Clinical trial • Phase III • Oncology
JNJ-78278343 for Metastatic castration-resistant prostate cancer (mCRPC) | Hormone-refractory prostate cancer
Phase III trial of JNJ-78278343 for Metastatic castration-resistant prostate cancer (mCRPC) | Hormone-refractory prostate cancer.
Overview
- Trial Therapeutic Area
- Oncology
- Trial Disease
- Metastatic castration-resistant prostate cancer (mCRPC) | Hormone-refractory prostate cancer
- Trial Stage
- Phase III
- Drug Modality
- Other antibody
Key dates
- Initial CTIS Submission Date
- 30-07-2025
- First CTIS Authorization Date
- 18-11-2025
Trial design
Randomised, placebo arm: placebo jnj-78278343 + best supportive care (placebo named 'placebo jnj-78278343'); active comparator: pasritamig (jnj-78278343) + best supportive care. dose and schedule not specified in available records.-controlled Phase III trial in Germany, Italy, Netherlands and others.
- Randomised
- Yes
- Comparator
- Placebo arm: Placebo JNJ-78278343 + Best Supportive Care (placebo named 'Placebo JNJ-78278343'); Active comparator: pasritamig (JNJ-78278343) + Best Supportive Care. Dose and schedule not specified in available records.
- Target Sample Size
- 416
Eligibility
Recruits 416 No vulnerable populations selected (isVulnerablePopulationSelected = false). Trial population comprises adult male patients with mCRPC. Subject information and informed consent forms are provided (multiple ICF documents listed) and consent is obtained from participants..
- Vulnerable Population
- No vulnerable populations selected (isVulnerablePopulationSelected = false). Trial population comprises adult male patients with mCRPC. Subject information and informed consent forms are provided (multiple ICF documents listed) and consent is obtained from participants.
Inclusion criteria
- {"criterion_text":"- 1. Histologically confirmed adenocarcinoma of the prostate. Primary (or pathologic evidence of conversion to) small cell carcinoma, carcinoid tumor, mixed NE carcinoma, large cell NE carcinoma, or sarcoma of the prostate is disallowed.\n- 10. Hematologic Values Participants should have: - ANC ≥1.0 x 109/L. - Hemoglobin ≥8.0 g/dL. - Platelet count ≥75 x 109/L Note, transfusion or growth factor usage within 28 days of randomization is not allowed.\n- 2. mCRPC: Disease that is metastatic either to bone, any lymph node, or both without clear evidence of metastasis to visceral organs at the time of screening. Local-regional invasion (rectum, bladder) can be included.\n- 3. PSA ≥2 ng/mL at screening.\n- 4. In the opinion of the investigator, the next best treatment option is a clinical trial.\n- 5. Prior Therapy Requirements Participants should have had all life-prolonging therapies for which they are clinically eligible in the opinion of the investigator and to which they have access. Prior therapies could have been given in any disease setting (not limited to mCRPC). In particular, prior treatment specifications include receipt of the following: ARPI: Must have progressed on at least 1 ARPI and unlikely to benefit from retreatment with another ARPI. Taxanes: Should have received at least 2 previous taxane-based regimens. If a participant has received only 1 taxane regimen, the participant is eligible if: a) Cabazitaxel is not available. b) The participant’s physician deems the participant unsuitable to receive a second taxane regimen due to toxicity risk or prior intolerance. Note: a taxane-based regimen consists of at least 2 cycles of a taxane (either as a single agent or in combination with