LORLATINIB for Advanced ROS1-positive non-small cell lung cancer

Inclusion criteria

• {"criterion_text":"- Signed Written Informed Consent: Subjects must have signed and dated an IRB/IEC approved written informed consent form in accordance with regulatory and institutional guidelines. This must be obtained before the performance of any protocol related procedures that are not part of normal subject care. Subjects must be willing and able to comply with scheduled visits, treatment schedule, and laboratory testing"}
• {"criterion_text":"- Evidence of a personally signed and dated informed consent document indicating that the patient has been informed of all pertinent aspects of the study."}
• {"criterion_text":"- Willingness and ability to comply with the study scheduled visits, treatment plans, laboratory tests and other procedure."}
• {"criterion_text":"- Patients with histologically or cytologically confirmed diagnosis of locally advanced not eligible to a local treatment or metastatic NSCLC (Stage IIIB or IIIC non irradiable or IV accordingly to 8th classification TNM, UICC 2015) that carries an ROS1 rearrangement, as determined by the molecular biology platform of the investigator by FISH assay or by Immunohistochemistry (IHC), or Next Generation Sequencing (NGS) or RNA sequencing approach. If the determination of ROS rearrangement was done by immunohistochemistry, a second method performed locally is required."}
• {"criterion_text":"- Participant has national health insurance coverage."}
• {"criterion_text":"- Washout period: if previous progression on ROS1-TKI: 7 days from last dose of the drug. The washout period may be shortened to 2 days at investigator discretion."}
• {"criterion_text":"- Disease Status Requirements: Disease progression meeting RECISTv1.1 after one prior line of treatment with crizotinib or entrectinib (+ one line of chemotherapy with or without immunotherapy before TKI treatment). Note: patient with disease progression after treatment with another ROS1-TKI may still be eligible upon discussion with IFCT"}
• {"criterion_text":"- Tumor Requirements: All Patients must have at least one measurable target lesion according to RECIST v1.1. The radiological assessment has to be done within the timelines indicated. In addition, patients with asymptomatic and neurologically stable CNS metastases (including patients controlled with stable or decreasing steroid use within the last week prior to study entry) will be eligible. The brain metastases may be newly diagnosed after disease progression with crizotinib or entrectinib or be present as progressive disease after surgery, whole brain radiotherapy or stereotactic radiosurgery (see Exclusion Criterion for the lapsed time period required between the end of radiotherapy and study entry). Patients who have leptomeningeal disease (LM) or carcinomatous meningitis (CM) will be eligible if the LM/CM is visualized on MRI or if documented baseline cerebral spinal fluid (CSF) positive cytology is available and asymptomatic and neurologically stable (including patients controlled with stable or decreasing steroid use within the last week prior to study entry)."}
• {"criterion_text":"- Tumor Sample Requirement: Tumour biopsy sampling on fresh tissue (FFPE blocks required) obtained after progression on crizotinib or entrectinib. Tumour biopsy should be exploitable for molecular analysis. If the tumour biopsy is not exploitable, the inclusion will be allowed if two blood samples are provided for tumoral cfDNA analysis. The Sponsor will monitor a posteriori the exploitability of provided tumour biopsies and will investigate the impossibility to perform or repeat tissue tumor sampling."}
• {"criterion_text":"- Age ≥18 years."}
• {"criterion_text":"- Life expectancy of at least 12 weeks, in the opinion of the Investigator."}
• {"criterion_text":"- Adequate Bone Marrow Function, including: Absolute Neutrophil Count (ANC) ≥1.5 x 109/L; Platelets ≥100 x 109/L; Hemoglobin ≥9 g/dL."}
• {"criterion_text":"- Eastern Cooperative Oncology Group Performance Status (ECOG PS) ≤ 2"}
• {"criterion_text":"- Adequate Pancreatic Function, including: Serum lipase ≤1.5 x ULN."}
• {"criterion_text":"- Renal Function, including: Serum creatinine ≤1.5 x ULN or estimated creatinine clearance ≥45 mL/min as calculated using the method standard for the institution."}
• {"criterion_text":"- Adequate Liver Function, including: Total serum bilirubin ≤1.5 x ULN; Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT) ≤2.5 x ULN; ≤5.0 x ULN if there is liver metastases involvement."}
• {"criterion_text":"- Participants must have recovered from treatment toxicities to CTCAE Grade ≤ 1 (for participants who have developed interstitial lung disease [ILD], they must have fully recovered) except for AEs that in the investigator’ judgment do not constitute a safety risk for the patient."}
• {"criterion_text":"- Participants must have recovered from effects of any major surgery, or significant traumatic injury, at least 35 days before the first dose of lorlatinib."}
• {"criterion_text":"- For all females of childbearing potential, a negative pregnancy test must be obtained within the screening period. A patient is of childbearing potential if, in the opinion of the investigator, she is biologically capable of having children and is sexually active. Additionally, all females of childbearing potential must provide an agreement to remain abstinent or use two adequate methods of contraception, including at least one method with a failure rate of < 1% per year, during the treatment period and for at least 90 days after the last dose of study drug."}
• {"criterion_text":"- For men: agreement to remain abstinent or use an effective method of contraception (e.g., condom) during the treatment period and for at least 14 weeks after the last dose of study drug and agreement to refrain from donating sperm during this same period."}

