Clinical trial • Phase III • Cardiology
BOMEDEMSTAT for Essential thrombocythemia
Phase III trial of BOMEDEMSTAT for Essential thrombocythemia.
Overview
- Trial Therapeutic Area
- Cardiology
- Trial Disease
- Essential thrombocythemia
- Trial Stage
- Phase III
- Drug Modality
- Small molecule|Peptide/protein/enzyme
Key dates
- Initial CTIS Submission Date
- 16-11-2023
- First CTIS Authorization Date
- 26-03-2024
Trial design
Randomised, open-label, best available therapy (bat) comparator options include: anagrelide hydrochloride monohydrate (oral, max daily dose 10 mg); ruxolitinib (oral, max daily dose 20 mg); peginterferon alfa-2a (subcutaneous injection, max single-day dose 6.43 µg as listed); busulfan (oral, max daily dose 4 mg). specific schedules not stated in the summary.-controlled Phase III trial across 50 sites in France, Italy, Netherlands and others.
- Randomised
- Yes
- Open Label
- Yes
- Comparator
- Best Available Therapy (BAT) comparator options include: ANAGRELIDE HYDROCHLORIDE MONOHYDRATE (oral, max daily dose 10 mg); RUXOLITINIB (oral, max daily dose 20 mg); PEGINTERFERON ALFA-2A (subcutaneous injection, max single-day dose 6.43 µg as listed); BUSULFAN (oral, max daily dose 4 mg). Specific schedules not stated in the summary.
- Target Sample Size
- 229
Eligibility
Recruits 229 Vulnerable population selected (isVulnerablePopulationSelected = true). Specific consent/assent handling details are not detailed in the provided record. Multiple country-specific subject information and informed consent forms (ICFs) and optional consent documents are listed for participating countries and languages..
- Vulnerable Population
- Vulnerable population selected (isVulnerablePopulationSelected = true). Specific consent/assent handling details are not detailed in the provided record. Multiple country-specific subject information and informed consent forms (ICFs) and optional consent documents are listed for participating countries and languages.
Inclusion criteria
- {"criterion_text":"- Has a diagnosis of essential thrombocythemia (ET) per World Health Organization (WHO) 2016 diagnostic criteria for myeloproliferative neoplasms. (confirmed by a central pathologist)."}
- {"criterion_text":"- Has a centrally assessed bone marrow fibrosis score of Grade 0 or Grade 1, as per a modified version of the European Consensus Criteria for Grading Myelofibrosis"}
- {"criterion_text":"- Has a history of inadequate response to or intolerance of hydroxyurea based on modified European LeukemiaNet (ELN) criteria for hydroxyurea resistance or intolerance."}
- {"criterion_text":"- Has an inadequate or loss of response to their most recent prior ET therapy, requiring a change of cytoreductive therapy"}
- {"criterion_text":"- Has a platelet count > 450 × 10^9/L (450k /μL) assessed up to 72 hours before first dose of study intervention"}
- {"criterion_text":"- Has an absolute neutrophil count (ANC) ≥0.75 × 10^9/L assessed up to 72 hours before first dose of study intervention"}
- {"criterion_text":"- Participants may have received up to 3 prior ET-directed cytoreductive agents including hydroxyurea"}
Exclusion criteria
- {"criterion_text":"- Known immediate or delayed hypersensitivity reaction or idiosyncrasy to drugs chemically related to bomedemstat or lysine demethylase or monoamine oxidase inhibitor (LSDi or MAOi) that contraindicates participation"}
