CAPIVASERTIB for Hormone receptor positive HER2-negative advanced breast cancer

Inclusion criteria

• {"criterion_text":"- Females (≥18 years, pre-, peri- or post-menopausal) and males (≥18 years) at the time of signing the informed consent form a. Pre-menopausal (and peri-menopausal, i.e., those that do not meet the criteria for post-menopausal defined below) women can be enrolled if amenable to treatment with an LHRH agonist. Patients are to have commenced concomitant treatment with LHRH agonist prior to or on Cycle 1, Day 1 and must be willing to continue it for the duration of the study. b. Post-menopausal women are defined as: i. aged ≥60 years of age, OR ii. aged <60 years of age and amenorrhoeic for at least 12 months following cessation of all exogenous hormonal treatments/chemotherapy/ovarian suppression/tamoxifen or similar. These patients should also have serum oestradiol and follicle stimulating hormone (FSH) levels confirmed as being within the standard laboratory reference range for post-menopausal females, OR iii. documented bilateral oophorectomy.\n- Histologically confirmed HR+/HER2− breast cancer determined from the most recent tumour sample (primary or metastatic) as per WHO classification. To fulfil the requirement of HR+ disease, a breast cancer must express ER with or without co-expression of progesterone receptor. Therefore, tumours must be: a. ER+ defined as ≥1% of tumour cells stain positive for ER on immunohistochemistry (IHC) or, if no percentage is available, then an Allred IHC score of ≥3/8, b. Progesterone receptor positive defined as ≥1% of tumour cells stain positive for progesterone receptor on IHC or, if no percentage is available, then an Allred IHC score of ≥3/8; or progesterone receptor negative defined as <1% of tumour cells stain positive for progesterone receptor on IHC or, if no percentage is available, then an Allred IHC score of ≤2/8; or progesterone receptor unknown, and c. HER2− defined as 0 or 1+ intensity on IHC, or 2+ intensity on IHC and no evidence of amplification on in situ hybridisation (ISH), or if IHC not done, no evidence of amplification on ISH.\n- Metastatic or locally advanced disease with radiological or objective evidence of recurrence or progression (the cancer should have shown progression during or after most recent therapy); locally advanced disease must not be amenable to resection with curative intent (patients who are considered suitable for surgical or ablative techniques following potential down-staging with study treatment are not eligible).\n- Patients are to have received treatment with an ET (endocrine-based therapy) containing regimen (single agent or in combination) and have: a. Radiological evidence of breast cancer recurrence or progression while on, or within 12 months of the end of (neo)adjuvant treatment with an ET, OR b. Radiological evidence of progression while on prior ET administered as a treatment line for locally advanced or metastatic breast cancer (this does not need to be the most recent therapy).\n- Presence of one or more of the PIK3CA/AKT1/PTEN biomarkers, preferably determined in tumour tissue\n- Decision to newly initiate capivasertib + fulvestrant\n- Informed consent provided by patient prior to participation in the trial and before initiation of any study-specific measures\n- A. Female patients of childbearing potential at inclusion must have a negative pregnancy test (serum) and additionally, - patients must be either 1 year post-menopausal, - surgically sterile, - carry an intrauterine device (combined with a barrier method), - having received a bilateral tubal ligation/occlusion (combined with a barrier method), - or using an acceptable method of contraception (an acceptable method of contraception is defined as a barrier method in conjunction with a spermicide) for the duration of the study (from the time they sign consent) and for 3 months after the last dose of capivasertib and for 2 years after the last dose of fulvestrant to prevent pregnancy. - Total/true abstinence When the patient refrains from any form of sexual intercourse and this is in line with their usual and/or preferred lifestyle; this must continue for the duration of the study and for 3 months after the last dose of capivasertib and for 2 years after the last dose of fulvestrant to prevent pregnancy. - Vasectomised sexual partner (with participant assurance that partner received post-vasectomy confirmation of azoospermia) or sexual partner with bilateral orchiectomy combined with a barrier method - Hormonal contraception is not acceptable. B. Male patients must either be - surgically sterile - or using an acceptable method of contraception (defined as barrier methods in conjunction with spermicides) for the duration of the study (from the time they sign consent) and for 4 months after the last dose of capivasertib and for 2 years after the last dose of fulvestrant to prevent pregnancy in a partner. - Sexually abstinent men (i.e., refraining from heterosexual intercourse during the entire study duration, must continue for 4 months after the last dose of capivasertib and for 2 years after the last dose of fulvestrant to prevent pregnancy in a partner. - Male patients who intend to be sexually active with a woman of childbearing potential, must use a condom upon entering the study and until 4 months after the last dose of capivasertib and for 2 years after the last dose of fulvestrant to prevent pregnancy in a partner.\n- Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 with no deterioration over the previous 2 weeks and life expectancy of ≥12 weeks"}

