Clinical trial • Phase III • Musculoskeletal
FILGOTINIB for Polyarticular juvenile idiopathic arthritis (pJIA)
Phase III trial of FILGOTINIB for Polyarticular juvenile idiopathic arthritis (pJIA). open-label, none/not specified-controlled. 65 participants.
Overview
- Trial Therapeutic Area
- Musculoskeletal
- Trial Disease
- Polyarticular juvenile idiopathic arthritis (pJIA)
- Trial Stage
- Phase III
- Drug Modality
- Small molecule
- Paediatric Trial
- Yes
Key dates
- Initial CTIS Submission Date
- 26-11-2025
- First CTIS Authorization Date
- 07-04-2026
Trial design
open-label, none/not specified-controlled Phase III trial across 46 sites in Belgium, Bulgaria, Czechia and others.
- Open Label
- Yes
- Comparator
- None/Not specified
- Target Sample Size
- 65
- Trial Duration For Participant
- 540
Eligibility
Recruits 65 paediatric patients.
- Vulnerable Population
- Participants are children and adolescents aged 8 to <18 years. Consent is provided by the parent/legal guardian and the participant must sign assent where required by local regulation (see inclusion criterion: "Subject and/or parent/legal guardian must be able and willing to comply ... and must sign and date the ICF and assent (if required per local regulation) ..."). Age-appropriate assent and information materials are provided (assent for non-readers, assent for young readers ages 8–12, assent for adolescents 12–<18, assent/turning-18 guidance), parent/guardian ICFs, and pregnancy information/ICF materials for adolescent girls. Country- and language-specific ICF/assent documents and recruitment materials are provided (multiple country translations and recruitment-arrangement documents listed per Member State).
Inclusion criteria
- {"criterion_text":"- Subject and/or parent/legal guardian must be able and willing to comply with the clinical study protocol requirements and must sign and date the ICF and assent (if required per local regulation) as approved by the Independent Ethics Committee / Institutional Review Board, prior to any screening evaluations.\n- Female or male subject 8 to <18 years of age, on the date of signing the informed consent and assent (per local regulation).\n- Subject must meet the ILAR classification and have moderately to severely active disease for one of the following categories that is not adequately controlled with his/her current therapy (see Protocol Appendix 1 for disease activity assessment criteria): • Extended oligoarthritis (i.e. affecting a total of more than 4 joints after the first 6 months of disease) • RF-positive polyarthritis • RF-negative polyarthritis • PsA • ERA\n- Subject with intolerance or a history of inadequate response to at least one of the following medications for the treatment of pJIA, administered for at least 3 months, based on current treatment guidelines: conventional synthetic disease modifying anti-rheumatic drugs (csDMARDs; including methotrexate) and/or biologic disease modifying anti-rheumatic drugs (bDMARDS) administered per local label, and/or non-steroidal anti-inflammatory drugs for ERA and PsA subtypes.\n- Female subject of childbearing potential who is sexually active and at risk for pregnancy must agree to use contraception/preventive exposure measures as described in the protocol."}
Exclusion criteria
- {"criterion_text":"- Subject with a body weight <15 kg.\n- Subject with persistent oligoarthritis (i.e. affecting not more than 4 joints throughout the disease course).\n- Subject with undifferentiated arthritis.\n- Subject with anterior uveitis (active or uncontrolled) ≤12 weeks prior to baseline.\n- Subject with systemic JIA.\n- Subject with any other rheumatic disease, inflammatory, or immunologic disease (e.g. inflammatory bowel disease, hypogammaglobulinemia, or systemic lupus erythematosus).\n- Subject has any condition or circumstances (including abnormalities in laboratory parameters) that, in the opinion of the investigator, may make a subject unlikely or unable to complete the study or comply with study procedures and requirements.\n- Subject has an active infection.\n- Subject with a history of complicated herpes zoster infection (with multi-dermatomal, disseminated, ophthalmic, or central nervous system involvement)."}
