Clinical trial • Phase III • Other
ELINZANETANT for Vasomotor symptoms (hot flashes) due to adjuvant endocrine therapy
Phase III trial of ELINZANETANT for Vasomotor symptoms (hot flashes) due to adjuvant endocrine therapy.
Overview
- Trial Therapeutic Area
- Other
- Trial Disease
- Vasomotor symptoms (hot flashes) due to adjuvant endocrine therapy
- Trial Stage
- Phase III
- Drug Modality
- Small molecule
Key dates
- Initial CTIS Submission Date
- 12-01-2024
- First CTIS Authorization Date
- 20-02-2024
Trial design
Randomised, placebo: bay 3427080 60 mg capsules placebo administered orally once daily for the first 12 weeks (placebo-controlled arm). test arm: elinzanetant (bay 3427080) 120 mg orally once daily for 52 weeks (and optionally up to an additional 3.5 years). Phase III trial in France, Hungary, Italy and others.
- Randomised
- Yes
- Comparator
- Placebo: BAY 3427080 60 mg capsules placebo administered orally once daily for the first 12 weeks (placebo-controlled arm). Test arm: elinzanetant (BAY 3427080) 120 mg orally once daily for 52 weeks (and optionally up to an additional 3.5 years).
- Target Sample Size
- 57
- Trial Duration For Participant
- 392
Eligibility
Recruits 57 isVulnerablePopulationSelected flag is true. Participants are adults (females aged 18 to 70). Informed consent is required from each participant. Subject information and informed consent forms (ICFs) and participant information sheets are provided in multiple country/language-specific versions (documents list includes ICFs in FR, HU, IT, DE, PL, RO, EN, ES, PT, FI among others). No assent or parental consent handling is specified (participants are adults)..
- Vulnerable Population
- isVulnerablePopulationSelected flag is true. Participants are adults (females aged 18 to 70). Informed consent is required from each participant. Subject information and informed consent forms (ICFs) and participant information sheets are provided in multiple country/language-specific versions (documents list includes ICFs in FR, HU, IT, DE, PL, RO, EN, ES, PT, FI among others). No assent or parental consent handling is specified (participants are adults).
Inclusion criteria
- {"criterion_text":"- Females aged 18 to 70 years of age inclusive, at the time of signing the informed consent.\n- Women experiencing vasomotor symptoms (VMS) caused by adjuvant endocrine therapy that they are expected to use for the duration of the study a) Tamoxifen with or without the use of gonadotropin-releasing hormone (GnRH) analogues or b) Aromatase inhibitors with or without the use of GnRH analogues\n- Women must have a. a personal history of hormone-receptor positive breast cancer or b. a high risk for developing breast cancer.\n- Participant has completed Hot Flash Daily Diary (HFDD) for at least 11 days during the two weeks preceding baseline visit, and participant has recorded at least 35 moderate to severe hot flash (HF) (including night-time HF) over the last 7 days that the HFDD was completed (assessed at the Baseline Visit).\n- Contraceptive use by women (except for post-menopausal women or Women of Non childbearing potential [WONCBP]) should be consistent with local regulations regarding the methods of contraception for those participating in clinical studies."}
Exclusion criteria
- {"criterion_text":"- Initial diagnosis of metastatic hormone-receptor positive breast cancer (stage IV) or recurrence under adjuvant endocrine therapy of hormonereceptor positive breast cancer.\n- Current or history (except complete remission for 5 years or more prior to signing informed consent) of any malignancy, except for hormone-receptor positive breast cancer (Stage 0-III), basal and squamous cell skin tumors.\n- Surgery or non-surgical (e.g., chemotherapy, radiotherapy, immunotherapy) treatment for breast cancer within the last 3 months prior to signing informed consent (except use of tamoxifen, aromatase inhibitors, GnRH analogues).\n- Any clinically significant prior or ongoing history of arrhythmias, heart block and QT prolongation either determined through clinical history or on electrocardiogram (ECG) evaluation.\n- Any active ongoing condition that could cause difficulty in interpreting VMS such as: infection that could cause pyrexia, pheochromocytoma, carcinoid syndrome.\n- Any unexplained vaginal bleeding.\n- Mammogram with clinically relevant malignant or suspicious findings that will require surgery, radiotherapy or chemotherapy as per local guidelines (mammogram should not be older than 12 months prior to signing informed consent). If a mammogram is not possible after partial mastectomy an ultrasound could be performed instead.\n- Disordered proliferative endometrium, endometrial hyperplasia, polyp, or endometrial cancer diagnosed based on endometrial biopsy during screening.\n- Current arterial or venous vascular event (e.g., Myocardial infarction (MI), Transient ischemic attack (TIA), stroke, deep vein thrombosis (DVT), i.e., within the last 6 months prior to signing informed consent."}