other therapies) administered within the same 2-month period. Radioligand therapy: Should have been previously treated with at least 1 dose of PSMA-targeted lutetium radioligand therapy (eg, lutetium Lu-177 vipivotide tetraxetan), unless one of the following applies: a) PSMA-targeted lutetium radioligand therapy is unavailable, not accessible, or not clinically indicated. b) The participant’s physician deems the participant unsuitable to receive PSMA-targeted lutetium radioligand therapy. PARPi: Should have been previously treated with PARPi, if the participant has a known germline or somatic BRCA mutation and treatment is available.\n- 6. Prior orchiectomy or medical castration (receiving ongoing ADT with a GnRH analog [agonist or antagonist]) prior to the first dose of study treatment and must continue this therapy throughout the treatment phase.\n- 7. Have an ECOG performance status of 0 to 2.\n- 8. Renal Function . Have an eGFR ≥30 mL/min, calculated with the CKD-epi formula, before randomization. Participants with obstructive uropathy should have treatment prior to randomization (eg, foley catheter, nephrostomy tubes, etc).\n- 9. Hepatic Function Participants are eligible if they have the following values: - ALT and AST ≤5 ×ULN. - Serum total bilirubin ≤3 x ULN"}
Exclusion criteria
- {"criterion_text":"- 1. Venous thromboembolic events (eg, pulmonary embolism) within 1 month prior to the first dose of study treatment; uncomplicated (Grade ≤2) deep vein thrombosis is not exclusionary.\n- 2. Active autoimmune disease within the 12 months prior to signing consent that quires systemic immunosuppressive medications (eg, chronic corticosteroid, methotrexate, or tacrolimus).\n- 3. Clinically significant pulmonary compromise, particularly a requirement for supplemental oxygen use (>2 L/min by nasal cannula) to maintain adequate oxygenation.\n- 4. Participant has a prior or concurrent second malignancy (other than the disease under study) for which natural history or treatment could likely interfere with any study endpoints of safety or the efficacy of the study treatment(s)\n- 5. Any of the following within 6 months prior to first dose of study treatment: - Myocardial infarction - Severe or unstable angina - Clinically significant ventricular arrhythmias - Congestive heart failure (New York Heart Association class II to IV) - Transient ischemic attack - Cerebrovascular accident\n- 6. Prior treatment with any CD3-directed therapy.\n- 7. Received immunosuppressive doses of systemic medications, such as glucocorticoids (doses >10 mg/day prednisone or equivalent) within 3 days prior to the first dose of study treatment. A single course of glucocorticoids is permitted as prophylaxis for imaging contrast (ie, for participants with allergies to contrast). If glucocorticoids were used to treat immune-related adverse events associated with prior therapy, ≥7 days must have elapsed since the last dose of corticosteroid."}
Endpoints
Primary endpoints
- {"endpoint_text":"- Overall survival","definition_or_measurement_approach":"To determine if pasritamig + BSC compared to placebo + BSC is superior in OS"}
Recruitment
- Planned Sample Size
- 416
- Recruitment Window Months
- 41
- Consent Approach
- Informed consent is obtained from participants using subject information and informed consent forms (SIS/ICF). ICF/SIS documents are provided in multiple languages as listed in the documents (including English, German, Italian, Dutch, Spanish, French, Polish); participant signs consent prior to enrolment.
