Clinical trial • Phase III • Cardiology
FINERENONE for Heart failure with left ventricular systolic dysfunction
Phase III trial of FINERENONE for Heart failure with left ventricular systolic dysfunction.
Overview
- Trial Therapeutic Area
- Cardiology
- Trial Disease
- Heart failure with left ventricular systolic dysfunction
- Trial Stage
- Phase III
- Drug Modality
- Small molecule
- Paediatric Trial
- Yes
Key dates
- Initial CTIS Submission Date
- 19-08-2025
- First CTIS Authorization Date
- 05-12-2025
Trial design
Randomised, finerenone (bay 94-8862 / finerenone bayer) added to standard of care versus matched placebo (placebo bay 948862) added to standard of care. (dosing strength variants listed in product records include 10 mg, 20 mg and 40 mg formulations; specific dosing schedule not specified in the available record.)-controlled Phase III trial in Belgium, Bulgaria, Czechia and others.
- Randomised
- Yes
- Comparator
- Finerenone (BAY 94-8862 / Finerenone Bayer) added to standard of care versus matched placebo (Placebo BAY 948862) added to standard of care. (Dosing strength variants listed in product records include 10 mg, 20 mg and 40 mg formulations; specific dosing schedule not specified in the available record.)
- Target Sample Size
- 51
- Trial Duration For Participant
- 90
Eligibility
Recruits 51 paediatric patients.
- Vulnerable Population
- Participants are children aged 6 months to <18 years (vulnerable population). Consent is obtained from parents/legal guardians and assent is obtained from children as appropriate. Age-specific subject information sheets and informed consent/assent forms are provided (small child, pre-teen, teenager, parent documents) in local languages as indicated in the provided SIS/ICF documents.
Inclusion criteria
- {"criterion_text":"- Participants must be 6 months to <18 years old at the time when the informed consent/assent is signed."}
- {"criterion_text":"- LV systolic dysfunction (LVSD) with left ventricular ejection fraction (LVEF) ≤ 50% at screening assessed by echocardiography"}
- {"criterion_text":"- Elevated NT-pro BNP levels • >500 ng/l for children ≥ 6 months to < 2 years of age • >300 ng/l, for children ≥ 2 years to <18 years"}
- {"criterion_text":"- Heart failure etiologies including congenital heart defects (CHD) with biventricular physiology and systemic LV; idiopathic cardiomyopathy (CM); familial/inherited and/or genetic CM; history of myocarditis (diagnosis of an acute episode was at least 3 months prior to randomization); neuromuscular disorder (eg, duchenne muscular dystrophy); inborn error of metabolism; mitochondrial disorder; acquired (chemotherapy, iatrogenic, infection, rheumatic, or nutritional); ischemic (eg, Kawasaki disease and postoperative heart failure [HF]); LV noncompaction."}
- {"criterion_text":"- Receiving standard of care (SoC) treatment for heart failure according to local guidelines or investigator´s discretion and being on a stable regimen for 30 days prior to randomization"}
- {"criterion_text":"- Study participants must have a body weight ≥ 4.0 kg at Visit 1."}
Exclusion criteria
- {"criterion_text":"- Serum potassium: • >5.0 mmol/L for children ≥ 2 years of age at either screening or randomization visit • >5.3 mmol/L for children ≥ 6 months to < 2 years of age at either screening or randomization visit (if estimated glomerular filtration rate [eGFR] < 60 mL/min/1.73m², threshold of > 5.0 mmol/L will be used)"}
- {"criterion_text":"- Severe renal dysfunction with eGFR < 30 ml/min/1.73m2 at screening or randomization visit"}
- {"criterion_text":"- Systolic blood pressure (SBP) < 5th percentile for age, sex and height at screening or randomization"}
- {"criterion_text":"- Sustained or symptomatic arrhythmias not controlled by drug or device therapy within 30 days prior to randomization"}
- {"criterion_text":"- Treatment with a mineralocorticoid receptor antagonist (e.g., spironolactone, eplerenone) within 30 days of randomization."}