Exclusion criteria

• {"criterion_text":"- Absence of an alteration in the PIK3CA/AKT1/PTEN biomarkers\n- Inadequate bone marrow reserve or organ function as demonstrated by any of the following laboratory values: a. Absolute neutrophil count <1.5 × 109/L b. Platelet count <100 × 109/L c. Haemoglobin <9 g/dL (<5.59 mmol/L). [NOTE: any blood transfusion must be >14 days prior to the determination of a haemoglobin ≥9 g/dL (≥5.59 mmol/L)] d. Alanine aminotransferase (ALT) and Aspartate aminotransferase (AST) >2.5 times upper limit of normal (ULN) if no demonstrable liver metastases or >5 × ULN in the presence of liver metastases e. Total bilirubin >1.5 × ULN (Patients with confirmed Gilbert’s syndrome may be included in the study) f. Creatinine >1.5 × ULN concurrent with creatinine clearance <50 mL/min (measured or calculated by Cockcroft and Gault equation); creatinine clearance is only required when creatinine is >1.5 × ULN\n- Any evidence of severe or uncontrolled systemic diseases, including uncontrolled hypertension, or active infection including tuberculosis, hepatitis B, hepatitis C, and human immunodeficiency virus (HIV), including those who have confirmed COVID-19 and any other disease, metabolic dysfunction, physical examination finding, or clinical laboratory finding that, in the investigator’s opinion, gives reasonable suspicion of a disease or condition that contraindicates the use of an investigational drug, may affect the interpretation of the results, render the patient at high risk from treatment complications or interferes with obtaining informed consent. Screening for chronic conditions is not required. Note: Known active hepatitis B or C infection, positive hepatitis C antibody, positive hepatitis B virus surface antigen. Participants positive for HCV antibody are eligible only if polymerase chain reaction is negative for HCV RNA. Patients receiving antiretroviral therapies which are strong inhibitors or inducers of CYP3A4 will be excluded due to the potential for drug-drug interaction with capivasertib\n- Known abnormalities in coagulation such as bleeding diathesis, or treatment with anticoagulants precluding intramuscular injections of fulvestrant or subcutaneous injections of LHRH agonist (if applicable)\n- Refractory nausea and vomiting, malabsorption syndrome, chronic gastrointestinal diseases, inability to swallow the formulated product or previous significant bowel resection, or other condition that would preclude adequate absorption of capivasertib\n- Previous allogenic bone marrow or solid organ transplant\n- History of another primary malignancy\n- Known immunodeficiency syndrome\n- Mean resting corrected QT interval >470 ms, obtained from triplicate ECGs performed at screening. History of QT prolongation associated with other medications that required discontinuation of that medication [Congenital long QT syndrome, family history of long QT syndrome, or unexplained sudden death under 40 years of age in first-degree relatives.]\n- Medical history significant for arrhythmia (e.g., multifocal premature ventricular contractions, bigeminy, trigeminy, ventricular tachycardia), which is symptomatic or requires treatment (CTCAE Grade 3), symptomatic or uncontrolled atrial fibrillation despite treatment, or asymptomatic sustained ventricular tachycardia. Participants with atrial fibrillation controlled by medication or arrhythmias controlled by pacemakers may be permitted to enter the study based on the Investigator judgement with cardiologist consultation recommended.