Clinical trial • Phase III • Oncology
Durvalumab for Non-small cell lung cancer (advanced/metastatic) | Non-small cell lung cancer (locally advanced, unresectable; Stage III) | Small-cell lung cancer (extensive disease, Stage IV) | Urothelial carcinoma of the urinary tract (post-chemotherapy)
Phase III trial of Durvalumab for Non-small cell lung cancer (advanced/metastatic) | Non-small cell lung cancer (locally advanced, unresectable; Stage III…
Overview
- Trial Therapeutic Area
- Oncology
- Trial Disease
- Non-small cell lung cancer (advanced/metastatic) | Non-small cell lung cancer (locally advanced, unresectable; Stage III) | Small-cell lung cancer (extensive disease, Stage IV) | Urothelial carcinoma of the urinary tract (post-chemotherapy)
- Trial Stage
- Phase III
- Drug Modality
- Monoclonal antibody | Small molecule | Monoclonal antibody
Key dates
- Initial CTIS Submission Date
- 25-01-2024
- First CTIS Authorization Date
- 10-04-2024
Trial design
open-label, none/not specified-controlled Phase III trial in Poland, Czechia, Germany and others.
- Open Label
- Yes
- Comparator
- None/Not specified
- Target Sample Size
- 142
- Trial Duration For Participant
- 728
Eligibility
Recruits 142 Vulnerable population selected. Informed consent must be provided: "Provision of signed and dated, written ICF". Country-specific subject information and informed consent forms are available in multiple languages (country ICF documents listed)..
- Pregnancy Exclusion
- Additional exclusion criteria for the ROSY-D sub-study: Male or female patients of reproductive potential who are not willing to employ effective birth control from study inclusion up to 90 days after the last dose of durvalumab monotherapy.
- Vulnerable Population
- Vulnerable population selected. Informed consent must be provided: "Provision of signed and dated, written ICF". Country-specific subject information and informed consent forms are available in multiple languages (country ICF documents listed).
Inclusion criteria
- {"criterion_text":"- Provision of signed and dated, written ICF"}
- {"criterion_text":"- Patient is currently deriving clinical benefit, as judged by the Investigator, from continued treatment in an AZ parent study using an AZ compound that has met its endpoints, or has otherwise stopped, or the patient has reached maximum treatment duration allowed in the parent study's protocol"}
- {"criterion_text":"- Patient can receive durvalumab as a fixed dose of 1500 mg Q4W at study entry."}
Exclusion criteria
- {"criterion_text":"- Core Protocol exclusion criteria: Ongoing, unresolved, Grade 3 or above toxicity requiring interruption of treatment at the time of the termination of the parent study"}
- {"criterion_text":"- Core Protocol exclusion criteria: Currently receiving treatment with any prohibited medication(s)."}
- {"criterion_text":"- Core Protocol exclusion criteria: Concurrently enrolled in any other type of medical research judged not to be scientifically or medically compatible with this study."}
- {"criterion_text":"- Core Protocol exclusion criteria: Permanent discontinuation from the parent study due to toxicity or disease progression (increase in the severity of the disease under study and/or increases in the symptoms of a patient’s condition attributable to the disease, as assessed and documented by the Investigator. Physician-defined progression can be radiological [eg, Response Evaluation Criteria in Solid Tumours] progression or clinical progression)."}
- {"criterion_text":"- Core Protocol exclusion criteria: Local access to commercially-available drug at no cost to the patient as permitted by local/country regulation."}
- {"criterion_text":"- Additional exclusion criteria for the ROSY-D sub-study: Active infection including COVID-19 (PCR confirmed and/or clinically suspected), tuberculosis, hepatitis B (known positive HBsAg result), hepatitis C, or HIV (positive HIV 1/2 antibodies)."}
- {"criterion_text":"- Additional exclusion criteria for the ROSY-D sub-study: Male or female patients of reproductive potential who are not willing to employ effective birth control from study inclusion up to 90 days after the last dose of durvalumab monotherapy."}
- {"criterion_text":"- Additional exclusion criteria for the ROSY-D sub-study: Ongoing, unresolved, Grade 2 toxicity with an inability to reduce corticosteroid to a dose of ≤ 10 mg of prednisone per day (or equivalent) within 12 weeks after last dose of study treatment/study regimen, as per Toxicity Dose Modification and TMGs for Immune-mediated, Infusion-related, and Non-Immune-mediated Reactions Guidelines of the parent study."}
Endpoints
Primary endpoints
- {"endpoint_text":"- SAEs reported until 90 days after the last dose of study treatment.","definition_or_measurement_approach":"Serious adverse events (SAEs) reported and collected up to 90 days after the participant's last dose of study treatment."}
Recruitment
- Planned Sample Size
- 142
- Recruitment Window Months
- 48
- Consent Approach
- Signed and dated written informed consent required from participants ('Provision of signed and dated, written ICF'). Country-specific ICFs and participant information documents are provided in multiple languages; contact for study information: Clinical Study Information Center (information.centre@astrazeneca.com).
