":"- 6. Annual rate of percent change from baseline in thalamic volume","definition_or_measurement_approach":""}
- {"endpoint_text":"- 7. Time to 12-week confirmed 4-point worsening in Symbol Digit Modalities Test (SDMT)","definition_or_measurement_approach":""}
- {"endpoint_text":"- 8. Change in NfL (i.e. ratio to baseline) at Week 96","definition_or_measurement_approach":""}
- {"endpoint_text":"- 9.Time to 12-week confirmed 8-point increase in 12-Item Multiple Sclerosis Walking Scale (MSWS12)","definition_or_measurement_approach":""}
- {"endpoint_text":"- 10. Change in NfL (i.e. ratio to baseline) at Week 96 for patients in the higher dose ocrelizumab group","definition_or_measurement_approach":""}
- {"endpoint_text":"- 11. Change in NfL (i.e. ratio to baseline) at Week 96 for patients in the approved dose ocrelizumab group","definition_or_measurement_approach":""}
- {"endpoint_text":"- 12. Incidence and severity of adverse events, with severity determined according to the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) Version 5.0","definition_or_measurement_approach":"Severity determined according to NCI CTCAE Version 5.0"}
- {"endpoint_text":"- 13. Change from baseline in clinical laboratory test results (including hematology, chemistry, and Ig levels)","definition_or_measurement_approach":""}
- {"endpoint_text":"- 14. Change from baseline in vital signs (including systolic and diastolic blood pressure, and pulse rate) following study treatment administration","definition_or_measurement_approach":""}
- {"endpoint_text":"- 15. Serum concentration of ocrelizumab at specified timepoints","definition_or_measurement_approach":""}
- {"endpoint_text":"- 16. B-cell levels in blood (including comparing the degree of B-cell depletion between the doses)","definition_or_measurement_approach":""}
- {"endpoint_text":"- 17. Proportion of participants achieving 5 or less B-cells per microliter of blood","definition_or_measurement_approach":""}
- {"endpoint_text":"- 18. Proportion of participants achieving 5 or less B-cells per microliter of blood in participants with the high versus low affinity Fcgamma Receptor 3A (FcγR3A) genotype per arm","definition_or_measurement_approach":""}
- {"endpoint_text":"- 19. Change from Baseline in the anti-drug antibodies (ADAs) levels","definition_or_measurement_approach":""}
- {"endpoint_text":"- 20. Levels of Neurofilament Light Chain (NfL) in blood","definition_or_measurement_approach":""}
- {"endpoint_text":"- 21. Levels of Interleukin-6 (IL-6) in blood","definition_or_measurement_approach":""}
- {"endpoint_text":"- 22. Levels of blood B-cells","definition_or_measurement_approach":""}
- {"endpoint_text":"- 23. Levels of Lymphocytes in blood","definition_or_measurement_approach":""}
- {"endpoint_text":"- 24. Proportion of participants with different DNA genotypes","definition_or_measurement_approach":""}
Recruitment
- Planned Sample Size
- 459
- Recruitment Window Months
- 103
- Consent Approach
- Informed consent is obtained from participants (adults). Multiple subject information and informed consent forms (ICFs) and localized versions are provided (examples in English, Greek, Bulgarian, Spanish, Portuguese, Hungarian, French, Polish, Italian, German, Dutch among others). Optional/ancillary consents are available for CSF biomarker substudy, open-label extension (OLE), MRI, genetic substudies, infant health questionnaire and other optional procedures as evidenced by multiple ICF documents titled for these optional components. Participants are adults (18-55) and consent is provided by the participant; no assent procedures for minors are specified.
