Clinical trial • Phase III • Oncology
NVL-655 (neladalkib) for Advanced ALK-positive non-small cell lung cancer
Phase III trial of NVL-655 (neladalkib) for Advanced ALK-positive non-small cell lung cancer.
Overview
- Trial Therapeutic Area
- Oncology
- Trial Disease
- Advanced ALK-positive non-small cell lung cancer
- Trial Stage
- Phase III
- Drug Modality
- Small molecule
Key dates
- Initial CTIS Submission Date
- 14-02-2025
- First CTIS Authorization Date
- 02-06-2025
Trial design
Randomised, open-label, alecensa 150 mg hard capsules (alectinib) - marketed comparator product (productname: alecensa 150 mg hard capsules; active substance: alectinib hydrochloride; product lists maxdailydoseamount: 1200 mg). specific dosing schedule in the protocol is not provided in the public record.-controlled Phase III trial in Italy, Germany, Austria and others.
- Randomised
- Yes
- Open Label
- Yes
- Comparator
- Alecensa 150 mg hard capsules (alectinib) - marketed comparator product (productName: Alecensa 150 mg hard capsules; active substance: alectinib hydrochloride; product lists maxDailyDoseAmount: 1200 mg). Specific dosing schedule in the protocol is not provided in the public record.
- Target Sample Size
- 159
- Trial Duration For Participant
- 1575
Stratification factors
- Brain metastases (yes vs. no)
- Ethnic origin (Asian vs. non-Asian)
- ECOG PS score
Eligibility
Recruits 159 Vulnerable population is selected in the trial record. Subject information and informed consent forms are provided (Main ICF and country-specific ICFs). There are specific ICF documents referenced for pregnancy and for partner/newborn in multiple countries. Assent or age-specific consent handling details are not specified in the available record..
- Vulnerable Population
- Vulnerable population is selected in the trial record. Subject information and informed consent forms are provided (Main ICF and country-specific ICFs). There are specific ICF documents referenced for pregnancy and for partner/newborn in multiple countries. Assent or age-specific consent handling details are not specified in the available record.
Inclusion criteria
- {"criterion_text":"- Patients must meet all of the following criteria to be eligible to enroll in the study: 1. Histologically or cytologically confirmed locally advanced (not amenable for multimodality treatment) or metastatic Non-small Cell Lung Cancer (NSCLC)\n- 2. Documented Anaplastic Lymphoma Kinase (ALK) rearrangement via testing of tissue or blood\n- 3. No prior systemic anticancer treatment for NSCLC (adjuvant/neoadjuvant chemotherapy allowed if 12 months prior to randomization; prior ALK tyrosine kinase inhibitor [TKI] such as alectinib is not allowed in any setting)\n- 4. Measurable disease (1 or more target lesions per Response Evaluation Criteria in Solid Tumors [RECIST] 1.1)\n- 5. Pretreatment tumor tissue (archived or a fresh biopsy)"}
Exclusion criteria
- {"criterion_text":"- 1. Patient’s cancer has a known oncogenic driver alteration other than ALK.\n- 2. Known allergy/hypersensitivity to excipients of NVL-655 or alectinib.\n- 3. Major surgery within 4 weeks prior to randomization\n- 4. Ongoing or recent radiotherapy as per protocol-specified timeframes prior to randomization\n- 5. Uncontrolled clinically relevant infection requiring systemic therapy\n- 6. Known active tuberculosis, known active Hepatitis B or C\n- 7. QT corrected for heart rate by Fridericia’s formula (QTcF) > 470 msec on repeated assessments\n- 8. Clinically significant cardiovascular disease\n- 9. Brain metastases associated with progressive neurological symptoms or requiring increasing doses of corticosteroids to control CNS disease\n- 10. Active malignancy requiring therapy within 2 years prior to randomization"}
Endpoints
Primary endpoints
- {"endpoint_text":"- Progression-free survival (PFS)","definition_or_measurement_approach":""}
Secondary endpoints
- {"endpoint_text":"- Overall survival (OS)\n- Progression-free survival (PFS) per investigator assessment\n- Time to intracranial progression per blinded independent central review (BICR)\n- Intracranial objective response rate (IC-ORR)\n- Intracranial duration of response (IC-DOR)\n- Objective response rate (ORR)\n- Duration of response (DOR)\n- Incidence and severity of treatment-emergent adverse events (TEAEs) and changes in clinically relevant laboratory parameters\n- Changes in patient-reported outcomes (PROs)","definition_or_measurement_approach":"PFS (secondary listing) specified as per investigator assessment for one measure; time to intracranial progression specified to be assessed per blinded independent central review (BICR); safety assessed by incidence and severity of TEAEs and clinically relevant laboratory parameter changes; PROs measured by patient-reported outcome instruments (quality of life questionnaires referenced in protocol documents)."}
Recruitment
- Digital Remote Recruitment
- Yes
- Planned Sample Size
- 159
- Recruitment Window Months
- 54
- Consent Approach
- Informed consent is obtained using Main ICF documents and country-specific ICFs (Main ICF versions listed for multiple countries). Additional ICFs are provided for pregnancy, treatment beyond progression, optional future research/genetic research, and partner/newborn where applicable. ICFs are available in country languages (examples: Italian, German, Spanish, Polish, Dutch/English for NL, Czech, French, Portuguese, Greek, Hungarian, Danish). Specific assent procedures for minors are not specified in the available documentation.