Geography
- Total Number Of Sites
- 56
- Total Number Of Participants
- 87
Poland
- Earliest CTIS Part Ii Submission Date
- 15-02-2024
- Latest Decision Or Authorization Date
- 22-04-2025
- Processing Time Days
- 432
- Number Of Sites
- 9
- Number Of Participants
- 15
Sites
- Site Name
- Zachodniopomorskie Centrum Onkologii
- Department Name
- 5705: Osrodek Badan Klinicznych
- Principal Investigator Name
- Katarzyna Hetman
- Principal Investigator Email
- Kk197@wp.pl
- Contact Person Name
- Katarzyna Hetman
- Contact Person Email
- Kk197@wp.pl
- Site Name
- Wojewodzkie Wielospecjalistyczne Centrum Onkologii I Traumatologii Im M.Kopernika W Lodzi
- Department Name
- 5701: Zaklad Teleradioterapii
- Principal Investigator Name
- Jacek Fijuth
- Principal Investigator Email
- jacek.f@poczta.onet.pl
- Contact Person Name
- Jacek Fijuth
- Contact Person Email
- jacek.f@poczta.onet.pl
- Site Name
- Bialostockie Centrum Onkologii Im. Marii Sklodowskiej-Curie W Bialymstoku
- Department Name
- 5702: Oddzial Onkologii Klinicznej im. dr E. Pileckiej z Pododdzialem Chemioterapii Dziennej
- Principal Investigator Name
- Krystyna Ostrowska-Cichocka
- Principal Investigator Email
- krysiaost@poczta.onet.pl
- Contact Person Name
- Krystyna Ostrowska-Cichocka
- Contact Person Email
- krysiaost@poczta.onet.pl
- Site Name
- Instytut Msf Sp. z o.o.
- Department Name
- 5703: Oncology
- Principal Investigator Name
- Ewa Kalinka
- Principal Investigator Email
- ewakalinka@wp.pl
- Contact Person Name
- Ewa Kalinka
- Contact Person Email
- ewakalinka@wp.pl
- Site Name
- Nu Med Grupa S.A.