Geography
- Total Number Of Sites
- 57
- Total Number Of Participants
- 310
Greece
- Latest Decision Or Authorization Date
- 27-03-2026
- Number Of Sites
- 2
- Number Of Participants
- 6
Sites
- Site Name
- 401 General Military Hospital Of Athens
- Department Name
- Neurology Clinic
- Contact Person Name
- Nikolaos Fakas
- Contact Person Email
- drfakas@yahoo.gr
- Site Name
- Eginitio Hospital
- Department Name
- A’ Neurology Clinic
- Contact Person Name
- Leonidas Stefanis
- Contact Person Email
- lstefanis@bioacademy.gr
Hungary
- Latest Decision Or Authorization Date
- 25-03-2026
- Number Of Sites
- 5
- Number Of Participants
- 13
Sites
- Site Name
- Gyor-Moson-Sopron Varmegyei Petz Aladar Egyetemi Oktato Korhaz
- Department Name
- Neurologiai Osztaly Stroke Reszleg
- Contact Person Name
- Attila Csanyi
- Contact Person Email
- csanyia@petz.gyor.hu
- Site Name
- Uno Medical Trials Kft.
- Department Name
- Neurologia
- Contact Person Name
- Krisztina Kovacs
- Contact Person Email
- kovacs.krisztina@otvkft.hu
- Site Name
- Somogy Varmegyei Kaposi Mor Oktato Korhaz
- Department Name
- Neurologiai Osztaly
- Contact Person Name
- Istvan Dema
- Contact Person Email
- deme.istvan@kmmk.hu
- Site Name
- Orszagos Mentalis Ideggyogyaszati Es Idegsebeszeti Intezet
- Department Name
- Neurologiai Osztaly
- Contact Person Name
- Adrienne Jori Birkas
- Contact Person Email
- dradricamino@yahoo.com
- Site Name
- Pest Megyei Flor Ferenc Korhaz
- Department Name
- Neurologia és Stroke Osztaly
- Contact Person Name
- Zita Biro
- Contact Person Email
- birozitamaria@gmail.com
Italy
- Latest Decision Or Authorization Date
- 27-03-2026
- Number Of Sites
- 7
- Number Of Participants
- 20
Sites
- Site Name
- Azienda Socio Sanitaria Territoriale Della Valle Olona
- Department Name
- Neurologia 2 – Sclerosi Multipla e Recupero Neurologico
- Contact Person Name
- Pietro Annovazzi
- Contact Person Email
- pietro.annovazzi@asst-valleolona.it
- Site Name
- Azienda Ospedaliera Universitaria Federico II Di Napoli
- Department Name
- Dipartimento Neuroscienze, Scienze Riproduttive ed Odontostomatologiche
- Contact Person Name
- Vincenzo Brescia Morra
- Contact Person Email
- vincenzo.bresciamorra2@unina.it
- Site Name
- Ospedale San Raffaele S.r.l.
- Department Name
- Unità Operativa di Neurologia
- Contact Person Name
- Massimo Filippi
- Contact Person Email
- filippi.massimo@hsr.it
- Site Name
- Azienda Ospedaliera Universitaria Citta' Della Salute E Della Scienza Di Torino
- Department Name
- S.C. Neurologia 1
- Contact Person Name
- Paola Cavalla
- Contact Person Email
- paola.cavalla@unito.it
- Site Name
- Neurological Institute Foundation Casimiro Mondino
- Department Name
- Dipartimento Neurologia Neuroriabilitazione S.S. Sclerosi Multipla
- Contact Person Name
- Roberto Bergamaschi
- Contact Person Email
- roberto.bergamaschi@mondino.it
- Site Name
- Azienda Ospedaliera Universitaria Universita' Degli Studi Della Campania Luigi Vanvitelli
- Department Name
- I Clinica Neurologica
- Contact Person Name
- Antonio Gallo
- Contact Person Email
- antonio.gallo@unicampania.it
- Site Name
- Azienda Ospedaliero-Universitaria Sant Andre
- Department Name
- UOC Neurologia
- Contact Person Name
- Marco Salvetti
- Contact Person Email
- marco.salvetti@uniroma1.it
Spain
- Latest Decision Or Authorization Date
- 11-05-2026
- Number Of Sites
- 4
- Number Of Participants
- 25
Sites
- Site Name
- Hospital Universitari Vall D Hebron
- Department Name