Methods
- Physician referral letters (country-specific physician referral letters provided)
- GP letters (GP/primary care letters for selected countries)
- Patient brochures (digital and print versions available in multiple languages)
- Site flyers (digital site flyers for sites to display/reach potential participants)
- Country-specific recruitment/informed consent procedures (K1/K2 documents listed for each Member State)
Geography
- Total Number Of Sites
- 71
- Total Number Of Participants
- 291
Italy
- Earliest CTIS Part Ii Submission Date
- 26-02-2025
- Latest Decision Or Authorization Date
- 12-11-2025
- Processing Time Days
- 259
- Number Of Sites
- 13
- Number Of Participants
- 65
Sites
- Site Name
- Istituto Di Candiolo Fondazione Del Piemonte Per L'Oncologia IRCCS
- Department Name
- Oncologia Medica
- Contact Person Name
- Vanesa Gregorc
- Contact Person Email
- vanesa.gregorc@ircc.it
- Site Name
- Fondazione IRCCS San Gerardo Dei Tintori
- Department Name
- S.C.Oncologia Medica
- Contact Person Name
- Diego Cortinovis
- Contact Person Email
- d.cortinovis@asst-monza.it
- Site Name
- Istituto Tumori Bari Giovanni Paolo II
- Department Name
- Oncologia Medica Toracica
- Contact Person Name
- Domenico Galetta
- Contact Person Email
- galetta@oncologico.bari.it
- Site Name
- Istituto Europeo Di Oncologia S.r.l.
- Department Name
- Oncologia Toracica
- Contact Person Name
- Gianluca Spitaleri
- Contact Person Email
- gianluca.spitaleri@ieo.it
- Site Name
- Azienda Ospedaliero Universitaria Delle Marche
- Department Name
- SOD Clinica Oncologica
- Contact Person Name
- Rossana Berardi
- Contact Person Email
- rossana.berardi@ospedaliriuniti.marche.it
- Site Name
- Humanitas Mirasole S.p.A.
- Department Name
- Oncologia Medica ed Ematologia
- Contact Person Name
- Giovanna Finocchiaro
- Contact Person Email
- giovanna.finocchiaro@cancercenter.humanitas.it
- Site Name
- Azienda Ospedaliero Universitaria Pisana
- Department Name
- Oncology Department – SD Oncopneumologia
- Contact Person Name
- Antonio Chella
- Contact Person Email
- a.chella@ao-pisa.toscana.it
- Site Name
- Fondazione IRCCS Istituto Nazionale Dei Tumori
- Department Name
- S. C. Oncologia Medica 1
- Contact Person Name
- Arsela Prelaj
- Contact Person Email
- arsela20@hotmail.it
- Site Name
- Istituto Oncologico Veneto
- Department Name
- Second Medical Oncology Unit
- Contact Person Name
- Giulia Pasello
- Contact Person Email
- giulia.pasello@ioveneto.it
- Site Name
- Istituto Romagnolo Per Lo Studio Dei Tumori Dino Amadori IRST S.r.l.