Endpoints
Primary endpoints
- {"endpoint_text":"- Mean change in frequency of moderate to severe hot flash (HF) from baseline to Week 4 (assessed by hot flash daily diary [HFDD]).","definition_or_measurement_approach":"Assessed by hot flash daily diary (HFDD); endpoint is mean change in frequency of moderate to severe hot flashes from baseline to Week 4."}
- {"endpoint_text":"- Mean change in frequency of moderate to severe HF from baseline to Week 12 (assessed by HFDD).","definition_or_measurement_approach":"Assessed by hot flash daily diary (HFDD); endpoint is mean change in frequency of moderate to severe hot flashes from baseline to Week 12."}
Secondary endpoints
- {"endpoint_text":"- Mean change in severity of moderate to severe HF from baseline to Week 4 (assessed by HFDD).","definition_or_measurement_approach":"Assessed by HFDD; mean change in severity of moderate to severe hot flashes from baseline to Week 4."}
- {"endpoint_text":"- Mean change in severity of moderate to severe HF from baseline to Week 12 (assessed by HFDD).","definition_or_measurement_approach":"Assessed by HFDD; mean change in severity of moderate to severe hot flashes from baseline to Week 12."}
- {"endpoint_text":"- Mean change in frequency of moderate to severe HF from baseline to Week 1 (assessed by HFDD).","definition_or_measurement_approach":"Assessed by HFDD; mean change in frequency from baseline to Week 1."}
- {"endpoint_text":"- Mean change in frequency of moderate to severe HF from baseline over time.","definition_or_measurement_approach":"Assessed by HFDD; mean change in frequency over time relative to baseline."}
- {"endpoint_text":"- Mean change in patient-reported outcomes measurement information system sleep disturbance short form 8b (PROMIS SD SF 8b) total score from baseline to Week 12.","definition_or_measurement_approach":"Assessed using PROMIS SD SF 8b; mean change in total score from baseline to Week 12."}
- {"endpoint_text":"- Mean change in menopause specific quality of life scale (MENQOL) total score from baseline to Week 12.","definition_or_measurement_approach":"Assessed using MENQOL questionnaire; mean change in total score from baseline to Week 12."}
Recruitment
- Digital Remote Recruitment
- True, recruitment includes digital/remote methods: social media ads, website landing pages, digital ad creatives, patient web videos, online user flows and digital recruitment workflows (documents reference Social Media, Digital Ads, Website Creative Pack, Web Video storyboard, and Probando platform materials).
- Planned Sample Size
- 57
- Recruitment Window Months
- 68
- Consent Approach
- Informed consent is obtained from each participant (adult females 18–70). Subject information and informed consent forms (ICFs) and participant information sheets are provided in multiple country/language versions (documents list includes ICFs in FR, HU, IT, DE, PL, RO, EN, ES, PT, FI etc.). No mention of parental consent or assent (participants are adults).
Methods
- Posters (country/language specific) — patient-facing posters listed in recruitment materials for multiple countries.
- Trifold brochures / patient brochures for distribution at sites.
- Flipcharts and IC flipcharts for site staff.
- Local advertisements and local newspaper advertisements (country specific).
- Social media advertising / Social Media Ad Text (digital ads, teaser text) including XFactor Digital Ads creative and Social Media scripts.
- Website landing pages / study webpages and website creative packs.
- Patient Web Video / Video Pack study overview and web video storyboards.
- Patient letters and patient booklets sent by sites.
- Patient feedback surveys and access cards.
- Digital recruitment workflows and online user flows (Probando platform materials referenced).
- Posting materials across multiple channels (print, digital, video) adapted by country.
