Clinical trial • Phase III • Cardiology
FINERENONE for Heart failure | Left ventricular systolic dysfunction
Phase III trial of FINERENONE for Heart failure | Left ventricular systolic dysfunction. open-label. 56 participants.
Overview
- Trial Therapeutic Area
- Cardiology
- Trial Disease
- Heart failure | Left ventricular systolic dysfunction
- Trial Stage
- Phase III
- Drug Modality
- Small molecule
- Paediatric Trial
- Yes
Key dates
- Initial CTIS Submission Date
- 19-08-2025
- First CTIS Authorization Date
- 05-12-2025
Trial design
open-label Phase III trial in Hungary, Austria, Belgium and others.
- Open Label
- Yes
- Target Sample Size
- 56
- Trial Duration For Participant
- 270
Eligibility
Recruits 56 paediatric patients.
- Vulnerable Population
- Paediatric population (from birth to 18 years). Vulnerability recognised and managed via parent/legal guardian informed consent and age‑appropriate assent documents. The submission includes multiple subject information and informed consent forms and assent forms for children and adolescents (examples in the dossier: child ICFs and assent forms for various age groups, parent ICFs, and expecting-parents materials). Materials are provided per-country / language (country-specific ICFs and recruitment leaflets), indicating consent by guardian and assent where appropriate for younger participants.
Inclusion criteria
- {"criterion_text":"- For participants rolling over from randomized controlled trial (RCT): Prior participation in the finerenone Phase 3 study FIORE (21466) and not permanently discontinued from the study intervention prior to the end of treatment (EoT) visit in FIORE"}
- {"criterion_text":"- For newly enrolled infants <6 months of age: LV systolic dysfunction (LVSD) with left ventricular ejection fraction (LVEF) ≤ 50% at screening assessed by echocardiography"}
- {"criterion_text":"- For newly enrolled infants <6 months of age: Elevated NT-pro BNP levels (> 500 mg/L) at screening"}
- {"criterion_text":"- For newly enrolled infants <6 months of age: Heart failure etiologies include congenital heart defects (CHD) with biventricular physiology and systemic LV; idiopathic cardiomyopathy (CM); familial/inherited and/or genetic CM; history of myocarditis (diagnosis of an acute episode at least 3 months prior to treatment assignment); neuromuscular disorder; inborn error of metabolism; mitochondrial disorder; acquired (chemotherapy, iatrogenic, infection, rheumatic, or nutritional); ischemic (e.g., Kawasaki disease and postoperative HF); LV noncompaction"}
- {"criterion_text":"- For newly enrolled infants < 6 months of age: Receiving standard of care (SoC) treatment for heart failure according to local guidelines or investigator´s discretion (on a stable regimen for 30 days before baseline)."}
- {"criterion_text":"- Newly enrolled newborns and infants < 6 months of age must have a body weight of ≥3 kg at Visit 1."}
Exclusion criteria
- {"criterion_text":"- For participants rolling over from RCT: To roll-over to FIORELLO, all participants: Potassium (K+) >5.5 mmol/L After unblinding: • For participants who received finerenone in FIORE: K+ >5.5 mmol/ L • For participants who received placebo in FIORE: K+ >5.0 mmol/L for children ≥2 years of age, and >5.3 mmol/L for children <2 years of age (if eGFR is <60 mL/min/1.73m² for participants <2 years of age, the serum potassium threshold of >5.0 mmol/L will be used for exclusion)."}
- {"criterion_text":"- For newly enrolled newborns and infants < 6 months of age: Potassium ≥ 5.3 mmol/l (if eGFR is <60 mL/min/1.73m², the serum potassium threshold of >5.0 mmol/L will be used for exclusion)"}
- {"criterion_text":"- For participants rolling over from RCT: Severe renal dysfunction with estimated glomerular filtration rate (eGFR) < 30 ml/min/1.73m2 at FIORE EoT or Visit 1."}