- Department Name
- 5706: Centrum Radioterapii i Onkologii
- Principal Investigator Name
- Barbara Szostakiewicz
- Principal Investigator Email
- barbara.szostakiewicz@nu-med.pl
- Contact Person Name
- Barbara Szostakiewicz
- Contact Person Email
- barbara.szostakiewicz@nu-med.pl
- Site Name
- Narodowy Instytut Onkologii Im. Marii Sklodowskiej-Curie Panstwowy Instytut Badawczy
- Department Name
- 5708: Klinika Nowotworow Pluca i Klatki Piersiowej
- Principal Investigator Name
- Dariusz kowalski
- Principal Investigator Email
- dariusz.kowalski@pib-nio.pl
- Contact Person Name
- Dariusz kowalski
- Contact Person Email
- dariusz.kowalski@pib-nio.pl
- Site Name
- Centrum Onkologii Im. Prof. Franciszka Lukaszczyka W Bydgoszczy
- Department Name
- 5707: Ambulatorium Chemioterapii
- Principal Investigator Name
- Bogdan Zurawski
- Principal Investigator Email
- zurawskib@co.bydgoszcz.pl
- Contact Person Name
- Bogdan Zurawski
- Contact Person Email
- zurawskib@co.bydgoszcz.pl
- Site Name
- Warminsko-Mazurskie Centrum Chorob Pluc W Olsztynie
- Department Name
- 5704: Oddzial Onkologii z Pododdzialem Chemioterapii
- Principal Investigator Name
- Andrzej Kazarnowicz
- Principal Investigator Email
- andrzej_kazarnowicz@wp.pl
- Contact Person Name
- Andrzej Kazarnowicz
- Contact Person Email
- andrzej_kazarnowicz@wp.pl
- Site Name
- Wojewodzki Szpital Zespolony W Elblagu SPZOZ
- Department Name
- 5706: Oddzial Onkologiczny z Poddodzialem Chemioterapii, Apteka
- Principal Investigator Name
- Barbara Szostakiewicz
- Principal Investigator Email
- barbara.szostakiewicz@nu-med.pl
- Contact Person Name
- Barbara Szostakiewicz
- Contact Person Email
- barbara.szostakiewicz@nu-med.pl
Czechia
- Earliest CTIS Part Ii Submission Date
- 17-04-2024
- Latest Decision Or Authorization Date
- 17-04-2025
- Processing Time Days
- 427
- Number Of Sites
- 1
- Number Of Participants
- 1
Sites
- Site Name
- University Hospital Olomouc
- Department Name
- 1901: Onkologicka klinika
- Principal Investigator Name
- Bohuslav Melichar
- Principal Investigator Email
- bohuslav.melichar@fnol.cz
- Contact Person Name
- Bohuslav Melichar
- Contact Person Email
- bohuslav.melichar@fnol.cz
Germany
- Earliest CTIS Part Ii Submission Date
- 17-04-2024
- Latest Decision Or Authorization Date
- 23-04-2025
- Processing Time Days
- 433
- Number Of Sites
- 3
- Number Of Participants
- 4
Sites
- Site Name
- Universitaet Muenster
- Department Name
- 2601: Klinik fuer Urologie und Kinderurologie
- Principal Investigator Name
- Martin Boegemann
- Principal Investigator Email
- martin.boegemann@ukmuenster.de
- Contact Person Name
- Martin Boegemann
- Contact Person Email
- martin.boegemann@ukmuenster.de
- Site Name
- Onkodok GmbH
- Department Name
- 2602
- Principal Investigator Name
- Philipp Schütt
- Principal Investigator Email
- philipp.schuett@uni-due.de
- Contact Person Name
- Philipp Schütt
- Contact Person Email
- philipp.schuett@uni-due.de
- Site Name
- Pius-Hospital Oldenburg
- Department Name
- 2603: Oncology
- Principal Investigator Name
- Frank Griesinger
- Principal Investigator Email
- frank.griesinger@pius-hospital.de
- Contact Person Name
- Frank Griesinger
- Contact Person Email
- frank.griesinger@pius-hospital.de
Greece
- Earliest CTIS Part Ii Submission Date
- 20-03-2025
- Latest Decision Or Authorization Date
- 22-04-2025
- Processing Time Days
- 155
- Number Of Sites
- 1
- Number Of Participants
- 1
Sites
- Site Name
- General Oncological Hospital Of Kifissia Agioi Anargyroi
- Department Name
- 3001: Department of Medical Oncology
- Principal Investigator Name
- Eleni Res
- Principal Investigator Email
- nellieres@yahoo.gr
- Contact Person Name
- Eleni Res
- Contact Person Email
- nellieres@yahoo.gr
Romania
- Earliest CTIS Part Ii Submission Date
- 17-04-2024
- Latest Decision Or Authorization Date
- 22-04-2025
- Processing Time Days
- 432
- Number Of Sites
- 1
- Number Of Participants
- 1
Sites
- Site Name
- Sigmedical Services S.R.L.