Geography
- Total Number Of Sites
- 60
- Total Number Of Participants
- 247
Germany
- Earliest CTIS Part Ii Submission Date
- 03-11-2025
- Latest Decision Or Authorization Date
- 24-11-2025
- Processing Time Days
- 21
- Number Of Sites
- 11
- Number Of Participants
- 43
Sites
- Site Name
- Universitaetsklinikum Essen AöR
- Department Name
- Klinik fuer Urologie
- Principal Investigator Name
- Christopher Darr
- Principal Investigator Email
- Christopher.Darr@uk-essen.de
- Contact Person Name
- Christopher Darr
- Contact Person Email
- Christopher.Darr@uk-essen.de
- Site Name
- Staedtisches Klinikum Braunschweig gGmbH
- Department Name
- Urologische Klinik
- Principal Investigator Name
- Lukas Manka
- Principal Investigator Email
- l.manka@skbs.de
- Contact Person Name
- Lukas Manka
- Contact Person Email
- l.manka@skbs.de
- Site Name
- Studienpraxis Urologie Susan Feyerabend MD Tilman Todenhoefer MD PhD GbR
- Department Name
- Studienpraxis fuer Urologie
- Principal Investigator Name
- Tilman Todenhoefer
- Principal Investigator Email
- todenhoefer@studienurologie.de
- Contact Person Name
- Tilman Todenhoefer
- Contact Person Email
- todenhoefer@studienurologie.de
- Site Name
- Urologicum Duisburg
- Department Name
- Urologie
- Principal Investigator Name
- Eva Hellmis
- Principal Investigator Email
- hellmis@urologicum-duisburg.de
- Contact Person Name
- Eva Hellmis
- Contact Person Email
- hellmis@urologicum-duisburg.de
- Site Name
- Universitaet Muenster
- Department Name
- Klinik fuer Urologie
- Principal Investigator Name
- Martin Boegemann
- Principal Investigator Email
- martin.boegemann@ukmuenster.de
- Contact Person Name
- Martin Boegemann
- Contact Person Email
- martin.boegemann@ukmuenster.de
- Site Name
- University Medical Center Hamburg-Eppendorf
- Department Name
- Zentrum für Hematologie & Onkologie
- Principal Investigator Name
- Gunhild von Amsberg
- Principal Investigator Email
- g.von-amsberg@uke.de
- Contact Person Name
- Gunhild von Amsberg
- Contact Person Email
- g.von-amsberg@uke.de
- Site Name
- Klinikum Nuernberg
- Department Name
- Klinik fuer Innere Medizin
- Principal Investigator Name
- Marinela Augustin
- Principal Investigator Email
- marinela.augustin@klinikum-nuernberg.de
- Contact Person Name
- Marinela Augustin
- Contact Person Email
- marinela.augustin@klinikum-nuernberg.de
- Site Name
- Universitaetsklinikum Duesseldorf AöR
- Department Name
- Urologische Klinik
- Principal Investigator Name
- Guenter Niegisch
- Principal Investigator Email
- guenter.niegisch@med.uni-duesseldorf.de
- Contact Person Name
- Guenter Niegisch
- Contact Person Email
- guenter.niegisch@med.uni-duesseldorf.de
- Site Name
- Krankenhaus Nordwest GmbH
- Department Name
- Oncology and Hematology
- Principal Investigator Name
- Mohammad Reza Rafiyan
- Principal Investigator Email
- rafiyan.reza@khnw.de
- Contact Person Name
- Mohammad Reza Rafiyan
- Contact Person Email
- rafiyan.reza@khnw.de
- Site Name
- Klinikum der Technischen Universitaet Muenchen (TUM Klinikum)
- Department Name
- Urooncology
- Principal Investigator Name
- Margitta Retz
- Principal Investigator Email
- margitta.retz@tum.de
- Contact Person Name
- Margitta Retz
- Contact Person Email
- margitta.retz@tum.de
- Site Name
- National Center For Tumor Diseases (NCT) Heidelberg
- Department Name
- Med. Oncology
- Principal Investigator Name
- Stefanie Zschaebitz
- Principal Investigator Email
- stefanie.zschaebitz@med.uni-heidelberg.de
- Contact Person Name
- Stefanie Zschaebitz
- Contact Person Email
- stefanie.zschaebitz@med.uni-heidelberg.de
Italy
- Earliest CTIS Part Ii Submission Date
- 02-10-2025
- Latest Decision Or Authorization Date
- 20-11-2025
- Processing Time Days
- 49
- Number Of Sites
- 8
- Number Of Participants
- 34
Sites
- Site Name
- Humanitas Mirasole S.p.A.