- Department Name
- Dipartimentale di Oncologia Toracica
- Contact Person Name
- Angelo Delmonte
- Contact Person Email
- angelo.delmonte@irst.emr.it
- Site Name
- Azienda Unita Sanitaria Locale Della Romagna
- Department Name
- Dipartimento di Oncologia ed Ematologia
- Contact Person Name
- Chiara Bennati
- Contact Person Email
- chiara.bennati@auslromagna.it
- Site Name
- I.F.O. Istituti Fisioterapici Ospitalieri
- Department Name
- UOSD Sperimentazioni cliniche
- Contact Person Name
- Lorenza Landi
- Contact Person Email
- landi.lorenza@gmail.com
- Site Name
- Ospedale S G Moscati
- Department Name
- Department of Oncology
- Contact Person Name
- Salvatore Pisconti
- Contact Person Email
- salvatore.pisconti@asl.taranto.it
Germany
- Earliest CTIS Part Ii Submission Date
- 20-05-2025
- Latest Decision Or Authorization Date
- 12-11-2025
- Processing Time Days
- 176
- Number Of Sites
- 6
- Number Of Participants
- 17
Sites
- Site Name
- HELIOS Klinikum Emil von Behring GmbH
- Department Name
- Helios Klinikum Emil von Behring
- Contact Person Name
- Jens Kollmeier
- Contact Person Email
- studienbuero-evb@helios-gesundheit.de
- Site Name
- Klinikum der Universitaet Muenchen AöR
- Department Name
- Medizinische Klinik und Poliklinik V
- Contact Person Name
- Amanda Tufman
- Contact Person Email
- Amanda.Tufman@med.uni-muenchen.de
- Site Name
- LungenClinic Grosshansdorf GmbH
- Department Name
- LungenClinic Grosshansdorf
- Contact Person Name
- Martin Reck
- Contact Person Email
- m.reck@lungenclinic.de
- Site Name
- MVZ-Onkologie Velbert GbR
- Department Name
- MVZ-Onkologie Velbert
- Contact Person Name
- Arnd Nusch
- Contact Person Email
- nusch@aol.com
- Site Name
- Lungenfachklinik Immenhausen
- Department Name
- Lungenfachklinik Immenhausen
- Contact Person Name
- Achim Rittmeyer
- Contact Person Email
- a.rittmeyer@lungenfachklinik-immenhausen.de
- Site Name
- Klinikum Esslingen GmbH
- Department Name
- Klinik für Kardiologie, Angiologie und Pneumologie
- Contact Person Name
- Martin Faehling
- Contact Person Email
- m.faehling@klinikum-esslingen.de
Austria
- Earliest CTIS Part Ii Submission Date
- 21-05-2025
- Latest Decision Or Authorization Date
- 17-11-2025
- Processing Time Days
- 180
- Number Of Sites
- 2
- Number Of Participants
- 11
Sites
- Site Name
- Stadt Wien Wiener Gesundheitsverbund
- Department Name
- Klinik Floridsdorf Abteilung für Innere Medizin und Pneumologie
- Contact Person Name
- Maximilian Hochmair
- Contact Person Email
- maximilian.hochmair@gesundheitsverbund.at
- Site Name
- Medizinische Universitaet Innsbruck
- Department Name
- Universitätsklinik für Innere Medizin V Innsbruck
- Contact Person Name
- Arno Amann
- Contact Person Email
- arno.amann@tirol-kliniken.at
Spain
- Earliest CTIS Part Ii Submission Date
- 08-05-2025
- Latest Decision Or Authorization Date
- 17-11-2025
- Processing Time Days
- 193
- Number Of Sites
- 11
- Number Of Participants
- 32
Sites
- Site Name
- Hospital General Universitario Gregorio Maranon
- Department Name
- Oncología Médica
- Contact Person Name
- Antonio Calles Blanco
- Contact Person Email
- antonio.calles@live.com
- Site Name
- Micancer Center S.L.P.
