Clinical trial • Phase II/III • Immunology
Frexalimab for Kidney transplant rejection
Phase II/III trial of Frexalimab for Kidney transplant rejection.
Overview
- Trial Therapeutic Area
- Immunology
- Trial Disease
- Kidney transplant rejection
- Trial Stage
- Phase II/III
- Drug Modality
- Monoclonal antibody|Small molecule
Key dates
- Initial CTIS Submission Date
- 20-10-2025
- First CTIS Authorization Date
- 23-02-2026
Trial design
Randomised, open-label, prograf / prograft (tacrolimus) oral capsules (0.5 mg, 1 mg, 5 mg) — comparator (dosing/schedule not specified in registry).-controlled Phase II/III trial in Sweden, Belgium, Germany and others.
- Randomised
- Yes
- Open Label
- Yes
- Comparator
- Prograf / Prograft (tacrolimus) oral capsules (0.5 mg, 1 mg, 5 mg) — comparator (dosing/schedule not specified in registry).
- Target Sample Size
- 343
- Trial Duration For Participant
- 1825
Eligibility
Recruits 343 adults.
Inclusion criteria
- {"criterion_text":"- Participants who are scheduled to receive their first kidney transplant from a living or deceased donor.\n- Participants with low to moderate immunological risk."}
Exclusion criteria
- {"criterion_text":"- Deceased donor kidney graft qualified as expanded criteria donor or donor after cardiac death.\n- Positive T or B cell crossmatch, or positive virtual crossmatch per local practice at screening.\n- Participants receiving a kidney graft from HLA-identical living-related donors, or have current or previous solid organ, cell, or multi-organ transplantation, or paired kidney transplantation.\n- Participants whose primary causes of ESKD are idiopathic FSGS, C3 glomerulopathy, lupus nephritis, or thrombotic microangiopathy\n- Evidence of active or latent TB, HIV, HBV or HCV infection.\n- Participants who have known genetically predisposed thrombophilia, have history of thromboembolic events, or who need long-term anti-coagulation therapy.\n- Participants who have severe medical co-morbidities, active infection, or severely limited life expectancy due to underlying medical conditions that are generally precluded from kidney transplant."}
Endpoints
Primary endpoints
- {"endpoint_text":"- Composite efficacy failure rate (BPAR, graft loss, and death) by 1 year post kidney transplantation","definition_or_measurement_approach":"Composite includes BPAR (biopsy-confirmed acute rejection), graft loss, and death assessed up to 1 year post kidney transplantation."}
Secondary endpoints
- {"endpoint_text":"- eGFR at 1 year post kidney transplantation","definition_or_measurement_approach":"Estimated glomerular filtration rate (eGFR) measured at 1 year post transplant."}
- {"endpoint_text":"- eGFR at 6 months, 2 years, 3 years, 4 years, and 5 years post kidney transplantation","definition_or_measurement_approach":"eGFR measured at the specified timepoints post transplant."}
- {"endpoint_text":"- Change of eGFR from Month 3 over time up to 5 years post kidney transplantation","definition_or_measurement_approach":"Change in eGFR from Month 3 through follow-up visits up to 5 years."}
- {"endpoint_text":"- Participant status of eGFR >60 mL/min/1.73 m2 at 1, 2, 3, and 5 years post kidney transplantation","definition_or_measurement_approach":"Proportion of participants with eGFR >60 mL/min/1.73 m2 at specified timepoints."}
- {"endpoint_text":"- Participant status of eGFR <60 mL/min/1.73 m² at Month 12 or with a >10 mL/min/1.73 m² decrease in eGFR from Month 3 to 12","definition_or_measurement_approach":"Binary status evaluated at Month 12 or based on change from Month 3 to 12."}
- {"endpoint_text":"- Proteinuria at 6 months, 1 year, 2 years, 3 years, 4 years, and 5 years post kidney transplantation","definition_or_measurement_approach":"Proteinuria measured at specified timepoints."}
- {"endpoint_text":"- iBox score at 1 year post kidney transplantation","definition_or_measurement_approach":"iBox prognostic score assessed at 1 year."}
- {"endpoint_text":"- Composite of participant and graft survival at 5 years post kidney transplantation","definition_or_measurement_approach":"Composite outcome of participant and graft survival assessed at 5 years."}
- {"endpoint_text":"- Composite of participant and graft survival over time and at 6 months, 1 year, 2 years, 3 years, and 4 years post kidney transplantation","definition_or_measurement_approach":"Composite survival measures assessed over time and at specified timepoints."}
