Clinical trial • Phase III • Respiratory
CAMLIPIXANT for Refractory chronic cough | Unexplained chronic cough
Phase III trial of CAMLIPIXANT for Refractory chronic cough | Unexplained chronic cough.
Overview
- Trial Therapeutic Area
- Respiratory
- Trial Disease
- Refractory chronic cough | Unexplained chronic cough
- Trial Stage
- Phase III
- Drug Modality
- Small molecule
Key dates
- Initial CTIS Submission Date
- 12-09-2024
- First CTIS Authorization Date
- 24-09-2024
Trial design
Randomised, open-label, placebo (matching tablets); no dose specified for placebo-controlled Phase III trial in Netherlands, Poland, Belgium and others.
- Randomised
- Yes
- Open Label
- Yes
- Comparator
- Placebo (matching tablets); no dose specified for placebo
- Target Sample Size
- 592
- Trial Duration For Participant
- 364
Eligibility
Recruits 592 The record indicates isVulnerablePopulationSelected = true. Inclusion requires participants to be "Capable of understanding the written informed consent", indicating that adults must provide written informed consent; no further details on assent or additional consent procedures for specific vulnerable groups are provided in the available data..
- Pregnancy Exclusion
- 5. A female participant is eligible to participate if she is not pregnant, not breastfeeding, and at least 1 of the following conditions applies: Not a woman of childbearing potential (WOCBP) OR A WOCBP who agrees to the contraceptive guidance
- Vulnerable Population
- The record indicates isVulnerablePopulationSelected = true. Inclusion requires participants to be "Capable of understanding the written informed consent", indicating that adults must provide written informed consent; no further details on assent or additional consent procedures for specific vulnerable groups are provided in the available data.
Inclusion criteria
- {"criterion_text":"- 1. Between 18 and 80 years of age inclusive"}
- {"criterion_text":"- 2. Capable of understanding the written informed consent"}
- {"criterion_text":"- 3. Diagnosis of Refractory chronic cough (including unexplained chronic cough) for ≥ 1 year prior to Screening"}
- {"criterion_text":"- 4. Participants must meet the cough frequency criteria"}
- {"criterion_text":"- 5. A female participant is eligible to participate if she is not pregnant, not breastfeeding, and at least 1 of the following conditions applies: Not a woman of childbearing potential (WOCBP) OR A WOCBP who agrees to the contraceptive guidance"}
Exclusion criteria
- {"criterion_text":"- 1. Current smoker or vaper or current use of tobacco smoke, cannabis smoke, or nicotine vapors or individuals who have given up smoking or vaping within the past 6 months, or those with > 20 pack-year smoking history"}
- {"criterion_text":"- 2. Diagnosis of chronic obstructive pulmonary disease, bronchiectasis, chronic bronchitis, cystic fibrosis, pulmonary sarcoidosis, idiopathic pulmonary fibrosis, or uncontrolled asthma"}
- {"criterion_text":"- 3. History of upper and/or lower respiratory tract infection or significant change in pulmonary status within 28 days of Screening"}
- {"criterion_text":"- 4. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection at Screening"}
- {"criterion_text":"- 5. Medical history of malignancy and treatment completed ≤ 5 years prior to Screening"}
- {"criterion_text":"- 6. History of a diagnosis of drug or alcohol dependency or abuse within the last 3 years"}
- {"criterion_text":"- 7. Positive serological test for HIV, hepatitis B, or hepatitis C at Screening"}
- {"criterion_text":"- 8. Previous participation in an investigational study of BLU-5937 For the full list of exclusion criteria please refer to the study protocol."}
Endpoints
Primary endpoints
- {"endpoint_text":"- 24-hour cough frequency at Week 12 by a cough monitor.","definition_or_measurement_approach":"Measured by a cough monitor; assessment at Week 12 (24-hour cough frequency)."}
- {"endpoint_text":"- Incidence of AEs and SAEs up to Week 52","definition_or_measurement_approach":"Capture and reporting of adverse events (AEs) and serious adverse events (SAEs) through Week 52 (incidence counts)."}