- Department Name
- 6101: Oncology
- Principal Investigator Name
- Doina Ganea
- Principal Investigator Email
- motan_doina@yahoo.com
- Contact Person Name
- Doina Ganea
- Contact Person Email
- motan_doina@yahoo.com
Spain
- Earliest CTIS Part Ii Submission Date
- 17-04-2024
- Latest Decision Or Authorization Date
- 21-04-2025
- Processing Time Days
- 431
- Number Of Sites
- 8
- Number Of Participants
- 12
Sites
- Site Name
- Hospital Universitari De Girona Doctor Josep Trueta
- Department Name
- 7005: Oncología Médica
- Principal Investigator Name
- Joaquim Bosch Barrera
- Principal Investigator Email
- jbosch@iconcologia.net
- Contact Person Name
- Joaquim Bosch Barrera
- Contact Person Email
- jbosch@iconcologia.net
- Site Name
- Hospital Universitario Y Politecnico La Fe
- Department Name
- 7002: Oncología
- Principal Investigator Name
- Oscar Juan Vidal
- Principal Investigator Email
- juan_osc@gva.es
- Contact Person Name
- Oscar Juan Vidal
- Contact Person Email
- juan_osc@gva.es
- Site Name
- Fundacion Instituto De Investigacion Sanitaria De Santiago De Compostela
- Department Name
- 7008: Departamento de Oncologia
- Principal Investigator Name
- Urbano Anido Herránz
- Principal Investigator Email
- urbano.anido.herranz@sergas.es
- Contact Person Name
- Urbano Anido Herránz
- Contact Person Email
- urbano.anido.herranz@sergas.es
- Site Name
- Hospital Costa Del Sol
- Department Name
- 7001: Oncología Médica
- Principal Investigator Name
- Victor Navarro Perez
- Principal Investigator Email
- vnavarroonco@gmail.com
- Contact Person Name
- Victor Navarro Perez
- Contact Person Email
- vnavarroonco@gmail.com
- Site Name
- Hospital Universitari Vall D Hebron
- Department Name
- 7004: Oncología Médica
- Principal Investigator Name
- Enriqueta Felip Font
- Principal Investigator Email
- efelip@vhio.net
- Contact Person Name
- Enriqueta Felip Font
- Contact Person Email
- efelip@vhio.net
- Site Name
- Hospital Universitario La Paz
- Department Name
- 7003: Oncología Médica
- Principal Investigator Name
- Javier de Castro Carpeño
- Principal Investigator Email
- javier.decastro@salud.madrid.org
- Contact Person Name
- Javier de Castro Carpeño
- Contact Person Email
- javier.decastro@salud.madrid.org
- Site Name
- Hospital De La Santa Creu I Sant Pau
- Department Name
- 7006: Oncología Médica
- Principal Investigator Name
- Andrés Barba Joaquín
- Principal Investigator Email
- abarba@santpau.cat
- Contact Person Name
- Andrés Barba Joaquín
- Contact Person Email
- abarba@santpau.cat
- Site Name
- Hospital Universitari De Girona Doctor Josep Trueta (additional listed site)
- Department Name
- 7005: Oncología Médica
Hungary
- Earliest CTIS Part Ii Submission Date
- 17-04-2024
- Latest Decision Or Authorization Date
- 22-04-2025
- Processing Time Days
- 432
- Number Of Sites
- 4
- Number Of Participants
- 3
Sites
- Site Name
- Fejer Varmegyei Szent Gyoergy Egyetemi Oktato Korhaz
- Department Name
- 3301: Pulmonológiai Osztál
- Principal Investigator Name
- Zsolt PÁPAI-SZÉKELY
- Principal Investigator Email
- zsoltpapai@yahoo.com
- Contact Person Name
- Zsolt PÁPAI-SZÉKELY
- Contact Person Email