- {"endpoint_text":"- Death-censored graft survival over time and at 6 months, 1 year, 2 years, 3 years, 4 years, and 5 years post kidney transplantation (including the causes of graft loss)","definition_or_measurement_approach":"Death-censored graft survival assessed over time and at specified timepoints; causes of graft loss recorded."}
- {"endpoint_text":"- Participant survival over time and at 6 months, 1 year, 2 years, 3 years, 4 years, and 5 years post kidney transplantation (including the causes of death)","definition_or_measurement_approach":"Participant survival assessed over time and at specified timepoints; causes of death recorded."}
- {"endpoint_text":"- Incidence of BPAR (yearly and cumulative) up to 5 years post kidney transplantation","definition_or_measurement_approach":"Annual and cumulative incidence of biopsy-proven acute rejection (BPAR) up to 5 years."}
- {"endpoint_text":"- Time to first BPAR","definition_or_measurement_approach":"Time from transplant to first occurrence of BPAR."}
- {"endpoint_text":"- Incidence of graft rejection at 6 months, 1 year, 2 years, 3 years, 4 years, and 5 years post kidney transplantation","definition_or_measurement_approach":"Incidence of graft rejection at specified timepoints."}
- {"endpoint_text":"- Incidence of rejection episodes with clinical resolution up to 5 years post kidney transplantation","definition_or_measurement_approach":"Incidence of rejection episodes that resolve clinically, up to 5 years."}
- {"endpoint_text":"- Composite efficacy failure rate (BPAR, graft loss, and death) by 6 months post kidney transplantation","definition_or_measurement_approach":"Composite of BPAR, graft loss, and death assessed at 6 months."}
- {"endpoint_text":"- Incidence of de novo donor-specific antibodies at 1 year post kidney transplantation","definition_or_measurement_approach":"Incidence of newly formed donor-specific antibodies at 1 year."}
- {"endpoint_text":"- Incidence of de novo donor-specific antibodies at 5 years post kidney transplantation","definition_or_measurement_approach":"Incidence of newly formed donor-specific antibodies at 5 years."}
- {"endpoint_text":"- Participants with AEs, SAEs, AEs leading to permanent study intervention discontinuation, AESIs, and PCSAs in laboratory tests, ECG, and vital signs during the study period","definition_or_measurement_approach":"Safety outcomes including AEs, SAEs, AESIs and clinically significant abnormalities in labs, ECG and vitals during study."}
- {"endpoint_text":"- Participants with medical device AEs, ADEs, medical device SAEs, SADEs, and device deficiencies during the study period","definition_or_measurement_approach":"Device-related safety events and deficiencies collected during study."}
- {"endpoint_text":"- Side effects of immunosuppressive therapy evaluated by MTSOSD-59R score at Months 1, 2, 3, 4, 5, 6 and then every 6 months until the end of the study","definition_or_measurement_approach":"MTSOSD-59R score used to evaluate side effects at specified intervals."}
- {"endpoint_text":"- Frexalimab plasma concentration over time","definition_or_measurement_approach":"Plasma pharmacokinetic measurements of frexalimab over time."}
- {"endpoint_text":"- Incidence, titer, and persistence of ADA","definition_or_measurement_approach":"Incidence, titers and persistence of anti-drug antibodies (ADA) measured during study."}
- {"endpoint_text":"- Incidence of new-onset diabetes post kidney transplantation","definition_or_measurement_approach":"Incidence of new-onset diabetes after transplant measured over follow-up."}
- {"endpoint_text":"- Incidence and prevalence of hypertension, anti-hypertensive regimen, and systolic and diastolic blood pressure","definition_or_measurement_approach":"Incidence/prevalence of hypertension, treatment regimens and BP measures recorded."}
- {"endpoint_text":"- Incidence and prevalence of dyslipidemia, lipid-lowering regimen, and measures of dyslipidemia, including serum TG and total, non-HDL, LDL, and HDL cholesterol","definition_or_measurement_approach":"Incidence/prevalence of dyslipidemia and lipid measures including triglycerides and cholesterol fractions."}
Recruitment
- Digital Remote Recruitment
- Yes
- Planned Sample Size
- 343
- Recruitment Window Months
- 89
- Consent Approach
- Informed consent obtained using subject information and informed consent forms (L1 redacted SIS ICF main and related ICFs). Consent materials and related partner/pregnancy and caregiver information forms are available in multiple languages (examples in the registry: en, fr, nl, de, hu, it, sv, es, cs, fi). Participants provide consent; partner/pregnancy and caregiver-specific information/consent documents are included in the document set.