- Neurologia
- Contact Person Name
- Mar Tintoré Subirana
- Contact Person Email
- mtintore@cem-cat.org
- Site Name
- Hospital Universitario Quironsalud Madrid
- Department Name
- Neurologia
- Contact Person Name
- Rafael Arroyo
- Contact Person Email
- rafaelarroyo09@gmail.com
- Site Name
- University Clinical Hospital Virgen De La Arrixaca
- Department Name
- Neurologia
- Contact Person Name
- José Meca Lallana
- Contact Person Email
- jose.meca@carm.es
- Site Name
- Hospital Universitario Puerta De Hierro De Majadahonda
- Department Name
- Neurologia
- Contact Person Name
- Maria Rosario Blasco Quilez
- Contact Person Email
- charoblascoquilez@yahoo.es
France
- Latest Decision Or Authorization Date
- 25-03-2026
- Number Of Sites
- 7
- Number Of Participants
- 24
Sites
- Site Name
- CHRU De Nancy
- Department Name
- Neurology
- Contact Person Name
- Guillaume Mathey
- Contact Person Email
- g.mathey@chru-nancy.fr
- Site Name
- Centre Hospitalier Regional Et Universitaire De Brest
- Department Name
- Neurology
- Contact Person Name
- Aurore Jourdain
- Contact Person Email
- Aurore.jourdain@chu-brest.fr
- Site Name
- Les Hopitaux Universitaires De Strasbourg
- Department Name
- Neurology
- Contact Person Name
- Jérome De Seze
- Contact Person Email
- jerome.deseze@chru-strasbourg.fr
- Site Name
- Besancon University Hospital Center
- Department Name
- Neurology
- Contact Person Name
- Eric Berger
- Contact Person Email
- ccappe@chu-besancon.fr
- Site Name
- Groupement Des Hopitaux De L'Institut Catholique De Lille
- Department Name
- Neurology
- Contact Person Name
- Arnaud kwi atkowski
- Contact Person Email
- kwiatkowski.arnaud@ghicl.net
- Site Name
- Centre Hospitalier Universitaire De Caen Normandie
- Department Name
- Neurology
- Contact Person Name
- Pierre Branger
- Contact Person Email
- branger-p@chu-caen.fr
- Site Name
- CHU Gabriel-Montpied
- Department Name
- Neurology
- Contact Person Name
- Pierre Clavelou
- Contact Person Email
- pclavelou@chu-clermontferrand.fr
Bulgaria
- Latest Decision Or Authorization Date
- 27-03-2026
- Number Of Sites
- 2
- Number Of Participants
- 13
Sites
- Site Name
- Multiprofile Hospital For Active Treatment In Neurology And Psychiatry St. Naum EAD
- Department Name
- Department of Movement Disorders, Multiple Sclerosis
- Contact Person Name
- Ivan Milanov
- Contact Person Email
- ubalnp@yahoo.com
- Site Name
- University Multiprofile Hospital For Active Treatment Dr. Georgi Stranski EAD
- Department Name
- Neurology Clinic
- Contact Person Name
- Maya Danovska-Mladenova
- Contact Person Email
- mdanovska@yahoo.com
Belgium
- Latest Decision Or Authorization Date
- 25-03-2026
- Number Of Sites
- 1
- Number Of Participants
- 3
Sites
- Site Name
- Noorderhart
- Department Name
- Revalidatie en MS Centrum
- Contact Person Name
- Veronica Popescu
- Contact Person Email
- veronica.popescu@noorderhart.be
Portugal
- Latest Decision Or Authorization Date
- 26-03-2026
- Number Of Sites
- 4
- Number Of Participants
- 11
Sites
- Site Name
- Centro Hospitalar De Lisboa Ocidental E.P.E.
- Department Name
- Serviço de Neurologia
- Contact Person Name
- Manuel Salavisa
- Contact Person Email
- mtteixeira@chlo.min-saude.pt
- Site Name
- CCAB Centro Clinico Academico Braga Associacao
- Department Name
- Unidade de Investigação Clínica
- Contact Person Name
- João Cerqueira
- Contact Person Email
- jcerqueira@ecsaude.uminho.pt
- Site Name
- Centro Hospitalar Universitario Lisboa Central E.P.E.