- zsoltpapai@yahoo.com
- Site Name
- Clinic Of Pulmonology Semmelweis University
- Department Name
- 3302: Pulmonológiai Klinika
- Principal Investigator Name
- György LOSONCZY
- Principal Investigator Email
- losonczy.gyorgy@med.semmelweis-univ.hu
- Contact Person Name
- György LOSONCZY
- Contact Person Email
- losonczy.gyorgy@med.semmelweis-univ.hu
- Site Name
- Orszagos Koranyi Pulmonologiai Intezet
- Department Name
- 3303: IV.Tüdőgyógyászati osztály
- Principal Investigator Name
- Krisztina BOGOS
- Principal Investigator Email
- bogos@koranyi.hu
- Contact Person Name
- Krisztina BOGOS
- Contact Person Email
- bogos@koranyi.hu
- Site Name
- Gyor-Moson-Sopron Varmegyei Petz Aladar Egyetemi Oktato Korhaz
- Department Name
- 3304: Pulmonológiai osztály
- Principal Investigator Name
- Zsuzsanna SZALAI
- Principal Investigator Email
- clinstudy@gmail.com
- Contact Person Name
- Zsuzsanna SZALAI
- Contact Person Email
- clinstudy@gmail.com
Belgium
- Earliest CTIS Part Ii Submission Date
- 31-10-2024
- Latest Decision Or Authorization Date
- 17-04-2025
- Processing Time Days
- 168
- Number Of Sites
- 1
- Number Of Participants
- 1
Sites
- Site Name
- Grand Hopital De Charleroi
- Department Name
- 503: Oncology
- Principal Investigator Name
- Benoit Colinet
- Principal Investigator Email
- benoit.colinet2@ghdc.be
- Contact Person Name
- Benoit Colinet
- Contact Person Email
- benoit.colinet2@ghdc.be
Bulgaria
- Earliest CTIS Part Ii Submission Date
- 19-04-2024
- Latest Decision Or Authorization Date
- 28-04-2025
- Processing Time Days
- 438
- Number Of Sites
- 2
- Number Of Participants
- 2
Sites
- Site Name
- MBAL Serdika Ltd.
- Department Name
- 0902: Second Department of Medical Oncology
- Principal Investigator Name
- Krassimir Koynov
- Principal Investigator Email
- Kdkoynov@Yahoo.Co.Uk
- Contact Person Name
- Krassimir Koynov
- Contact Person Email
- Kdkoynov@Yahoo.Co.Uk
- Site Name
- University Multiprofile Hospital For Active Treatment St. Ivan Rilski EAD
- Department Name
- 0901: Medical Oncology Department
- Principal Investigator Name
- Bozhil Robev
- Principal Investigator Email
- bostro@abv.bg
- Contact Person Name
- Bozhil Robev
- Contact Person Email
- bostro@abv.bg
Italy
- Earliest CTIS Part Ii Submission Date
- 19-04-2024
- Latest Decision Or Authorization Date
- 09-09-2025
- Processing Time Days
- 572
- Number Of Sites
- 12
- Number Of Participants
- 24
Sites
- Site Name
- Azienda Ospedaliera Per L'Emergenza Cannizzaro
- Department Name
- 4104: UOS Oncologia Medica
- Principal Investigator Name
- Giuseppa Scandurra
- Principal Investigator Email
- giusy.scandurra@gmail.com
- Contact Person Name
- Giuseppa Scandurra
- Contact Person Email
- giusy.scandurra@gmail.com
- Site Name
- San Camillo Forlanini Hospital
- Department Name
- 4101: Oncologia Medica
- Principal Investigator Name
- Antonietta D’Alessio
- Principal Investigator Email
- adalessio@scamilloforlanini.rm.it
- Contact Person Name
- Antonietta D’Alessio
- Contact Person Email
- adalessio@scamilloforlanini.rm.it
- Site Name
- Fondazione IRCCS Istituto Nazionale Dei Tumori
- Department Name