Geography
- Total Number Of Sites
- 91
- Total Number Of Participants
- 421
France
- Earliest CTIS Part Ii Submission Date
- 06-02-2024
- Latest Decision Or Authorization Date
- 05-12-2025
- Processing Time Days
- 668
- Number Of Sites
- 7
- Number Of Participants
- 36
Sites
- Site Name
- Institut Regional Du Cancer De Montpellier
- Department Name
- Oncogynecologie et senologie
- Contact Person Name
- Sophie Gau
- Contact Person Email
- contact.crc@icm.unicancer.fr
- Site Name
- Centre Francois Baclesse
- Department Name
- Pathologie mammaire
- Contact Person Name
- George Emile
- Contact Person Email
- g.emile@baclesse.unicancer.fr
- Site Name
- Institut De Cancerologie De L Ouest
- Department Name
- Gynecologie medicale
- Contact Person Name
- Aliette Dezellus
- Contact Person Email
- aliette.dezellus@ico.unicancer.fr
- Site Name
- Centre Leon Berard
- Department Name
- Gynecologie médicale
- Contact Person Name
- Christine Rousset-Jablonski
- Contact Person Email
- christine.rousset-jablonski@lyon.unicancer.fr
- Site Name
- Hopital Tenon
- Department Name
- Gynecologie Obstetrique Medecine de la Reproduction
- Contact Person Name
- Nathalie Chabbert-Buffet
- Contact Person Email
- nathalie.chabert-buffet@aphp.fr
- Site Name
- Centre Regional Lutte Contre Le Cancer
- Department Name
- Oncologie
- Contact Person Name
- Thierry Petit
- Contact Person Email
- t.petit@icans.eu
- Site Name
- Institut De Cancerologie De L Ouest (Angers)
- Department Name
- Oncologie
- Contact Person Name
- Baptiste Sauterey
- Contact Person Email
- baptiste.sauterey@ico.unicancer.fr
Hungary
- Earliest CTIS Part Ii Submission Date
- 06-02-2024
- Latest Decision Or Authorization Date
- 15-12-2025
- Processing Time Days
- 678
- Number Of Sites
- 3
- Number Of Participants
- 20
Sites
- Site Name
- Thoeris Psy Kft.
- Department Name
- Rub-Int Noi Egeszsegcentrum
- Contact Person Name
- Levente Rubliczky
- Contact Person Email
- dr.rubliczky@gmail.com
- Site Name
- Axon Kft.
- Contact Person Name
- Tamas Nyirady
- Contact Person Email
- nyiradyt@hotmail.com
- Site Name
- Szabolcs-Szatmar-Bereg Varmegyei Oktatokorhaz
- Department Name
- Onkoradiologia
- Contact Person Name
- Agnes Weber
- Contact Person Email
- agneswebermd@gmail.com
Italy
- Earliest CTIS Part Ii Submission Date
- 06-02-2024
- Latest Decision Or Authorization Date
- 10-12-2025
- Processing Time Days
- 673
- Number Of Sites
- 9
- Number Of Participants
- 47
Sites
- Site Name
- Centro Ricerche Cliniche Di Verona S.r.l.
- Department Name
- Centro di Ricerche Cliniche
- Contact Person Name
- Valentino Bergamini
- Contact Person Email
- valentino.bergamini@aovr.veneto.it
- Site Name
- Azienda Ospedaliera Ordine Mauriziano Di Torino
- Department Name
- SCDU Ginecologia e Ostetricia – settore MED 40
- Contact Person Name
- Valentina Elisabetta Bounous
- Contact Person Email
- valentinaelisabetta.bounous@unito.it
- Site Name
- IRCCS Ospedale Policlinico San Martino
- Department Name
- UOC Clinica Ostetrica e Ginecologica
- Contact Person Name
- Angelo Cagnacci
- Contact Person Email
- angelo.cagnacci@unige.it
- Site Name
- Azienda Ospedaliero Universitaria Di Modena
- Department Name
- Centro Hub e Spoke del CTF-MO
- Contact Person Name
- Federico Piacentini
- Contact Person Email
- federico.piacentini@unimore.it
- Site Name
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
- Department Name
- Unità Operativa di Ginecologia Oncologica Area Salute della Donna
- Contact Person Name
- Paola Villa
- Contact Person Email
- paola.villa@policlinicogemelli.it
- Site Name
- European Institute Of Oncology S.r.l.