- {"criterion_text":"- For newly enrolled infants < 6 months of age: Severe renal dysfunction with eGFR < 30 ml/min/1.73m2 at screening or Visit 1."}
- {"criterion_text":"- Treatment with a mineralocorticoid receptor antagonist, other than the study intervention, (e.g., spironolactone, eplerenone) within 30 days of Visit 1."}
- {"criterion_text":"- Requirement of any intravenous (IV) vasoactive agents; mechanical ventilation; mechanical circulatory support; sustained or symptomatic arrhythmias not controlled by drug or device therapy within 30 days prior to study treatment."}
Endpoints
Primary endpoints
- {"endpoint_text":"- Number of participants with treatment emergent adverse events (TEAEs)","definition_or_measurement_approach":"Counting participants with TEAEs (treatment-emergent adverse events) reported during study treatment"}
- {"endpoint_text":"- Change in serum potassium levels from baseline to Day 270± 7 (Visit 6, EoT)","definition_or_measurement_approach":"Change from baseline to Day 270±7 in serum potassium (laboratory measurement)"}
- {"endpoint_text":"- Change in systolic blood pressure (SBP) from baseline to Day 270± 7 (Visit 6, EoT)","definition_or_measurement_approach":"Change from baseline to Day 270±7 in systolic blood pressure measured clinically"}
- {"endpoint_text":"- Change in estimated glomerular filtration rate (eGFR) from baseline to Day 270± 7 (Visit 6, EoT)","definition_or_measurement_approach":"Change from baseline to Day 270±7 in estimated GFR (clinical laboratory calculation)"}
Secondary endpoints
- {"endpoint_text":"- Change in NT-proBNP from baseline to Day 270± 7 (Visit 6, EoT)","definition_or_measurement_approach":"Change from baseline to Day 270±7 in NT-proBNP (biomarker laboratory measurement)"}
- {"endpoint_text":"- Change in key echocardiographic parameters of left ventricular systolic function from baseline to Day 270± 7 (Visit 6, EoT)","definition_or_measurement_approach":"Change from baseline to Day 270±7 in key echocardiographic measures of LV systolic function (echocardiography)"}
- {"endpoint_text":"- Maximum observed finerenone concentration in plasma after multiple doses (Cmax, md)","definition_or_measurement_approach":"Pharmacokinetic measurement: observed maximum plasma concentration after multiple dosing"}
- {"endpoint_text":"- Area under the curve for finerenone concentration in plasma after multiple doses (AUCτ,md)","definition_or_measurement_approach":"Pharmacokinetic parameter: AUC over dosing interval after multiple doses"}
- {"endpoint_text":"- Taste and texture questionnaire of the pediatric formulation","definition_or_measurement_approach":"Patient/parent-reported questionnaire assessing acceptability/palatability of pediatric formulation"}
Recruitment
- Planned Sample Size
- 56
- Recruitment Window Months
- 58
- Consent Approach
- Informed consent is obtained from parent(s)/legal guardian(s) for paediatric participants; age-appropriate assent forms are used for children and adolescents. The dossier includes multiple subject information sheets and ICFs for parents, adults, and children in age-specific editions (examples: core child ICFs, assent forms for various age bands, expecting-parents documents). Materials are prepared per country/language as evidenced by multiple country-specific ICF and recruitment documents.
Methods
- Recruitment via participating hospital and clinic sites (site-based recruitment) across the listed countries (see country-specific recruitment documents K1/K2).
- Roll-over recruitment of participants from the prior finerenone Phase 3 study FIORE (21466) (participants rolling over from the RCT).
- Use of site-specific parent leaflets, visit schemes and recruitment materials (K2 parent leaflets and visit scheme documents referenced per country).