- {"endpoint_text":"- Incidence of AEMIs up to Week 52","definition_or_measurement_approach":"Capture and reporting of adverse events of special interest (AEMIs) through Week 52 (incidence counts)."}
- {"endpoint_text":"- Occurrences of study treatment discontinuations due to AEs and SAEs up to Week 52","definition_or_measurement_approach":"Recording of treatment discontinuations attributed to AEs or SAEs through Week 52 (occurrence counts)."}
- {"endpoint_text":"- Occurrences of AEs and SAEs leading to study withdrawal up to Week 52","definition_or_measurement_approach":"Recording of AEs/SAEs that result in withdrawal from the study through Week 52 (occurrence counts)."}
Secondary endpoints
- {"endpoint_text":"- CS-VAS","definition_or_measurement_approach":""}
- {"endpoint_text":"- Change from Baseline in CS-VAS at Week 12","definition_or_measurement_approach":"Change from baseline measured using the CS-VAS instrument at Week 12."}
- {"endpoint_text":"- CS-VAS response at Week 12","definition_or_measurement_approach":"Responder analysis based on CS-VAS at Week 12."}
- {"endpoint_text":"- Objective cough frequency recording","definition_or_measurement_approach":"Objective cough frequency captured (method: cough monitor/recording)."}
- {"endpoint_text":"- Awake cough frequency at Week 12","definition_or_measurement_approach":"Objective measurement of cough frequency during awake periods at Week 12."}
- {"endpoint_text":"- 24-hour cough response at Week 12","definition_or_measurement_approach":"24-hour cough response measured at Week 12 (likely via cough monitor)."}
- {"endpoint_text":"- LCQ","definition_or_measurement_approach":""}
- {"endpoint_text":"- Change from Baseline in the LCQ total score at Week 12","definition_or_measurement_approach":"Change from baseline in Leicester Cough Questionnaire total score at Week 12."}
- {"endpoint_text":"- LCQ response at Week 12","definition_or_measurement_approach":"Responder analysis based on LCQ at Week 12."}
Recruitment
- Digital Remote Recruitment
- Yes
- Planned Sample Size
- 592
- Recruitment Window Months
- 36
- Consent Approach
- Adults must be capable of understanding and provide written informed consent ("Capable of understanding the written informed consent"). Subject information and informed consent forms (ICFs/PIS) are available in multiple languages (English, French, Dutch, Polish, Hungarian, Spanish) as indicated in the submitted documents.
Methods
- Patient Brochure (language-specific versions present: EN, NL, FR, ES)
- Patient Flyer (language-specific versions: EN, NL, FR, ES)
- Patient Poster (language-specific versions: EN, NL, FR, ES)
- Patient Study Guide (EN/NL/FR versions listed)
- Study Overview Video Storyboard / Study Video (storyboards present in multiple languages)
- Cough Monitor Instructions Video Storyboard (global EN and language-specific versions)
- Pre-screener Module / Patient Pre-Screening Website Content
- DTP call scripts and scheduling scripts (inbound/outbound) for participant contact and scheduling
- ePR Scheduling Chatbot scripts
- Participant Journey Emails and Patient eDiary / Medication compliance materials
- Greenphire ClinCard materials and travel/reimbursement guides (patient reimbursement and travel support)
- Local recruitment arrangements and consent form documents (K1) and localized ICF/PIS documents
Geography
- Total Number Of Sites
- 55
- Total Number Of Participants
- 275
Netherlands
- Earliest CTIS Part Ii Submission Date
- 12-07-2024
- Latest Decision Or Authorization Date
- 16-09-2025
- Processing Time Days
- 431
- Number Of Sites
- 8
- Number Of Participants
- 27
Sites
- Site Name
- Catharina Ziekenhuis Stichting
- Department Name
- pulmonology
- Principal Investigator Name
- Pascal Wielders
- Principal Investigator Email
- pascal.wielders@catharinaziekenhuis.nl
- Contact Person Name
- Pascal Wielders
- Contact Person Email
- pascal.wielders@catharinaziekenhuis.nl
- Site Name
- Bernhoven B.V.