- Department Name
- Medical Oncology and Hematology Unit
- Principal Investigator Name
- Paolo Zucali
- Principal Investigator Email
- paolo.zucali@hunimed.eu
- Contact Person Name
- Paolo Zucali
- Contact Person Email
- paolo.zucali@hunimed.eu
- Site Name
- Azienda Ospedaliera Universitaria Citta Della Salute E Della Scienza Di Torino
- Department Name
- Medical Oncology 1U
- Principal Investigator Name
- Massimo Di Maio
- Principal Investigator Email
- massimo.dimaio@unito.it
- Contact Person Name
- Massimo Di Maio
- Contact Person Email
- massimo.dimaio@unito.it
- Site Name
- Istituto Oncologico Veneto
- Department Name
- Oncology Unit 3
- Principal Investigator Name
- Marco Maruzzo
- Principal Investigator Email
- marco.maruzzo@iov.veneto.it
- Contact Person Name
- Marco Maruzzo
- Contact Person Email
- marco.maruzzo@iov.veneto.it
- Site Name
- Azienda Ospedaliero Universitaria Ospedali Riuniti
- Department Name
- Unit of Medical Oncology and Biomolecular Therapy
- Principal Investigator Name
- Vincenza Conteduca
- Principal Investigator Email
- vincenza.conteduca@unifg.it
- Contact Person Name
- Vincenza Conteduca
- Contact Person Email
- vincenza.conteduca@unifg.it
- Site Name
- ARNAS Civico Di Cristina Benfratelli
- Department Name
- Medical Oncology Unit
- Principal Investigator Name
- Carlo Messina
- Principal Investigator Email
- carlo.messina@arnascivico.it
- Contact Person Name
- Carlo Messina
- Contact Person Email
- carlo.messina@arnascivico.it
- Site Name
- Azienda Ospedaliera Universitaria Federico II Di Napoli
- Department Name
- Medical Oncology Operating Unit
- Principal Investigator Name
- Luigi Formisano
- Principal Investigator Email
- luigi.formisano1@unina.it
- Contact Person Name
- Luigi Formisano
- Contact Person Email
- luigi.formisano1@unina.it
- Site Name
- Istituto Nazionale Dei Tumori
- Department Name
- Medical Oncology Genitourinary Unit
- Principal Investigator Name
- Giuseppe Procopio
- Principal Investigator Email
- giuseppe.procopio@istitutotumori.mi.it
- Contact Person Name
- Giuseppe Procopio
- Contact Person Email
- giuseppe.procopio@istitutotumori.mi.it
- Site Name
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
- Department Name
- Medical Oncology Operating Unit
- Principal Investigator Name
- Roberto Iacovelli
- Principal Investigator Email
- roberto.iacovelli@policlinicogemelli.it
- Contact Person Name
- Roberto Iacovelli
- Contact Person Email
- roberto.iacovelli@policlinicogemelli.it
Netherlands
- Earliest CTIS Part Ii Submission Date
- 13-11-2025
- Latest Decision Or Authorization Date
- 24-11-2025
- Processing Time Days
- 11
- Number Of Sites
- 9
- Number Of Participants
- 36
Sites
- Site Name
- Erasmus Universitair Medisch Centrum Rotterdam (Erasmus MC)
- Department Name
- Oncology
- Principal Investigator Name
- Nick Beije
- Principal Investigator Email
- n.beije@erasmusmc.nl
- Contact Person Name
- Nick Beije
- Contact Person Email
- n.beije@erasmusmc.nl
- Site Name
- Reinier de Graaf Groep
- Department Name
- Oncology
- Principal Investigator Name
- Addy van de Luijtgaarden
- Principal Investigator Email
- a.vandeluijtgaarden@rdgg.nl
- Contact Person Name
- Addy van de Luijtgaarden
- Contact Person Email
- a.vandeluijtgaarden@rdgg.nl
- Site Name
- Spaarne Gasthuis Stichting
- Department Name