Methods
- Site-based recruitment at participating transplant centres (materials and arrangements documented per-country via K1 recruitment arrangements).
- Participant letters (K2 recruitment-material-participant-letter) provided in multiple languages.
- Printed materials: flyers, posters, trifold leaflets (K2 recruitment-material-flyer / poster / trifold).
- IC flipchart materials for site staff (K2-recruitment-material-ic-flipchart).
- Video storyboard materials (K2-recruitment-material-uys-video-storyboard) used as part of recruitment materials.
Geography
- Total Number Of Sites
- 46
- Total Number Of Participants
- 269
Sweden
- Earliest CTIS Part Ii Submission Date
- 05-11-2025
- Latest Decision Or Authorization Date
- 28-04-2026
- Processing Time Days
- 174
- Number Of Sites
- 3
- Number Of Participants
- 12
Sites
- Site Name
- Karolinska University Hospital
- Department Name
- Karolinska Universitetssjukhuset Huddinge
- Contact Person Name
- Lars Wennberg
- Contact Person Email
- lars.wennberg@regionstockholm.se
- Site Name
- Uppsala University Hospital
- Department Name
- Akademiska Sjukhuset Department of Transplant Surgery
- Contact Person Name
- Tomas Lorant
- Contact Person Email
- tomas.lorant@surgsci.uu.se
- Site Name
- Sahlgrenska University Hospital-Vaestra Goetalandsregionen
- Department Name
- Sahlgrenska Universitetssjukhuset Transplant Centre, KPE
- Contact Person Name
- Jana Ekberg
- Contact Person Email
- jana.ekberg@vgregion.se
Belgium
- Earliest CTIS Part Ii Submission Date
- 26-01-2026
- Latest Decision Or Authorization Date
- 29-04-2026
- Processing Time Days
- 93
- Number Of Sites
- 2
- Number Of Participants
- 11
Sites
- Site Name
- UZ Leuven
- Department Name
- UZ Leuven Campus Gasthuisberg - Nefrology
- Contact Person Name
- Dirk Kuypers
- Contact Person Email
- dirk.kuypers@uzleuven.be
- Site Name
- Cliniques Universitaires Saint-Luc
- Department Name
- Cliniques Universitaires Saint-Luc - Nefrology
- Contact Person Name
- Arnaud Devresse
- Contact Person Email
- arnaud.devresse@saintluc.uclouvain.be
Germany
- Earliest CTIS Part Ii Submission Date
- 28-01-2026
- Latest Decision Or Authorization Date
- 29-04-2026
- Processing Time Days
- 91
- Number Of Sites
- 3
- Number Of Participants
- 38
Sites
- Site Name
- Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz KöR
- Department Name
- Universitätsklinikum Mainz, I. Medizinische Klinik und Poliklinik
- Contact Person Name
- Julia Weinmann-Menke
- Contact Person Email
- julia.weinmann-menke@unimedizin-mainz.de
- Site Name
- Charite Universitaetsmedizin Berlin KöR
- Department Name
- Charité-Campus Virchow-Klinikum Nephrologie/Intensivmedizin
- Contact Person Name
- Fabian Halleck
- Contact Person Email
- fabian.halleck@charite.de
- Site Name
- Universitaet Muenster
- Department Name
- Universitätsklinikum Münster, Innere Med. Med.Klinik D, Nephrology
- Contact Person Name
- Stefan Reuter
- Contact Person Email
- stefan.reuter@ukmuenster.de
Netherlands
- Earliest CTIS Part Ii Submission Date
- 11-02-2026
- Latest Decision Or Authorization Date
- 29-04-2026
- Processing Time Days
- 77
- Number Of Sites
- 2
- Number Of Participants
- 34
Sites
- Site Name
- Leids Universitair Medisch Centrum (LUMC)
- Department Name
- Leiden University Medical Center
- Contact Person Name
- Aiko De Vries
- Contact Person Email
- a.p.j.de_vries@lumc.nl
- Site Name