- {"criterion_text":"- History of any illness/impairment of gastrointestinal (GI) function that might interfere with drug absorption (eg, chronic diarrhea or history of gastric bypass surgical procedure), confound the study results or pose an additional risk to the individual by participation in the study"}
- {"criterion_text":"- Evidence at the time of Screening of increased risk of bleeding"}
- {"criterion_text":"- History of a malignancy, unless potentially curative treatment has been completed with no evidence of malignancy for 2 years. Note: The time requirement does not apply to participants who underwent successful definitive resection of basal cell carcinoma of the skin, squamous cell carcinoma of the skin, or carcinoma in situ, excluding carcinoma in situ of the bladder"}
- {"criterion_text":"- Human immunodeficiency virus (HIV)-infected participants with a history of Kaposi’s sarcoma and/or Multicentric Castleman’s Disease"}
Endpoints
Primary endpoints
- {"endpoint_text":"- Durable Clinicohematologic Response (DCHR) Rate","definition_or_measurement_approach":""}
Secondary endpoints
- {"endpoint_text":"- Change from Baseline in Myelofibrosis Symptom Assessment Form (MFSAF) v4.0 Individual Fatigue Symptom Item Score","definition_or_measurement_approach":"Measured by MFSAF v4.0 individual fatigue symptom item score (change from baseline)."}
- {"endpoint_text":"- Change from Baseline in Patient-reported Outcomes Measurement Information System (PROMIS) Fatigue SF-7a Total Fatigue Score","definition_or_measurement_approach":"Measured by PROMIS Fatigue SF-7a total fatigue score (change from baseline)."}
- {"endpoint_text":"- Change from Baseline in Total Symptom Score as Measured on the MFSAF v4.0","definition_or_measurement_approach":"Measured by MFSAF v4.0 total symptom score (change from baseline)."}
- {"endpoint_text":"- Duration of Clinicohematologic Response (DOCHR)","definition_or_measurement_approach":""}
- {"endpoint_text":"- Duration of Hematologic Remission (DOHR)","definition_or_measurement_approach":""}
- {"endpoint_text":"- Percentage of Participants with Thrombotic Events","definition_or_measurement_approach":"Proportion/percentage of participants experiencing thrombotic events as captured in safety/AE reporting."}
- {"endpoint_text":"- Percentage of Participants with Major Hemorrhagic Events","definition_or_measurement_approach":"Proportion/percentage of participants experiencing major hemorrhagic events as captured in safety/AE reporting."}
- {"endpoint_text":"- Disease Progression Rate","definition_or_measurement_approach":""}
- {"endpoint_text":"- Number of Participants with An Adverse Event (AE)","definition_or_measurement_approach":"Count of participants reporting at least one adverse event (AE)."}
- {"endpoint_text":"- Number of Participants Discontinuing from Study Therapy Due to an AE","definition_or_measurement_approach":"Count of participants who discontinue study therapy because of an adverse event (AE)."}
Recruitment
- Planned Sample Size
- 229
- Recruitment Window Months
- 56
- Consent Approach
- Informed consent is obtained using country-specific subject information and informed consent forms (multiple L1_ICF documents listed across participating countries and languages). Optional prescreening consent forms and optional/addendum documents (e.g., for prescreening, pregnancy follow-up, genetic consent) are provided per country. The record does not specify age-specific assent procedures.