- {"criterion_text":"- Requirement of any intravenous (IV) vasoactive agents, mechanical ventilation, mechanical circulatory support within 30 days prior to randomization."}
- {"criterion_text":"- Recent surgical procedure or other intervention to correct or palliate CHD within 3 months prior to randomization or anticipated to undergo cardiac surgery during the 3 months after randomization."}
Endpoints
Primary endpoints
- {"endpoint_text":"- Change in NT-proBNP from baseline to 3 months in participants receiving active study intervention compared to placebo","definition_or_measurement_approach":"Change from baseline to 3 months in NT-proBNP levels; comparison between finerenone plus standard of care versus placebo plus standard of care."}
Secondary endpoints
- {"endpoint_text":"- Number of participants with treatment-emergent adverse events (TEAEs)","definition_or_measurement_approach":"Count of participants experiencing TEAEs during the study period."}
- {"endpoint_text":"- Change in serum potassium levels from baseline to end of treatment (EoT)","definition_or_measurement_approach":"Change from baseline to EoT in serum potassium."}
- {"endpoint_text":"- Change in systolic blood pressure (SBP) from baseline to EoT","definition_or_measurement_approach":"Change from baseline to EoT in systolic blood pressure."}
- {"endpoint_text":"- Change in renal function from baseline to EoT","definition_or_measurement_approach":"Change from baseline to EoT in renal function parameters (e.g., eGFR)."}
- {"endpoint_text":"- Change in echocardiographic parameters of left ventricular systolic function and size from baseline to EoT","definition_or_measurement_approach":"Change from baseline to EoT in echocardiographic measures of LV systolic function and size (e.g., LVEF, LV dimensions)."}
- {"endpoint_text":"- Total number of cardiovascular outcome events, including cardiovascular death, heart transplantation, and clinical worsening of heart failure from baseline to EoT","definition_or_measurement_approach":"Count of predefined cardiovascular outcome events from baseline to EoT."}
- {"endpoint_text":"- Maximum observed finerenone concentration in plasma after multiple doses (Cmax, md)","definition_or_measurement_approach":"Pharmacokinetic measurement of Cmax after multiple dosing."}
- {"endpoint_text":"- Area under the curve for finerenone concentration in plasma after multiple doses (AUCτ,md)","definition_or_measurement_approach":"Pharmacokinetic measurement of AUCτ after multiple dosing."}
Recruitment
- Digital Remote Recruitment
- Yes
- Planned Sample Size
- 51
- Recruitment Window Months
- 49
- Consent Approach
- Parental/legal guardian informed consent is required for minor participants; assent is obtained from children as appropriate by age. Age-specific subject information sheets and informed consent/assent forms are provided (small child, pre-teen, teen, parent documents) and are available in local languages as per the document list (e.g., EN, DE, FR, NL and multiple country-specific language versions).
Methods
- Cartoon and animated videos (K2_Recruitment_material_Public_Cartoon_Video_*) — child-facing digital videos designed for recruitment (country-specific versions available).
- Child comic booklets (K2_Recruitment_material_Public_Child_Comic_Booklet_*) — printed/digital materials targeting children.
- Parent booklets (K2_Recruitment_material_Public_Parent_Booklet_*) — informational booklets for parents/guardians in country-specific languages.
- Teen booklets (K2_Recruitment_material_Public_Teen_Booklet_*) — materials targeted to adolescent participants.
- Tabletop materials (K2_Recruitment_material_Public_Tabletop_*) — clinic/display materials for site-based recruitment.
- Visit scheme and recruitment procedure documents (K1_Recruitment_arrangements_Public_*) — outlines of recruitment procedures and site-level processes (country-specific documents provided).