- Department Name
- pulmonology
- Principal Investigator Name
- JPH Van den Bogart
- Principal Investigator Email
- m.vandenbogart@bernhoven.nl
- Contact Person Name
- JPH Van den Bogart
- Contact Person Email
- m.vandenbogart@bernhoven.nl
- Site Name
- Isala Klinieken Stichting
- Department Name
- pulmonology
- Principal Investigator Name
- Jan Willem van den Berg
- Principal Investigator Email
- j.w.k.van.den.berg@isala.nl
- Contact Person Name
- Jan Willem van den Berg
- Contact Person Email
- j.w.k.van.den.berg@isala.nl
- Site Name
- Amphia Hospital
- Department Name
- pulmonology
- Principal Investigator Name
- Simone van der Sar
- Principal Investigator Email
- svandersar@amphia.nl
- Contact Person Name
- Simone van der Sar
- Contact Person Email
- svandersar@amphia.nl
- Site Name
- Gelre Hospitals
- Department Name
- Pulmonology
- Principal Investigator Name
- Martijn Goosens
- Principal Investigator Email
- m.goosens@gelre.nl
- Contact Person Name
- Martijn Goosens
- Contact Person Email
- m.goosens@gelre.nl
- Site Name
- Rijnstate Ziekenhuis Stichting
- Department Name
- pulmonology
- Principal Investigator Name
- Marjo van de Ven
- Principal Investigator Email
- mvandeven@rijnstate.nl
- Contact Person Name
- Marjo van de Ven
- Contact Person Email
- mvandeven@rijnstate.nl
- Site Name
- Ziekenhuis St Jansdal
- Department Name
- pulmonology
- Principal Investigator Name
- Lisenka Boom
- Principal Investigator Email
- ln.boom@stjansdal.nl
- Contact Person Name
- Lisenka Boom
- Contact Person Email
- ln.boom@stjansdal.nl
- Site Name
- Noordwest Ziekenhuisgroep Stichting
- Department Name
- pulmonology
- Principal Investigator Name
- Astrid Aardenburg van Huisstede
- Principal Investigator Email
- a.aardenburg-van.huisstede@nwz.nl
- Contact Person Name
- Astrid Aardenburg van Huisstede
- Contact Person Email
- a.aardenburg-van.huisstede@nwz.nl
Poland
- Earliest CTIS Part Ii Submission Date
- 12-07-2024
- Latest Decision Or Authorization Date
- 18-08-2025
- Processing Time Days
- 402
- Number Of Sites
- 10
- Number Of Participants
- 99
Sites
- Site Name
- Prywatny Gabinet Lekarski Malgorzata Pawlukiewicz
- Principal Investigator Name
- Małgorzata Pawlukiewicz
- Principal Investigator Email
- mpawlu@onet.eu
- Contact Person Name
- Małgorzata Pawlukiewicz
- Contact Person Email
- mpawlu@onet.eu
- Site Name
- Ostrowieckie Centrum Medyczne Anna Olech Cudzik Krzysztof Cudzik s.c.
- Principal Investigator Name
- Anna Olech-Cudzik
- Principal Investigator Email
- annacudzik@cudmed.pl
- Contact Person Name
- Anna Olech-Cudzik
- Contact Person Email
- annacudzik@cudmed.pl
- Site Name
- Pratia S.A.
- Principal Investigator Name
- Jacek Dulęba
- Principal Investigator Email
- jduleba@pratia.pl
- Contact Person Name
- Jacek Dulęba
- Contact Person Email
- jduleba@pratia.pl
- Site Name
- Centrum Medyczne Lucyna Andrzej Dymek s.c.