- Universitair Medisch Centrum Groningen
- Department Name
- Universitair Medisch Centrum Groningen
- Contact Person Name
- Stefan Berger
- Contact Person Email
- s.p.berger@umcg.nl
Czechia
- Earliest CTIS Part Ii Submission Date
- 20-01-2026
- Latest Decision Or Authorization Date
- 29-04-2026
- Processing Time Days
- 99
- Number Of Sites
- 2
- Number Of Participants
- 17
Sites
- Site Name
- Fakultni Nemocnice Ostrava
- Department Name
- Fakultni nemocnice Ostrava Interni klinika, nefrologicka ambulance
- Contact Person Name
- Zdenek Lys
- Contact Person Email
- zdenek.lys@fno.cz
- Site Name
- Institute For Clinical And Experimental Medicine
- Department Name
- Institut klinicke a experimentalni mediciny Klinika nefrologie
- Contact Person Name
- Ondrej Viklicky
- Contact Person Email
- ondrej.viklicky@ikem.cz
Hungary
- Earliest CTIS Part Ii Submission Date
- 16-12-2025
- Latest Decision Or Authorization Date
- 29-04-2026
- Processing Time Days
- 134
- Number Of Sites
- 3
- Number Of Participants
- 12
Sites
- Site Name
- Semmelweis University
- Department Name
- Semmelweis Egyetem Sebeszeti, Transzplantacios és Gasztroenterologiai Klinika
- Contact Person Name
- László Wágner
- Contact Person Email
- wagner.laszlo@semmelweis.hu
- Site Name
- University Of Debrecen
- Department Name
- Debreceni Egyetem Klinikai Központ Sebészeti Klinika
- Contact Person Name
- Balázs Áron Nemes
- Contact Person Email
- bnemes@hotmail.com
- Site Name
- University Of Pecs
- Department Name
- University Of Pecs-Pecsi Tudomanyegyetem Klinikai Kozpont,Sebészeti Klinika,Transzplantációs Osztály
- Contact Person Name
- Peter Szakaly
- Contact Person Email
- szakaly.peter@pte.hu
Austria
- Earliest CTIS Part Ii Submission Date
- 18-02-2026
- Latest Decision Or Authorization Date
- 29-04-2026
- Processing Time Days
- 70
- Number Of Sites
- 1
- Number Of Participants
- 5
Sites
- Site Name
- Medical University Of Vienna
- Department Name
- AKH Wien, Universitätsklinikum, Klinik für Innere Medizin III, Abteilung für Nephrologie und Dialyse
- Contact Person Name
- Rainer Oberbauer
- Contact Person Email
- rainer.oberbauer@meduniwien.ac.at
Spain
- Earliest CTIS Part Ii Submission Date
- 23-01-2026
- Latest Decision Or Authorization Date
- 29-04-2026
- Processing Time Days
- 96
- Number Of Sites
- 5
- Number Of Participants
- 43
Sites
- Site Name
- Bellvitge University Hospital
- Department Name
- Nephrology and Renal Transplantation
- Contact Person Name
- Josep Maria Cruzado Garrit
- Contact Person Email
- jmcruzado@bellvitgehospital.cat
- Site Name
- Hospital Universitario Regional De Malaga
- Department Name
- Nephrology
- Contact Person Name
- Veronica Lopez Jimenez
- Contact Person Email
- verolopezjim@yahoo.es
- Site Name
- Complexo Hospitalario Universitario A Coruna
- Department Name
- Nephrology
- Contact Person Name
- Constantino Fernandez Rivera
- Contact Person Email
- constantino.fernandez.rivera@sergas.es
- Site Name
- Hospital Clinic De Barcelona
- Department Name
- Nephrology
- Contact Person Name
- Fritz Herbert Diekmann
- Contact Person Email
- fdiekman@clinic.cat
- Site Name
- Fundacio Hospital Universitari Vall D’Hebron Institut De Recerca
- Department Name
- Nephrology
- Contact Person Name
- Oriol Bestard Matamoros
- Contact Person Email
- oriol.bestard@vallhebron.cat
Denmark
- Earliest CTIS Part Ii Submission Date
- 23-01-2026