\n- Any factors that increase the risk of QTc prolongation or risk of arrhythmic events, hypokalaemia of Grade >1, potential for Torsades de Pointes, congenital long QT syndrome\n- Previous enrolment in the present study\n- Experience of any of the following procedures or conditions in the preceding 3 months: coronary artery bypass graft, angioplasty, myocardial infarction, unstable angina pectoris. Congestive heart failure New York Heart Association (NYHA) ≥grade 2. History of hypersensitivity to active or inactive excipients of capivasertib, fulvestrant and LHRH agonists (if applicable, i.e., concomitant LHRH agonist required in this study) or drugs with a similar chemical structure or class to capivasertib, fulvestrant or LHRH agonists (if applicable)\n- Radiotherapy within 14 days prior to first dose of capivasertib\n- Major surgical procedure (excluding placement of vascular access) or significant traumatic injury within 4 weeks of the first dose of study intervention or an anticipated need for major surgery during the study.\n- Evidence of dementia altered mental status or any psychiatric condition that would prohibit understanding or rendering of informed consent\n- Pregnancy or breastfeeding\n- Patients who at time of data collection for this study are participating in or have participated in an interventional study that remains blinded\n- More than 2 lines of endocrine-based therapy for inoperable locally advanced or mBC\n- More than 1 line of chemotherapy for inoperable locally advanced or mBC. Adjuvant and neoadjuvant chemotherapy are not classed as lines of chemotherapy for mBC\n- Prior treatment with any of the following: a. AKT, PIK3 and mTOR inhibitors b. ngSERD (Note: prior treatment with fulvestrant (=SERD) is allowed!) c. Nitrosourea or mitomycin C within 6 weeks prior to study treatment initiation d. Any other chemotherapy, immunotherapy, immunosuppressant medication (other than corticosteroids) or anticancer agents within 3 weeks prior to study treatment initiation. A longer washout period may be required for drugs with a long half-life (e.g., biologics) as agreed by the sponsor e. Potent inhibitors or inducers of CYP3A4 within 2 weeks prior to the first dose of study treatment (3 weeks for St John’s wort) or drugs that are sensitive to CYP3A4 inhibition within 1 week prior to study treatment initiation. f. Any concomitant medication that may interfere with capivasertib or fulvestrant safety and efficacy based on the Investigator´s Brochure of capivasertib and the prescribing information of fulvestrant and local clinical guidelines, e.g., that are known to be associated with Torsade de Pointes or potent inducers of cytochrome P450 3A4 (CYP3A4).\n- Participation in another clinical study with any investigational medicinal product and still on IMP treatment or have participated in an interventional study that remains blinded\n- A disease burden that makes the patient ineligible for endocrine-based therapy per the investigator’s best judgement (e.g., symptomatic visceral disease that is potentially life-threatening in the short-term)\n- Known history of drug or alcohol abuse within 1 year of screening\n- Except for alopecia, any unresolved toxicities from prior therapy CTCAE Grade ≥2 at the time of starting study treatment\n- Leptomeningeal metastases\n- Spinal cord compression or brain metastases unless asymptomatic, treated and stable, and not requiring steroids within 4 weeks prior to study treatment initiation\n- Clinically significant abnormalities of glucose metabolism as defined by any of the following: a. HbA1c ≥8.0% (63.9 mmol/mol) at screening. Note: for any patient with evidence of impaired glucose control or insulin resistance refer to the Capivasertib Toxicity Management Guidelines."}