- Principal Investigator Name
- Lucyna Dymek
- Principal Investigator Email
- ladymek@centrummedyczne.com
- Contact Person Name
- Lucyna Dymek
- Contact Person Email
- ladymek@centrummedyczne.com
- Site Name
- Uniwersytecki Szpital Kliniczny Nr 1 im. Norberta Barlickiego Uniwersytetu Medycznego w Łodzi
- Department Name
- Poradnia Alergologiczna
- Principal Investigator Name
- Piotr Kuna
- Principal Investigator Email
- piotr.kuna@umed.lodz.pl
- Contact Person Name
- Piotr Kuna
- Contact Person Email
- piotr.kuna@umed.lodz.pl
- Site Name
- Prywatny Gabinet Internistyczno-Alergologiczny Zenon Siergiejko
- Principal Investigator Name
- Zenon Sergiejko
- Principal Investigator Email
- zenonsiergiejko1@gmail.com
- Contact Person Name
- Zenon Sergiejko
- Contact Person Email
- zenonsiergiejko1@gmail.com
- Site Name
- Vitamed Galaj I Cichomski Sp. j.
- Principal Investigator Name
- Iwona Patyk
- Principal Investigator Email
- iwonapatyk@yahoo.fr
- Contact Person Name
- Iwona Patyk
- Contact Person Email
- iwonapatyk@yahoo.fr
- Site Name
- Centrum Innowacyjnych Terapii Sp. z o.o.
- Principal Investigator Name
- Luiza Jonczak
- Principal Investigator Email
- l.jonczak@etg-network.com
- Contact Person Name
- Luiza Jonczak
- Contact Person Email
- l.jonczak@etg-network.com
- Site Name
- Alergo Med Osrodek Badan Klinicznych Sp. z o.o.
- Principal Investigator Name
- Bernadetta Majorek-Olechowska
- Principal Investigator Email
- bernadettaolechowska@gmail.com
- Contact Person Name
- Bernadetta Majorek-Olechowska
- Contact Person Email
- bernadettaolechowska@gmail.com
- Site Name
- Samodzielny Publiczny Zaklad Opieki Zdrowotnej Uniwersytecki Szpital Kliniczny Nr 1 Im. Norberta Barlickiego Uniwersytetu Medycznego W Lodzi
- Department Name
- Oddzial Kliniczny Pulmunologii i Alergologii
- Principal Investigator Name
- Wojciech Piotrowski
- Principal Investigator Email
- wojciech.piotrowski@umed.lodz.pl
- Contact Person Name
- Wojciech Piotrowski
- Contact Person Email
- wojciech.piotrowski@umed.lodz.pl
Belgium
- Earliest CTIS Part Ii Submission Date
- 12-07-2024
- Latest Decision Or Authorization Date
- 12-08-2025
- Processing Time Days
- 396
- Number Of Sites
- 7
- Number Of Participants
- 42
Sites
- Site Name
- Centre Hospitalier Regional De La Citadelle
- Department Name
- Pneumolgy
- Principal Investigator Name
- Maud Deschampheleire
- Principal Investigator Email
- maud.deschampheleire@citadelle.be
- Contact Person Name
- Maud Deschampheleire
- Contact Person Email
- maud.deschampheleire@citadelle.be
- Site Name
- Algemeen Ziekenhuis Delta
- Department Name
- Pneumolgy
- Principal Investigator Name
- Ingel DEMEDTS
- Principal Investigator Email
- ingel.demedts@azdelta.be
- Contact Person Name
- Ingel DEMEDTS
- Contact Person Email
- ingel.demedts@azdelta.be
- Site Name
- Cliniques Universitaires Saint-Luc
- Department Name