- Latest Decision Or Authorization Date
- 29-04-2026
- Processing Time Days
- 96
- Number Of Sites
- 1
- Number Of Participants
- 4
Sites
- Site Name
- Region Midtjylland
- Department Name
- Aarhus Universitetshospital The Renal Research Lab
- Contact Person Name
- Henrik Birn
- Contact Person Email
- hb@clin.au.dk
France
- Earliest CTIS Part Ii Submission Date
- 13-02-2026
- Latest Decision Or Authorization Date
- 29-04-2026
- Processing Time Days
- 75
- Number Of Sites
- 10
- Number Of Participants
- 39
Sites
- Site Name
- Centre Hospitalier Universitaire De Lille
- Department Name
- CHRU Lille - Hopital Claude Huriez Nephrologie
- Contact Person Name
- Francois Provot
- Contact Person Email
- Francois.provot@chru-lille.fr
- Site Name
- Centre Hospitalier Universitaire De Nantes
- Department Name
- CHU Nantes - Hopital Hotel Dieu-Institut de transplantation urologie-néphrologie
- Contact Person Name
- Gilles Blancho
- Contact Person Email
- gilles.blancho@chu-nantes.fr
- Site Name
- Centre Hospitalier Universitaire De Toulouse
- Department Name
- CHU de Toulouse - Hopital Rangueil Service de Nephrologie
- Contact Person Name
- Nassim Kamar
- Contact Person Email
- kamar.n@chu-toulouse.fr
- Site Name
- Assistance Publique Hopitaux De Paris
- Department Name
- APHP - Centre Hospitalier la Pitie Salpetriere Service de Néphrologie et Transplantation rénale
- Contact Person Name
- Helene Francois
- Contact Person Email
- helene.francois@aphp.fr
- Site Name
- Centre Hospitalier Universitaire De Bordeaux
- Department Name
- CHU Bordeaux - Hopital Pellegrin Service de Néphrologie-Transplantation-Dialyse-Aphérèses
- Contact Person Name
- Lionel Couzi
- Contact Person Email
- lionel.couzi@chu-bordeaux.fr
- Site Name
- Centre Hospitalier Regional Universitaire De Tours
- Department Name
- CHU Tours - Hopital Bretonneau Service de Nephrologie
- Contact Person Name
- Philippe Gatault
- Contact Person Email
- philippe.gatault@univ-tours.fr
- Site Name
- APHP-Hopital Necker Enfants Malades
- Department Name
- Service de Nephrologie
- Contact Person Name
- Olivier Aubert
- Contact Person Email
- olivier.aubert@aphp.fr
- Site Name
- Hospices Civils De Lyon
- Department Name
- HCL Lyon - Hopital Edouard Herriot Departement de Nephrologie et d'Immunologie Clinique
- Contact Person Name
- Olivier Thaunat
- Contact Person Email
- olivier.thaunat@chu-lyon.fr
- Site Name
- Les Hopitaux Universitaires De Strasbourg
- Department Name
- CHU de Strasbourg - Nouvel Hôpital Civil Service Néphrologie-Transplantation rénale
- Contact Person Name
- Sophie Caillard Ohlmann
- Contact Person Email
- sophie.ohlmann@chru-strasbourg.fr
- Site Name
- Centre Hospitalier Universitaire Grenoble Alpes
- Department Name
- CHU Grenoble Alpes Nord – Hopital Michallon Sommeil et Respiration EFCR
- Contact Person Name
- Lionel Rostaing
- Contact Person Email
- lrostaing@chu-grenoble.fr
Italy
- Earliest CTIS Part Ii Submission Date
- 13-01-2026
- Latest Decision Or Authorization Date
- 29-04-2026
- Processing Time Days
- 106
- Number Of Sites
- 13
- Number Of Participants
- 50
Sites
- Site Name
- ASST Grande Ospedale Metropolitano Niguarda
- Department Name
- ASST Grande Ospedale Metropolitano Niguarda
- Contact Person Name
- Enrico Minetti
- Contact Person Email
- enrico.minetti@ospedaleniguarda.it
- Site Name
- Azienda Ospedaliero-Universitaria Di Bologna IRCCS Istituto Di Ricerca E Di Cura A Carattere Scientifico