Geography
- Total Number Of Sites
- 47
- Total Number Of Participants
- 60
Belgium
- Earliest CTIS Part Ii Submission Date
- 27-11-2025
- Latest Decision Or Authorization Date
- 05-12-2025
- Processing Time Days
- 8
- Number Of Sites
- 5
- Number Of Participants
- 6
Sites
- Site Name
- Cliniques Universitaires Saint-Luc
- Department Name
- Pediatric Cardiology
- Principal Investigator Name
- Stephane Moniotte
- Principal Investigator Email
- stephane.moniotte@saintluc.uclouvain.be
- Contact Person Name
- Stephane Moniotte
- Contact Person Email
- stephane.moniotte@saintluc.uclouvain.be
- Site Name
- UZ Leuven
- Department Name
- Pediatric Cardiology
- Principal Investigator Name
- Bjorn Cools
- Principal Investigator Email
- Bjorn.Cools@uzleuven.be
- Contact Person Name
- Bjorn Cools
- Contact Person Email
- Bjorn.Cools@uzleuven.be
- Site Name
- CHC MontLegia
- Department Name
- Pediatric Cardiology
- Principal Investigator Name
- Isabelle Loeckx
- Principal Investigator Email
- Isabelle.loeckx@chc.be
- Contact Person Name
- Isabelle Loeckx
- Contact Person Email
- Isabelle.loeckx@chc.be
- Site Name
- Universitair Ziekenhuis Gent
- Department Name
- Pediatric Cardiology
- Principal Investigator Name
- Laura Muino Mosquera
- Principal Investigator Email
- laura.muinomosquera@uzgent.be
- Contact Person Name
- Laura Muino Mosquera
- Contact Person Email
- laura.muinomosquera@uzgent.be
- Site Name
- Universitair Ziekenhuis Antwerpen
- Department Name
- Pediatric Cardiology
- Principal Investigator Name
- Luc Bruyndonckx
- Principal Investigator Email
- luc.bruyndonckx@uza.be
- Contact Person Name
- Luc Bruyndonckx
- Contact Person Email
- luc.bruyndonckx@uza.be
Bulgaria
- Earliest CTIS Part Ii Submission Date
- 10-11-2025
- Latest Decision Or Authorization Date
- 10-12-2025
- Processing Time Days
- 30
- Number Of Sites
- 4
- Number Of Participants
- 4
Sites
- Site Name
- University Multidisciplinary Hospital For Active Treatment Sveta Ekaterina EAD
- Department Name
- TBD
- Principal Investigator Name
- Pencho Kratunkov
- Principal Investigator Email
- contact@i-health.bg
- Contact Person Name
- Pencho Kratunkov
- Contact Person Email
- contact@i-health.bg
- Site Name
- MHAT National Heart Hospital EAD
- Department Name
- Dept. Pediatric Cardiology
- Principal Investigator Name
- Anna Kaneva Nencheva
- Principal Investigator Email
- nkb@hearthospital.bg
- Contact Person Name
- Anna Kaneva Nencheva
- Contact Person Email
- nkb@hearthospital.bg
- Site Name
- Medical Center Nora-Heart Ltd.