- Hematology
- Principal Investigator Name
- Aart Beeker
- Principal Investigator Email
- abeeker@spaarnegasthuis.nl
- Contact Person Name
- Aart Beeker
- Contact Person Email
- abeeker@spaarnegasthuis.nl
- Site Name
- Stichting Martini Ziekenhuis
- Department Name
- Oncology
- Principal Investigator Name
- Bart Kuenen
- Principal Investigator Email
- b.kuenen@mzh.nl
- Contact Person Name
- Bart Kuenen
- Contact Person Email
- b.kuenen@mzh.nl
- Site Name
- Canisius Wilhelmina Ziekenhuis
- Department Name
- Oncology
- Principal Investigator Name
- Marieke Berends
- Principal Investigator Email
- marieke.berends@cwz.nl
- Contact Person Name
- Marieke Berends
- Contact Person Email
- marieke.berends@cwz.nl
- Site Name
- Isala Klinieken Stichting
- Department Name
- Oncology
- Principal Investigator Name
- Metin Tascilar
- Principal Investigator Email
- m.tascilar@isala.nl
- Contact Person Name
- Metin Tascilar
- Contact Person Email
- m.tascilar@isala.nl
- Site Name
- Tergooiziekenhuizen
- Department Name
- Oncology
- Principal Investigator Name
- Pieter van den Berg
- Principal Investigator Email
- pvandenberg@tergooi.nl
- Contact Person Name
- Pieter van den Berg
- Contact Person Email
- pvandenberg@tergooi.nl
- Site Name
- Academisch Ziekenhuis Maastricht
- Department Name
- Oncology
- Principal Investigator Name
- Thomas Kerkhofs
- Principal Investigator Email
- thomas.kerkhofs@mumc.nl
- Contact Person Name
- Thomas Kerkhofs
- Contact Person Email
- thomas.kerkhofs@mumc.nl
- Site Name
- Reinier de Graaf Groep (additional listed site record)
- Department Name
- Oncology
- Principal Investigator Name
- Addy van de Luijtgaarden
- Principal Investigator Email
- a.vandeluijtgaarden@rdgg.nl
- Contact Person Name
- Addy van de Luijtgaarden
- Contact Person Email
- a.vandeluijtgaarden@rdgg.nl
Poland
- Earliest CTIS Part Ii Submission Date
- 21-10-2025
- Latest Decision Or Authorization Date
- 21-11-2025
- Processing Time Days
- 31
- Number Of Sites
- 5
- Number Of Participants
- 20
Sites
- Site Name
- Narodowy Instytut Onkologii Im. Marii Sklodowskiej-Curie Panstwowy Instytut Badawczy
- Department Name
- Klinika Nowotworów Układu Moczowego
- Principal Investigator Name
- Pawel Wiechno
- Principal Investigator Email
- sekretariatk3@nio.gov.pl
- Contact Person Name
- Pawel Wiechno
- Contact Person Email
- sekretariatk3@nio.gov.pl
- Site Name
- In Vivo Sp. z o.o.
- Department Name
- In Vivo Sp. z o.o.
- Principal Investigator Name
- Marcin Zaremba
- Principal Investigator Email
- kontakt@in-vivo.pl
- Contact Person Name
- Marcin Zaremba
- Contact Person Email
- kontakt@in-vivo.pl
- Site Name
- Szpital Wojewodzki Im. Mikolaja Kopernika W Koszalinie
- Department Name
- Oddział Dzienny Chemioterapii
- Principal Investigator Name
- Mariusz Kwiatkowski
- Principal Investigator Email
- szpital@swk.med.pl
- Contact Person Name
- Mariusz Kwiatkowski
- Contact Person Email
- szpital@swk.med.pl
- Site Name
- Uniwersytecki Szpital Kliniczny W Bialymstoku
- Department Name
- Klinika Urologii i Urologii Klinicznej
- Principal Investigator Name
- Jacek Kudelski
- Principal Investigator Email
- kl.urologii@uskwb.pl
- Contact Person Name
- Jacek Kudelski
- Contact Person Email
- kl.urologii@uskwb.pl
- Site Name
- Szpital Grochowski Im.Dr Med. Rafała Masztaka Sp. z o.o.