Geography
- Total Number Of Sites
- 51
- Total Number Of Participants
- 61
Hungary
- Earliest CTIS Part Ii Submission Date
- 10-10-2025
- Latest Decision Or Authorization Date
- 10-12-2025
- Processing Time Days
- 61
- Number Of Sites
- 1
- Number Of Participants
- 2
Sites
- Site Name
- Gottsegen National Cardiovascular Center
- Department Name
- Gyermekszív Kozpont
- Principal Investigator Name
- Laszlo Ablonczy
- Principal Investigator Email
- ablonczyl@gmail.com
- Contact Person Name
- Laszlo Ablonczy
- Contact Person Email
- ablonczyl@gmail.com
Austria
- Earliest CTIS Part Ii Submission Date
- 21-11-2025
- Latest Decision Or Authorization Date
- 08-12-2025
- Processing Time Days
- 17
- Number Of Sites
- 2
- Number Of Participants
- 2
Sites
- Site Name
- Kepler Universitaetsklinikum GmbH
- Department Name
- Klinik für Kinderkardiologie
- Principal Investigator Name
- Andreas Tulzer
- Principal Investigator Email
- andreas.tulzer@kepleruniklinikum.at
- Contact Person Name
- Andreas Tulzer
- Contact Person Email
- andreas.tulzer@kepleruniklinikum.at
- Site Name
- Medical University Of Vienna
- Department Name
- Klinik für Kinder- und Jugendheilkunde, Abteilung für Pädiatrische Kardiologie
- Principal Investigator Name
- Andreas Hanslik
- Principal Investigator Email
- andreas.hanslik@meduniwien.ac.at
- Contact Person Name
- Andreas Hanslik
- Contact Person Email
- andreas.hanslik@meduniwien.ac.at
Belgium
- Earliest CTIS Part Ii Submission Date
- 27-11-2025
- Latest Decision Or Authorization Date
- 09-12-2025
- Processing Time Days
- 12
- Number Of Sites
- 5
- Number Of Participants
- 4
Sites
- Site Name
- Universitair Ziekenhuis Antwerpen
- Department Name
- Pediatric Cardiology
- Principal Investigator Name
- Luc Bruyndonckx
- Principal Investigator Email
- luc.bruyndonckx@uza.be
- Contact Person Name
- Luc Bruyndonckx
- Contact Person Email
- luc.bruyndonckx@uza.be
- Site Name
- CHC MontLegia
- Department Name
- Pediatric Cardiology
- Principal Investigator Name
- Isabelle Loeckx
- Principal Investigator Email
- Isabelle.loeckx@chc.be
- Contact Person Name
- Isabelle Loeckx
- Contact Person Email
- Isabelle.loeckx@chc.be
- Site Name
- Universitair Ziekenhuis Gent
- Department Name
- Pediatric Cardiology
- Principal Investigator Name
- Laura Muino Mosquera
- Principal Investigator Email
- laura.muinomosquera@uzgent.be
- Contact Person Name
- Laura Muino Mosquera
- Contact Person Email
- laura.muinomosquera@uzgent.be
- Site Name
- UZ Leuven
- Department Name
- Pediatric Cardiology
- Principal Investigator Name
- Bjorn Cools
- Principal Investigator Email
- Bjorn.Cools@uzleuven.be
- Contact Person Name
- Bjorn Cools
- Contact Person Email
- Bjorn.Cools@uzleuven.be
- Site Name
- Cliniques Universitaires Saint-Luc
- Department Name
- Pediatric Cardiology
- Principal Investigator Name
- Stephane Moniotte
- Principal Investigator Email
- stephane.moniotte@saintluc.uclouvain.be
- Contact Person Name
- Stephane Moniotte
- Contact Person Email
- stephane.moniotte@saintluc.uclouvain.be
Bulgaria
- Earliest CTIS Part Ii Submission Date
- 10-11-2025
- Latest Decision Or Authorization Date
- 10-12-2025
- Processing Time Days
- 30
- Number Of Sites
- 4
- Number Of Participants
- 4
Sites
- Site Name
- MHAT National Heart Hospital EAD
- Department Name
- Department of Child Cardiology at Pediatric Clinic
- Principal Investigator Name
- Anna Kaneva Nencheva
- Principal Investigator Email
- nkb@hearthospital.bg
- Contact Person Name
- Anna Kaneva Nencheva
- Contact Person Email
- nkb@hearthospital.bg
- Site Name
- Medical Center Nora-Heart Ltd.