Geography
- Total Number Of Sites
- 50
- Total Number Of Participants
- 155
France
- Earliest CTIS Part Ii Submission Date
- 12-01-2024
- Latest Decision Or Authorization Date
- 28-10-2025
- Processing Time Days
- 655
- Number Of Sites
- 8
- Number Of Participants
- 24
Sites
- Site Name
- Centre Hospitalier Universitaire De Rennes
- Department Name
- Hematology
- Principal Investigator Name
- Marc Bernard
- Principal Investigator Email
- marc.bernard@chu-rennes.fr
- Contact Person Name
- Marc Bernard
- Contact Person Email
- marc.bernard@chu-rennes.fr
- Site Name
- Centre Hospitalier De Roubaix
- Department Name
- Hematology unit
- Principal Investigator Name
- Mathieu Wemeau
- Principal Investigator Email
- mathieu.wemeau@ch-roubaix.fr
- Contact Person Name
- Mathieu Wemeau
- Contact Person Email
- mathieu.wemeau@ch-roubaix.fr
- Site Name
- Hopital Saint Louis
- Department Name
- Pharmacologic and Clinical Investigations
- Principal Investigator Name
- Jean-Jacques Kiladjian
- Principal Investigator Email
- jean-jacques.kiladjian@aphp.fr
- Contact Person Name
- Jean-Jacques Kiladjian
- Contact Person Email
- jean-jacques.kiladjian@aphp.fr
- Site Name
- Centre Hospitalier Et Universitaire De Limoges
- Department Name
- Clinical hematology and cell therapy
- Principal Investigator Name
- Amelie Penot
- Principal Investigator Email
- amelie.penot@chu-limoges.fr
- Contact Person Name
- Amelie Penot
- Contact Person Email
- amelie.penot@chu-limoges.fr
- Site Name
- CHRU De Nancy
- Department Name
- Hematology and Intern Medicine
- Principal Investigator Name
- Dana Ranta
- Principal Investigator Email
- d.ranta@chru-nancy.fr
- Contact Person Name
- Dana Ranta
- Contact Person Email
- d.ranta@chru-nancy.fr
- Site Name
- Centre Hospitalier Regional Universitaire De Tours
- Department Name
- Hematology and cell therapy
- Principal Investigator Name
- Antoine Machet
- Principal Investigator Email
- a.machet@chu-tours.fr
- Contact Person Name
- Antoine Machet
- Contact Person Email
- a.machet@chu-tours.fr
- Site Name
- Centre Hospitalier Lyon Sud
- Department Name
- Hematology
- Principal Investigator Name
- Fiorenza Barraco
- Principal Investigator Email
- fiorenza.barraco@chu-lyon.fr
- Contact Person Name
- Fiorenza Barraco
- Contact Person Email
- fiorenza.barraco@chu-lyon.fr
- Site Name
- Centre Hospitalier Universitaire De Rennes (duplicate entry not expected)
Italy
- Earliest CTIS Part Ii Submission Date
- 19-03-2024
- Latest Decision Or Authorization Date
- 15-05-2026
- Processing Time Days
- 787
- Number Of Sites
- 12
- Number Of Participants
- 33
Sites
- Site Name
- Careggi University Hospital
- Department Name
- Ematologia
- Principal Investigator Name
- Alessandro Maria Vannucchi
- Principal Investigator Email
- studiclinici-emato@sc-saluteumana.unifi.it
- Contact Person Name
- Alessandro Maria Vannucchi
- Contact Person Email
- studiclinici-emato@sc-saluteumana.unifi.it
- Site Name
- Azienda Ospedaliera Nazionale Ss Antonio E Biagio E C Arrigo Alessandria
- Department Name
- SCDU Ematologia
- Principal Investigator Name
- Monia Marchetti
- Principal Investigator Email
- monia.marchetti@ospedale.al.it
- Contact Person Name
- Monia Marchetti
- Contact Person Email
- monia.marchetti@ospedale.al.it
- Site Name
- Azienda Ospedaliera Ospedale Di Circolo E Fondazione Macchi
- Department Name
- S.C. Ematologia Trial Unit
- Principal Investigator Name
- Marco Brociner
- Principal Investigator Email
- marco.brociner@asst-settelaghi.it
- Contact Person Name
- Marco Brociner
- Contact Person Email
- marco.brociner@asst-settelaghi.it
- Site Name
- Istituto Romagnolo Per Lo Studio Dei Tumori Dino Amadori IRST S.r.l.