- Department Name
- Serviço de Neurologia
- Contact Person Name
- João Sequeira
- Contact Person Email
- joaospsequeira@gmail.com
- Site Name
- Centro Hospitalar Universitario De Santo Antonio E.P.E.
- Department Name
- Serviço Neurologia/Departament Neurociências
- Contact Person Name
- Raquel Samões
- Contact Person Email
- araquelfsamoes@hotmail.com
Denmark
- Latest Decision Or Authorization Date
- 21-04-2026
- Number Of Sites
- 2
- Number Of Participants
- 9
Sites
- Site Name
- Aalborg University Hospital
- Department Name
- Neurologisk Afdeling
- Contact Person Name
- Inga Urbonaviciute
- Contact Person Email
- i.urbonaviciute@rn.dk
- Site Name
- Rigshospitalet
- Department Name
- Neurologisk Klinik
- Contact Person Name
- Finn Sellebjerg
- Contact Person Email
- finn.thorup.sellebjerg@regionh.dk
Germany
- Latest Decision Or Authorization Date
- 25-03-2026
- Number Of Sites
- 9
- Number Of Participants
- 31
Sites
- Site Name
- Universitaetsklinikum Ulm AöR
- Department Name
- Neurology
- Contact Person Name
- Makbule Senel
- Contact Person Email
- makbule.senel@uni-ulm.de
- Site Name
- Medizinische Hochschule Hannover
- Department Name
- Neurology
- Contact Person Name
- Thomas Skripuletz
- Contact Person Email
- skripuletz.thomas@mh-hannover.de
- Site Name
- Universitaet Leipzig
- Department Name
- Neurology
- Contact Person Name
- Florian Then Bergh
- Contact Person Email
- florian.thenbergh@medizin.uni-leipzig.de
- Site Name
- Universitaetsmedizin Greifswald KöR
- Department Name
- Neurology
- Contact Person Name
- Matthias Grothe
- Contact Person Email
- matthias.grothe@uni-greifswald.de
- Site Name
- DKD HELIOS Klinik Wiesbaden GmbH
- Department Name
- Neurology
- Contact Person Name
- Ann-Sophie Lauenstein
- Contact Person Email
- ann-sophie.lauenstein@helios-gesundheit.de
- Site Name
- Universitaetsklinikum Carl Gustav Carus Dresden an der Technischen Universitaet Dresden AöR
- Department Name
- Zentrum für Klinische Neurowissenschaften
- Contact Person Name
- Tjalf Ziemssen
- Contact Person Email
- tjalf.ziemssen@uniklinikum-dresden.de
- Site Name
- Universitaet Muenster
- Department Name
- Neurology
- Contact Person Name
- Luisa Klotz
- Contact Person Email
- luisa.klotz@ukmuenster.de
- Site Name
- Universitaetsklinikum Tuebingen AöR
- Department Name
- Neurology
- Contact Person Name
- Markus Kowarik
- Contact Person Email
- markus.kowarik@med.uni-tuebingen.de
- Site Name
- Universitaetsklinikum Ulm AöR (additional/contact entry)
- Department Name
- Neurology
Poland
- Latest Decision Or Authorization Date
- 24-03-2026
- Number Of Sites
- 14
- Number Of Participants
- 155
Sites
- Site Name
- Instytut Psychiatrii I Neurologii
- Department Name
- II Klinika Neurologiczna
- Principal Investigator Name
- Iwona Kurkowska-Jastrzębska
- Principal Investigator Email
- neuro2@ipin.edu.pl
- Contact Person Name
- Iwona Kurkowska-Jastrzębska
- Contact Person Email
- neuro2@ipin.edu.pl
- Site Name
- Euromedis Sp. z o.o.
- Department Name
- Centrum Medyczne EUROMEDIS
- Principal Investigator Name
- Marcin Ratajczak
- Principal Investigator Email
- rejestracjabk@euromedis.pl
- Contact Person Name
- Marcin Ratajczak
- Contact Person Email
- rejestracjabk@euromedis.pl
- Site Name
- Copernicus Podmiot Leczniczy Sp. z o.o.