- Pneumolgy
- Principal Investigator Name
- Charles Pilette
- Principal Investigator Email
- hcharles.pilette@saintluc.uclouvain.be
- Contact Person Name
- Charles Pilette
- Contact Person Email
- hcharles.pilette@saintluc.uclouvain.be
- Site Name
- Algemeen Ziekenhuis Groeninge
- Department Name
- Pneumolgy
- Principal Investigator Name
- Martijn Vandebotermet
- Principal Investigator Email
- studieslongziekten@azgroeninge.be
- Contact Person Name
- Martijn Vandebotermet
- Contact Person Email
- studieslongziekten@azgroeninge.be
- Site Name
- A.Z. Sint-Maarten
- Department Name
- Pneumolgy
- Principal Investigator Name
- Muriel Lins
- Principal Investigator Email
- muriel.lins@emmaus.be
- Contact Person Name
- Muriel Lins
- Contact Person Email
- muriel.lins@emmaus.be
- Site Name
- Universitair Ziekenhuis Gent
- Department Name
- Pneumolgy
- Principal Investigator Name
- Guy Brusselle
- Principal Investigator Email
- guy.brusselle@uzgent.be
- Contact Person Name
- Guy Brusselle
- Contact Person Email
- guy.brusselle@uzgent.be
- Site Name
- UZ Leuven
- Department Name
- Pneumolgy
- Principal Investigator Name
- Lieven Dupont
- Principal Investigator Email
- lieven.dupont@uzleuven.be
- Contact Person Name
- Lieven Dupont
- Contact Person Email
- lieven.dupont@uzleuven.be
France
- Earliest CTIS Part Ii Submission Date
- 11-10-2024
- Latest Decision Or Authorization Date
- 11-08-2025
- Processing Time Days
- 304
- Number Of Sites
- 9
- Number Of Participants
- 21
Sites
- Site Name
- Les Hopitaux Universitaires De Strasbourg
- Department Name
- Pneumology
- Principal Investigator Name
- Naji KHAYATH
- Principal Investigator Email
- naji.khayath@chru-strasbourg.fr
- Contact Person Name
- Naji KHAYATH
- Contact Person Email
- naji.khayath@chru-strasbourg.fr
- Site Name
- Centre Hospitalier Universitaire De Dijon
- Department Name
- Pneumology
- Principal Investigator Name
- Philippe BONNIAUD
- Principal Investigator Email
- philippe.bonniaud@chu-dijon.fr
- Contact Person Name
- Philippe BONNIAUD
- Contact Person Email
- philippe.bonniaud@chu-dijon.fr
- Site Name
- Assistance Publique Hopitaux De Paris
- Department Name
- Pneumology
- Principal Investigator Name
- Nicolas ROCHE
- Principal Investigator Email
- nicolas.roche@aphp.mssante.fr
- Contact Person Name
- Nicolas ROCHE
- Contact Person Email
- nicolas.roche@aphp.mssante.fr
- Site Name
- Centre Hospitalier Universitaire De Toulouse
- Department Name
- Pneumology
- Principal Investigator Name
- Laurent GUILLEMINAULT
- Principal Investigator Email
- guilleminault.l@chu-toulouse.fr
- Contact Person Name
- Laurent GUILLEMINAULT
- Contact Person Email
- guilleminault.l@chu-toulouse.fr
- Site Name
- Centre Hospitalier Regional De Marseille
- Department Name
- Pneumology
- Principal Investigator Name
- Pascal CHANEZ
- Principal Investigator Email
- pascal.chanez@univ-amu.fr