- Department Name
- Oddział Chemioterapii
- Principal Investigator Name
- Iwona Skoneczna
- Principal Investigator Email
- rejestracja-onkologiczna@grochowski.waw.pl
- Contact Person Name
- Iwona Skoneczna
- Contact Person Email
- rejestracja-onkologiczna@grochowski.waw.pl
Spain
- Earliest CTIS Part Ii Submission Date
- 24-10-2025
- Latest Decision Or Authorization Date
- 20-11-2025
- Processing Time Days
- 27
- Number Of Sites
- 6
- Number Of Participants
- 20
Sites
- Site Name
- Hospital Universitari Vall D Hebron
- Department Name
- Medical Oncology
- Principal Investigator Name
- María Dolores Fenor de la Maza López Olmedo
- Principal Investigator Email
- mfenor@vhio.net
- Contact Person Name
- María Dolores Fenor de la Maza López Olmedo
- Contact Person Email
- mfenor@vhio.net
- Site Name
- Hospital Universitario Ramon Y Cajal
- Department Name
- Medical Oncology
- Principal Investigator Name
- Teresa Alonso Gordoa
- Principal Investigator Email
- talonsogordoa@gmail.com
- Contact Person Name
- Teresa Alonso Gordoa
- Contact Person Email
- talonsogordoa@gmail.com
- Site Name
- Hospital Universitario 12 De Octubre
- Department Name
- Medical Oncology
- Principal Investigator Name
- Elena Castro Marcos
- Principal Investigator Email
- ecastro.imas12@h2o.es
- Contact Person Name
- Elena Castro Marcos
- Contact Person Email
- ecastro.imas12@h2o.es
- Site Name
- Hospital De Jerez De La Frontera
- Department Name
- Medical Oncology
- Principal Investigator Name
- Ana Isabel Vacas Rama
- Principal Investigator Email
- anavrama@gmail.com
- Contact Person Name
- Ana Isabel Vacas Rama
- Contact Person Email
- anavrama@gmail.com
- Site Name
- Hospital Universitario Virgen De La Victoria
- Department Name
- Medical Oncology
- Principal Investigator Name
- Lucía Oliva Fernández
- Principal Investigator Email
- luciaolifer3@gmail.com
- Contact Person Name
- Lucía Oliva Fernández
- Contact Person Email
- luciaolifer3@gmail.com
- Site Name
- Hospital Universitari Vall D Hebron (additional listed record)
- Department Name
- Medical Oncology
- Principal Investigator Name
- María Dolores Fenor de la Maza López Olmedo
- Principal Investigator Email
- mfenor@vhio.net
- Contact Person Name
- María Dolores Fenor de la Maza López Olmedo
- Contact Person Email
- mfenor@vhio.net
Belgium
- Earliest CTIS Part Ii Submission Date
- 21-10-2025
- Latest Decision Or Authorization Date
- 18-11-2025
- Processing Time Days
- 28
- Number Of Sites
- 9
- Number Of Participants
- 46
Sites
- Site Name
- Ziekenhuis Aan De Stroom
- Department Name
- Oncology
- Principal Investigator Name
- Tom Van den Mooter
- Principal Investigator Email
- tom.vandenmooter@zas.be
- Contact Person Name
- Tom Van den Mooter
- Contact Person Email
- tom.vandenmooter@zas.be
- Site Name
- Clinique Saint-Pierre
- Department Name
- Oncology
- Principal Investigator Name
- Nicolas Whenham
- Principal Investigator Email
- Nicolas.WHENHAM@cspo.be
- Contact Person Name
- Nicolas Whenham
- Contact Person Email
- Nicolas.WHENHAM@cspo.be
- Site Name
- Universiteit Gent
- Department Name
- Oncology
- Principal Investigator Name
- Sylvie Rottey
- Principal Investigator Email
- sylvie.rottey@ugent.be
- Contact Person Name
- Sylvie Rottey
- Contact Person Email
- sylvie.rottey@ugent.be
- Site Name
- CHC MontLegia
- Department Name
- Oncology
- Principal Investigator Name
- Geoffrey Matus
- Principal Investigator Email
- geoffrey.matus@chc.be
- Contact Person Name
- Geoffrey Matus
- Contact Person Email
- geoffrey.matus@chc.be
- Site Name
- CHU Helora
- Department Name
- Oncology
- Principal Investigator Name
- Guillaume Grisay
- Principal Investigator Email
- guillaume.grisay@jolimont.be
- Contact Person Name
- Guillaume Grisay
- Contact Person Email
- guillaume.grisay@jolimont.be
- Site Name
- Az St-Jan Brugge-Oostende A.V.