- Department Name
- Unità di Ginecologia Preventiva
- Contact Person Name
- Dorella Franchi
- Contact Person Email
- dorella.franchi@ieo.it
- Site Name
- Fondazione IRCCS Policlinico San Matteo
- Department Name
- U.O. Clinica Ostetrica e Ginecologica e Riproduzione Umana
- Contact Person Name
- Rossella Nappi
- Contact Person Email
- r.nappi@smatteo.pv.it
- Site Name
- Azienda Ospedaliera Universitaria Federico II Di Napoli
- Department Name
- Unità di Ostetricia e Ginecologia
- Contact Person Name
- Giuseppe Bifulco
- Contact Person Email
- giuseppe.bifulco@unina.it
- Site Name
- Centro Ricerche Cliniche Di Verona S.r.l. (additional listing)
- Department Name
- Centro di Ricerche Cliniche
Austria
- Earliest CTIS Part Ii Submission Date
- 06-02-2024
- Latest Decision Or Authorization Date
- 05-12-2025
- Processing Time Days
- 668
- Number Of Sites
- 3
- Number Of Participants
- 16
Sites
- Site Name
- Medizinische Universitaet Innsbruck
- Department Name
- Universitaetsklinik fuer Gynaekologie und Geburtshilfe
- Contact Person Name
- Christine Brunner
- Contact Person Email
- c.brunner@tirol-kliniken.at
- Site Name
- Medical University Of Vienna
- Department Name
- Universitaetsklinik fuer Frauenheilkunde
- Contact Person Name
- Georg Pfeiler
- Contact Person Email
- georg.pfeiler@meduniwien.ac.at
- Site Name
- Medical University Of Graz
- Department Name
- Universitaetsklinik fuer Frauenheilkunde und Geburtshilfe
- Contact Person Name
- Karl Tamussino
- Contact Person Email
- karl.tamussino@medunigraz.at
Poland
- Earliest CTIS Part Ii Submission Date
- 06-02-2024
- Latest Decision Or Authorization Date
- 09-12-2025
- Processing Time Days
- 672
- Number Of Sites
- 7
- Number Of Participants
- 75
Sites
- Site Name
- Pratia S.A. (Cracow)
- Department Name
- Not Applicable
- Contact Person Name
- Bozena Cybulska-Stopa
- Contact Person Email
- bcybulska-stopa@pratia.pl
- Site Name
- Niepubliczny Zaklad Opieki Zdrowotnej Medem Wilk Sp. j.
- Department Name
- Not Applicable
- Contact Person Name
- Krzysztof Wilk
- Contact Person Email
- krzysztof.wilk@onet.pl
- Site Name
- Clinical Medical Research Sp. z o.o.
- Department Name
- Not Applicable
- Contact Person Name
- Dagmara Makowska-Mainka
- Contact Person Email
- dagmara.m.mainka@clinicalmedicalresearch.pl
- Site Name
- Prywatny Gabinet Lekarski Ginekologia, Poloznictwo i Ultrasonografia prof. dr med. Jacek Suzin
- Department Name
- Not Applicable
- Contact Person Name
- Jacek Suzin
- Contact Person Email
- grabskakobylecka@gmail.com
- Site Name
- Specjalistyczna Poradnia Ginekologiczna Janusz Tomaszewski sp.k.
- Department Name
- Not Applicable
- Contact Person Name
- Janusz Tomaszewski
- Contact Person Email
- klinika.jtomaszewski@wp.pl
- Site Name
- Pratia S.A. (Poznan)
- Department Name
- Not Applicable
- Contact Person Name
- Krzysztof Szymanowski
- Contact Person Email
- kszymanowski@pratia.pl
- Site Name
- Clinical Medical Research / additional listed site
- Department Name
- Not Applicable
Romania
- Earliest CTIS Part Ii Submission Date
- 06-02-2024
- Latest Decision Or Authorization Date
- 15-12-2025
- Processing Time Days
- 678
- Number Of Sites
- 2
- Number Of Participants
- 17
Sites
- Site Name
- Oncolab S.R.L.
- Department Name
- Oncology
- Contact Person Name
- Dan Stelian Stefan Lungulescu
- Contact Person Email
- dan.lungulescu@yahoo.com
- Site Name
- Ovidius Clinical Hospital S.R.L.