- Contact Person Name
- Pascal CHANEZ
- Contact Person Email
- pascal.chanez@univ-amu.fr
- Site Name
- Hopital Europeen Marseille
- Department Name
- Pneumology
- Principal Investigator Name
- Hervé PEGLIASCO
- Principal Investigator Email
- h.pegliasco@hopital-europeen.fr
- Contact Person Name
- Hervé PEGLIASCO
- Contact Person Email
- h.pegliasco@hopital-europeen.fr
- Site Name
- Centre Hospitalier Universitaire De Montpellier
- Department Name
- Pneumology
- Principal Investigator Name
- Arnaud BOURDIN
- Principal Investigator Email
- a-bourdin@chu-montpellier.fr
- Contact Person Name
- Arnaud BOURDIN
- Contact Person Email
- a-bourdin@chu-montpellier.fr
- Site Name
- Centre Hospitalier Universitaire De Lille
- Department Name
- Pneumology
- Principal Investigator Name
- Silvia DEMOULIN
- Principal Investigator Email
- silvia.alexikova@chu-lille.fr
- Contact Person Name
- Silvia DEMOULIN
- Contact Person Email
- silvia.alexikova@chu-lille.fr
- Site Name
- Centre Hospitalier Universitaire De Toulouse (additional listed site)
- Department Name
- Pneumology
Hungary
- Earliest CTIS Part Ii Submission Date
- 12-07-2024
- Latest Decision Or Authorization Date
- 18-09-2025
- Processing Time Days
- 433
- Number Of Sites
- 8
- Number Of Participants
- 21
Sites
- Site Name
- Szalay Janos Rendelointezet
- Principal Investigator Name
- Edina Kurucz
- Principal Investigator Email
- drkuruczedina@gmail.com
- Contact Person Name
- Edina Kurucz
- Contact Person Email
- drkuruczedina@gmail.com
- Site Name
- Da Vinci Spa Kft.
- Principal Investigator Name
- Márta Papp
- Principal Investigator Email
- drpappm@gmail.com
- Contact Person Name
- Márta Papp
- Contact Person Email
- drpappm@gmail.com
- Site Name
- Püspökladányi Egészségügyi Szolgáltató Intézmény
- Principal Investigator Name
- Nelli Kosztyu
- Principal Investigator Email
- nellypharmanex@gmail.com
- Contact Person Name
- Nelli Kosztyu
- Contact Person Email
- nellypharmanex@gmail.com
- Site Name
- DRC Kft.
- Principal Investigator Name
- Krisztina Czebe
- Principal Investigator Email
- czebekriszta@gmail.com
- Contact Person Name
- Krisztina Czebe
- Contact Person Email
- czebekriszta@gmail.com
- Site Name
- High Tech Medical Kft.
- Principal Investigator Name
- Katalin Várdi
- Principal Investigator Email
- ceo@hightechmedicalkft.com
- Contact Person Name
- Katalin Várdi
- Contact Person Email
- ceo@hightechmedicalkft.com
- Site Name
- Erzsebet Gondozohaz Kft.
- Principal Investigator Name
- János Mucsi
- Principal Investigator Email
- mucsitrial@gmail.com
- Contact Person Name
- János Mucsi
- Contact Person Email
- mucsitrial@gmail.com
- Site Name
- Omnimodus Elixir Kft.
- Principal Investigator Name
- Erika Unger
- Principal Investigator Email
- ungerstudy@gmail.com
- Contact Person Name
- Erika Unger
- Contact Person Email
- ungerstudy@gmail.com
- Site Name
- Clinexpert Kft.