- Department Name
- Child Cardiology
- Principal Investigator Name
- Rumen Marinov
- Principal Investigator Email
- reception@medcenterheart.com
- Contact Person Name
- Rumen Marinov
- Contact Person Email
- reception@medcenterheart.com
- Site Name
- University Multiprofile Hospital For Active Treatment Saint Georgi EAD
- Department Name
- Paediatric Cardiology and Rheumatology
- Principal Investigator Name
- Lyubov Atanasova Chochkova Bukova
- Principal Investigator Email
- klinikadetska@gmail.com
- Contact Person Name
- Lyubov Atanasova Chochkova Bukova
- Contact Person Email
- klinikadetska@gmail.com
Czechia
- Earliest CTIS Part Ii Submission Date
- 11-11-2025
- Latest Decision Or Authorization Date
- 09-12-2025
- Processing Time Days
- 28
- Number Of Sites
- 2
- Number Of Participants
- 2
Sites
- Site Name
- Fakultni Nemocnice V Motole
- Department Name
- Dětské kardiocentrum 2. LF UK a FN Motol
- Principal Investigator Name
- Karel Koubsky
- Principal Investigator Email
- detske.kardiocentrum@fnmotol.cz
- Contact Person Name
- Karel Koubsky
- Contact Person Email
- detske.kardiocentrum@fnmotol.cz
- Site Name
- Fakultni Nemocnice Brno
- Department Name
- Dětská nemocnice - Pediatrická klinika
- Principal Investigator Name
- Jana Tuckova
- Principal Investigator Email
- fnbrno@fnbrno.cz
- Contact Person Name
- Jana Tuckova
- Contact Person Email
- fnbrno@fnbrno.cz
Germany
- Earliest CTIS Part Ii Submission Date
- 25-11-2025
- Latest Decision Or Authorization Date
- 10-12-2025
- Processing Time Days
- 15
- Number Of Sites
- 3
- Number Of Participants
- 3
Sites
- Site Name
- University Hospital Cologne AöR
- Department Name
- Kinderkardiologie
- Principal Investigator Name
- Markus Khalil
- Principal Investigator Email
- Kinderklinik-Studiensekretariat@uk-koeln.de
- Contact Person Name
- Markus Khalil
- Contact Person Email
- Kinderklinik-Studiensekretariat@uk-koeln.de
- Site Name
- Universitaetsklinikum Tuebingen AöR
- Department Name
- Kinderheilkunde II - Kinderkardiologie, Pulmologie, Intensivmedizin
- Principal Investigator Name
- Vanya Icheva
- Principal Investigator Email
- vanya.icheva@med.uni-tuebingen.de
- Contact Person Name
- Vanya Icheva
- Contact Person Email
- vanya.icheva@med.uni-tuebingen.de
- Site Name
- Universitaetsklinikum Giessen und Marburg GmbH
- Department Name
- Kinderherzzentrum und Zentrum für angeborene Herzfehler
- Principal Investigator Name
- David Backhoff
- Principal Investigator Email
- Kinderkardiologie.Gi@uk-gm.de
- Contact Person Name
- David Backhoff
- Contact Person Email
- Kinderkardiologie.Gi@uk-gm.de
Greece
- Earliest CTIS Part Ii Submission Date
- 09-09-2025
- Latest Decision Or Authorization Date
- 08-12-2025
- Processing Time Days
- 90
- Number Of Sites
- 4
- Number Of Participants
- 5
Sites
- Site Name
- Nosokomeio Paidon I Agia Sofia
- Department Name
- Cardiology Department
- Principal Investigator Name
- Aikaterini Giannakopoulou
- Principal Investigator Email
- paidocardio.agsofia1@gmail.com
- Contact Person Name
- Aikaterini Giannakopoulou
- Contact Person Email
- paidocardio.agsofia1@gmail.com
- Site Name
- Onassis Cardiac Surgery Center
- Department Name
- Department of Pediatric Cardiology and Adult Congenital Heart Disease
- Principal Investigator Name
- George Vagenakis
- Principal Investigator Email
- pediatric.cardio.onasseio@gmail.com
- Contact Person Name
- George Vagenakis
- Contact Person Email
- pediatric.cardio.onasseio@gmail.com
- Site Name
- Athens General Children's Hospital Panagioti And Aglaia Kyriakou
- Department Name
- Cardiology Department
- Principal Investigator Name
- Sofia Loukopoulou
- Principal Investigator Email
- kardiologiko@aglaiakyriakou.gr
