Clinical trial • Phase I • Oncology
CK-301 for Cutaneous squamous cell carcinoma (unresectable or metastatic)
Phase I trial of CK-301 for Cutaneous squamous cell carcinoma (unresectable or metastatic). open-label, none/not specified-controlled, adaptive.
Overview
- Trial Therapeutic Area
- Oncology
- Trial Disease
- Cutaneous squamous cell carcinoma (unresectable or metastatic)
- Trial Stage
- Phase I
Key dates
- Initial CTIS Submission Date
- 06-09-2024
- First CTIS Authorization Date
- 24-09-2024
Trial design
open-label, none/not specified-controlled, adaptive Phase I trial across 10 sites in Spain, France.
- Open Label
- Yes
- Comparator
- None/Not specified
- Adaptive
- True - dose-escalation design; escalation of CK-301 doses; no specific escalation algorithm, dose levels, or stopping rules provided in source.
- Single Multiple Or Escalation Dose Combined
- Yes
- Target Sample Size
- 357
Eligibility
Recruits 357 Vulnerable population selected; no details on consent or assent handling provided in source..
- Vulnerable Population
- Vulnerable population selected; no details on consent or assent handling provided in source.
Recruitment
- Planned Sample Size
- 357
- Recruitment Window Months
- 88
Geography
- Total Number Of Sites
- 10
- Total Number Of Participants
- 63
Spain
- Earliest CTIS Part Ii Submission Date
- 26-08-2024
- Latest Decision Or Authorization Date
- 24-09-2024
- Processing Time Days
- 29
- Number Of Sites
- 4
- Number Of Participants
- 29
Sites
- Site Name
- Hospital Universitario Virgen De La Macarena
- Department Name
- Oncology
- Contact Person Name
- María Carmen Álamo de Gala
- Contact Person Email
- alamodelagala@gmail.com
- Site Name
- Fundacion Instituto Valenciano De Oncologia
- Department Name
- Oncology
- Contact Person Name
- Ricardo Yaya
- Contact Person Email
- ryaya@fivo.org
- Site Name
- Hospital Universitari Vall D Hebron
- Department Name
- Oncology
- Contact Person Name
- Eva Muñoz
- Contact Person Email
- emunoz@vhio.net
- Site Name
- Hospital Universitario Regional De Malaga
- Department Name
- Oncology
- Contact Person Name
- Miguel Angel Berciano
- Contact Person Email
- migueberci@gmail.com
France
- Earliest CTIS Part Ii Submission Date
- 26-08-2024
- Latest Decision Or Authorization Date
- 13-11-2024
- Processing Time Days
- 79
- Number Of Sites
- 6
- Number Of Participants
- 34
Sites
- Site Name
- Centre Hospitalier Universitaire De Nantes
- Department Name
- Onco-Dermatology
- Contact Person Name
- Gaëlle Quereux
- Contact Person Email
- gaelle.quereux@chu-nantes.fr
- Site Name
- Centre Hospitalier Universitaire Grenoble Alpes
- Department Name
- Onco-Dermatology
- Contact Person Name
- Julie Charles
- Contact Person Email
- jcharles@chugrenoble.fr
- Site Name
- Centre Hospitalier Universitaire De Nice
- Department Name
- Onco-Dermatology
- Contact Person Name
- Henri Montaudié
- Contact Person Email
- montaudie.h@chu-nice.fr
- Site Name
- CHU Besancon
- Department Name
- Onco-Dermatology
- Contact Person Name
- Charlee Nardin
- Contact Person Email
- cnardin@chu-besancon.fr
- Site Name
- Centre Hospitalier Universitaire De Bordeaux
- Department Name
- Onco-Dermatology
- Contact Person Name
- Marie Beylot-Barry
- Contact Person Email
- marie.beylot-barry@chu-bordeaux.fr
- Site Name
- Centre Hospitalier Universitaire De Nice
- Department Name
- Onco-Dermatology
Sponsor
Primary sponsor
- Full Name
- Checkpoint Therapeutics Inc.
- Organisation Type
- Pharmaceutical company
- Country Of Registered Address
- United States
Investigational products
- Investigational Product Name
- CK-301
- Routes Of Administration
- Intravenous
- Route
- Intravenous
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