- Department Name
- Oncology
- Contact Person Name
- Laura Mazilu
- Contact Person Email
- office@ovidius-ch.ro
Spain
- Earliest CTIS Part Ii Submission Date
- 06-02-2024
- Latest Decision Or Authorization Date
- 20-01-2026
- Processing Time Days
- 714
- Number Of Sites
- 7
- Number Of Participants
- 37
Sites
- Site Name
- Sanitas Sociedad Anonima De Hospitales
- Department Name
- Oncology
- Contact Person Name
- Oscar Torres Lantada
- Contact Person Email
- otorres@sanitas.es
- Site Name
- Hospital General Universitario Gregorio Maranon
- Department Name
- Oncology
- Contact Person Name
- Yolanda Jerez Gilarranz
- Contact Person Email
- yolanda.jerez@salud.madrid.org
- Site Name
- Hospital Universitario Virgen De Las Nieves
- Department Name
- Oncology
- Contact Person Name
- Encarna Gonzalez Flores
- Contact Person Email
- encarnacion.gonzalez.flores.sspa@juntadeandalucia.es
- Site Name
- Complexo Hospitalario Universitario De Santiago
- Department Name
- Oncology
- Contact Person Name
- Patricia Palacios Ozores
- Contact Person Email
- patricia.palacios.ozores@sergas.es
- Site Name
- University Hospital Virgen Del Rocio S.L.
- Department Name
- Oncology
- Contact Person Name
- Javier Salvador Bofill
- Contact Person Email
- franciscoj.salvador.sspa@juntadeandalucia.es
- Site Name
- Hospital Del Mar
- Department Name
- Ginecology and Obstetrics
- Contact Person Name
- Mireia Gonzalez Comadran
- Contact Person Email
- mgonzalezcomadran@psmar.cat
- Site Name
- University Hospital Virgen Del Rocio S.L. (additional listing)
Portugal
- Earliest CTIS Part Ii Submission Date
- 06-02-2024
- Latest Decision Or Authorization Date
- 09-03-2026
- Processing Time Days
- 763
- Number Of Sites
- 8
- Number Of Participants
- 31
Sites
- Site Name
- Centro Hospitalar E Universitario De Coimbra E.P.E.
- Department Name
- Ginecology
- Contact Person Name
- Fernanda Águas
- Contact Person Email
- faguas@netcabo.pt
- Site Name
- Champalimaud Clinical Centre
- Department Name
- Oncology
- Contact Person Name
- Leonor Matos
- Contact Person Email
- leonor.matos@fundacaochampalimaud.pt
- Site Name
- Hospital Da Luz S.A.
- Department Name
- Oncology
- Contact Person Name
- João Godinho
- Contact Person Email
- joao.godinho@hbeatrizangelo.pt
- Site Name
- CCAB Centro Clinico Academico Braga Associacao
- Department Name
- Senology
- Contact Person Name
- Rafaela Pires
- Contact Person Email
- rafaela.pires@hb.min-saude.pt
- Site Name
- Centro Hospitalar De Lisboa Ocidental E.P.E.
- Department Name
- Oncology
- Contact Person Name
- Ana Martins
- Contact Person Email
- ammourao@chlo.min-saude.pt
- Site Name
- Hospital CUF Porto S.A.