Exclusion criteria

• {"criterion_text":"- Participants with disease progression on front-line treatment with TKI i.e. crizotinib or entrectinib limited to CNS or one non-CNS site (oligometastasis) and eligible to a local ablative treatment (surgery or stereotaxic radiotherapy)."}
• {"criterion_text":"- Patients with predisposing characteristics for acute pancreatitis according to investigator judgment (eg, uncontrolled hyperglycemia, current gallstone disease, alcoholism [more than 4 drinks on any day or 14 drinks per week where 1 drink is defined as the alcoholic beverage containing approximately 14 grams of pure alcohol, eg, 12 fl oz/360 mL regular beer or 5 fl oz/150 mL of wine] in the last month."}
• {"criterion_text":"- History of bilateral or Grade 3 or 4 interstitial fibrosis or diffuse interstitial lung disease. Patients with history of prior radiation pneumonitis are not excluded."}
• {"criterion_text":"- Other severe acute or chronic medical or psychiatric condition, including recent (within the past year) or active suicidal ideation or behavior, or laboratory abnormality that may increase the risk associated with study participation or investigational product administration or may interfere with the interpretation of study results and, in the judgment of the investigator, would make the patient inappropriate for entry into this study."}
• {"criterion_text":"- Evidence of active malignancy (other than current NSCLC, non-melanoma skin cancer, in situ cervical cancer, papillary thyroid cancer, DCIS of the breast or localized and presumed cured prostate cancer) within the last 3 years."}
• {"criterion_text":"- Active inflammatory gastrointestinal disease, chronic diarrhea, symptomatic diverticular disease or previous gastric resection or lap band."}
• {"criterion_text":"- Current use or anticipated need for food or drugs prohibited (see chapter 7.9.1 for details)."}
• {"criterion_text":"- Patients presenting with abnormal Left Ventricular Ejection Fraction (LVEF) by echocardiogram or Multi-Gated Acquisition Scan (MUGA) according to institutional lower limits."}
• {"criterion_text":"- Breastfeeding female patients (including patients who intend to interrupt breastfeeding)."}
• {"criterion_text":"- Liver disease characterized by: ALT or AST level > 3 the upper normal limit (UNL) (≥ 5 x UNL for patients with liver metastases) confirmed on 2 consecutives measures OR impaired excretory function (e.g.. hyperbilirubinemia) or synthetic function or other conditions of decompensated liver disease e.g.: coagulopathy, Hepatic encephalopathy, hypoalbuminemia, ascites and bleeding from esophageal varices OR Acute viral or autoimmune or other types of hepatitis."}
• {"criterion_text":"- Histological transformation with neuro-endocrine differentiation."}
• {"criterion_text":"- Spinal cord compression is excluded unless the patient demonstrates good pain control attained through therapy and there is stabilization or recovery of neurological function for the 4 weeks prior to study entry."}
• {"criterion_text":"- Patients with symptomatic and neurologically instable CNS metastases or leptomeningeal metastasis (including patients that require increasing doses of steroids within one week prior to Day 0 of screening phase and during the screening phase to manage CNS symptoms)."}
• {"criterion_text":"- Major surgery within 35 days of study entry. Minor surgical procedures (eg, port insertion, mediastinoscopy, surgical procedure for re-sampling) are not excluded, but sufficient time at investigator discretion should have passed for wound healing."}
• {"criterion_text":"- Radiation therapy within 2 weeks of study entry (except palliative to relieve bone pain). Palliative radiation (≤15 fractions) must have been completed at least 48 hours prior to study entry. Stereotactic or small field brain irradiation must have completed at least 2 weeks prior to study entry. Whole brain radiation must have completed at least 4 weeks prior to study entry."}
• {"criterion_text":"- Active and clinically significant bacterial, fungal, or viral infection including hepatitis B (HBV), hepatitis C (HCV), known human immunodeficiency virus (HIV), or acquired immunodeficiency syndrome (AIDS)-related illness."}
• {"criterion_text":"- Clinically significant cardiovascular disease (that is, active or <3 months prior to enrollment): cerebral vascular accident/stroke, myocardial infarction, unstable angina, congestive heart failure (New York Heart Association Classification Class ≥ II), second-degree or third-degree AV block (unless paced) or any AV block with PR >220 msec."}
• {"criterion_text":"- Ongoing cardiac dysrhythmias of NCI CTCAE Grade ≥ 2, uncontrolled atrial fibrillation of any grade, bradycardia defined as <50 bpm (unless patient is otherwise healthy such as long-distance runners, athletic patients etc.), machine-read ECG with QTc >470 msec, or congenital long QT syndrome."}