- Department Name
- Child Cardiology
- Principal Investigator Name
- Rumen Marinov
- Principal Investigator Email
- reception@medcenterheart.com
- Contact Person Name
- Rumen Marinov
- Contact Person Email
- reception@medcenterheart.com
- Site Name
- University Multidisciplinary Hospital For Active Treatment Sveta Ekaterina EAD
- Department Name
- Clinic of cardiology
- Principal Investigator Name
- Pencho Kratunkov
- Principal Investigator Email
- contact@i-health.bg
- Contact Person Name
- Pencho Kratunkov
- Contact Person Email
- contact@i-health.bg
- Site Name
- University Multiprofile Hospital For Active Treatment Saint Georgi EAD
- Department Name
- Pediatric Clinic
- Principal Investigator Name
- Lyubov Atanasova Chochkova Bukova
- Principal Investigator Email
- klinikadetska@gmail.com
- Contact Person Name
- Lyubov Atanasova Chochkova Bukova
- Contact Person Email
- klinikadetska@gmail.com
Czechia
- Earliest CTIS Part Ii Submission Date
- 31-10-2025
- Latest Decision Or Authorization Date
- 09-12-2025
- Processing Time Days
- 39
- Number Of Sites
- 2
- Number Of Participants
- 3
Sites
- Site Name
- Fakultni Nemocnice Brno
- Department Name
- Dětská nemocnice - Pediatrická klinika
- Principal Investigator Name
- Jana Tuckova
- Principal Investigator Email
- fnbrno@fnbrno.cz
- Contact Person Name
- Jana Tuckova
- Contact Person Email
- fnbrno@fnbrno.cz
- Site Name
- Fakultni Nemocnice V Motole
- Department Name
- Dětské kardiocentrum 2. LF UK a FN Motol
- Principal Investigator Name
- Karel Koubsky
- Principal Investigator Email
- detske.kardiocentrum@fnmotol.cz
- Contact Person Name
- Karel Koubsky
- Contact Person Email
- detske.kardiocentrum@fnmotol.cz
Germany
- Earliest CTIS Part Ii Submission Date
- 07-11-2025
- Latest Decision Or Authorization Date
- 08-12-2025
- Processing Time Days
- 31
- Number Of Sites
- 3
- Number Of Participants
- 3
Sites
- Site Name
- Universitaetsklinikum Koeln AöR
- Department Name
- Kinderkardiologie
- Principal Investigator Name
- Markus Khalil
- Principal Investigator Email
- Kinderklinik-Studiensekretariat@uk-koeln.de
- Contact Person Name
- Markus Khalil
- Contact Person Email
- Kinderklinik-Studiensekretariat@uk-koeln.de
- Site Name
- Universitaetsklinikum Tuebingen AöR
- Department Name
- Kinderheilkunde II - Kinderkardiologie, Pulmologie, Intensivmedizin
- Principal Investigator Name
- Vanya Icheva
- Principal Investigator Email
- vanya.icheva@med.uni-tuebingen.de
- Contact Person Name
- Vanya Icheva
- Contact Person Email
- vanya.icheva@med.uni-tuebingen.de
- Site Name
- Universitaetsklinikum Giessen und Marburg GmbH
- Department Name
- Kinderherzzentrum und Zentrum für angeborene Herzfehler
- Principal Investigator Name
- David Backhoff
- Principal Investigator Email
- Kinderkardiologie.Gi@uk-gm.de
- Contact Person Name
- David Backhoff
- Contact Person Email
- Kinderkardiologie.Gi@uk-gm.de
Greece
- Earliest CTIS Part Ii Submission Date
- 17-09-2025
- Latest Decision Or Authorization Date
- 08-12-2025
- Processing Time Days
- 82
- Number Of Sites
- 4
- Number Of Participants
- 6
Sites
- Site Name
- Athens General Children's Hospital Panagioti And Aglaia Kyriakou
- Department Name
- Cardiology Department
- Principal Investigator Name
- Sofia Loukopoulou
- Principal Investigator Email
- kardiologiko@aglaiakyriakou.gr
- Contact Person Name
- Sofia Loukopoulou
- Contact Person Email
- kardiologiko@aglaiakyriakou.gr
- Site Name
- Onassis Cardiac Surgery Center
- Department Name
- Department of Pediatric Cardiology and Adult Congenital Heart Disease
- Principal Investigator Name
- George Vagenakis
- Principal Investigator Email
- pediatric.cardio.onasseio@gmail.com
- Contact Person Name
- George Vagenakis
- Contact Person Email
- pediatric.cardio.onasseio@gmail.com
- Site Name
- Athens General Children's Hospital Panagioti And Aglaia Kyriakou
- Department Name
- 2nd University Department of Pediatrics
- Principal Investigator Name
- Marietta Charakida
- Principal Investigator Email
- 2ppk@med.uoa.gr
- Contact Person Name
- Marietta Charakida
- Contact Person Email
- 2ppk@med.uoa.gr
- Site Name
- Nosokomeio Paidon I Agia Sofia
- Department Name
- Cardiology Department
- Principal Investigator Name
- Aikaterini Giannakopoulou
- Principal Investigator Email
- paidocardio.agsofia1@gmail.com
- Contact Person Name
- Aikaterini Giannakopoulou
- Contact Person Email
- paidocardio.agsofia1@gmail.com
Portugal
- Earliest CTIS Part Ii Submission Date
- 10-10-2025
- Latest Decision Or Authorization Date
- 05-12-2025
- Processing Time Days
- 56
- Number Of Sites
- 5
- Number Of Participants
- 7
Sites
- Site Name
- Unidade Local De Saude De Coimbra E.P.E.