- Department Name
- Oncology
- Contact Person Name
- Yuliya Shvets
- Contact Person Email
- yuliya.shvets@cuf.pt
- Site Name
- Hospital Beatriz Angelo
- Department Name
- Ginecology
- Contact Person Name
- Sara Valadares
- Contact Person Email
- sara.valadares.onofre@hbeatrizangelo.pt
- Site Name
- Centro Hospitalar E Universitario De Coimbra E.P.E. (additional listing)
Belgium
- Earliest CTIS Part Ii Submission Date
- 06-02-2024
- Latest Decision Or Authorization Date
- 16-03-2026
- Processing Time Days
- 769
- Number Of Sites
- 7
- Number Of Participants
- 41
Sites
- Site Name
- Ziekenhuis Oost Limburg
- Department Name
- gynecology and obstetrics
- Contact Person Name
- Eric De Jonge
- Contact Person Email
- eric.dejonge@zol.be
- Site Name
- CHU Saint Pierre
- Department Name
- Gynécologie-Obstétrique
- Contact Person Name
- Serge Rozenberg
- Contact Person Email
- serge.rozenberg@stpierre-bru.be
- Site Name
- Universitair Ziekenhuis Gent
- Department Name
- Vrouwenkliniek
- Contact Person Name
- Herman Depypere
- Contact Person Email
- Herman.Depypere@UGent.be
- Site Name
- UZ Leuven
- Department Name
- Gynaecologie - Verloskunde
- Contact Person Name
- Patrick Neven
- Contact Person Email
- Patrick.neven@uzleuven.be
- Site Name
- Femicare
- Department Name
- Not Applicable
- Contact Person Name
- Veerle Van Gerven
- Contact Person Email
- veerle.van.gerven@femicare.net
- Site Name
- GasthuisZusters Antwerpen
- Department Name
- Medische oncologie
- Contact Person Name
- An Vandebroek
- Contact Person Email
- An.vandebroek@zas.be
- Site Name
- Hopital Erasme
- Department Name
- Gynécologie-Obstétrique
- Contact Person Name
- Philippe Simon
- Contact Person Email
- Philippe.Simon@erasme.ulb.ac.be
Ireland
- Earliest CTIS Part Ii Submission Date
- 06-02-2024
- Latest Decision Or Authorization Date
- 09-03-2026
- Processing Time Days
- 763
- Number Of Sites
- 5
- Number Of Participants
- 18
Sites
- Site Name
- University Hospital Galway
- Department Name
- Advanced Therapies and Cancer
- Contact Person Name
- Maccon Keane
- Contact Person Email
- maccon.keane@hse.ie
- Site Name
- St James's Hospital
- Department Name
- Cancer Clinical Trials Unit
- Contact Person Name
- Ciara O'Hanlon Brown
- Contact Person Email
- cancerclinicaltrials@stjames.ie
- Site Name
- St Vincent's University Hospital
- Department Name
- Medical Oncology Research Department
- Contact Person Name
- Michaela Higgins
- Contact Person Email
- patientsupport@svhg.ie
- Site Name
- Mater Misericordiae University Hospital
- Department Name
- Catherine McAuley Research Centre
- Contact Person Name
- Donal Brennan
- Contact Person Email
- mater.medicine@ucd.ie
- Site Name
- University Hospital Waterford
- Department Name
- Old School of Nursing
- Contact Person Name
- Rizwan Sheikh
- Contact Person Email
- Rizwan.Sheikh@hse.ie
Finland
- Earliest CTIS Part Ii Submission Date
- 06-02-2024
- Latest Decision Or Authorization Date
- 23-03-2026
- Processing Time Days
- 776
- Number Of Sites
- 5
- Number Of Participants
- 23
Sites
- Site Name
- Tampere University Hospital
- Department Name
- Syopatautien poliklinikka
- Contact Person Name
- Krista Kankaanranta
- Contact Person Email
- krista.kankaanranta@pirha.fi
- Site Name
- Vaasa Central Hospital
- Department Name
- Onkologian poliklinikka
- Contact Person Name
- Antti Jekunen
- Contact Person Email
- antti.jekunen@ovph.fi
- Site Name
- Laeaekaerikeskus Gyneko Oy
- Contact Person Name
- Anne Talvensaari-Mattila
- Contact Person Email
- anne.talvensaari-mattila@gyneko.fi
- Site Name
- Mehilaeinen Oy (Kuopio)
- Contact Person Name
- Marjo Tuppurainen
- Contact Person Email
- marjo.tuppurainen@mehilainen.fi
- Site Name
- Mehilaeinen Oy (Helsinki)
- Contact Person Name
- Johanna Maenpaa
- Contact Person Email
- johanna.maenpaa@docrates.com