- Department Name
- Oncología Médica
- Contact Person Name
- Santiago Viteri Ramires
- Contact Person Email
- sviteri@uomi.es
- Site Name
- Hospital Universitario Ramon Y Cajal
- Department Name
- Oncología Médica
- Contact Person Name
- Pilar Garrido Lopez
- Contact Person Email
- pgarrido@salud.madrid.org
- Site Name
- Institut Catala D'oncologia (Badalona)
- Department Name
- Oncología Médica
- Contact Person Name
- Maria Teresa Moran Bueno
- Contact Person Email
- mmoran@iconcologia.net
- Site Name
- Hospital Universitario 12 De Octubre
- Department Name
- Oncología Médica
- Contact Person Name
- Luis Gonzaga Paz-Ares Rodriguez
- Contact Person Email
- lpazaresr@seom.org
- Site Name
- University Hospital Virgen Del Rocio S.L.
- Department Name
- Oncología Médica
- Contact Person Name
- Miriam Alonso Garcia
- Contact Person Email
- miriamag3@hotmail.com
- Site Name
- Hospital Universitario Virgen De La Macarena
- Department Name
- Oncología Médica
- Contact Person Name
- Teresa García Manrique
- Contact Person Email
- tgarciamanrique.onco@gmail.com
- Site Name
- Complexo Hospitalario Universitario A Coruna
- Department Name
- Oncología Médica
- Contact Person Name
- María Rosario Garcia Campelo
- Contact Person Email
- ma.rosario.garcia.campelo@sergas.es
- Site Name
- Hospital Universitario Regional De Malaga
- Department Name
- Oncología Médica
- Contact Person Name
- Manuel Cobo Dols
- Contact Person Email
- manuelcobodols@yahoo.es
- Site Name
- Institut Catala D'oncologia (L'hospitalet De Llobregat)
- Department Name
- Oncología Médica
- Contact Person Name
- Ernest Nada Alforja
- Contact Person Email
- contactfortrialsICOLH@iconcologia.net
- Site Name
- Institut Catala D'oncologia (Girona)
- Department Name
- Oncología Médica
- Contact Person Name
- Elia Sais Girona
- Contact Person Email
- contactfortrialicogir@iconcologia.net
Poland
- Earliest CTIS Part Ii Submission Date
- 09-05-2025
- Latest Decision Or Authorization Date
- 15-11-2025
- Processing Time Days
- 190
- Number Of Sites
- 4
- Number Of Participants
- 20
Sites
- Site Name
- One Day Med Sp. z o.o.
- Contact Person Name
- Piotr Serwatowski
- Contact Person Email
- piotrserwatowski@wp.pl
- Site Name
- Zanamed Medical Clinic Sp. z o.o.
- Contact Person Name
- Ludmiła Grzybowska-Szatkowska
- Contact Person Email
- ludmila.szatkowska@zanamed.pl
- Site Name
- Szpital Specjalistyczny W Brzozowie Podkarpacki Osrodek Onkologiczny Im.Ks.B.Markiewicza
- Department Name
- Oddział Dzienny Chemioterapii i Hematologii Onkologicznej
- Contact Person Name
- Dariusz Sawka
- Contact Person Email
- badaniadsawka@szpital-brzozow.pl
- Site Name
- Uniwersyteckie Centrum Kliniczne
- Department Name
- Klinika Onkologii i Radioterapii
- Contact Person Name
- Anna Wrona
- Contact Person Email
- anna.wrona@gumed.edu.pl
Netherlands
- Earliest CTIS Part Ii Submission Date
- 23-05-2025
- Latest Decision Or Authorization Date
- 11-11-2025
- Processing Time Days
- 172
- Number Of Sites
- 3
- Number Of Participants
- 22
Sites
- Site Name
- Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Stichting
- Department Name
- Lung Cancer Center and Thoracic Oncology
- Contact Person Name
- Adrianus Johannes (Joop) De Langen
- Contact Person Email
- j.d.langen@nki.nl
- Site Name
- Universitair Medisch Centrum Utrecht
- Department Name
- Cancer Center / Pulmonary Diseases
- Contact Person Name
- Anne van Lindert
- Contact Person Email
- a.s.r.vanlindert-2@umcutrecht.nl
- Site Name
- Radboud universitair medisch centrum Stichting
- Department Name
- Thoracic Oncology
- Contact Person Name
- Miep van der Drift
- Contact Person Email
- miep.vanderdrift@radboudumc.nl
Czechia
- Earliest CTIS Part Ii Submission Date
- 08-05-2025
- Latest Decision Or Authorization Date
- 11-11-2025
- Processing Time Days
- 187
- Number Of Sites
- 2
- Number Of Participants
- 7
Sites
- Site Name
- Multiscan s.r.o.