- Contact Person Name
- Gaetano La-Manna
- Contact Person Email
- gaetano.lamanna@unibo.it
- Site Name
- Azienda Ospedaliero Universitaria Delle Marche
- Department Name
- Azienda Ospedaliero Universitaria delle Marche
- Contact Person Name
- Andrea Ranghino
- Contact Person Email
- andrea.ranghino@ospedaliriuniti.marche.it
- Site Name
- Azienda Ospedaliera di Padova
- Department Name
- Azienda Ospedale - Università Padova
- Contact Person Name
- Lucrezia Furian
- Contact Person Email
- lucrezia.furian@unipd.it
- Site Name
- Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico
- Department Name
- Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico
- Contact Person Name
- Evaldo Favi
- Contact Person Email
- evaldo.favi@unimi.it
- Site Name
- Azienda Ospedaliero-Universitaria Maggiore Della Carita
- Department Name
- Azienda Ospedaliero-Universitaria Maggiore Della Carita
- Contact Person Name
- Vincenzo Cantaluppi
- Contact Person Email
- vincenzo.cantaluppi@med.uniupo.it
- Site Name
- Ospedale San Raffaele S.r.l.
- Department Name
- IRCCS Ospedale San Raffaele
- Contact Person Name
- Rossana Caldara
- Contact Person Email
- caldara.rossana@hsr.it
- Site Name
- Azienda Socio Sanitaria Territoriale Degli Spedali Civili Di Brescia
- Department Name
- Azienda Socio Sanitaria Territoriale Degli Spedali Civili Di Brescia
- Contact Person Name
- Federico Alberici
- Contact Person Email
- federico.alberici@unibs.it
- Site Name
- Istituto Mediterraneo Per I Trapianti E Terapie Ad Alta Specializzazione S.r.l. I.S.M.E.T.T. S.r.l.
- Department Name
- Istituto Mediterraneo Per I Trapianti E Terapie Ad Alta Specializzazione S.r.l. I.S.M.E.T.T. S.r.l.
- Contact Person Name
- Barbara Buscemi
- Contact Person Email
- bbuscemi@ismett.edu
- Site Name
- Azienda Ospedaliero Universitaria Parma
- Department Name
- Azienda Ospedaliero Universitaria di Parma
- Contact Person Name
- Umberto Maggiore
- Contact Person Email
- umberto.maggiore@unipr.it
- Site Name
- Azienda Ospedaliero Universitaria Careggi
- Department Name
- Azienda Ospedaliero-Universitaria Careggi Nephrology Dialysis and Transplant Unit
- Contact Person Name
- Lino Caloger Cirami
- Contact Person Email
- ciramil@aou-careggi.toscana.it
- Site Name
- Azienda Ospedaliera Policlinico Universitario Tor Vergata
- Department Name
- A. O. U. Policlinico Tor Vergata
- Contact Person Name
- Giuseppe Tisone
- Contact Person Email
- tisone@uniroma2.it
- Site Name
- Azienda Ospedaliera Universitaria Citta Della Salute E Della Scienza Di Torino
- Department Name
- A.O.U Città della Salute e della Scienza di Torino
- Contact Person Name
- Luigi Biancone
- Contact Person Email
- luigi.biancone@unito.it
Finland
- Earliest CTIS Part Ii Submission Date
- 30-01-2026
- Latest Decision Or Authorization Date
- 29-04-2026
- Processing Time Days
- 89
- Number Of Sites
- 1
- Number Of Participants
- 4
Sites
- Site Name
- HUS-yhtymae
- Department Name
- HUS Helsinki University Hospital
- Contact Person Name
- Fernanda Ortiz
- Contact Person Email
- Fernanda.Ortiz@hus.fi
Sponsor
Primary sponsor
- Full Name
- Sanofi-Aventis Recherche & Developpement
- Organisation Type
- Pharmaceutical company
- Country Of Registered Address
- France
Contract research organisations
- Name
- Evidera Limited
- Responsibilities
- Participants' interviews
- Name
- Endpoint Clinical Inc.