- Department Name
- Oncologia ed Ematologia Clinica e Sperimentale
- Principal Investigator Name
- Alessandro Lucchesi
- Principal Investigator Email
- alessandro.lucchesi@irst.emr.it
- Contact Person Name
- Alessandro Lucchesi
- Contact Person Email
- alessandro.lucchesi@irst.emr.it
- Site Name
- Azienda USL IRCCS Di Reggio Emilia
- Department Name
- Ematologia
- Principal Investigator Name
- Alessia Tieghi
- Principal Investigator Email
- alessia.tieghi@ausl.re.it
- Contact Person Name
- Alessia Tieghi
- Contact Person Email
- alessia.tieghi@ausl.re.it
- Site Name
- Universita' Degli Studi Di Ferrara
- Department Name
- U.O. di Ematologia
- Principal Investigator Name
- Francesco Cavazzini
- Principal Investigator Email
- cvzfnc@unife.it
- Contact Person Name
- Francesco Cavazzini
- Contact Person Email
- cvzfnc@unife.it
- Site Name
- Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico
- Department Name
- SC Ematologia
- Principal Investigator Name
- Daniele Cattaneo
- Principal Investigator Email
- daniele.cattaneo@policlinico.mi.it
- Contact Person Name
- Daniele Cattaneo
- Contact Person Email
- daniele.cattaneo@policlinico.mi.it
- Site Name
- Istituto Oncologico Veneto
- Department Name
- UOC Oncoematologia
- Principal Investigator Name
- Elisabetta Calistri
- Principal Investigator Email
- elisabetta.calistri@iov.veneto.it
- Contact Person Name
- Elisabetta Calistri
- Contact Person Email
- elisabetta.calistri@iov.veneto.it
- Site Name
- Azienda Ospedaliera Ordine Mauriziano Di Torino
- Department Name
- SCDU Ematologia
- Principal Investigator Name
- Daniela Cilloni
- Principal Investigator Email
- daniela.cilloni@unito.it
- Contact Person Name
- Daniela Cilloni
- Contact Person Email
- daniela.cilloni@unito.it
- Site Name
- Azienda Ospedaliero Universitaria Delle Marche
- Department Name
- SOD Clinica Ematologica
- Principal Investigator Name
- Erika Morsi
- Principal Investigator Email
- erika.morsia@ospedaliriuniti.marche.it
- Contact Person Name
- Erika Morsi
- Contact Person Email
- erika.morsia@ospedaliriuniti.marche.it
- Site Name
- Other Italy site (entry present in record)
- Site Name
- Other Italy site (entry present in record)
Netherlands
- Earliest CTIS Part Ii Submission Date
- 20-03-2024
- Latest Decision Or Authorization Date
- 12-05-2026
- Processing Time Days
- 783
- Number Of Sites
- 3
- Number Of Participants
- 12
Sites
- Site Name
- Albert Schweitzer Ziekenhuis
- Department Name
- Hematology
- Principal Investigator Name
- Peter Westerweel
- Principal Investigator Email
- p.e.westerweel@asz.nl
- Contact Person Name
- Peter Westerweel
- Contact Person Email
- p.e.westerweel@asz.nl
- Site Name
- Stichting Martini Ziekenhuis
- Department Name
- Internal medicine
- Principal Investigator Name
- Coty Bruggeman
- Principal Investigator Email
- coty.bruggeman@mzh.nl
- Contact Person Name
- Coty Bruggeman
- Contact Person Email
- coty.bruggeman@mzh.nl
- Site Name
- Universitair Medisch Centrum Groningen
- Department Name
- Hematology
- Principal Investigator Name
- Emanuele Ammatuna
- Principal Investigator Email
- e.ammatuna@umcg.nl
- Contact Person Name
- Emanuele Ammatuna
- Contact Person Email
- e.ammatuna@umcg.nl
Germany
- Earliest CTIS Part Ii Submission Date
- 06-03-2024
- Latest Decision Or Authorization Date
- 12-05-2026
- Processing Time Days
- 797
- Number Of Sites
- 3
- Number Of Participants
- 12
Sites
- Site Name
- Universitaetsklinikum Aachen AöR
- Department Name
- Klinik für Hämatologie, Onkologie, Hämostaseologie und Stammzelltransplantation
- Principal Investigator Name
- Steffen Koschmieder
- Principal Investigator Email