- Department Name
- Komplexni Onkologicke Centrum Pardubickeho kraje
- Contact Person Name
- Karel Odrážka
- Contact Person Email
- odrazka@multiscan.cz
- Site Name
- Nemocnice AGEL Novy Jicin a.s.
- Department Name
- Komplexni onkologicke centrum Oddeleni onkologie a radioterapie
- Contact Person Name
- Vojtech Tlusty
- Contact Person Email
- vojtech.tlusty@nnjagel.cz
Belgium
- Earliest CTIS Part Ii Submission Date
- 06-05-2025
- Latest Decision Or Authorization Date
- 12-11-2025
- Processing Time Days
- 190
- Number Of Sites
- 3
- Number Of Participants
- 11
Sites
- Site Name
- Cliniques Universitaires Saint-Luc
- Department Name
- Pneumology
- Contact Person Name
- Frank Aboubakar
- Contact Person Email
- frank.aboubakar@saintluc.uclouvain.be
- Site Name
- Universitair Ziekenhuis Antwerpen
- Department Name
- Pneumology
- Contact Person Name
- Jo Raskin
- Contact Person Email
- jo.raskin@uza.be
- Site Name
- UZ Leuven
- Department Name
- Pneumology
- Contact Person Name
- Christophe Dooms
- Contact Person Email
- christophe.dooms@uzleuven.be
Portugal
- Earliest CTIS Part Ii Submission Date
- 26-02-2025
- Latest Decision Or Authorization Date
- 11-11-2025
- Processing Time Days
- 258
- Number Of Sites
- 4
- Number Of Participants
- 15
Sites
- Site Name
- Instituto Portugues De Oncologia Do Porto Francisco Gentil E.P.E.
- Department Name
- Medical Oncology
- Contact Person Name
- Marta Soares
- Contact Person Email
- martasoares@ipoporto.min-saude.pt
- Site Name
- Champalimaud Clinical Centre
- Department Name
- Pneumology Unit
- Contact Person Name
- Marcos Pantarotto
- Contact Person Email
- marcos.pantarotto@fundacaochampalimaud.pt
- Site Name
- Galo Saude Parcerias Cascais S.A.
- Department Name
- Oncology
- Contact Person Name
- Diogo Alpuim Costa
- Contact Person Email
- diogo.santos.costa@hospitaldecascais.pt
- Site Name
- Hospital CUF Porto S.A.
- Department Name
- Oncology
- Contact Person Name
- Venceslau Hespanhol
- Contact Person Email
- hespanholv@gmail.com
France
- Earliest CTIS Part Ii Submission Date
- 23-05-2025
- Latest Decision Or Authorization Date
- 06-01-2026
- Processing Time Days
- 228
- Number Of Sites
- 11
- Number Of Participants
- 56
Sites
- Site Name
- Assistance Publique Hopitaux De Paris
- Department Name
- Service de pneumologie
- Contact Person Name
- Jacques CADRANEL
- Contact Person Email
- Jacques.cadranel@aphp.fr
- Site Name
- Institut Bergonie
- Department Name
- Medical Oncology, 229 cours de l’Argonne
- Contact Person Name
- Sophie COUSIN
- Contact Person Email
- s.cousin@bordeaux.unicancer.fr
- Site Name
- Centre Hospitalier Regional De Marseille
- Department Name
- Multidisciplinary oncology and therapeutic innovations
- Contact Person Name
- Pascale TOMASINI
- Contact Person Email
- pascale.tomasini@ap-hm.fr
- Site Name
- Centre Hospitalier Universitaire De Nantes
- Department Name
- Oncology Medical Department
- Contact Person Name
- Elvire PONS-TOSTIVINT
- Contact Person Email
- Elvire.pons@chu-nantes.fr
- Site Name
- Institut Regional Du Cancer De Montpellier
- Department Name
- Medical oncology
- Contact Person Name
- Xavier QUANTIN
- Contact Person Email
- xavier.quantin@icm.unicancer.fr
- Site Name
- Centre Hospitalier Universitaire De Bordeaux
- Department Name