- Department Name
- Pediatric Cardiology Department
- Principal Investigator Name
- Antonio Pires
- Principal Investigator Email
- antonio.pires@ulscoimbra.min-saude.pt
- Contact Person Name
- Antonio Pires
- Contact Person Email
- antonio.pires@ulscoimbra.min-saude.pt
- Site Name
- Unidade Local De Saude De Sao Jose E.P.E.
- Department Name
- Pediatric Cardiology
- Principal Investigator Name
- Conceicao Trigo Pereira
- Principal Investigator Email
- maria.pereira8@ulssjose.min-saude.pt
- Contact Person Name
- Conceicao Trigo Pereira
- Contact Person Email
- maria.pereira8@ulssjose.min-saude.pt
- Site Name
- Unidade Local De Saude De Santo Antonio E.P.E.
- Department Name
- Pediatric Cardiology
- Principal Investigator Name
- Joana Miranda
- Principal Investigator Email
- joana.miranda@chporto.min-saude.pt
- Contact Person Name
- Joana Miranda
- Contact Person Email
- joana.miranda@chporto.min-saude.pt
- Site Name
- Unidade Local de Saude de Sao Joao E.P.E.
- Department Name
- Pediatric Department
- Principal Investigator Name
- Ana Luísa Costa
- Principal Investigator Email
- ana.rodrigues.costa@ulssjoao.min-saude.pt
- Contact Person Name
- Ana Luísa Costa
- Contact Person Email
- ana.rodrigues.costa@ulssjoao.min-saude.pt
- Site Name
- Unidade Local De Saude De Lisboa Ocidental E.P.E.
- Department Name
- Pediatric Cardiology Department
- Principal Investigator Name
- Rui Anjos
- Principal Investigator Email
- ranjos@chlo.min-saude.pt
- Contact Person Name
- Rui Anjos
- Contact Person Email
- ranjos@chlo.min-saude.pt
Spain
- Earliest CTIS Part Ii Submission Date
- 05-11-2025
- Latest Decision Or Authorization Date
- 10-12-2025
- Processing Time Days
- 35
- Number Of Sites
- 9
- Number Of Participants
- 9
Sites
- Site Name
- Hospital Universitario Regional De Malaga
- Department Name
- Cardiologia pediatrica - Patient Visits
- Principal Investigator Name
- Gonzalo Cortazar Rocandio
- Principal Investigator Email
- secretaria.urgenc.hrmal.sspa@juntadeandalucia.es
- Contact Person Name
- Gonzalo Cortazar Rocandio
- Contact Person Email
- secretaria.urgenc.hrmal.sspa@juntadeandalucia.es
- Site Name
- Hospital Universitario 12 De Octubre
- Department Name
- Cardiologia pediatrica - Patient Visits
- Principal Investigator Name
- Belen Toral Vazquez
- Principal Investigator Email
- hospitalpac.hdoc@salud.madrid.org
- Contact Person Name
- Belen Toral Vazquez
- Contact Person Email
- hospitalpac.hdoc@salud.madrid.org
- Site Name
- Hospital Universitari Vall D Hebron
- Department Name
- Cardiologia pediatrica - Patient Visits
- Principal Investigator Name
- Diana Carolina Juzga Corrales
- Principal Investigator Email
- uac_ami@vallhebron.cat
- Contact Person Name
- Diana Carolina Juzga Corrales
- Contact Person Email
- uac_ami@vallhebron.cat
- Site Name
- Hospital Universitario Reina Sofia
- Department Name
- Cardiologia pediatrica - Patient Visits
- Principal Investigator Name
- Elena Gomez Guzman
- Principal Investigator Email
- sau.hrs.sspa@juntadeandalucia.es
- Contact Person Name
- Elena Gomez Guzman
- Contact Person Email
- sau.hrs.sspa@juntadeandalucia.es
- Site Name
- Hospital Sant Joan De Deu Barcelona
- Department Name
- Cardiologia pediatrica - Patient Visits
- Principal Investigator Name
- Georgia Sarquella Brugada
- Principal Investigator Email
- hospitalbarcelona.atenciousuari@sjd.es
- Contact Person Name
- Georgia Sarquella Brugada
- Contact Person Email
- hospitalbarcelona.atenciousuari@sjd.es
- Site Name
- Hospital Universitario La Paz
- Department Name
- Cardiologia pediatrica - Patient Visits
- Principal Investigator Name
- Diana Salas Mera
- Principal Investigator Email
- atepac.hulp@salud.madrid.org
- Contact Person Name
- Diana Salas Mera
- Contact Person Email
- atepac.hulp@salud.madrid.org
- Site Name
- University Hospital Virgen Del Rocio S.L.