Endpoints
Primary endpoints
- {"endpoint_text":"- Frequency and severity of treatment-emergent adverse events (TEAEs), treatment-emergent serious adverse events (SAEs), and TEAEs leading to treatment discontinuation (up to approximately Week 22 or throughout the duration of the study)","definition_or_measurement_approach":"Safety assessment by recording frequency and severity of TEAEs, treatment-emergent SAEs, and TEAEs leading to discontinuation up to ~Week 22 or throughout study duration (as stated in endpoint)."}
Secondary endpoints
- {"endpoint_text":"- − Percentage of subjects with juvenile idiopathic arthritis (JIA) American College of Rheumatology (ACR) 30 response at Week 12 and Week 18 − Percentage of subjects with JIA ACR inactive disease at Week 12 and Week 18 − Change from baseline in Juvenile Arthritis Disease Activity Score (JADAS)-27 erythrocyte sedimentation rate (ESR) and JADAS-27 C-reactive protein (CRP) at Week 12 and Week 18","definition_or_measurement_approach":"Clinical efficacy measured by JIA ACR response rates (ACR 30) and ACR inactive disease status at Weeks 12 and 18; change from baseline in JADAS-27 using ESR and CRP at Weeks 12 and 18."}
- {"endpoint_text":"- Incidence of uveitis at various timepoints (including occurrence, type, and severity)","definition_or_measurement_approach":"Uveitis events captured at prespecified timepoints, recording occurrence, type and severity."}
- {"endpoint_text":"- PK parameters of filgotinib and its primary metabolite GS-829845 (including maximum observed plasma concentration at steady-state [Cmax,ss], area under the plasma concentration-time curve over the dosing interval at steady-state [AUC0-24,ss], and area under the plasma concentration-time curve over the dosing interval at steady-state for the effective exposure [AUCeff,ss])","definition_or_measurement_approach":"Pharmacokinetic sampling and analysis to determine Cmax,ss, AUC0-24,ss, AUCeff,ss for filgotinib and GS-829845."}
- {"endpoint_text":"- Acceptability of the age-appropriate pediatric formulation and the adult commercially developed film-coated tablet formulation assessed by Pediatric Oral Medicine Acceptability Questionnaire for Patients (POMAQ-P)","definition_or_measurement_approach":"Acceptability measured using the POMAQ-P questionnaire completed by patients to assess formulation acceptability."}
Recruitment
- Planned Sample Size
- 65
- Recruitment Window Months
- 24
- Consent Approach
- Informed consent is provided by the parent/legal guardian and the subject where applicable; assent is required per local regulation. Age-appropriate assent forms and information materials are provided (assent for non-readers, assent for young readers ages 8–12, assent for adolescents 12–<18, 'turning 18' materials). Parent/guardian ICFs, pregnancy ICF and pregnancy handouts for adolescent girls are provided. Multiple language and country-specific versions of ICF/assent/recruitment materials are available as indicated in the submission (e.g. English, French, Dutch, Bulgarian, Czech, German, Greek, Hungarian, Italian, Polish, Spanish and others as per Member State documents).
Methods
- Physician referral letters (country-specific physician referral letter documents listed: e.g. Physician Referral Letter _English/Dutch/French and country-specific versions).
- Participant brochures / patient brochures (country-specific Participant Brochure documents listed).
- Recruitment arrangements documents (K1 documents) per Member State describing local recruitment procedures and materials.
- Use of site/hospital-based recruitment via clinical sites listed (pediatric rheumatology departments).