- Hôpital du Haut Lévêque, Centre François Magendie, Service des Maladies Respiratoires
- Contact Person Name
- Rémi VEILLON
- Contact Person Email
- Remi.veillon@chu-bordeaux.fr
- Site Name
- Centre Francois Baclesse
- Department Name
- Department of Pneumology
- Contact Person Name
- Hubert CURCIO
- Contact Person Email
- h.curcio@baclesse.unicancer.fr
- Site Name
- Centre Hospitalier Universitaire D'Angers
- Department Name
- Pneumology
- Contact Person Name
- Youssef OULKHOUIR
- Contact Person Email
- Youssef.Oulkhouir@chu-angers.fr
- Site Name
- Centre Leon Berard
- Department Name
- Department of Medical Oncology
- Contact Person Name
- Aurélie SWALDUZ
- Contact Person Email
- aurelie.swalduz@lyon.unicancer.fr
- Site Name
- Centre Hospitalier Universitaire De Toulouse
- Department Name
- Pneumology
- Contact Person Name
- Julien MAZIERES
- Contact Person Email
- mazieres.j@chu-toulouse.fr
- Site Name
- Institut Gustave Roussy
- Department Name
- Medical oncology
- Contact Person Name
- Benjamin BESSE
- Contact Person Email
- Benjamin.besse@gustaveroussy.fr
Hungary
- Earliest CTIS Part Ii Submission Date
- 15-05-2025
- Latest Decision Or Authorization Date
- 13-02-2026
- Processing Time Days
- 274
- Number Of Sites
- 4
- Number Of Participants
- 11
Sites
- Site Name
- Bacs-Kiskun Varmegyei Oktatokorhaz
- Department Name
- Onkoradiológiai Központ
- Contact Person Name
- Zsuzsanna Kelemen
- Contact Person Email
- study.zsuzsannadrkelemen@gmail.com
- Site Name
- Matrai Gyogyintezet
- Department Name
- Oncológiai
- Contact Person Name
- Albert István
- Contact Person Email
- albert.magy@gmail.com
- Site Name
- University Of Debrecen
- Department Name
- Tüdőgyógyászati Klinika
- Contact Person Name
- Ildikó Horváth
- Contact Person Email
- horvath.ildiko@med.unideb.hu
- Site Name
- Bekes Varmegyei Koezponti Korhaz
- Department Name
- Aktív Tüdőgyógyászati Osztály
- Contact Person Name
- Ibolya Laczó
- Contact Person Email
- laczoibolya@gmail.com
Denmark
- Earliest CTIS Part Ii Submission Date
- 12-05-2025
- Latest Decision Or Authorization Date
- 25-02-2026
- Processing Time Days
- 289
- Number Of Sites
- 3
- Number Of Participants
- 6
Sites
- Site Name
- Region Midtjylland
- Department Name
- Department of Oncology
- Contact Person Name
- Peter Meldgaard
- Contact Person Email
- petemeld@rm.dk
- Site Name
- Odense University Hospital
- Department Name
- Department of Oncology
- Contact Person Name
- Lotte Holm Land
- Contact Person Email
- ouh.ode.r.ctis@rsyd.dk
- Site Name
- Region Hovedstaden
- Department Name
- Department of Oncology
- Contact Person Name
- Rikke Andersen
- Contact Person Email
- Rikke.andersen.02@regionh.dk
Greece
- Earliest CTIS Part Ii Submission Date
- 26-02-2025
- Latest Decision Or Authorization Date
- 22-04-2026
- Processing Time Days
- 420
- Number Of Sites
- 5
- Number Of Participants
- 18
Sites
- Site Name
- Thoracic General Hospital Of Athens I Sotiria
- Department Name
- Oncology Unit, 3'd Department of Ιnternal Medicine and Laboratory
- Contact Person Name
- Konstantinos Syrigos
- Contact Person Email
- ksyrigos.trials@gmail.com
- Site Name
- General University Hospital Of Larissa
- Department Name
- Dpt of Medical Oncology
- Contact Person Name
- Athanasios Kotsakis
- Contact Person Email
- thankotsakis@hotmail.com
- Site Name
- Athens Medical Center S.A.