- Department Name
- Cardiologia pediatrica - Patient Visits
- Principal Investigator Name
- Inmaculada Guillen Rodriguez
- Principal Investigator Email
- cma.hg.hvr.sspa@juntadeandalucia.es
- Contact Person Name
- Inmaculada Guillen Rodriguez
- Contact Person Email
- cma.hg.hvr.sspa@juntadeandalucia.es
- Site Name
- Hospital Universitario Reina Sofia (additional site listed)
- Department Name
- Cardiologia pediatrica - Patient Visits
- Principal Investigator Name
- Elena Gomez Guzman
- Principal Investigator Email
- sau.hrs.sspa@juntadeandalucia.es
- Contact Person Name
- Elena Gomez Guzman
- Contact Person Email
- sau.hrs.sspa@juntadeandalucia.es
- Site Name
- Hospital Universitario Regional De Malaga (additional site entry)
- Department Name
- Cardiologia pediatrica - Patient Visits
- Principal Investigator Name
- Gonzalo Cortazar Rocandio
- Principal Investigator Email
- secretaria.urgenc.hrmal.sspa@juntadeandalucia.es
- Contact Person Name
- Gonzalo Cortazar Rocandio
- Contact Person Email
- secretaria.urgenc.hrmal.sspa@juntadeandalucia.es
Sweden
- Earliest CTIS Part Ii Submission Date
- 09-09-2025
- Latest Decision Or Authorization Date
- 05-12-2025
- Processing Time Days
- 87
- Number Of Sites
- 1
- Number Of Participants
- 4
Sites
- Site Name
- Region Skane Skanes Universitetssjukhus
- Department Name
- Barnhjärtcentrum
- Principal Investigator Name
- Michal Odermarsky
- Principal Investigator Email
- studiesupport.sus@skane.se
- Contact Person Name
- Michal Odermarsky
- Contact Person Email
- studiesupport.sus@skane.se
Poland
- Earliest CTIS Part Ii Submission Date
- 11-11-2025
- Latest Decision Or Authorization Date
- 09-12-2025
- Processing Time Days
- 28
- Number Of Sites
- 4
- Number Of Participants
- 5
Sites
- Site Name
- Instytut Centrum Zdrowia Matki Polki
- Department Name
- Klinika Kardiologii
- Principal Investigator Name
- Anna Mazurek-Kula
- Principal Investigator Email
- sek43@iczmp.edu.pl
- Contact Person Name
- Anna Mazurek-Kula
- Contact Person Email
- sek43@iczmp.edu.pl
- Site Name
- Instytut Pomnik Centrum Zdrowia Dziecka
- Department Name
- Klinika Kardiologii
- Principal Investigator Name
- Lidia Ziolkowska
- Principal Investigator Email
- oddzial.kardiologia@ipczd.pl
- Contact Person Name
- Lidia Ziolkowska
- Contact Person Email
- oddzial.kardiologia@ipczd.pl
- Site Name
- Gornoslaskie Centrum Zdrowia Dziecka Im. Sw. Jana Pawla II Samodzielny Publiczny Szpital Kliniczny Nr 6 Slaskiego Uniwersytetu Medycznego W Katowicach
- Department Name
- Oddział Kardiologii Dziecięcej
- Principal Investigator Name
- Jacek Kusa
- Principal Investigator Email
- kardiologia@gczd.katowice.pl
- Contact Person Name
- Jacek Kusa
- Contact Person Email
- kardiologia@gczd.katowice.pl
- Site Name
- Wojewodzki Szpital Specjalistyczny We Wroclawiu
- Department Name
- Rozwojowy Oddział Kardiologii Dzięcięcej
- Principal Investigator Name
- Pawel Czesniewicz
- Principal Investigator Email
- kardiolodz@wssk.wroc.pl
- Contact Person Name
- Pawel Czesniewicz
- Contact Person Email
- kardiolodz@wssk.wroc.pl
Italy
- Earliest CTIS Part Ii Submission Date
- 07-11-2025
- Latest Decision Or Authorization Date
- 10-12-2025
