Clinical trial • Phase I • Immunology

LCA-0321 for Graves' disease

Phase I trial of LCA-0321 for Graves' disease. adaptive. 48 participants.

Overview

Trial Therapeutic Area
Immunology
Trial Disease
Graves' disease
Trial Stage
Phase I

Key dates

Initial CTIS Submission Date
17-12-2025
First CTIS Authorization Date
06-03-2026

Trial design

adaptive Phase I trial across 3 sites in Netherlands.

Adaptive
True - dose escalation design: single ascending dose (SAD) and multiple ascending dose (MAD) cohorts; specific escalation rules not provided
Single Multiple Or Escalation Dose Combined
Yes
Target Sample Size
48

Eligibility

Recruits 48 Vulnerable populations not selected; no consent/assent details provided..

Vulnerable Population
Vulnerable populations not selected; no consent/assent details provided.

Recruitment

Planned Sample Size
48
Recruitment Window Months
29

Geography

Total Number Of Sites
3
Total Number Of Participants
48

Netherlands

Earliest CTIS Part Ii Submission Date
27-02-2026
Latest Decision Or Authorization Date
17-03-2026
Processing Time Days
18
Number Of Sites
3
Number Of Participants
48

Sites

Site Name
Erasmus Universitair Medisch Centrum Rotterdam (Erasmus MC)
Department Name
Endocrinology
Principal Investigator Name
Marco Medici
Principal Investigator Email
m.medici@erasmusmc.nl
Contact Person Name
Marco Medici
Contact Person Email
m.medici@erasmusmc.nl
Site Name
Brain Research Center Den Bosch B.V.
Department Name
Internal medicine/ endocrinology
Principal Investigator Name
Marieke de Vries
Principal Investigator Email
mar.d.vries@jbz.nl
Contact Person Name
Marieke de Vries
Contact Person Email
mar.d.vries@jbz.nl
Site Name
CTC Netherlands B.V.
Department Name
CTC
Principal Investigator Name
Khalid Sayed Abd-Elaziz
Principal Investigator Email
khalid.abdelaziz@ctc-netherlands.com
Contact Person Name
Khalid Sayed Abd-Elaziz

Sponsor

Primary sponsor

Full Name
Lycia Therapeutics Inc.
Organisation Type
Pharmaceutical company
Country Of Registered Address
United States

Investigational products

Investigational Product Name
LCA-0321

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