- 4117: Struttura Complessa Oncologia Medica 1
- Principal Investigator Name
- Filippo De Braud
- Principal Investigator Email
- debraud_studiclinici@istitutotumori.mi.it
- Contact Person Name
- Filippo De Braud
- Contact Person Email
- debraud_studiclinici@istitutotumori.mi.it
- Site Name
- Azienda Ospedaliero Universitaria Pisana
- Department Name
- 4108: UOC di Oncologia
- Principal Investigator Name
- Gianluca Masi
- Principal Investigator Email
- gianluca.masi@unipi.it
- Contact Person Name
- Gianluca Masi
- Contact Person Email
- gianluca.masi@unipi.it
- Site Name
- Istituto Romagnolo Per Lo Studio Dei Tumori Dino Amadori IRST S.r.l.
- Department Name
- 4106: U.O. Oncologia Medica
- Principal Investigator Name
- Giuseppe Schepisi
- Principal Investigator Email
- giuseppe.schepisi@irst.emr.it
- Contact Person Name
- Giuseppe Schepisi
- Contact Person Email
- giuseppe.schepisi@irst.emr.it
- Site Name
- Azienda USL Toscana Sud Est
- Department Name
- 4103: U.O.C. Oncologia Medica
- Principal Investigator Name
- Alketa Hamzaj
- Principal Investigator Email
- alketa.hamzaj@uslsudest.toscana.it
- Contact Person Name
- Alketa Hamzaj
- Contact Person Email
- alketa.hamzaj@uslsudest.toscana.it
- Site Name
- European Institute Of Oncology S.r.l.
- Department Name
- 4105: Oncologia Medica Urogenitale e Cervico Facciale
- Principal Investigator Name
- Franco Nolè
- Principal Investigator Email
- franco.nole@ieo.it
- Contact Person Name
- Franco Nolè
- Contact Person Email
- franco.nole@ieo.it
- Site Name
- Istituto Tumori Bari Giovanni Paolo II
- Department Name
- 4115: SSD Oncologia Medica per la Patologia Toracica
- Principal Investigator Name
- Domenico Galetta
- Principal Investigator Email
- galetta@oncologico.bari.it
- Contact Person Name
- Domenico Galetta
- Contact Person Email
- galetta@oncologico.bari.it
- Site Name
- Fondazione Policlinico Universitario Campus Bio-Medico
- Department Name
- 4109: Oncologia Medica
- Principal Investigator Name
- Giuseppe Tonini
- Principal Investigator Email
- g.tonini@policlinicocampus.it
- Contact Person Name
- Giuseppe Tonini
- Contact Person Email
- g.tonini@policlinicocampus.it
- Site Name
- Azienda Ospedaliero Universitaria Di Modena
- Department Name
- 4113: SC Radioterapia
- Principal Investigator Name
- Alessio Bruni
- Principal Investigator Email
- bruni.alessio@aou.mo.it
- Contact Person Name
- Alessio Bruni
- Contact Person Email
- bruni.alessio@aou.mo.it
- Site Name
- Istituto Oncologico Veneto
- Department Name
- 4102: UOC Oncologia Medica 1
- Principal Investigator Name
- Marco Maruzzo
- Principal Investigator Email
- marco.maruzzo@iov.veneto.it
- Contact Person Name
- Marco Maruzzo
- Contact Person Email
- marco.maruzzo@iov.veneto.it
- Site Name
- Azienda Ospedaliera Per L'Emergenza Cannizzaro (additional listed site)
France
- Earliest CTIS Part Ii Submission Date
- 19-04-2024
- Latest Decision Or Authorization Date
- 29-09-2025
- Processing Time Days
- 592
- Number Of Sites
- 14
- Number Of Participants
- 23
Sites
- Site Name
- CHU De Rouen
- Department Name
- 2301: Urology
- Principal Investigator Name
- Christian Pfister