- Contact Person Name
- Sofia Loukopoulou
- Contact Person Email
- kardiologiko@aglaiakyriakou.gr
- Site Name
- Athens General Children's Hospital Panagioti And Aglaia Kyriakou (2nd Department)
- Department Name
- 2nd University Department of Pediatrics
- Principal Investigator Name
- Marietta Charakida
- Principal Investigator Email
- 2ppk@med.uoa.gr
- Contact Person Name
- Marietta Charakida
- Contact Person Email
- 2ppk@med.uoa.gr
Italy
- Earliest CTIS Part Ii Submission Date
- 11-11-2025
- Latest Decision Or Authorization Date
- 10-12-2025
- Processing Time Days
- 29
- Number Of Sites
- 8
- Number Of Participants
- 10
Sites
- Site Name
- Azienda Ospedaliera di Padova
- Department Name
- UOC Cardiologia Pediatrica
- Principal Investigator Name
- Giovanni Di Salvo
- Principal Investigator Email
- segreteria.cardiologiapediatrica@aopd.veneto.it
- Contact Person Name
- Giovanni Di Salvo
- Contact Person Email
- segreteria.cardiologiapediatrica@aopd.veneto.it
- Site Name
- Azienda Ospedaliera Universitaria Citta Della Salute E Della Scienza Di Torino
- Department Name
- Cadiologia pediatrica e cardiopatie congenite
- Principal Investigator Name
- Chiara Riggi
- Principal Investigator Email
- direzioneaziendale@cittadellasalute.to.it
- Contact Person Name
- Chiara Riggi
- Contact Person Email
- direzioneaziendale@cittadellasalute.to.it
- Site Name
- Azienda Ospedaliero-Universitaria Di Bologna IRCCS Istituto Di Ricerca E Di Cura A Carattere Scientifico
- Department Name
- Cardiologia pediatrica ed dell'età evolutiva
- Principal Investigator Name
- Andrea Donti
- Principal Investigator Email
- segr.card.ped@aosp.bo.it
- Contact Person Name
- Andrea Donti
- Contact Person Email
- segr.card.ped@aosp.bo.it
- Site Name
- ASST Grande Ospedale Metropolitano Niguarda
- Department Name
- Struttura semplice dipartimentale cardiologia pediatrica
- Principal Investigator Name
- Simona Anna Marcora
- Principal Investigator Email
- cardioped@ospedaleniguarda.it
- Contact Person Name
- Simona Anna Marcora
- Contact Person Email
- cardioped@ospedaleniguarda.it
- Site Name
- Azienda Socio Sanitaria Territoriale Papa Giovanni Xxiii
- Department Name
- Cardiologia 2 - Cardiopatie Congenite del bambino e dell'adulto
- Principal Investigator Name
- Francesca Raimondi
- Principal Investigator Email
- cardiologia2cardiopatie.segreteria@asst-pg23.it
- Contact Person Name
- Francesca Raimondi
- Contact Person Email
- cardiologia2cardiopatie.segreteria@asst-pg23.it
- Site Name
- Ospedale Pediatrico Bambino Gesu
- Department Name
- Scompenso, Trapianto e Assistenza Meccanica Cardiocircolatoria
- Principal Investigator Name
- Rachele Adorisio
- Principal Investigator Email
- scompenso@opbg.net
- Contact Person Name
- Rachele Adorisio
- Contact Person Email
- scompenso@opbg.net
- Site Name
- Azienda Ospedaliera Dei Colli
- Department Name
- Malattie Rare e Genetiche Cardiovascolari
- Principal Investigator Name
- Giuseppe Limongelli
- Principal Investigator Email
- malattierarecardiovascolari@ospedalideicolli.it
- Contact Person Name
- Giuseppe Limongelli
- Contact Person Email
- malattierarecardiovascolari@ospedalideicolli.it
- Site Name
- IRCCS Istituto Giannina Gaslini
- Department Name
- Cardiologia
- Principal Investigator Name
- Maria Elena Derchi
- Principal Investigator Email
- ambulatoriocardiologia@gaslini.org
- Contact Person Name
- Maria Elena Derchi
- Contact Person Email
- ambulatoriocardiologia@gaslini.org
Portugal
- Earliest CTIS Part Ii Submission Date
- 20-10-2025
- Latest Decision Or Authorization Date
- 10-12-2025
- Processing Time Days
- 51
- Number Of Sites
- 5
- Number Of Participants
- 7
Sites
- Site Name
- Unidade Local De Saude De Sao Jose E.P.E.