Geography
- Total Number Of Sites
- 46
- Total Number Of Participants
- 57
Belgium
- Earliest CTIS Part Ii Submission Date
- 18-03-2026
- Latest Decision Or Authorization Date
- 07-04-2026
- Processing Time Days
- 20
- Number Of Sites
- 6
- Number Of Participants
- 6
Sites
- Site Name
- Ziekenhuis Aan De Stroom
- Department Name
- Rheumatology
- Principal Investigator Name
- Rik Joos
- Principal Investigator Email
- rik.joos@zas.be
- Contact Person Name
- Rik Joos
- Contact Person Email
- rik.joos@zas.be
- Site Name
- Universitair Ziekenhuis Antwerpen
- Department Name
- Rheumatology
- Principal Investigator Name
- Benson Ogunjimi
- Principal Investigator Email
- benson.ogunjimi@uza.be
- Contact Person Name
- Benson Ogunjimi
- Contact Person Email
- benson.ogunjimi@uza.be
- Site Name
- Universitair Ziekenhuis Gent
- Department Name
- Rheumatology
- Principal Investigator Name
- Joke Dehoorne
- Principal Investigator Email
- joke.dehoorne@uzgent.be
- Contact Person Name
- Joke Dehoorne
- Contact Person Email
- joke.dehoorne@uzgent.be
- Site Name
- UZ Leuven
- Department Name
- Rheumatology
- Principal Investigator Name
- Lien De Somer
- Principal Investigator Email
- lien.desomer@uzleuven.be
- Contact Person Name
- Lien De Somer
- Contact Person Email
- lien.desomer@uzleuven.be
- Site Name
- Centre Hospitalier Regional De La Citadelle
- Department Name
- Rheumatology
- Principal Investigator Name
- Benoît Florkin
- Principal Investigator Email
- benoit.florkin@chrcitadelle.be
- Contact Person Name
- Benoît Florkin
- Contact Person Email
- benoit.florkin@chrcitadelle.be
- Site Name
- Cliniques Universitaires Saint-Luc
- Department Name
- Rheumatology
- Principal Investigator Name
- Patrick Durez
- Principal Investigator Email
- patrick.durez@saintluc.uclouvain.be
- Contact Person Name
- Patrick Durez
- Contact Person Email
- patrick.durez@saintluc.uclouvain.be
Bulgaria
- Earliest CTIS Part Ii Submission Date
- 20-03-2026
- Latest Decision Or Authorization Date
- 14-04-2026
- Processing Time Days
- 25
- Number Of Sites
- 3
- Number Of Participants
- 4
Sites
- Site Name
- University Multiprofile Hospital For Active Treatment Saint Georgi EAD
- Department Name
- Clinic of Pediatrics
- Principal Investigator Name
- Krastina Stefanova-Kelly
- Principal Investigator Email
- krastinakelly@yahoo.co.uk
- Contact Person Name
- Krastina Stefanova-Kelly
- Contact Person Email
- krastinakelly@yahoo.co.uk
- Site Name
- Specialized Hospital For Active Treatment Of Childrens Diseases Professor Ivan Mitev
- Department Name
- Clinic of Pediatric Rheumatology
- Principal Investigator Name
- Katya Temelkova
- Principal Investigator Email
- temelkovakatya@gmail.com
- Contact Person Name
- Katya Temelkova
- Contact Person Email
- temelkovakatya@gmail.com
- Site Name
- Medical Center For Specialized Medical Care For Cardiovascular Diseases EAD
- Principal Investigator Name
- Stefan Stefanov
- Principal Investigator Email
- prof.s.stefanov.md@gmail.com
- Contact Person Name
- Stefan Stefanov
- Contact Person Email
- prof.s.stefanov.md@gmail.com
Czechia
- Earliest CTIS Part Ii Submission Date
- 05-03-2026
- Latest Decision Or Authorization Date
- 08-04-2026
- Processing Time Days
- 34
- Number Of Sites
- 4
- Number Of Participants
- 5
Sites
- Site Name
- Vseobecna Fakultni Nemocnice V Praze
- Department Name
- Klinika pediatrie a dědičných poruch metabolismu
- Principal Investigator Name
- Pavla Doležalová
- Principal Investigator Email
- pavla.dolezalova@vfn.cz
- Contact Person Name
- Pavla Doležalová
- Contact Person Email
- pavla.dolezalova@vfn.cz
- Site Name
- Fakultni Nemocnice Brno
- Department Name
- Pediatrická klinika
- Principal Investigator Name
- Marcel Schüller
- Principal Investigator Email
- Schuller.Marcel@fnbrno.cz
- Contact Person Name