- Principal Investigator Email
- christian.pfister@chu-rouen.fr
- Contact Person Name
- Christian Pfister
- Contact Person Email
- christian.pfister@chu-rouen.fr
- Site Name
- Centre Hospitalier Regional Universitaire De Tours
- Department Name
- 2312: Oncologie Medicale
- Principal Investigator Name
- Bérengère Narciso
- Principal Investigator Email
- berengere.narciso@univ-tours.fr
- Contact Person Name
- Bérengère Narciso
- Contact Person Email
- berengere.narciso@univ-tours.fr
- Site Name
- Besancon University Hospital Center
- Department Name
- 2314: Service d'Oncologie Médicale
- Principal Investigator Name
- Tristan MAURINA
- Principal Investigator Email
- t1maurina@chu-besancon.fr
- Contact Person Name
- Tristan MAURINA
- Contact Person Email
- t1maurina@chu-besancon.fr
- Site Name
- Institut Bergonie
- Department Name
- 2311: Oncologie Médicale et Pédiatrique
- Principal Investigator Name
- Guilhem Roubaud
- Principal Investigator Email
- g.roubaud@bordeaux.unicancer.fr
- Contact Person Name
- Guilhem Roubaud
- Contact Person Email
- g.roubaud@bordeaux.unicancer.fr
- Site Name
- Institut Gustave Roussy
- Department Name
- 2309: Medical Oncology (Thoracic Unit)
- Principal Investigator Name
- Yohann Loriot
- Principal Investigator Email
- yohann.loriot@gustaveroussy.fr
- Contact Person Name
- Yohann Loriot
- Contact Person Email
- yohann.loriot@gustaveroussy.fr
- Site Name
- Centre Leon Berard
- Department Name
- 2310: département d'oncologie médica
- Principal Investigator Name
- Aude Fléchon
- Principal Investigator Email
- aude.flechon@lyon.unicancer.fr
- Contact Person Name
- Aude Fléchon
- Contact Person Email
- aude.flechon@lyon.unicancer.fr
- Site Name
- Centre De Lutte Contre Le Cancer Eugene Marquis
- Department Name
- 2321: medical oncology
- Principal Investigator Name
- Thibault De La Motte Rouge
- Principal Investigator Email
- t.delamotterouge@rennes.unicancer.fr
- Contact Person Name
- Thibault De La Motte Rouge
- Contact Person Email
- t.delamotterouge@rennes.unicancer.fr
- Site Name
- Centre Hospitalier Regional De Marseille
- Department Name
- 2307: Medical oncology
- Principal Investigator Name
- Jean Laurent Deville
- Principal Investigator Email
- jean-laurent.deville@ap-hm.fr
- Contact Person Name
- Jean Laurent Deville
- Contact Person Email
- jean-laurent.deville@ap-hm.fr
- Site Name
- Institut Regional Du Cancer De Montpellier
- Department Name
- 2305: Oncologie Médicale
- Principal Investigator Name
- Diego Tosi
- Principal Investigator Email
- diego.tosi@icm.unicancer.fr
- Contact Person Name
- Diego Tosi
- Contact Person Email
- diego.tosi@icm.unicancer.fr
- Site Name
- Institut De Cancerologie De L Ouest
- Department Name
- 2308: Département d'oncologie
- Principal Investigator Name
- Frédéric Rolland
- Principal Investigator Email
- frederic.rolland@ico.unicancer.fr
- Contact Person Name
- Frédéric Rolland
- Contact Person Email
- frederic.rolland@ico.unicancer.fr
- Site Name
- Institut De Cancerologie Strasbourg Europe
- Department Name
- 2306: Oncology
- Principal Investigator Name
- Philippe BARTHELEMY
- Principal Investigator Email
- p.barthelemy@icans.eu