- Department Name
- Pediatric Cardiology
- Principal Investigator Name
- Conceicao Trigo Pereira
- Principal Investigator Email
- maria.pereira8@ulssjose.min-saude.pt
- Contact Person Name
- Conceicao Trigo Pereira
- Contact Person Email
- maria.pereira8@ulssjose.min-saude.pt
- Site Name
- Unidade Local de Saude de Sao Joao E.P.E.
- Department Name
- Pediatric Department
- Principal Investigator Name
- Ana Luísa Costa
- Principal Investigator Email
- ana.rodrigues.costa@ulssjoao.min-saude.pt
- Contact Person Name
- Ana Luísa Costa
- Contact Person Email
- ana.rodrigues.costa@ulssjoao.min-saude.pt
- Site Name
- Unidade Local De Saude De Lisboa Ocidental E.P.E.
- Department Name
- Pediatric Cardiology Department
- Principal Investigator Name
- Rui Anjos
- Principal Investigator Email
- ranjos@chlo.min-saude.pt
- Contact Person Name
- Rui Anjos
- Contact Person Email
- ranjos@chlo.min-saude.pt
- Site Name
- Unidade Local De Saude De Coimbra E.P.E.
- Department Name
- Pediatric Cardiology Department
- Principal Investigator Name
- Antonio Pires
- Principal Investigator Email
- antonio.pires@ulscoimbra.min-saude.pt
- Contact Person Name
- Antonio Pires
- Contact Person Email
- antonio.pires@ulscoimbra.min-saude.pt
- Site Name
- Unidade Local De Saude De Santo Antonio E.P.E.
- Department Name
- Pediatric Cardiology
- Principal Investigator Name
- Joana Miranda
- Principal Investigator Email
- joana.miranda@chporto.min-saude.pt
- Contact Person Name
- Joana Miranda
- Contact Person Email
- joana.miranda@chporto.min-saude.pt
Spain
- Earliest CTIS Part Ii Submission Date
- 11-11-2025
- Latest Decision Or Authorization Date
- 10-12-2025
- Processing Time Days
- 29
- Number Of Sites
- 7
- Number Of Participants
- 9
Sites
- Site Name
- Hospital Universitario La Paz
- Department Name
- Cardiologia pediatrica
- Principal Investigator Name
- Diana Salas Mera
- Principal Investigator Email
- atepac.hulp@salud.madrid.org
- Contact Person Name
- Diana Salas Mera
- Contact Person Email
- atepac.hulp@salud.madrid.org
- Site Name
- Hospital Universitario 12 De Octubre
- Department Name
- Cardiologia pediatrica
- Principal Investigator Name
- Belen Toral Vazquez
- Principal Investigator Email
- hospitalpac.hdoc@salud.madrid.org
- Contact Person Name
- Belen Toral Vazquez
- Contact Person Email
- hospitalpac.hdoc@salud.madrid.org
- Site Name
- Hospital Universitario Regional De Malaga
- Department Name
- Cardiologia pediatrica
- Principal Investigator Name
- Gonzalo Cortazar Rocandio
- Principal Investigator Email
- secretaria.urgenc.hrmal.sspa@juntadeandalucia.es
- Contact Person Name
- Gonzalo Cortazar Rocandio
- Contact Person Email
- secretaria.urgenc.hrmal.sspa@juntadeandalucia.es
- Site Name
- University Hospital Virgen Del Rocio S.L.