- Marcel Schüller
- Contact Person Email
- Schuller.Marcel@fnbrno.cz
- Site Name
- Fakultni Nemocnice V Motole
- Department Name
- Oddělení revmatologie dětí a dospělých
- Principal Investigator Name
- Rudolf Horváth
- Principal Investigator Email
- rudolf.horvath@fnmotol.cz
- Contact Person Name
- Rudolf Horváth
- Contact Person Email
- rudolf.horvath@fnmotol.cz
- Site Name
- University Hospital Olomouc
- Department Name
- Dětská klinika, Dětská revmatologie
- Principal Investigator Name
- Kateřina Bouchalová
- Principal Investigator Email
- katerina.bouchalova@fnol.cz
- Contact Person Name
- Kateřina Bouchalová
- Contact Person Email
- katerina.bouchalova@fnol.cz
France
- Earliest CTIS Part Ii Submission Date
- 06-03-2026
- Latest Decision Or Authorization Date
- 07-04-2026
- Processing Time Days
- 32
- Number Of Sites
- 4
- Number Of Participants
- 5
Sites
- Site Name
- Assistance Publique Hopitaux De Paris
- Department Name
- Pediatric Immunology-Hematology and Rheumatology
- Principal Investigator Name
- Pierre QUARTIER DIT MAIRE
- Principal Investigator Email
- pierre.quartier@aphp.fr
- Contact Person Name
- Pierre QUARTIER DIT MAIRE
- Contact Person Email
- pierre.quartier@aphp.fr
- Site Name
- Assistance Publique Hopitaux De Paris
- Department Name
- Immuno-Hematology and Rheumatology
- Principal Investigator Name
- Isabelle KONE-PAUT
- Principal Investigator Email
- isabelle.kone-paut@aphp.fr
- Contact Person Name
- Isabelle KONE-PAUT
- Contact Person Email
- isabelle.kone-paut@aphp.fr
- Site Name
- Centre Hospitalier Universitaire De Montpellier
- Department Name
- General pediatrics
- Principal Investigator Name
- Aurelia CARBASSE
- Principal Investigator Email
- a-carbasse@chu-montpellier.fr
- Contact Person Name
- Aurelia CARBASSE
- Contact Person Email
- a-carbasse@chu-montpellier.fr
- Site Name
- Centre Hospitalier Regional Universitaire De Tours
- Department Name
- Pediatric Rheumatology and Pediatric pain
- Principal Investigator Name
- Florence UETTWILLER
- Principal Investigator Email
- f.uettwiller@chu-tours.fr
- Contact Person Name
- Florence UETTWILLER
- Contact Person Email
- f.uettwiller@chu-tours.fr
Germany
- Earliest CTIS Part Ii Submission Date
- 20-03-2026
- Latest Decision Or Authorization Date
- 09-04-2026
- Processing Time Days
- 20
- Number Of Sites
- 4
- Number Of Participants
- 6
Sites
- Site Name
- Charite Universitaetsmedizin Berlin KöR
- Department Name
- paediatric rheumatology
- Principal Investigator Name
- Kirsten Minden
- Principal Investigator Email
- kirsten.minden@charite.de
- Contact Person Name
- Kirsten Minden
- Contact Person Email
- kirsten.minden@charite.de
- Site Name
- Hamburger Zentrum fuer Kinder und Jugendrheumatologie
- Department Name
- Pediatric rheumatology
- Principal Investigator Name
- Ivan Foeldvari
- Principal Investigator Email
- foeldvari@t-online.de
- Contact Person Name
- Ivan Foeldvari
- Contact Person Email
- foeldvari@t-online.de
- Site Name
- Klinikum St. Georg gGmbH
- Department Name
- paediatric rheumatology
- Principal Investigator Name
- Maria Fasshauer
- Principal Investigator Email
- maria.fasshauer@sanktgeorg.de
- Contact Person Name
- Maria Fasshauer
- Contact Person Email
- maria.fasshauer@sanktgeorg.de
- Site Name
- Asklepios Klinik Sankt Augustin GmbH
- Department Name
- Pediatric rheumatology, immunology
- Principal Investigator Name
- Gerd Horneff
- Principal Investigator Email
- g.horneff@asklepios.com
- Contact Person Name
- Gerd Horneff
- Contact Person Email
- g.horneff@asklepios.com
Greece
- Earliest CTIS Part Ii Submission Date
- 19-01-2026
- Latest Decision Or Authorization Date
- 08-04-2026
- Processing Time Days
- 79
- Number Of Sites
- 3
- Number Of Participants
- 4
Sites
- Site Name
- Nosokomeio Paidon I Agia Sofia
- Department Name