- Department Name
- Oncology Department
- Contact Person Name
- Vasileios Ramfidis
- Contact Person Email
- ramfidis@gmail.com
- Site Name
- Henry Dunant Hospital Center
- Department Name
- 4th’ Oncology Dept & Clinical Trials unit
- Contact Person Name
- Ioannis Mountzios
- Contact Person Email
- gmountzios@gmail.com
- Site Name
- Genesis Idiotiki Geniki Maieftiki Gynaikologiki Kliniki S.A.
- Department Name
- Medical Oncology
- Contact Person Name
- Ioannis Boukovinas
- Contact Person Email
- ibouk@bioncology.gr
Sponsor
Primary sponsor
- Full Name
- Nuvalent Inc.
- Organisation Type
- Pharmaceutical company
- Country Of Registered Address
- United States
Contract research organisations
- Name
- PPD International Holdings LLC
- Responsibilities
- Kit supplies, Processing of Biomarker samples, Project manager, Sample management
- Name
- PPD Development LP
- Name
- PPD Global Ltd.
- Name
- PPD Global Central Labs (S) Pte Ltd
- Responsibilities
- Kit supplies, Processing of Biomarker samples, Project manager, Sample management
- Name
- Pra International
- Responsibilities
- Central Imaging for tumor assessments
- Name
- Fortrea Inc.
- Responsibilities
- Safety case processing
- Name
- Almac Clinical Services Limited
- Responsibilities
- Labelling and QP release for NVL-655 (neladalkib) and ALECENSA (alectinib)
- Name
- WCG Clinical Inc.
- Responsibilities
- ePROs
- Name
- Scout Clinical
- Responsibilities
- Travel Management and Expense Reimbursement
- Name
- Pharmaceutical Product Development LLC
- Responsibilities
- Kit supplies, Processing of Biomarker samples, Project manager, Sample management
Third parties
- {"country":"Belgium","full_name":"PPD International Holdings LLC","duties_or_roles":"Kit supplies, Processing of Biomarker samples, Project manager, Sample management","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"PPD Development LP","duties_or_roles":"","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Pra International","duties_or_roles":"Central Imaging for tumor assessments","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Fortrea Inc.","duties_or_roles":"Safety case processing","organisation_type":"Pharmaceutical company"}
- {"country":"Singapore","full_name":"PPD Global Central Labs (S) Pte Ltd","duties_or_roles":"Kit supplies, Processing of Biomarker samples, Project manager, Sample management","organisation_type":"Pharmaceutical company"}
- {"country":"Greece","full_name":"PPD Global Ltd.","duties_or_roles":"","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Scout Clinical","duties_or_roles":"Travel Management and Expense Reimbursement","organisation_type":"Hospital/Clinic/Other health care facility"}
- {"country":"United Kingdom (Northern Ireland)","full_name":"Almac Clinical Services Limited","duties_or_roles":"Labelling and QP release for NVL-655 (neladalkib) and ALECENSA (alectinib)","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"WCG Clinical Inc.","duties_or_roles":"ePROs","organisation_type":"Pharmaceutical company"}
- {"country":"France","full_name":"Voisin Consulting Life Sciences","duties_or_roles":"EU Data Protection Representative","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Pharmaceutical Product Development LLC","duties_or_roles":"Kit supplies, Processing of Biomarker samples, Project manager, Sample management","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Medidata Solutions Inc.","duties_or_roles":"","organisation_type":"Non-Pharmaceutical company"}
- {"country":"United States","full_name":"Suvoda LLC","duties_or_roles":"","organisation_type":"Non-Pharmaceutical company"}
Investigational products
- Investigational Product Name
- NVL-655
- Active Substance
- NVL-655 (neladalkib)
- Modality
- Small molecule
- Routes Of Administration
- ORAL
- Route
- ORAL
- Authorisation Status
- Not authorised / Investigational (prodAuthStatus: 1)
- Maximum Dose
- Max daily dose amount 150 mg
- Investigational Product Name
- Alecensa 150 mg hard capsules
- Active Substance
- ALECTINIB HYDROCHLORIDE
- Modality
- Small molecule
- Routes Of Administration
- ORAL
- Route
- ORAL
- Authorisation Status
- Authorised (prodAuthStatus: 2)
- Starting Dose
- 150 mg (capsule strength listed)
- Maximum Dose
- Max daily dose amount 1200 mg
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