Primary endpoints

• {"endpoint_text":"- The primary endpoint is the objective response rate (ORR) at 8 weeks (confirmation needed at 16 weeks) Objective response rate will be assessed by the investigators. ORR is defined as the percentage of subjects with a confirmed complete response (CR) or partial response (PR) as per RECIST v1.1 criteria.","definition_or_measurement_approach":"Objective response rate assessed by investigators; ORR defined as percentage of subjects with confirmed CR or PR per RECIST v1.1; assessed at 8 weeks with confirmation at 16 weeks."}

Secondary endpoints

• {"endpoint_text":"- ORR at 8 weeks, which is defined as the percentage of subjects with a confirmed at 16 weeks complete response (CR) or partial response (PR) by independent reviewer committee (IRC) as per RECIST v1.1 criteria.","definition_or_measurement_approach":"Objective response rate assessed by Independent Reviewer Committee per RECIST v1.1 with confirmation at 16 weeks."}
• {"endpoint_text":"- Progression Free Survival (PFS) defined as the time between the date of first dose of study drug and the first date of documented disease progression, as determined by Investigator review or by IRC of radiographic disease assessments per RECIST v1.1, or death due to any cause, whichever occurs first.","definition_or_measurement_approach":"Time from first dose to documented progression by Investigator or IRC per RECIST v1.1, or death."}
• {"endpoint_text":"- Time to progression (TTP) defined as the time from the date of first dose of study drug to the earliest date of disease progression, as determined by Investigator review or by independent reviewer of radiographic disease assessments per RECIST v1.1.","definition_or_measurement_approach":"Time from first dose to earliest date of disease progression per Investigator or independent reviewer using RECIST v1.1."}
• {"endpoint_text":"- Disease control rate (DCR) at 8 weeks (confirmation needed at 16 weeks) defined as the proportion of patients have achieved a confirmed overall response of CR, PR or SD, as determined by Investigator review or by independent reviewer of radiographic disease assessments per RECIST v1.1.","definition_or_measurement_approach":"Proportion with confirmed CR, PR or SD at 8 weeks (confirmation at 16 weeks) by Investigator or independent reviewer per RECIST v1.1."}
• {"endpoint_text":"- Duration of response (DOR) defined as the time from the date of the first documented response (CR or PR) to the earliest date of disease progression, as determined by Investigator review or by independent reviewer of radiographic disease assessments per RECIST v1.1, or death due to any cause.","definition_or_measurement_approach":"Time from first documented CR/PR to progression or death as per Investigator or independent reviewer using RECIST v1.1."}
• {"endpoint_text":"- Overall survival (OS) defined as the time from the date of first dose of study drug to the date of death due to any cause. OS will be assessed at 12 months and at 24 months.","definition_or_measurement_approach":"Time from first dose to death from any cause; assessed at 12 and 24 months."}
• {"endpoint_text":"- CNS Objective response rate (C-ORR) estimated in patients with measurable CNS metastases at baseline.","definition_or_measurement_approach":"CNS objective response rate evaluated in patients with measurable CNS metastases at baseline (assessment method per protocol)."}
• {"endpoint_text":"- CNS duration of response (C-DOR) estimated in patients with measurable CNS metastases at baseline.","definition_or_measurement_approach":"Duration of CNS response in patients with measurable CNS metastases at baseline."}
• {"endpoint_text":"- Time to CNS progression in patients without brain metastases at baseline.","definition_or_measurement_approach":"Time from first dose to CNS progression in patients without brain metastases at baseline."}
• {"endpoint_text":"- Change from baseline of EuroQol Quality of Life 5-Dimension 5-Level Scale (EQ-5D-5L) at all scheduled time points.","definition_or_measurement_approach":"Change from baseline in EQ-5D-5L measured at scheduled visits."}

France

Earliest CTIS Part Ii Submission Date

22-05-2024

Latest Decision Or Authorization Date

17-09-2025

Processing Time Days

483

Number Of Participants

84

Primary sponsor

Full Name

Intergroupe Francophone De Cancerologie Thoracique

Organisation Type

Patient organisation/association

Country Of Registered Address

France

Third parties

• {"country":"","full_name":"AstraZeneca","duties_or_roles":"Monetary support","organisation_type":""}
• {"country":"","full_name":"IFCT","duties_or_roles":"Monetary support","organisation_type":""}