Clinical trial • Phase I • Oncology

GSK5764227 for Advanced solid tumours

Phase I trial of GSK5764227 for Advanced solid tumours. 376 participants.

Overview

Trial Therapeutic Area
Oncology
Trial Disease
Advanced solid tumours
Trial Stage
Phase I

Key dates

Initial CTIS Submission Date
14-04-2025
First CTIS Authorization Date
11-08-2025

Trial design

Phase I trial across 17 sites in Italy, Spain, France.

Single Multiple Or Escalation Dose Combined
Yes
Target Sample Size
376

Eligibility

Recruits 376 No vulnerable population selected (isVulnerablePopulationSelected=false).

Vulnerable Population
No vulnerable population selected (isVulnerablePopulationSelected=false)

Recruitment

Planned Sample Size
376
Recruitment Window Months
21
Consent Approach
Not specified in CTIS; CTIS indicates adult participants only (isVulnerablePopulationSelected=false). No details on assent, consent documents or languages provided in the available record.

Geography

Total Number Of Sites
17
Total Number Of Participants
160

Italy

Earliest CTIS Part Ii Submission Date
23-07-2025
Latest Decision Or Authorization Date
19-02-2026
Processing Time Days
211
Number Of Sites
5
Number Of Participants
40

Sites

Site Name
Humanitas Mirasole S.p.A.
Department Name
Phase I Clinical Trial Unit
Principal Investigator Name
Matteo Simonelli
Principal Investigator Email
matteo.simonelli@cancercenter.humanitas.it
Contact Person Name
Matteo Simonelli
Site Name
Istituto Europeo Di Oncologia S.r.l.
Department Name
Divisione Sviluppo di Nuovi Farmaci per Terapie Innovative
Principal Investigator Name
Giuseppe Curigliano
Principal Investigator Email
giuseppe.curigliano@ieo.it
Contact Person Name
Giuseppe Curigliano
Contact Person Email
giuseppe.curigliano@ieo.it
Site Name
Centro Ricerche Cliniche Di Verona S.r.l.
Department Name
Centro Ricerche Cliniche di Verona
Principal Investigator Name
Andrea Zivi
Principal Investigator Email
andrea.zivi@aovr.veneto.it
Contact Person Name
Andrea Zivi
Contact Person Email
andrea.zivi@aovr.veneto.it
Site Name
IRCCS Istituto Nazionale Tumori Fondazione Pascale
Department Name
S.C. Sperimentazioni Cliniche
Principal Investigator Name
Adriano Gravina
Principal Investigator Email
a.gravina@istitutotumori.na.it
Contact Person Name
Adriano Gravina
Contact Person Email
a.gravina@istitutotumori.na.it
Site Name
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Department Name
Unità Operativa di Fase 1
Principal Investigator Name
Gennaro Daniele
Principal Investigator Email
gennaro.daniele@policlinogemelli.it
Contact Person Name
Gennaro Daniele

Spain

Earliest CTIS Part Ii Submission Date
18-07-2025
Latest Decision Or Authorization Date
26-02-2026
Processing Time Days
223
Number Of Sites
9
Number Of Participants
60

Sites

Site Name
Hospital Universitari Vall D Hebron
Department Name
Oncología Médica
Principal Investigator Name
Enriqueta Felip Font
Principal Investigator Email
enriqueta.felip@vallhebron.cat
Contact Person Name
Enriqueta Felip Font
Contact Person Email
enriqueta.felip@vallhebron.cat
Site Name
Hospital Universitario Y Politecnico La Fe
Department Name
Oncología Médica
Principal Investigator Name
Oscar Juan Vidal
Principal Investigator Email
juan_osc@gva.es
Contact Person Name
Oscar Juan Vidal
Contact Person Email
juan_osc@gva.es
Site Name
Hospital Clinic De Barcelona
Department Name
Oncología, Unidad de Ensayos Clínicos de Fase Temprana
Principal Investigator Name
Iván Victoria Ruiz
Principal Investigator Email
ivictori@recerca.clinic.cat
Contact Person Name
Iván Victoria Ruiz
Contact Person Email
ivictori@recerca.clinic.cat
Site Name
Hospital Universitario Fundacion Jimenez Diaz
Department Name
Oncología, Unidad de Fase 1
Principal Investigator Name
Victor Moreno García
Principal Investigator Email
victor.moreno@startmadrid.com
Contact Person Name
Victor Moreno García
Contact Person Email
victor.moreno@startmadrid.com
Site Name
Hospital Universitario Virgen De La Victoria
Department Name
Oncología, IBIMA Unidad de Fase 1
Principal Investigator Name
Javier García Corbacho
Principal Investigator Email
fasestempranas@ibima.eu
Contact Person Name
Javier García Corbacho
Contact Person Email
fasestempranas@ibima.eu
Site Name
Hospital Universitario Ramon Y Cajal
Department Name
Oncología Médica
Principal Investigator Name
María Eugenia Olmedo García
Principal Investigator Email
mariaeugenia.olmedo@salud.madrid.org
Contact Person Name
María Eugenia Olmedo García
Site Name
Hospital Clinico Universitario Lozano Blesa
Department Name
Oncología Médica
Principal Investigator Name
Maria Dolores Isla Casado
Principal Investigator Email
disla@salud.aragon.es
Contact Person Name
Maria Dolores Isla Casado
Contact Person Email
disla@salud.aragon.es
Site Name
Hospital Universitario 12 De Octubre
Department Name
Oncología Médica
Principal Investigator Name
Jon Zugazagoitia Fraile
Principal Investigator Email
j.zugazagoitia.imas12@h12o.es
Contact Person Name
Jon Zugazagoitia Fraile
Contact Person Email
j.zugazagoitia.imas12@h12o.es
Site Name
Hospital Universitario De Badajoz
Department Name
Oncología Médica
Principal Investigator Name
Marta González Cordero
Principal Investigator Email
marta.gonzalezc@salud-juntaex.es
Contact Person Name
Marta González Cordero

France

Earliest CTIS Part Ii Submission Date
21-07-2025
Latest Decision Or Authorization Date
19-02-2026
Processing Time Days
213
Number Of Sites
3
Number Of Participants
60

Sites

Site Name
Centre Leon Berard
Department Name
Departement de Cancerologie Medicale
Principal Investigator Name
Philippe CASSIER
Principal Investigator Email
philippe.cassier@lyon.unicancer.fr
Contact Person Name
Philippe CASSIER
Site Name
Institut Bergonie
Department Name
Departement d'Oncologie Medicale
Principal Investigator Name
Antoine ITALIANO
Principal Investigator Email
a.italiano@bordeaux.unicancer.fr
Contact Person Name
Antoine ITALIANO
Site Name
Institut Gustave Roussy
Department Name
Departement Innovations Therapeutiques et Groupe Oncologie Genito-Urinaire
Principal Investigator Name
Yohann LORIOT
Principal Investigator Email
yohann.loriot@gustaveroussy.fr
Contact Person Name
Yohann LORIOT
Contact Person Email
yohann.loriot@gustaveroussy.fr

Sponsor

Primary sponsor

Full Name
Glaxosmithkline Research & Development Limited
Organisation Type
Pharmaceutical company
Country Of Registered Address
United Kingdom

Investigational products

Investigational Product Name
GSK5764227

Related trials

Other published trials that may interest you.