- Processing Time Days
- 33
- Number Of Sites
- 10
- Number Of Participants
- 10
Sites
- Site Name
- Azienda Ospedaliera Universitaria Citta Della Salute E Della Scienza Di Torino
- Department Name
- Cadiologia pediatrica
- Principal Investigator Name
- Chiara Riggi
- Principal Investigator Email
- direzioneaziendale@cittadellasalute.to.it
- Contact Person Name
- Chiara Riggi
- Contact Person Email
- direzioneaziendale@cittadellasalute.to.it
- Site Name
- Azienda Ospedaliero-Universitaria Di Bologna IRCCS Istituto Di Ricerca E Di Cura A Carattere Scientifico
- Department Name
- Cardiologia pediatrica ed dell'età evolutiva
- Principal Investigator Name
- Andrea Donti
- Principal Investigator Email
- segr.card.ped@aosp.bo.it
- Contact Person Name
- Andrea Donti
- Contact Person Email
- segr.card.ped@aosp.bo.it
- Site Name
- Ospedale Pediatrico Bambino Gesu
- Department Name
- Unità Terapie Cardiovascolari Avanzate
- Principal Investigator Name
- Rachele Adorisio
- Principal Investigator Email
- scompenso@opbg.net
- Contact Person Name
- Rachele Adorisio
- Contact Person Email
- scompenso@opbg.net
- Site Name
- Azienda Ospedaliera Dei Colli
- Department Name
- Malattie Rare e Genetiche Cardiovascolari
- Principal Investigator Name
- Giuseppe Limongelli
- Principal Investigator Email
- malattierarecardiovascolari@ospedalideicolli.it
- Contact Person Name
- Giuseppe Limongelli
- Contact Person Email
- malattierarecardiovascolari@ospedalideicolli.it
- Site Name
- ASST Grande Ospedale Metropolitano Niguarda
- Department Name
- Struttura semplice dipartimentale cardiologia pediatrica
- Principal Investigator Name
- Simona Anna Marcora
- Principal Investigator Email
- cardioped@ospedaleniguarda.it
- Contact Person Name
- Simona Anna Marcora
- Contact Person Email
- cardioped@ospedaleniguarda.it
- Site Name
- Azienda Ospedaliera di Padova
- Department Name
- UOC Cardiologia Pediatrica
- Principal Investigator Name
- Giovanni Di Salvo
- Principal Investigator Email
- segreteria.cardiologiapediatrica@aopd.veneto.it
- Contact Person Name
- Giovanni Di Salvo
- Contact Person Email
- segreteria.cardiologiapediatrica@aopd.veneto.it
- Site Name
- IRCCS Istituto Giannina Gaslini
- Department Name
- Cardiologia
- Principal Investigator Name
- Maria Elena Derchi
- Principal Investigator Email
- ambulatoriocardiologia@gaslini.org
- Contact Person Name
- Maria Elena Derchi
- Contact Person Email
- ambulatoriocardiologia@gaslini.org
- Site Name
- Azienda Socio Sanitaria Territoriale Papa Giovanni Xxiii
- Department Name
- Cardiologia 2 - Cardiopatie Congenite del bambino e dell'adulto
- Principal Investigator Name
- Francesca Raimondi
- Principal Investigator Email
- cardiologia2cardiopatie.segreteria@asst-pg23.it
- Contact Person Name
- Francesca Raimondi
- Contact Person Email
- cardiologia2cardiopatie.segreteria@asst-pg23.it
- Site Name
- Azienda Ospedaliera Dei Colli (repeat entry)
- Department Name
- Malattie Rare e Genetiche Cardiovascolari
- Principal Investigator Name
- Giuseppe Limongelli
- Principal Investigator Email
- malattierarecardiovascolari@ospedalideicolli.it
- Contact Person Name
- Giuseppe Limongelli
- Contact Person Email