- 1st University Pediatric Clinic
- Principal Investigator Name
- Elena Tsitsami
- Principal Investigator Email
- elena@tsitsamis.gr
- Contact Person Name
- Elena Tsitsami
- Contact Person Email
- elena@tsitsamis.gr
- Site Name
- Athens General Children's Hospital Panagioti And Aglaia Kyriakou
- Department Name
- Second Department of Pediatrics
- Principal Investigator Name
- Despoina Maritsi
- Principal Investigator Email
- dmaritsi@yahoo.co.uk
- Contact Person Name
- Despoina Maritsi
- Contact Person Email
- dmaritsi@yahoo.co.uk
- Site Name
- Hippokration Hospital
- Department Name
- 1st Department of Pediatrics
- Principal Investigator Name
- Vasiliki Sgouropoulou
- Principal Investigator Email
- vsgouro@auth.gr
- Contact Person Name
- Vasiliki Sgouropoulou
- Contact Person Email
- vsgouro@auth.gr
Hungary
- Earliest CTIS Part Ii Submission Date
- 03-02-2026
- Latest Decision Or Authorization Date
- 13-04-2026
- Processing Time Days
- 69
- Number Of Sites
- 3
- Number Of Participants
- 5
Sites
- Site Name
- University Of Szeged
- Department Name
- Rheumatology and Immunology
- Principal Investigator Name
- Viktoria Sumegi
- Principal Investigator Email
- sumegi.viktoria@med.u.szeged.hu
- Contact Person Name
- Viktoria Sumegi
- Contact Person Email
- sumegi.viktoria@med.u.szeged.hu
- Site Name
- Semmelweis University
- Department Name
- Gyermekgyógyászati Klinika Tűzoltó utcai részleg
- Principal Investigator Name
- Tamas Constantin
- Principal Investigator Email
- constantin.tamas@semmelweis.hu
- Contact Person Name
- Tamas Constantin
- Contact Person Email
- constantin.tamas@semmelweis.hu
- Site Name
- University Of Pecs
- Department Name
- Pediatric Clinic
- Principal Investigator Name
- Bernadett Mosdosi
- Principal Investigator Email
- mosdosi.bernadett@pte.hu
- Contact Person Name
- Bernadett Mosdosi
- Contact Person Email
- mosdosi.bernadett@pte.hu
Italy
- Earliest CTIS Part Ii Submission Date
- 06-03-2026
- Latest Decision Or Authorization Date
- 08-04-2026
- Processing Time Days
- 33
- Number Of Sites
- 8
- Number Of Participants
- 10
Sites
- Site Name
- Asst Centro Specialistico Ortopedico Traumatologico Gaetano Pini Cto
- Department Name
- Pediatric Rheumatology
- Principal Investigator Name
- Achille Marino
- Principal Investigator Email
- achille.marino@asst-pini-cto.it
- Contact Person Name
- Achille Marino
- Contact Person Email
- achille.marino@asst-pini-cto.it
- Site Name
- Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico
- Department Name
- SC Pediatria Immunoreumatologia
- Principal Investigator Name
- Stefano Lanni
- Principal Investigator Email
- stefano.lanni@policlinico.mi.it
- Contact Person Name
- Stefano Lanni
- Contact Person Email
- stefano.lanni@policlinico.mi.it
- Site Name
- Azienda Unita' Locale Socio Sanitaria N. 2 Marca Trevigiana
- Department Name
- UOC pediatria
- Principal Investigator Name
- Francesca Biscaro
- Principal Investigator Email
- francesca.biscaro@aulss2.veneto.it
- Contact Person Name
- Francesca Biscaro
- Contact Person Email
- francesca.biscaro@aulss2.veneto.it
- Site Name
- Azienda Ospedaliera Universitaria Meyer IRCCS
- Department Name
- Pediatric Rheumatology
- Principal Investigator Name
- Gabriele Simonini
- Principal Investigator Email
- gabriele.simonini@unifi.it
- Contact Person Name
- Gabriele Simonini
- Contact Person Email
- gabriele.simonini@unifi.it
- Site Name
- Ospedale Vito Fazzi Lecce
- Department Name
- Pediatric
- Principal Investigator Name
- Adele Civino
- Principal Investigator Email
- adele.civino@asl.lecce.it
- Contact Person Name
- Adele Civino
- Contact Person Email
- adele.civino@asl.lecce.it
- Site Name
- Azienda Ospedaliera Universitaria Gaetano Martino Messina
- Department Name
- Pediatric Rheumatology
- Principal Investigator Name
- Giovanni Conti