- Contact Person Name
- Philippe BARTHELEMY
- Contact Person Email
- p.barthelemy@icans.eu
- Site Name
- Institut Universitaire Du Cancer Toulouse-Oncopole
- Department Name
- 2320: Service d´Oncologie Médicale
- Principal Investigator Name
- Carlos-Alberto Gomez-Roca
- Principal Investigator Email
- GomezRoca.Carlos@iuct-oncopole.fr
- Contact Person Name
- Carlos-Alberto Gomez-Roca
- Contact Person Email
- GomezRoca.Carlos@iuct-oncopole.fr
- Site Name
- Centr Georges Francois Leclerc
- Department Name
- 2316: Service d'oncologie medicale
- Principal Investigator Name
- Isabelle Desmoulins
- Principal Investigator Email
- idesmoulins@cgfl.fr
- Contact Person Name
- Isabelle Desmoulins
- Contact Person Email
- idesmoulins@cgfl.fr
- Site Name
- Centre Hospitalier Regional Et Universitaire De Brest
- Department Name
- 2303: Oncologie Médicale
- Principal Investigator Name
- Benjamin Auberger
- Principal Investigator Email
- benjamin.auberger@chu-brest.fr
- Contact Person Name
- Benjamin Auberger
- Contact Person Email
- benjamin.auberger@chu-brest.fr
Sponsor
Primary sponsor
- Full Name
- Astrazeneca AB
- Organisation Type
- Pharmaceutical company
- Country Of Registered Address
- Sweden
Contract research organisations
- Name
- Excelya Greece CRO Single Member S.A.
- Responsibilities
- Study start-up; Site contracting
- Name
- Parexel International (IRL) Limited
- Responsibilities
- Multiple sponsor duties including site contracting and other trial operational activities (codes listed: 1,10,11,12,15,5,6)
Third parties
- {"country":"Greece","full_name":"Excelya Greece CRO Single Member S.A.","duties_or_roles":"codes: 1; 15 (Study start-up; Site contracting)","organisation_type":"Pharmaceutical company"}
- {"country":"Ireland","full_name":"Parexel International (IRL) Limited","duties_or_roles":"codes: 1,10,11,12,15 (Site contracting),5,6","organisation_type":"Pharmaceutical company"}
Investigational products
- Investigational Product Name
- IMFINZI 50 mg/mL concentrate for solution for infusion.
- Active Substance
- Durvalumab
- Modality
- Monoclonal antibody
- Routes Of Administration
- Intravenous
- Route
- Intravenous infusion
- Authorisation Status
- Authorised - EU marketing authorisation EU/1/18/1322/001
- Starting Dose
- 1500 mg fixed dose (Q4W); weight-based 20 mg/kg Q4W if weight ≤ 30 kg until >30 kg
- Dose Levels
- 1500 mg fixed dose; alternative weight-based 20 mg/kg for patients ≤ 30 kg
- Frequency
- Every 4 weeks (Q4W)
- Maximum Dose
- 1500 mg
- Investigational Product Name
- MYCOPHENOLATE MOFETIL
- Active Substance
- Mycophenolate mofetil
- Modality
- Small molecule
- Routes Of Administration
- Oral
- Route
- Oral
- Authorisation Status
- Commercially available (sourced locally; specific national marketing authorisation applies)
- Investigational Product Name
- INFLIXIMAB
- Active Substance
- Infliximab
- Modality
- Monoclonal antibody
- Routes Of Administration
- Intravenous
- Route
- Intravenous infusion
- Authorisation Status
- Commercially available (sourced locally; specific national marketing authorisation applies)
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