Primary endpoints

• {"endpoint_text":"- Superiority* of TTNT1 in patients receiving capivasertib compared to an evidence-based “standard TTNT1 curve” for patients without capivasertib.","definition_or_measurement_approach":"Compare TTNT1 (time to next treatment, i.e. time “on treatment”) in patients receiving capivasertib to an evidence-based standard TTNT1 curve for patients not receiving capivasertib (external/evidence-based comparator)."}
• {"endpoint_text":"- Superiority* of PRO-adherence compared to non-adherence regarding TTDQoL (aka DQoL-free interval).","definition_or_measurement_approach":"Assessment of PRO-adherence versus non-adherence impact on TTDQoL (DQoL-free interval) as defined in objectives; superiority hypothesis comparing adherent vs non-adherent groups."}

Secondary endpoints

• {"endpoint_text":"- PFS: defined by either: evidence of disease progression as assessed by treating physician or death","definition_or_measurement_approach":"Progression-free survival defined as radiological or clinical evidence of disease progression as assessed by treating physician, or death."}
• {"endpoint_text":"- OS","definition_or_measurement_approach":""}
• {"endpoint_text":"- Superiority of eHealth support (and summary statistics) regarding TTDQoL compared to patients entering the trial without eHealth support.","definition_or_measurement_approach":""}
• {"endpoint_text":"- Multivariable analysis including factors that could contribute to ePRO-adherence.","definition_or_measurement_approach":""}
• {"endpoint_text":"- Among patients with eHealth support: Multivariable mediation analysis (PRO-non-adherence as a mediating factor for DQoL) controlling for clinical factors.","definition_or_measurement_approach":""}
• {"endpoint_text":"- Among patients without eHealth support: multivariable analysis of impact of clinical factors on DQoL.","definition_or_measurement_approach":""}
• {"endpoint_text":"- Evaluation of prophylactic and reactive treatments for AESI management","definition_or_measurement_approach":""}
• {"endpoint_text":"- TTTD","definition_or_measurement_approach":""}
• {"endpoint_text":"- ePROs","definition_or_measurement_approach":""}
• {"endpoint_text":"- AE with CTCAE v5 grade 3+4","definition_or_measurement_approach":"Adverse events graded using CTCAE v5; analysis of grade 3 and 4 events."}
• {"endpoint_text":"- AESI-rates","definition_or_measurement_approach":""}
• {"endpoint_text":"- ADR-, SADR-, and SAE-rates","definition_or_measurement_approach":""}
• {"endpoint_text":"- Physician-reported AESI and kind of prophylactic and reactive treatments for AESI management","definition_or_measurement_approach":""}
• {"endpoint_text":"- Physician-reported AESI, prophylactic and reactive treatments for AESI management and TTNT1","definition_or_measurement_approach":""}
• {"endpoint_text":"- Patient-reported tolerability with physician-reported AESI and AESI management","definition_or_measurement_approach":""}
• {"endpoint_text":"- Selected PROs (symptom clusters)","definition_or_measurement_approach":""}
• {"endpoint_text":"- Selected clinical endpoints","definition_or_measurement_approach":""}
• {"endpoint_text":"- Self-documented symptoms","definition_or_measurement_approach":""}
• {"endpoint_text":"- Socio-demographic data","definition_or_measurement_approach":""}
• {"endpoint_text":"- Time to Next Treatment 2 (TTNT2)","definition_or_measurement_approach":""}
• {"endpoint_text":"- Time to Discontinuation 2 (TTTD2)","definition_or_measurement_approach":""}
• {"endpoint_text":"- Progression Free Survival 2 (PFS2)","definition_or_measurement_approach":""}

Belgium

Earliest CTIS Part Ii Submission Date

23-04-2025

Latest Decision Or Authorization Date

07-10-2025

Processing Time Days

167

Number Of Sites

2

Number Of Participants

50

Germany

Earliest CTIS Part Ii Submission Date

12-05-2025

Latest Decision Or Authorization Date

07-10-2025

Processing Time Days

148

Number Of Sites

15

Number Of Participants

175

Portugal

Earliest CTIS Part Ii Submission Date

04-04-2025

Latest Decision Or Authorization Date

20-02-2026

Processing Time Days

322

Number Of Sites

1

Number Of Participants

25

Primary sponsor

Full Name

WSG Westdeutsche Studiengruppe GmbH

Organisation Type

Pharmaceutical company

Country Of Registered Address

Germany

Contract research organisations

Name

Almac Clinical Service Limited

Third parties

• {"country":"Germany","full_name":"Hannover Unified Biobank","duties_or_roles":"Future Biomedical Research","organisation_type":"Health care"}
• {"country":"Germany","full_name":"Medizinische Hochschule Hannover","duties_or_roles":"","organisation_type":"Educational Institution"}
• {"country":"Germany","full_name":"Universitätsklinikum Bonn, Studienzentrum Bonn","duties_or_roles":"","organisation_type":"Health care"}
• {"country":"United Kingdom","full_name":"Almac Clinical Service Limited","duties_or_roles":"","organisation_type":"Industry"}
• {"country":"Portugal","full_name":"NOVA Clinical Research Unit","duties_or_roles":"1;12;2;5","organisation_type":"Health care"}
• {"country":"Germany","full_name":"Foundation Medicine GmbH","duties_or_roles":"","organisation_type":"Pharmaceutical company"}
• {"country":"Germany","full_name":"Roche Diagnostics GmbH","duties_or_roles":"","organisation_type":"Pharmaceutical company"}
• {"country":"Germany","full_name":"CANKADO Service GmbH","duties_or_roles":"","organisation_type":"Health care"}
• {"country":"Sweden","full_name":"Viedoc Technologies AB","duties_or_roles":"","organisation_type":"Non-Pharmaceutical company"}
• {"country":"Belgium","full_name":"Clinical Trials Support Unit","duties_or_roles":"1;12;2;5","organisation_type":"Health care"}
• {"country":"Germany","full_name":"Lahn-Apotheke Klinikversorgung","duties_or_roles":"","organisation_type":"Health care"}