- Department Name
- Cardiologia pediatrica
- Principal Investigator Name
- Inmaculada Guillen Rodriguez
- Principal Investigator Email
- cma.hg.hvr.sspa@juntadeandalucia.es
- Contact Person Name
- Inmaculada Guillen Rodriguez
- Contact Person Email
- cma.hg.hvr.sspa@juntadeandalucia.es
- Site Name
- Hospital Sant Joan De Deu Barcelona
- Department Name
- Cardiologia pediatrica
- Principal Investigator Name
- Georgia Sarquella Brugada
- Principal Investigator Email
- hospitalbarcelona.atenciousuari@sjd.es
- Contact Person Name
- Georgia Sarquella Brugada
- Contact Person Email
- hospitalbarcelona.atenciousuari@sjd.es
- Site Name
- Hospital Universitari Vall D Hebron
- Department Name
- Cardiologia pediatrica
- Principal Investigator Name
- Diana Carolina Juzga Corrales
- Principal Investigator Email
- uac_ami@vallhebron.cat
- Contact Person Name
- Diana Carolina Juzga Corrales
- Contact Person Email
- uac_ami@vallhebron.cat
- Site Name
- Hospital Universitario Reina Sofia
- Department Name
- Cardiologia pediatrica
- Principal Investigator Name
- Elena Gomez Guzman
- Principal Investigator Email
- sau.hrs.sspa@juntadeandalucia.es
- Contact Person Name
- Elena Gomez Guzman
- Contact Person Email
- sau.hrs.sspa@juntadeandalucia.es
Sweden
- Earliest CTIS Part Ii Submission Date
- 09-09-2025
- Latest Decision Or Authorization Date
- 05-12-2025
- Processing Time Days
- 87
- Number Of Sites
- 1
- Number Of Participants
- 3
Sites
- Site Name
- Region Skane Skanes Universitetssjukhus
- Department Name
- Barnhjärtcentrum
- Principal Investigator Name
- Michal Odermarsky
- Principal Investigator Email
- studiesupport.sus@skane.se
- Contact Person Name
- Michal Odermarsky
- Contact Person Email
- studiesupport.sus@skane.se
Austria
- Earliest CTIS Part Ii Submission Date
- 25-11-2025
- Latest Decision Or Authorization Date
- 08-12-2025
- Processing Time Days
- 13
- Number Of Sites
- 2
- Number Of Participants
- 2
Sites
- Site Name
- Medical University Of Vienna
- Department Name
- Klinik für Kinder- und Jugendheilkunde, Abteilung für Pädiatrische Kardiologie
- Principal Investigator Name
- Andreas Hanslik
- Principal Investigator Email
- andreas.hanslik@meduniwien.ac.at
- Contact Person Name
- Andreas Hanslik
- Contact Person Email
- andreas.hanslik@meduniwien.ac.at
- Site Name
- Kepler Universitaetsklinikum GmbH
- Department Name
- Klinik für Kinderkardiologie
- Principal Investigator Name
- Andreas Tulzer
- Principal Investigator Email
- andreas.tulzer@kepleruniklinikum.at
- Contact Person Name
- Andreas Tulzer
- Contact Person Email
- andreas.tulzer@kepleruniklinikum.at
Hungary
- Earliest CTIS Part Ii Submission Date
- 10-10-2025
- Latest Decision Or Authorization Date
- 10-12-2025
- Processing Time Days
- 61
- Number Of Sites
- 1
- Number Of Participants
- 2
Sites
- Site Name
- Gottsegen National Cardiovascular Center
- Department Name
- Pediatric Heart Center
- Principal Investigator Name
- Laszlo Ablonczy
- Principal Investigator Email
- ablonczyl@gmail.com
- Contact Person Name
- Laszlo Ablonczy
- Contact Person Email
- ablonczyl@gmail.com
Poland
- Earliest CTIS Part Ii Submission Date
- 11-11-2025
- Latest Decision Or Authorization Date
- 09-12-2025
- Processing Time Days
- 28
- Number Of Sites
- 4
- Number Of Participants
- 5
Sites
- Site Name
- Wojewodzki Szpital Specjalistyczny We Wroclawiu
- Department Name
- Oddz. Kardiologii Dziecięcej z Pododdz. Kardiochirurgii i Intens. Nadzoru Kardiol.