- Principal Investigator Name
- Veronika Urbán
- Principal Investigator Email
- nyugalomvolgye@t-online.hu
- Contact Person Name
- Veronika Urbán
- Contact Person Email
- nyugalomvolgye@t-online.hu
Spain
- Earliest CTIS Part Ii Submission Date
- 12-07-2024
- Latest Decision Or Authorization Date
- 04-12-2025
- Processing Time Days
- 510
- Number Of Sites
- 13
- Number Of Participants
- 65
Sites
- Site Name
- Hospital Clinic De Barcelona
- Department Name
- Respiratory
- Principal Investigator Name
- Ebymar Arismendi Nunez
- Principal Investigator Email
- earismen@clinic.cat
- Contact Person Name
- Ebymar Arismendi Nunez
- Contact Person Email
- earismen@clinic.cat
- Site Name
- Hospital De La Santa Creu I Sant Pau
- Department Name
- Respiratory
- Principal Investigator Name
- Astrid Crespo Lessmann
- Principal Investigator Email
- acrespo@santpau.cat
- Contact Person Name
- Astrid Crespo Lessmann
- Contact Person Email
- acrespo@santpau.cat
- Site Name
- Hospital Universitario De La Princesa
- Department Name
- Respiratory
- Principal Investigator Name
- Carolina Cisneros Serrano
- Principal Investigator Email
- carol9199@yahoo.es
- Contact Person Name
- Carolina Cisneros Serrano
- Contact Person Email
- carol9199@yahoo.es
- Site Name
- Hospital Universitario Virgen De La Victoria
- Department Name
- Respiratory
- Principal Investigator Name
- Jose Luis Velasco Garrido
- Principal Investigator Email
- jlvelascogarrido@hotmail.com
- Contact Person Name
- Jose Luis Velasco Garrido
- Contact Person Email
- jlvelascogarrido@hotmail.com
- Site Name
- Hospital Universitario Virgen De Las Nieves
- Department Name
- Respiratory
- Principal Investigator Name
- Concepcion Morales Garcia
- Principal Investigator Email
- concepcion.morales.sspa@juntadeandalucia.es
- Contact Person Name
- Concepcion Morales Garcia
- Contact Person Email
- concepcion.morales.sspa@juntadeandalucia.es
- Site Name
- Hospital Universitario De Navarra
- Department Name
- Respiratory
- Principal Investigator Name
- Tamara Gutiérrez Urra
- Principal Investigator Email
- tamara.guitierrez.urra@navarra.es
- Contact Person Name
- Tamara Gutiérrez Urra
- Contact Person Email
- tamara.guitierrez.urra@navarra.es
- Site Name
- Complexo Hospitalario Universitario De Santiago
- Department Name
- Respiratory
- Principal Investigator Name
- Francisco Javier González Barcala
- Principal Investigator Email
- francisco.javier.gonzalez.barcala@sergas.es
- Contact Person Name
- Francisco Javier González Barcala
- Contact Person Email
- francisco.javier.gonzalez.barcala@sergas.es
- Site Name
- Hospital General Universitario Gregorio Maranon
- Department Name
- Respiratory
- Principal Investigator Name
- Luis Puente Maestu
- Principal Investigator Email
- luis.puente@salud.madrid.org
- Contact Person Name
- Luis Puente Maestu
- Contact Person Email
- luis.puente@salud.madrid.org
- Site Name
- Hospital Quironsalud Malaga
- Department Name
- Respiratory
- Principal Investigator Name
- Leticia Herrero Lifona
- Principal Investigator Email
- herrerolifona.leticia@gmail.com
- Contact Person Name
- Leticia Herrero Lifona
- Contact Person Email
- herrerolifona.leticia@gmail.com
- Site Name
- Pectus Respiratory Health S.L.
- Department Name
- Research Facility
- Principal Investigator Name
- Juan Roldan Sanchez
- Principal Investigator Email
- juan.roldan@giromedinstitute.com
- Contact Person Name
- Juan Roldan Sanchez
- Contact Person Email
- juan.roldan@giromedinstitute.com
- Site Name
- Accellacare Espana S.L.
- Department Name
- Respiratory
- Principal Investigator Name
- Jose Miguel Rodriguez Gonzalez-Moro
- Principal Investigator Email
- respirama@yahoo.es
- Contact Person Name
- Jose Miguel Rodriguez Gonzalez-Moro
- Contact Person Email
- respirama@yahoo.es
- Site Name
- Hospital Germans Trias I Pujol
- Department Name
- Department of Pneumology
- Principal Investigator Name
- Carlos Martinez Rivera
- Principal Investigator Email
- carlosmartinezrivera.cmr@gmail.com
- Contact Person Name
- Carlos Martinez Rivera
- Contact Person Email
- carlosmartinezrivera.cmr@gmail.com
- Site Name
- Hospital Universitario Quironsalud Madrid
- Department Name
- Respiratory
- Principal Investigator Name
- Jose Maria Echave Sustaeta
- Principal Investigator Email
- jose.echave@quironsalud.es
- Contact Person Name
- Jose Maria Echave Sustaeta
- Contact Person Email
- jose.echave@quironsalud.es
Sponsor
Primary sponsor
- Full Name
- Bellus Health Inc.