- malattierarecardiovascolari@ospedalideicolli.it
- Site Name
- Azienda Ospedaliera Universitaria Citta Della Salute E Della Scienza Di Torino (repeat entry)
- Department Name
- Cadiologia pediatrica
- Principal Investigator Name
- Chiara Riggi
- Principal Investigator Email
- direzioneaziendale@cittadellasalute.to.it
- Contact Person Name
- Chiara Riggi
- Contact Person Email
- direzioneaziendale@cittadellasalute.to.it
Finland
- Earliest CTIS Part Ii Submission Date
- 10-11-2025
- Latest Decision Or Authorization Date
- 08-12-2025
- Processing Time Days
- 28
- Number Of Sites
- 1
- Number Of Participants
- 2
Sites
- Site Name
- HUS-yhtymae
- Department Name
- Uusi lastensairaala, kardiologia
- Principal Investigator Name
- Maria Hurskainen
- Principal Investigator Email
- lastentutkimukset@hus.fi
- Contact Person Name
- Maria Hurskainen
- Contact Person Email
- lastentutkimukset@hus.fi
Sponsor
Primary sponsor
- Full Name
- Bayer AG
- Organisation Type
- Pharmaceutical company
- Country Of Registered Address
- Germany
Contract research organisations
- Name
- Fisher Clinical Services GmbH
- Responsibilities
- sponsorDuties code: 14
- Name
- Suvoda LLC
- Responsibilities
- sponsorDuties code: 3
- Name
- DATAN Analytics GmbH
- Responsibilities
- sponsorDuties code: 10
- Name
- Carelon Research Inc
- Responsibilities
- scientific advice
Third parties
- {"country":"Switzerland","full_name":"Fisher Clinical Services GmbH","duties_or_roles":"sponsorDuties code: 14","organisation_type":"Pharmaceutical company"}
- {"country":"Switzerland","full_name":"Swiss BioQuant AG","duties_or_roles":"sponsorDuties code: 4","organisation_type":"Laboratory/Research/Testing facility"}
- {"country":"Germany","full_name":"GBA Central Lab Services GmbH","duties_or_roles":"sponsorDuties code: 4","organisation_type":"Laboratory/Research/Testing facility"}
- {"country":"United States","full_name":"Suvoda LLC","duties_or_roles":"sponsorDuties code: 3","organisation_type":"Non-Pharmaceutical company"}
- {"country":"Germany","full_name":"DATAN Analytics GmbH","duties_or_roles":"sponsorDuties code: 10","organisation_type":"Non-Pharmaceutical company"}
- {"country":"United States","full_name":"Carelon Research Inc","duties_or_roles":"scientific advice","organisation_type":"Industry"}
Investigational products
- Investigational Product Name
- BAY 94-8862
- Active Substance
- FINERENONE
- Modality
- Small molecule
- Routes Of Administration
- Oral
- Route
- Oral
- Authorisation Status
- Authorised
- Dose Levels
- 20 mg
- Maximum Dose
- 20 mg
- Investigational Product Name
- Finerenone
- Active Substance
- FINERENONE
- Modality
- Small molecule
- Routes Of Administration
- Oral
- Route
- Oral
- Authorisation Status
- Authorised
- Dose Levels
- 10 mg
- Maximum Dose
- 10 mg
- Investigational Product Name
- Finerenone Bayer (granules for oral suspension)
- Active Substance
- FINERENONE
- Modality
- Small molecule
- Routes Of Administration
- Oral (oral suspension)
- Route
- Oral (suspension)
- Authorisation Status
- Authorised
- Dose Levels
- 40 mg
- Maximum Dose
- 40 mg
- Combination Treatment
- Yes
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