Clinical trial • Not applicable • Musculoskeletal

LEVOBUPIVACAINE for Total hip arthroplasty

Not applicable trial of LEVOBUPIVACAINE for Total hip arthroplasty.

Overview

Trial Therapeutic Area
Musculoskeletal
Trial Disease
Total hip arthroplasty
Trial Stage
Not applicable
Drug Modality
Small molecule

Key dates

Initial CTIS Submission Date
21-11-2023
First CTIS Authorization Date
15-03-2024

Trial design

Test: Levobupivacaína Altan 2,5 mg/ml solución inyectable y para perfusión EFG (active substance: LEVOBUPIVACAINE), max total dose 62.5 mg, route: perineural use. Comparator/Placebo: Suero Fisiológico Braun 0,9% (sodium chloride), max total dose 25 ml, route: perineural use.-controlled Not applicable trial in Spain.

Comparator
Test: Levobupivacaína Altan 2,5 mg/ml solución inyectable y para perfusión EFG (active substance: LEVOBUPIVACAINE), max total dose 62.5 mg, route: perineural use. Comparator/Placebo: Suero Fisiológico Braun 0,9% (sodium chloride), max total dose 25 ml, route: perineural use.
Target Sample Size
64
Trial Duration For Participant
366

Eligibility

Recruits 64 Vulnerable population not selected (isVulnerablePopulationSelected=false); participants must sign informed consent ("sign the informed consent"). No assent or paediatric consent arrangements specified..

Pregnancy Exclusion
Women of reproductive age without contraceptive control, maternity or breastfeeding
Vulnerable Population
Vulnerable population not selected (isVulnerablePopulationSelected=false); participants must sign informed consent ("sign the informed consent"). No assent or paediatric consent arrangements specified.

Inclusion criteria

  • {"criterion_text":"- Patients scheduled for primary hip replacement who agree to participate in the study and sign the informed consent"}

Exclusion criteria

  • {"criterion_text":"- Refusal to participate in the study"}
  • {"criterion_text":"- blood coagulation dysfunction"}
  • {"criterion_text":"- Neuropathies"}
  • {"criterion_text":"- Punction site or systemic infections"}
  • {"criterion_text":"- Local anesthestic alergies"}
  • {"criterion_text":"- Women of reproductive age without contraceptive control, maternity or breastfeeding"}

Endpoints

Primary endpoints

  • {"endpoint_text":"- Pain","definition_or_measurement_approach":""}
  • {"endpoint_text":"- Quadriceps muscular strength","definition_or_measurement_approach":""}

Secondary endpoints

  • {"endpoint_text":"- Adverse effects: Nausea, vomiting, sedation, toxicity, others","definition_or_measurement_approach":""}
  • {"endpoint_text":"- Opioid consumption","definition_or_measurement_approach":""}
  • {"endpoint_text":"- Need for additional analgesia","definition_or_measurement_approach":""}
  • {"endpoint_text":"- Length of hospital stay","definition_or_measurement_approach":""}
  • {"endpoint_text":"- Pain experience","definition_or_measurement_approach":""}

Recruitment

Planned Sample Size
64
Recruitment Window Months
12
Consent Approach
Participants must sign informed consent ('sign the informed consent'). No assent or paediatric consent procedures or languages specified.

Geography

Total Number Of Sites
1
Total Number Of Participants
64

Spain

Earliest CTIS Part Ii Submission Date
26-01-2024
Latest Decision Or Authorization Date
04-07-2024
Processing Time Days
160
Number Of Sites
1
Number Of Participants
64

Sites

Site Name
Parc De Salut Mar
Department Name
Anestesiología
Principal Investigator Name
Xavier Santiveri
Principal Investigator Email
fsantiveri@psmar.cat
Contact Person Name
Xavier Santiveri
Contact Person Email
fsantiveri@psmar.cat
Number Of Participants
64

Sponsor

Primary sponsor

Full Name
Hospital Del Mar
Organisation Type
Hospital/Clinic/Other health care facility
Country Of Registered Address
Spain

Investigational products

Investigational Product Name
Levobupivacaína Altan 2,5 mg/ml solución inyectable y para perfusión EFG
Active Substance
LEVOBUPIVACAINE
Modality
Small molecule
Routes Of Administration
PERINEURAL USE
Route
Perineural
Authorisation Status
Authorised (marketing authorisation number 78240, country ES)
Maximum Dose
62.5 mg
Investigational Product Name
Suero Fisiológico Braun 0,9% disolvente para uso parenteral Cloruro de sodio
Active Substance
SODIUM CHLORIDE
Modality
Small molecule
Routes Of Administration
PERINEURAL USE
Route
Perineural
Authorisation Status
Authorised (marketing authorisation number 58449, country ES)
Maximum Dose
25 ml

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