- skoschmieder@ukaachen.de
- Contact Person Name
- Steffen Koschmieder
- Contact Person Email
- skoschmieder@ukaachen.de
- Site Name
- Martin-Luther-Universitaet Halle-Wittenberg
- Department Name
- Universitätsklinik und Poliklinik für Innere Medizin IV
- Principal Investigator Name
- Haifa Al-Ali
- Principal Investigator Email
- dekanin@medizin.uni-halle.de
- Contact Person Name
- Haifa Al-Ali
- Contact Person Email
- dekanin@medizin.uni-halle.de
- Site Name
- Technische Universitat Dresden
- Department Name
- Medizinische Klinik und Poliklinik I
- Principal Investigator Name
- Katja Sockel
- Principal Investigator Email
- Katja.Sockel@ukdd.de
- Contact Person Name
- Katja Sockel
- Contact Person Email
- Katja.Sockel@ukdd.de
Sweden
- Earliest CTIS Part Ii Submission Date
- 27-02-2024
- Latest Decision Or Authorization Date
- 12-05-2026
- Processing Time Days
- 805
- Number Of Sites
- 2
- Number Of Participants
- 6
Sites
- Site Name
- Region Oerebro Laen
- Department Name
- Sektionen för hematologi
- Principal Investigator Name
- Erik Ahlstrand
- Principal Investigator Email
- erik.ahlstrand@regionorebrolan.se
- Contact Person Name
- Erik Ahlstrand
- Contact Person Email
- erik.ahlstrand@regionorebrolan.se
- Site Name
- Karolinska University Hospital
- Department Name
- ME Hematologi
- Principal Investigator Name
- Anna Ravn Landtblom
- Principal Investigator Email
- anna.ravn-landtblom@regionstockholm.se
- Contact Person Name
- Anna Ravn Landtblom
- Contact Person Email
- anna.ravn-landtblom@regionstockholm.se
Hungary
- Earliest CTIS Part Ii Submission Date
- 15-03-2024
- Latest Decision Or Authorization Date
- 15-05-2026
- Processing Time Days
- 791
- Number Of Sites
- 4
- Number Of Participants
- 12
Sites
- Site Name
- Semmelweis University
- Department Name
- Belgyógyászati és Hematológiai Klinika
- Principal Investigator Name
- Zsolt Nagy
- Principal Investigator Email
- nagy.zsolt@med.semmelweis-univ.hu
- Contact Person Name
- Zsolt Nagy
- Contact Person Email
- nagy.zsolt@med.semmelweis-univ.hu
- Site Name
- Szabolcs-Szatmar-Bereg Varmegyei Oktatokorhaz
- Department Name
- Haematológiai osztály
- Principal Investigator Name
- László Szerafin
- Principal Investigator Email
- szerafin@josa.hu
- Contact Person Name
- László Szerafin
- Contact Person Email
- szerafin@josa.hu
- Site Name
- University Of Debrecen
- Department Name
- Belgyógyászati Klinika
- Principal Investigator Name
- Árpád Illés
- Principal Investigator Email
- illes.arpad@med.unideb.hu
- Contact Person Name
- Árpád Illés
- Contact Person Email
- illes.arpad@med.unideb.hu
- Site Name
- Gyor-Moson-Sopron Varmegyei Petz Aladar Egyetemi Oktato Korhaz
- Department Name
- II. Belgyógyászat - Haematológia
- Principal Investigator Name
- Zsolt Lázár
- Principal Investigator Email
- lazarzsolt@petz.gyor.hu
- Contact Person Name
- Zsolt Lázár
- Contact Person Email
- lazarzsolt@petz.gyor.hu
Poland
- Earliest CTIS Part Ii Submission Date
- 15-03-2024
- Latest Decision Or Authorization Date
- 15-05-2026
- Processing Time Days
- 791
- Number Of Sites
- 1
- Number Of Participants
- 6
Sites
- Site Name
- Pratia Hematologia Sp. z o.o.
- Principal Investigator Name
- Sebastian Grosicki
- Principal Investigator Email
- anna.jakubiec@pratia.com
- Contact Person Name
- Sebastian Grosicki
- Contact Person Email
- anna.jakubiec@pratia.com
Portugal
- Earliest CTIS Part Ii Submission Date
- 28-02-2024
- Latest Decision Or Authorization Date
- 14-05-2026
- Processing Time Days
- 806
- Number Of Sites
- 3
- Number Of Participants
- 9
Sites
- Site Name
- Unidade Local De Saude De Lisboa Ocidental E.P.E.