- Principal Investigator Email
- gconti@unime.it
- Contact Person Name
- Giovanni Conti
- Contact Person Email
- gconti@unime.it
- Site Name
- IRCCS Istituto Giannina Gaslini
- Department Name
- Pediatric Rheumatology
- Principal Investigator Name
- Alessandro Consolaro
- Principal Investigator Email
- alessandroconsolaro@gaslini.org
- Contact Person Name
- Alessandro Consolaro
- Contact Person Email
- alessandroconsolaro@gaslini.org
- Site Name
- Azienda Ospedaliera Universitaria Gaetano Martino Messina
- Department Name
- Pediatric Rheumatology
Spain
- Earliest CTIS Part Ii Submission Date
- 04-02-2026
- Latest Decision Or Authorization Date
- 10-04-2026
- Processing Time Days
- 65
- Number Of Sites
- 7
- Number Of Participants
- 7
Sites
- Site Name
- Complexo Hospitalario Universitario De Santiago
- Department Name
- Rheumatology
- Principal Investigator Name
- Antonio Mera Varela
- Principal Investigator Email
- antonio.mera.varela@sergas.es
- Contact Person Name
- Antonio Mera Varela
- Contact Person Email
- antonio.mera.varela@sergas.es
- Site Name
- Hospital Universitario La Paz
- Department Name
- Pediatric Rheumatology
- Principal Investigator Name
- Rosa Maria Alcobendas Rueda
- Principal Investigator Email
- rosaalcobendasrueda@gmail.com
- Contact Person Name
- Rosa Maria Alcobendas Rueda
- Contact Person Email
- rosaalcobendasrueda@gmail.com
- Site Name
- Hospital Sant Joan De Deu Barcelona
- Department Name
- Rheumatology
- Principal Investigator Name
- Jordi Anton Lopez
- Principal Investigator Email
- janton@sjdhospitalbarcelona.org
- Contact Person Name
- Jordi Anton Lopez
- Contact Person Email
- janton@sjdhospitalbarcelona.org
- Site Name
- Hospital HM Nens
- Department Name
- Pediatric Rheumatology
- Principal Investigator Name
- Violeta Bittermann
- Principal Investigator Email
- vbittermann@fundacionhm.com
- Contact Person Name
- Violeta Bittermann
- Contact Person Email
- vbittermann@fundacionhm.com
- Site Name
- Hospital Universitario Y Politecnico La Fe
- Department Name
- Pediatric Rheumatology
- Principal Investigator Name
- Lucia Lacruz Perez
- Principal Investigator Email
- lacruz_lucper@gva.es
- Contact Person Name
- Lucia Lacruz Perez
- Contact Person Email
- lacruz_lucper@gva.es
- Site Name
- Hospital Universitario De Cruces
- Department Name
- Pediatrics
- Principal Investigator Name
- Maria del Carmen Pinedo Gago
- Principal Investigator Email
- MARIADELCARMEN.PINEDOGAGO@osakidetza.eus
- Contact Person Name
- Maria del Carmen Pinedo Gago
- Contact Person Email
- MARIADELCARMEN.PINEDOGAGO@osakidetza.eus
- Site Name
- Hospital Universitari Vall D Hebron
- Department Name
- Rheumatology
- Principal Investigator Name
- Estefania Moreno Ruzafa
- Principal Investigator Email
- estefania.moreno@vallhebron.cat
- Contact Person Name
- Estefania Moreno Ruzafa
- Contact Person Email
- estefania.moreno@vallhebron.cat
Poland
- Earliest CTIS Part Ii Submission Date
- 06-03-2026
- Latest Decision Or Authorization Date
- 09-04-2026
- Processing Time Days
- 34
- Number Of Sites
- 4
- Number Of Participants
- 5
Sites
- Site Name
- Centrum Medyczne Justmed Sp. z o.o.
- Department Name
- ETG JustMed
- Principal Investigator Name
- Marta Szwarc-Bronikowska
- Principal Investigator Email
- m.szwarcbronikowska@etg-network.com
- Contact Person Name
- Marta Szwarc-Bronikowska
- Contact Person Email
- m.szwarcbronikowska@etg-network.com
- Site Name
- Centrum Medyczne "Hipokrates" S.C. Elżbieta i Grzegorz Grześk
- Department Name
- Centrum Medyczne "Hipokrates" S.C Elżbieta i Grzegorz Grześk
- Principal Investigator Name
- Elżbieta Grześk
- Principal Investigator Email
- hipokrates@farmepo.com
- Contact Person Name
- Elżbieta Grześk
- Contact Person Email
- hipokrates@farmepo.com
- Site Name
- Malopolskie Badania Kliniczne Sp. z o.o.