- Principal Investigator Name
- Waldemar Fryze
- Principal Investigator Email
- jlewandowska@wss.gda.pl
- Contact Person Name
- Waldemar Fryze
- Contact Person Email
- jlewandowska@wss.gda.pl
- Site Name
- Samodzielny Publiczny Zaklad Opieki Zdrowotnej Wojewodzki Szpital Specjalistyczny Nr 3 W Rybniku
- Department Name
- Oddział Neurologiczny z Pododdziałem Udarowym
- Principal Investigator Name
- Maciej Świat
- Principal Investigator Email
- sekretariat@szpital.rybnik.pl
- Contact Person Name
- Maciej Świat
- Contact Person Email
- sekretariat@szpital.rybnik.pl
- Site Name
- Instytut Zdrowia Dr Boczarska-Jedynak Sp. z o.o. S.K.
- Department Name
- KLINIKA NEUROLOGII I MEDYCYNY REGENERACYJNEJ
- Principal Investigator Name
- Magdalena Boczarska-Jedynak
- Principal Investigator Email
- info@instytutboczarska.pl
- Contact Person Name
- Magdalena Boczarska-Jedynak
- Contact Person Email
- info@instytutboczarska.pl
- Site Name
- Indywidualna Praktyka Lekarska Prof. dr hab. n. med. Konrad Rejdak
- Principal Investigator Name
- Konrad Rejdak
- Principal Investigator Email
- indywidualnapraktykakr@gmail.com
- Contact Person Name
- Konrad Rejdak
- Contact Person Email
- indywidualnapraktykakr@gmail.com
- Site Name
- Szpital Specjalistyczny Im. Ludwika Rydygiera W Krakowie Sp. z o.o.
- Department Name
- Oddział Neurologii i Udarów Mózgu z Pododdziałem Udarów Mózgu
- Principal Investigator Name
- Stanisław Rusek
- Principal Investigator Email
- badaniakliniczne@rydygierkrakow.pl
- Contact Person Name
- Stanisław Rusek
- Contact Person Email
- badaniakliniczne@rydygierkrakow.pl
- Site Name
- Ma-Lek Clinical Sp. z o.o.
- Principal Investigator Name
- Maciej Maciejowski
- Principal Investigator Email
- m.m@ctsm.pl
- Contact Person Name
- Maciej Maciejowski
- Contact Person Email
- m.m@ctsm.pl
- Site Name
- Centrum Medyczne Neuroprotect
- Principal Investigator Name
- Maciej Czarnecki
- Principal Investigator Email
- marta.biel@neuroprotect.pl
- Contact Person Name
- Maciej Czarnecki
- Contact Person Email
- marta.biel@neuroprotect.pl
- Site Name
- EMC Instytut Medyczny S.A.
- Principal Investigator Name
- Alicja Kalinowska-Łyszczarz
- Principal Investigator Email
- alicjakal@yahoo.com
- Contact Person Name
- Alicja Kalinowska-Łyszczarz
- Contact Person Email
- alicjakal@yahoo.com
- Site Name
- Nmedis Sp. z o.o.
- Principal Investigator Name
- Iwona Rościszewska-Żukowska
- Principal Investigator Email
- iwona.rosciszewska@op.pl
- Contact Person Name
- Iwona Rościszewska-Żukowska
- Contact Person Email
- iwona.rosciszewska@op.pl
- Site Name
- Neurocentrum Bydgoszcz Sp. z o.o.
- Principal Investigator Name
- Robert Bonek
- Principal Investigator Email
- rejestracja@ncbydgoszcz.pl
- Contact Person Name
- Robert Bonek
- Contact Person Email
- rejestracja@ncbydgoszcz.pl
- Site Name
- Neurologiczny NZOZ Centrum Leczenia SM Ośrodek Badań Klinicznych im. dr n. med. Hanki Hertmanowskiej
- Principal Investigator Name
- Justyna Hryniewicz
- Principal Investigator Email
- j.dhryniewicz@gmail.com
- Contact Person Name
- Justyna Hryniewicz
- Contact Person Email
- j.dhryniewicz@gmail.com
Sponsor
Primary sponsor
- Full Name
- F. Hoffmann-La Roche AG
- Organisation Type
- Pharmaceutical company
- Country Of Registered Address
- Switzerland
Contract research organisations
- Name
- IQVIA RDS Hellas Single Member S.A.