- Department Name
- Hematology Service
- Principal Investigator Name
- Celina Afonso
- Principal Investigator Email
- ensaiosclinicos@chlo.min-saude.pt
- Contact Person Name
- Celina Afonso
- Contact Person Email
- ensaiosclinicos@chlo.min-saude.pt
- Site Name
- Instituto Portugues De Oncologia Do Porto Francisco Gentil E.P.E.
- Department Name
- Hematology and bone marrow transplantation service
- Principal Investigator Name
- Jose Mario Mariz
- Principal Investigator Email
- Clinicalstudies@ipoporto.min-saude.pt
- Contact Person Name
- Jose Mario Mariz
- Contact Person Email
- Clinicalstudies@ipoporto.min-saude.pt
- Site Name
- CCAB Centro Clinico Academico Braga Associacao
- Department Name
- Oncology Service
- Principal Investigator Name
- Claudia Moreira
- Principal Investigator Email
- claudia.p.moreira@hb.min-saude.pt
- Contact Person Name
- Claudia Moreira
- Contact Person Email
- claudia.p.moreira@hb.min-saude.pt
Spain
- Earliest CTIS Part Ii Submission Date
- 20-03-2024
- Latest Decision Or Authorization Date
- 13-05-2026
- Processing Time Days
- 784
- Number Of Sites
- 13
- Number Of Participants
- 38
Sites
- Site Name
- Hospital Clinic De Barcelona
- Department Name
- Servicio de hematología
- Principal Investigator Name
- Alberto Alvarez Larran
- Principal Investigator Email
- aalvar@clinic.cat
- Contact Person Name
- Alberto Alvarez Larran
- Contact Person Email
- aalvar@clinic.cat
- Site Name
- Institut Catala D'oncologia (Badalona)
- Department Name
- Servicio de hematología
- Principal Investigator Name
- Blanca Xicoy Cirici
- Principal Investigator Email
- uicico_badalona@iconcologia.net
- Contact Person Name
- Blanca Xicoy Cirici
- Contact Person Email
- uicico_badalona@iconcologia.net
- Site Name
- Hospital General Universitario De Albacete
- Department Name
- Servicio de hematología
- Principal Investigator Name
- Alberto Marín Sanchez
- Principal Investigator Email
- pibems@hotmail.com
- Contact Person Name
- Alberto Marín Sanchez
- Contact Person Email
- pibems@hotmail.com
- Site Name
- Hospital Universitario 12 De Octubre
- Department Name
- Servicio de hematología y hemoterapia
- Principal Investigator Name
- Gonzalo Carreño Gómez-Tarragona
- Principal Investigator Email
- gonzalo.carreno@salud.madrid.org
- Contact Person Name
- Gonzalo Carreño Gómez-Tarragona
- Contact Person Email
- gonzalo.carreno@salud.madrid.org
- Site Name
- Hospital Del Mar
- Department Name
- Hematology
- Principal Investigator Name
- Maria Alicia Senin Magan
- Principal Investigator Email
- msenin@psmar.cat
- Contact Person Name
- Maria Alicia Senin Magan
- Contact Person Email
- msenin@psmar.cat
- Site Name
- Complexo Hospitalario Universitario De Santiago
- Department Name
- Servicio de hematología
- Principal Investigator Name
- Manuel Mateo Pérez Encinas
- Principal Investigator Email
- Manuel.Mateo.Perez.Encinas@sergas.es
- Contact Person Name
- Manuel Mateo Pérez Encinas
- Contact Person Email
- Manuel.Mateo.Perez.Encinas@sergas.es
- Site Name
- Institut Catala D'oncologia (L'hospitalet De Llobregat)
- Department Name
- Servicio de hematología
- Principal Investigator Name
- Carolina Maria Martinez Gomez
- Principal Investigator Email
- carolinamariamartinez@iconcologia.net
- Contact Person Name
- Carolina Maria Martinez Gomez
- Contact Person Email
- carolinamariamartinez@iconcologia.net
- Site Name
- Hospital Universitari Vall D Hebron
- Department Name
- Servicio de hematología