- Department Name
- Oncology
- Principal Investigator Name
- Barbara Brouwers
- Principal Investigator Email
- barbara.brouwers@azsintjan.be
- Contact Person Name
- Barbara Brouwers
- Contact Person Email
- barbara.brouwers@azsintjan.be
- Site Name
- Cliniques Universitaires Saint-Luc
- Department Name
- Urology
- Principal Investigator Name
- Bertrand Tombal
- Principal Investigator Email
- bertrand.tombal@saintluc.uclouvain.be
- Contact Person Name
- Bertrand Tombal
- Contact Person Email
- bertrand.tombal@saintluc.uclouvain.be
- Site Name
- Az Maria Middelares Gent
- Department Name
- Oncology
- Principal Investigator Name
- Christof Vulsteke
- Principal Investigator Email
- christof.vulsteke@mijnziekenhuis.be
- Contact Person Name
- Christof Vulsteke
- Contact Person Email
- christof.vulsteke@mijnziekenhuis.be
- Site Name
- Algemeen Ziekenhuis Groeninge
- Department Name
- Oncology
- Principal Investigator Name
- Sofie Demasure
- Principal Investigator Email
- Sofie.demasure@azgroeninge.be
- Contact Person Name
- Sofie Demasure
- Contact Person Email
- Sofie.demasure@azgroeninge.be
France
- Earliest CTIS Part Ii Submission Date
- 27-10-2025
- Latest Decision Or Authorization Date
- 27-01-2026
- Processing Time Days
- 92
- Number Of Sites
- 12
- Number Of Participants
- 48
Sites
- Site Name
- Hospices Civils De Lyon
- Department Name
- Medical oncology
- Principal Investigator Name
- Denis MAILLET
- Principal Investigator Email
- denis.maillet@chu-lyon.fr
- Contact Person Name
- Denis MAILLET
- Contact Person Email
- denis.maillet@chu-lyon.fr
- Site Name
- Institut De Cancerologie De Lorraine
- Department Name
- Medical oncology
- Principal Investigator Name
- Vincent MASSARD
- Principal Investigator Email
- v.massard@nancy.unicancer.fr
- Contact Person Name
- Vincent MASSARD
- Contact Person Email
- v.massard@nancy.unicancer.fr
- Site Name
- Centr Georges Francois Leclerc
- Department Name
- Medical oncology
- Principal Investigator Name
- Sylvain LADOIRE
- Principal Investigator Email
- sladoire@cgfl.fr
- Contact Person Name
- Sylvain LADOIRE
- Contact Person Email
- sladoire@cgfl.fr
- Site Name
- Les Hopitaux Universitaires De Strasbourg
- Department Name
- Medical oncology
- Principal Investigator Name
- Philippe BARTHELEMY
- Principal Investigator Email
- p.barthelemy@icans.eu
- Contact Person Name
- Philippe BARTHELEMY
- Contact Person Email
- p.barthelemy@icans.eu
- Site Name
- Institut Bergonie
- Department Name
- Medical oncology
- Principal Investigator Name
- Guilhem ROUBAUD
- Principal Investigator Email
- g.roubaud@bordeaux.unicancer.fr
- Contact Person Name
- Guilhem ROUBAUD
- Contact Person Email
- g.roubaud@bordeaux.unicancer.fr
- Site Name
- Centre Leon Berard
- Department Name
- Medical oncology
- Principal Investigator Name
- Aude FLECHON
- Principal Investigator Email
- aude.flechon@lyon.unicancer.fr
- Contact Person Name
- Aude FLECHON
- Contact Person Email
- aude.flechon@lyon.unicancer.fr
- Site Name
- Institut Gustave Roussy
- Department Name
- Medical oncology
- Principal Investigator Name
- Ronan FLIPPOT