- Name
- Empatica Inc.
- Name
- Bioclinica Inc.
- Name
- Accellacare Limited
- Responsibilities
- Home nursing (decentralized trial solution)
- Name
- PetMobile Kft.
- Name
- Discovery Life Sciences Biomarker Services GmbH
- Responsibilities
- Central reading of biopsies
- Name
- ESMS Global Limited
- Responsibilities
- Centralized 24-Hour Emergency System: eSMS
- Name
- PHOENIX lekarensky velkoobchod s.r.o.
- Name
- Labcorp Central Laboratory Services SARL
Third parties
- {"country":"United Kingdom","full_name":"Evidera Limited","duties_or_roles":"Participants' interviews","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Endpoint Clinical Inc.","duties_or_roles":"","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Empatica Inc.","duties_or_roles":"","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Bioclinica Inc.","duties_or_roles":"","organisation_type":"Laboratory/Research/Testing facility"}
- {"country":"Ireland","full_name":"Accellacare Limited","duties_or_roles":"Home nursing (decentralized trial solution)","organisation_type":"Pharmaceutical company"}
- {"country":"Hungary","full_name":"PetMobile Kft.","duties_or_roles":"","organisation_type":"Non-Pharmaceutical company"}
- {"country":"Germany","full_name":"Discovery Life Sciences Biomarker Services GmbH","duties_or_roles":"Central reading of biopsies","organisation_type":"Pharmaceutical company"}
- {"country":"United Kingdom","full_name":"ESMS Global Limited","duties_or_roles":"Centralized 24-Hour Emergency System: eSMS","organisation_type":"Pharmaceutical company"}
- {"country":"Czechia","full_name":"PHOENIX lekarensky velkoobchod s.r.o.","duties_or_roles":"","organisation_type":"Pharmaceutical company"}
- {"country":"Switzerland","full_name":"Labcorp Central Laboratory Services SARL","duties_or_roles":"","organisation_type":"Pharmaceutical company"}
Investigational products
- Investigational Product Name
- Frexalimab
- Active Substance
- Frexalimab
- Modality
- Monoclonal antibody
- Routes Of Administration
- Intravenous; Subcutaneous; Intramuscular
- Route
- Intravenous/Subcutaneous/Intramuscular
- Authorisation Status
- Investigational
- Investigational Product Name
- Prograf 0,5 mg Hartkapseln
- Active Substance
- Tacrolimus
- Modality
- Small molecule
- Routes Of Administration
- Oral
- Route
- Oral
- Authorisation Status
- Licensed/authorized (marketed comparator)
- Investigational Product Name
- Prograf 1 mg Hartkapseln
- Active Substance
- Tacrolimus
- Modality
- Small molecule
- Routes Of Administration
- Oral
- Route
- Oral
- Authorisation Status
- Licensed/authorized (marketed comparator)
- Investigational Product Name
- Prograf 5 mg Hartkapseln
- Active Substance
- Tacrolimus
- Modality
- Small molecule
- Routes Of Administration
- Oral
- Route
- Oral
- Authorisation Status
- Licensed/authorized (marketed comparator)
- Investigational Product Name
- Prograft 0,5 mg capsules, hard
- Active Substance
- Tacrolimus
- Modality
- Small molecule
- Routes Of Administration
- Oral
- Route
- Oral
- Authorisation Status
- Licensed/authorized (marketed comparator)
- Investigational Product Name
- Prograft 1 mg capsules, hard
- Active Substance
- Tacrolimus
- Modality
- Small molecule
- Routes Of Administration
- Oral
- Route
- Oral
- Authorisation Status
- Licensed/authorized (marketed comparator)
- Investigational Product Name
- Prograft 5 mg capsules, hard
- Active Substance
- Tacrolimus
- Modality
- Small molecule
- Routes Of Administration
- Oral
- Route
- Oral
- Authorisation Status
- Licensed/authorized (marketed comparator)
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