- Organisation Type
- Pharmaceutical company
- Country Of Registered Address
- Canada
Contract research organisations
- Name
- Syneos Health Clinique Inc.
- Responsibilities
- Pharmacokinetic analysis
- Name
- IQVIA Limited
- Responsibilities
- Cough diary; site network, eCOA, patient study costs management and concierge; equipment rental; other clinical operations tasks
- Name
- Sitero LLC
- Responsibilities
- IVRS30 – treatment randomisation; site support functions
- Name
- Cisys Inc.
- Responsibilities
- Eligibility criteria adjudication platform
- Name
- Q Squared Solutions Limited
- Responsibilities
- Clinical laboratory services (clinical chemistry, haematology, serology, pregnancy tests, SARS-CoV-2 tests, urine drug screen, urinalysis)
- Name
- Greenphire LLC
- Responsibilities
- Patient reimbursement management (ClinCard solutions)
- Name
- Vitalograph Limited
- Responsibilities
- Measurement of recorded cough frequency
Third parties
- {"country":"Canada","full_name":"Syneos Health Clinique Inc.","duties_or_roles":"Pharmacokinetic analysis","organisation_type":"Hospital/Clinic/Other health care facility"}
- {"country":"United States","full_name":"Greenphire LLC","duties_or_roles":"Patient Reimbursements","organisation_type":"Non-Pharmaceutical company"}
- {"country":"United Kingdom","full_name":"IQVIA Limited","duties_or_roles":"Multiple duties including cough diary; site network, eCOA, patient study costs management and concierge; equipment rental (other coded duties present)","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Sitero LLC","duties_or_roles":"IVRS30 – treatment randomisation (and other coded duties)","organisation_type":"Pharmaceutical company"}
- {"country":"United Kingdom","full_name":"Q Squared Solutions Limited","duties_or_roles":"Clinical chemistry, Clinical haematology, Serology/ endocrinology, serum pregnancy tests, SARS-CoV-2 tests, urine drug screen, urinalysis","organisation_type":"Non-Pharmaceutical company"}
- {"country":"United Kingdom","full_name":"Glaxosmithkline Research & Development Limited","duties_or_roles":"SUSAR reporting","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Cisys Inc.","duties_or_roles":"Eligibility criteria adjudication platform","organisation_type":"Pharmaceutical company"}
- {"country":"United Kingdom","full_name":"Vitalograph Limited","duties_or_roles":"Measurement of recorded cough frequency","organisation_type":"Pharmaceutical company"}
Investigational products
- Investigational Product Name
- BLU-5937
- Active Substance
- CAMLIPIXANT
- Modality
- Small molecule
- Routes Of Administration
- ORAL USE
- Route
- oral
- Authorisation Status
- Authorised (prodAuthStatus=1)
- Maximum Dose
- 1111 mg
Related trials
Other published trials that may interest you.
- TAPLUCAINIUM CHLORIDE for Refractory chronic cough | Unexplained chronic cough
- CAMLIPIXANT for Refractory chronic cough | Unexplained chronic cough
- phospholipid fraction, bovine lung for Idiopathic pulmonary fibrosis
- Allogeneic bone marrow-derived mesenchymal adult stromal cells, ex-vivo expanded for Chronic lung allograft dysfunction (CLAD) | Bronchiolitis obliterans syndrome (BOS) in lung transplant recipients
- IVX-121; HUMAN METAPNEUMOVIRUS, VIRUS-LIKE PROTEIN for Respiratory syncytial virus infection | Human metapneumovirus infection