- Principal Investigator Email
- ronan.flippot@gustaveroussy.fr
- Contact Person Name
- Ronan FLIPPOT
- Contact Person Email
- ronan.flippot@gustaveroussy.fr
- Site Name
- Institut De Cancerologie De L Ouest
- Department Name
- Medical oncology
- Principal Investigator Name
- Emmanuelle BOMPAS
- Principal Investigator Email
- Emmanuelle.bompas@ico.unicancer.fr
- Contact Person Name
- Emmanuelle BOMPAS
- Contact Person Email
- Emmanuelle.bompas@ico.unicancer.fr
- Site Name
- Centre Oscar Lambret
- Department Name
- Medical oncology
- Principal Investigator Name
- Eric Amela
- Principal Investigator Email
- y-amela@o-lambret.fr
- Contact Person Name
- Eric Amela
- Contact Person Email
- y-amela@o-lambret.fr
- Site Name
- Oncopole Claudius Regaud
- Department Name
- Medical oncology
- Principal Investigator Name
- Loic MOUREY
- Principal Investigator Email
- mourey.loic@iuct-oncopole.fr
- Contact Person Name
- Loic MOUREY
- Contact Person Email
- mourey.loic@iuct-oncopole.fr
- Site Name
- Fondation Hopital Saint Joseph
- Department Name
- Oncology
- Principal Investigator Name
- Carole Helissey
- Principal Investigator Email
- chelissey@ghpsj.fr
- Contact Person Name
- Carole Helissey
- Contact Person Email
- chelissey@ghpsj.fr
- Site Name
- Centre Hospitalier Regional Et Universitaire De Brest
- Department Name
- Oncology
- Principal Investigator Name
- Benjamin AUBERGER
- Principal Investigator Email
- benjamin.auberger@chu-brest.fr
- Contact Person Name
- Benjamin AUBERGER
- Contact Person Email
- benjamin.auberger@chu-brest.fr
Sponsor
Primary sponsor
- Full Name
- Janssen Cilag International
- Organisation Type
- Pharmaceutical company
- Country Of Registered Address
- Belgium
Contract research organisations
- Name
- 4g Clinical LLC
- Responsibilities
- sponsorDuties code: 3 (role as listed in third party entries)
- Name
- Labcorp Central Laboratory Services LP
- Responsibilities
- laboratory services (sponsorDuties code: 4; contact Medical.affairs@labcorp.com)
- Name
- Eresearchtechnology Inc.
- Responsibilities
- eCOA vendor (explicitly listed: 'eCOA vendor')
Third parties
- {"country":"United States","full_name":"Labcorp Central Laboratory Services LP","duties_or_roles":"sponsorDuties codes: 4 (contact: Medical.affairs@labcorp.com)","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"4g Clinical LLC","duties_or_roles":"sponsorDuties codes: 3 (contact: mscoville@4gclinical.com)","organisation_type":"Non-Pharmaceutical company"}
- {"country":"United States","full_name":"Eresearchtechnology Inc.","duties_or_roles":"eCOA vendor (value provided) (contact: Larmarrio.Harden@Clario.com)","organisation_type":"Pharmaceutical company"}
Investigational products
- Investigational Product Name
- JNJ-78278343
- Active Substance
- JNJ-78278343
- Modality
- Other antibody
- Routes Of Administration
- SOLUTION FOR INFUSION
- Route
- SOLUTION FOR INFUSION
- Authorisation Status
- Authorised (prodAuthStatus=1)
- Investigational Product Name
- Placebo JNJ-78278343
- Modality
- Other
- Combination Treatment
- Yes
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