Germany
- Earliest CTIS Part Ii Submission Date
- 06-02-2024
- Latest Decision Or Authorization Date
- 07-05-2026
- Processing Time Days
- 821
- Number Of Sites
- 9
- Number Of Participants
- 56
Sites
- Site Name
- Frauenärzte Am Schloss Borbeck
- Contact Person Name
- Steffen Tauber
- Contact Person Email
- praxis@fas-borbeck.de
- Site Name
- Dr. med. Stefan Fiedler
- Contact Person Name
- Stefan Fiedler
- Contact Person Email
- praxis.fiedler.gyn@web.de
- Site Name
- Praxis für Frauenheilkunde und Geburtshilfe
- Contact Person Name
- Inka Kiesche
- Contact Person Email
- kontakt@dr-kiesche.de
- Site Name
- Gynaekologisches Zentrum Bonn
- Contact Person Name
- Christian Kurbacher
- Contact Person Email
- Studienzentrale@praxis-kurbacher.de
- Site Name
- Praxis für Gynäkologie und Geburtshilfe
- Contact Person Name
- Andrea Heweker
- Contact Person Email
- frauenarzt@praxis-heweker.de
- Site Name
- Evangelisches Krankenhaus Bergisch Gladbach gGmbH
- Department Name
- Klinik für Gynäkologie
- Contact Person Name
- Christian Rudlowski
- Contact Person Email
- frauenklinik@evk.de
- Site Name
- Klinische Forschung Hannover-Mitte GmbH
- Contact Person Name
- Jürgen Anders
- Contact Person Email
- matilde.planer@pratia.com
- Site Name
- MedPlus
- Contact Person Name
- Adrian Flohr
- Contact Person Email
- study@medplus-krefeld.de
- Site Name
- Frauenarztpraxis Aurora
- Contact Person Name
- Martin Sillem
- Contact Person Email
- prof.sillem@aurora.med
Sponsor
Primary sponsor
- Full Name
- Bayer Consumer Care AG
- Organisation Type
- Pharmaceutical company
- Country Of Registered Address
- Switzerland
Contract research organisations
- Name
- Suvoda LLC
- Responsibilities
- [{"code":"3"}]
- Name
- Syneos Health Clinique Inc.
- Responsibilities
- [{"code":"4"}]
- Name
- Eresearchtechnology Inc.
- Responsibilities
- [{"code":"7"}]
- Name
- DATAN Analytics GmbH
- Responsibilities
- [{"code":"10"}]
Third parties
- {"country":"United States","full_name":"Suvoda LLC","duties_or_roles":"[{\"code\":\"3\"}]","organisation_type":"Non-Pharmaceutical company"}
- {"country":"Germany","full_name":"DATAN Analytics GmbH","duties_or_roles":"[{\"code\":\"10\"}]","organisation_type":"Non-Pharmaceutical company"}
- {"country":"Germany","full_name":"LKF Laboratorium fuer Klinische Forschung GmbH","duties_or_roles":"[{\"code\":\"4\"}]","organisation_type":"Laboratory/Research/Testing facility"}
- {"country":"Switzerland","full_name":"Swiss BioQuant AG","duties_or_roles":"[{\"code\":\"4\"}]","organisation_type":"Laboratory/Research/Testing facility"}
- {"country":"United States","full_name":"Eresearchtechnology Inc.","duties_or_roles":"[{\"code\":\"7\"}]","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Labcorp Early Development Laboratories Inc.","duties_or_roles":"[{\"code\":\"15\",\"value\":\"Long term storage\"},{\"code\":\"4\"}]","organisation_type":"Pharmaceutical company"}
- {"country":"Canada","full_name":"Syneos Health Clinique Inc.","duties_or_roles":"[{\"code\":\"4\"}]","organisation_type":"Hospital/Clinic/Other health care facility"}
- {"country":"Germany","full_name":"IMGM Laboratories GmbH","duties_or_roles":"[{\"code\":\"4\"}]","organisation_type":"Laboratory/Research/Testing facility"}
Co-sponsors
- Bayer AG
Investigational products
- Investigational Product Name
- BAY 3427080
- Active Substance
- ELINZANETANT
- Modality
- Small molecule
- Routes Of Administration
- ORAL
- Route
- oral
- Authorisation Status
- 1
- Starting Dose
- 120 mg
- Dose Levels
- 120 mg
- Frequency
- once daily
- Maximum Dose
- 120 mg
- Investigational Product Name
- BAY 3427080 60 mg capsules placebo
- Modality
- Other
- Dose Levels
- placebo
- Frequency
- once daily (placebo for first 12 weeks then active per protocol)
Related trials
Other published trials that may interest you.