- Principal Investigator Name
- Pawel Czesniewicz
- Principal Investigator Email
- kardiolodz@wssk.wroc.pl
- Contact Person Name
- Pawel Czesniewicz
- Contact Person Email
- kardiolodz@wssk.wroc.pl
- Site Name
- Instytut Pomnik Centrum Zdrowia Dziecka
- Department Name
- Klinika Kardiologii
- Principal Investigator Name
- Lidia Ziolkowska
- Principal Investigator Email
- oddzial.kardiologia@ipczd.pl
- Contact Person Name
- Lidia Ziolkowska
- Contact Person Email
- oddzial.kardiologia@ipczd.pl
- Site Name
- Gornoslaskie Centrum Zdrowia Dziecka Im. Sw. Jana Pawla II Samodzielny Publiczny Szpital Kliniczny Nr 6 Slaskiego Uniwersytetu Medycznego W Katowicach
- Department Name
- Oddział Kardiologii Dziecięcej
- Principal Investigator Name
- Jacek Kusa
- Principal Investigator Email
- kardiologia@gczd.katowice.pl
- Contact Person Name
- Jacek Kusa
- Contact Person Email
- kardiologia@gczd.katowice.pl
- Site Name
- Instytut Centrum Zdrowia Matki Polki
- Department Name
- Klinika Kardiologii
- Principal Investigator Name
- Anna Mazurek-Kula
- Principal Investigator Email
- sek43@iczmp.edu.pl
- Contact Person Name
- Anna Mazurek-Kula
- Contact Person Email
- sek43@iczmp.edu.pl
Finland
- Earliest CTIS Part Ii Submission Date
- 10-11-2025
- Latest Decision Or Authorization Date
- 05-03-2026
- Processing Time Days
- 115
- Number Of Sites
- 1
- Number Of Participants
- 2
Sites
- Site Name
- HUS-yhtymae
- Department Name
- Uusi lastensairaala, kardiologia
- Principal Investigator Name
- Maria Hurskainen
- Principal Investigator Email
- maria.hurskainen@hus.fi
- Contact Person Name
- Maria Hurskainen
- Contact Person Email
- maria.hurskainen@hus.fi
Sponsor
Primary sponsor
- Full Name
- Bayer AG
- Organisation Type
- Pharmaceutical company
- Country Of Registered Address
- Germany
Contract research organisations
- Name
- Suvoda LLC
- Responsibilities
- code 3
- Name
- DATAN Analytics GmbH
- Responsibilities
- code 10
- Name
- Carelon Research Inc
- Responsibilities
- Scientific advice
- Name
- Fisher Clinical Services GmbH
- Responsibilities
- code 14
- Name
- Swiss BioQuant AG
- Responsibilities
- code 4
- Name
- GBA Central Lab Services GmbH
- Responsibilities
- code 4
Third parties
- {"country":"Switzerland","full_name":"Swiss BioQuant AG","duties_or_roles":"code 4","organisation_type":"Laboratory/Research/Testing facility"}
- {"country":"United States","full_name":"Suvoda LLC","duties_or_roles":"code 3","organisation_type":"Non-Pharmaceutical company"}
- {"country":"Germany","full_name":"DATAN Analytics GmbH","duties_or_roles":"code 10","organisation_type":"Non-Pharmaceutical company"}
- {"country":"Switzerland","full_name":"Fisher Clinical Services GmbH","duties_or_roles":"code 14","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Carelon Research Inc","duties_or_roles":"Scientific advice","organisation_type":"Industry"}
- {"country":"Germany","full_name":"GBA Central Lab Services GmbH","duties_or_roles":"code 4","organisation_type":"Laboratory/Research/Testing facility"}
Investigational products
- Investigational Product Name
- Finerenone Bayer
- Active Substance
- FINERENONE
- Modality
- Small molecule
- Routes Of Administration
- ORAL
- Route
- ORAL
- Authorisation Status
- Authorised
- Maximum Dose
- 40 mg
- Investigational Product Name
- BAY 94-8862
- Active Substance
- FINERENONE
- Modality
- Small molecule
- Routes Of Administration
- ORAL
- Route
- ORAL
- Authorisation Status
- Authorised
- Dose Levels
- 10 mg; 20 mg; 40 mg
- Maximum Dose
- 40 mg
- Investigational Product Name
- Placebo BAY 948862
- Modality
- Other
- Combination Treatment
- Yes
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