- Responsibilities
- [{"id":1004049,"code":"1"}]
- Name
- IQVIA Limited
- Responsibilities
- [{"id":1004046,"code":"15","value":"Monitoring"}]
- Name
- PPD Development LP
- Responsibilities
- [{"id":1004052,"code":"4"}]
- Name
- Syneos Health Inc.
- Responsibilities
- [{"id":1004053,"code":"4"}]
Third parties
- {"country":"United Kingdom (Northern Ireland)","full_name":"Almac Group Limited","duties_or_roles":"[{\"id\":1004050,\"code\":\"3\"}]","organisation_type":"Pharmaceutical company"}
- {"country":"Greece","full_name":"IQVIA RDS Hellas Single Member S.A.","duties_or_roles":"[{\"id\":1004049,\"code\":\"1\"}]","organisation_type":"Non-Pharmaceutical company"}
- {"country":"Switzerland","full_name":"Neurostatus-UHB AG","duties_or_roles":"[{\"id\":1004047,\"code\":\"15\",\"value\":\"Other Third Party Duty\"}]","organisation_type":"Laboratory/Research/Testing facility"}
- {"country":"Denmark","full_name":"Unilabs A/S","duties_or_roles":"[{\"id\":1004044,\"code\":\"4\"}]","organisation_type":"Laboratory/Research/Testing facility"}
- {"country":"United Kingdom","full_name":"Publicis Healthcare Communications Group Limited","duties_or_roles":"[{\"id\":1004055,\"code\":\"15\",\"value\":\"Study materials, patient materials\"}]","organisation_type":"Non-Pharmaceutical company"}
- {"country":"Switzerland","full_name":"Labcorp Central Laboratory Services S.a.r.l.","duties_or_roles":"[{\"id\":1004056,\"code\":\"4\"}]","organisation_type":"Pharmaceutical company"}
- {"country":"Canada","full_name":"Neurorx Research Inc.","duties_or_roles":"[{\"id\":1004051,\"code\":\"4\"}]","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Roland Henry Lab UCSF; UCSF Department of Neurology, Sandler Neurosciences Center","duties_or_roles":"[{\"id\":1004054,\"code\":\"15\",\"value\":\"Other Third Party Duty\"}]","organisation_type":"Health care"}
- {"country":"United States","full_name":"PPD Development LP","duties_or_roles":"[{\"id\":1004052,\"code\":\"4\"}]","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Eresearchtechnology Inc.","duties_or_roles":"[{\"id\":1004048,\"code\":\"15\",\"value\":\"Other Third Party Duty\"}]","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Syneos Health Inc.","duties_or_roles":"[{\"id\":1004053,\"code\":\"4\"}]","organisation_type":"Pharmaceutical company"}
- {"country":"Germany","full_name":"MARKEN Germany GmbH","duties_or_roles":"[{\"id\":1004045,\"code\":\"15\",\"value\":\"Study Material Supply\"}]","organisation_type":"Pharmaceutical company"}
- {"country":"United Kingdom","full_name":"IQVIA Limited","duties_or_roles":"[{\"id\":1004046,\"code\":\"15\",\"value\":\"Monitoring\"}]","organisation_type":"Pharmaceutical company"}
Investigational products
- Investigational Product Name
- Ocrevus 300 mg concentrate for solution for infusion
- Active Substance
- OCRELIZUMAB
- Modality
- Monoclonal antibody
- Routes Of Administration
- INTRAVENOUS INFUSION
- Route
- Intravenous infusion
- Authorisation Status
- Authorised (marketing authorisation present: EU/1/17/1231)
- Maximum Dose
- 1800 mg
- Investigational Product Name
- Placebo Ocrelizumab
- Modality
- Other
- Authorisation Status
- Not applicable
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