- Department Name
- Małopolskie Badania Kliniczne
- Principal Investigator Name
- Zbigniew Żuber
- Principal Investigator Email
- zbyszekzuber@interia.pl
- Contact Person Name
- Zbigniew Żuber
- Contact Person Email
- zbyszekzuber@interia.pl
- Site Name
- Medicover Integrated Clinical Services Sp. z o.o.
- Department Name
- MICS Centrum Medyczne Toruń
- Principal Investigator Name
- Sławomir Jeka
- Principal Investigator Email
- s.jeka@wp.pl
- Contact Person Name
- Sławomir Jeka
- Contact Person Email
- s.jeka@wp.pl
Sponsor
Primary sponsor
- Full Name
- Alfasigma S.p.A.
- Organisation Type
- Pharmaceutical company
- Country Of Registered Address
- Italy
Contract research organisations
- Name
- IQVIA Limited
- Responsibilities
- sponsorDuties codes: 1,10,12,2,5,8 (as listed in submission)
- Name
- IQVIA RDS Hellas Single Member S.A.
- Responsibilities
- sponsorDuties codes: 1,8 (as listed in submission)
- Name
- Almac Clinical Services Limited
- Responsibilities
- Medicinal product production, QP certification and release, overall distribution and destruction of reconciled IMP
- Name
- QPS Netherlands B.V.
- Responsibilities
- sponsorDuties code 4
- Name
- Labcorp Central Laboratory Services SARL
- Responsibilities
- sponsorDuties code 4 (central laboratory services)
Third parties
- {"country":"United Kingdom","full_name":"Medical Equipment Supplies And Management Limited","duties_or_roles":"equipment supply (code 15)","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Medidata Solutions Inc.","duties_or_roles":"sponsorDuties code 7","organisation_type":"Non-Pharmaceutical company"}
- {"country":"Switzerland","full_name":"Labcorp Central Laboratory Services SARL","duties_or_roles":"sponsorDuties code 4","organisation_type":"Pharmaceutical company"}
- {"country":"United Kingdom (Northern Ireland)","full_name":"Almac Clinical Services Limited","duties_or_roles":"Medicinal product production, QP certification and release, overall distribution and destruction of reconciled IMP (code 15)","organisation_type":"Pharmaceutical company"}
- {"country":"Netherlands","full_name":"QPS Netherlands B.V.","duties_or_roles":"sponsorDuties code 4","organisation_type":"Pharmaceutical company"}
- {"country":"United Kingdom","full_name":"IQVIA Limited","duties_or_roles":"sponsorDuties codes: 1,10,12,2,5,8","organisation_type":"Pharmaceutical company"}
- {"country":"Greece","full_name":"IQVIA RDS Hellas Single Member S.A.","duties_or_roles":"sponsorDuties codes: 1,8","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Suvoda LLC","duties_or_roles":"sponsorDuties code 3","organisation_type":"Non-Pharmaceutical company"}
Investigational products
- Investigational Product Name
- GLPG0634
- Active Substance
- FILGOTINIB
- Modality
- Small molecule
- Routes Of Administration
- ORAL USE
- Route
- ORAL USE
- Authorisation Status
- prodAuthStatus: 1 (no marketing authorisation indicated in productDictionaryInfo)
- Maximum Dose
- 100 mg (maxDailyDoseAmount: 100)
- Investigational Product Name
- Jyseleca 100 mg film-coated tablets
- Active Substance
- FILGOTINIB
- Modality
- Small molecule
- Routes Of Administration
- ORAL USE
- Route
- ORAL USE
- Authorisation Status
- Authorised (marketingAuthNumber: EU/1/20/1480/001; prodAuthStatus: 2)
- Maximum Dose
- 100 mg (maxDailyDoseAmount: 100)
- Investigational Product Name
- Jyseleca 200 mg film-coated tablets
- Active Substance
- FILGOTINIB
- Modality
- Small molecule
- Routes Of Administration
- ORAL USE
- Route
- ORAL USE
- Authorisation Status
- Authorised (marketingAuthNumber: EU/1/20/1480/003; prodAuthStatus: 2)
- Maximum Dose
- 200 mg (maxDailyDoseAmount: 200)
Related trials
Other published trials that may interest you.