- Principal Investigator Name
- Maria Laura Fox
- Principal Investigator Email
- laura.fox@vallhebron.cat
- Contact Person Name
- Maria Laura Fox
- Contact Person Email
- laura.fox@vallhebron.cat
- Site Name
- Hospital Universitario Virgen De La Victoria
- Department Name
- Servicio de hematología
- Principal Investigator Name
- Regina García Delgado
- Principal Investigator Email
- reginagarciadel@yahoo.es
- Contact Person Name
- Regina García Delgado
- Contact Person Email
- reginagarciadel@yahoo.es
- Site Name
- Hospital Universitario De Salamanca
- Department Name
- Servicio de hematología
- Principal Investigator Name
- Jesus Maria Hernandez Rivas
- Principal Investigator Email
- jmhr@usal.es
- Contact Person Name
- Jesus Maria Hernandez Rivas
- Contact Person Email
- jmhr@usal.es
- Site Name
- Hospital Universitario Dr Peset Aleixandre
- Department Name
- Servicio de hematología
- Principal Investigator Name
- Maria Jose Fernandez Llavador
- Principal Investigator Email
- fernandez_mjolla@gva.es
- Contact Person Name
- Maria Jose Fernandez Llavador
- Contact Person Email
- fernandez_mjolla@gva.es
- Site Name
- Hospital Costa Del Sol
- Department Name
- Servicio de hematología
- Principal Investigator Name
- María Isabel Mata Vázquez
- Principal Investigator Email
- Maribelmata500@gmail.com
- Contact Person Name
- María Isabel Mata Vázquez
- Contact Person Email
- Maribelmata500@gmail.com
- Site Name
- Hospital Universitario Ramon Y Cajal
- Department Name
- Servicio de hematología
- Principal Investigator Name
- José Valentín García Gutierrez
- Principal Investigator Email
- jvalentin.garcia@salud.madrid.org
- Contact Person Name
- José Valentín García Gutierrez
- Contact Person Email
- jvalentin.garcia@salud.madrid.org
Belgium
- Earliest CTIS Part Ii Submission Date
- 27-02-2024
- Latest Decision Or Authorization Date
- 12-05-2026
- Processing Time Days
- 805
- Number Of Sites
- 1
- Number Of Participants
- 3
Sites
- Site Name
- Ziekenhuis Aan De Stroom
- Department Name
- Haematology
- Principal Investigator Name
- Nikki Granacher
- Principal Investigator Email
- nikki.granacher@zna.be
- Contact Person Name
- Nikki Granacher
- Contact Person Email
- nikki.granacher@zna.be
Sponsor
Primary sponsor
- Full Name
- Merck Sharp & Dohme LLC
- Organisation Type
- Pharmaceutical company
- Country Of Registered Address
- United States
Contract research organisations
- Name
- Perceptive Eclinical Limited
- Responsibilities
- EUB Call center and medical escalation service
- Name
- Parexel International Corp.
- Responsibilities
- Medical information (Physician Consulting)
- Name
- Signant Health Global Solutions Limited
- Responsibilities
- Electronic PRO/eCOA and related services (sponsor duties codes listed)
- Name
- AG Mednet Inc.
- Responsibilities
- Support services (sponsor duties code 13)
- Name
- Hematogenix Laboratory Services LLC
- Responsibilities
- Laboratory/testing services (sponsor duties code 4)
Third parties
- {"country":"United States","full_name":"Hematogenix Laboratory Services LLC","duties_or_roles":"Sponsor duties codes: 4","organisation_type":"Laboratory/Research/Testing facility"}
- {"country":"Ireland","full_name":"Signant Health Global Solutions Limited","duties_or_roles":"Sponsor duties codes: 3","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"AG Mednet Inc.","duties_or_roles":"Sponsor duties codes: 13","organisation_type":"Pharmaceutical company"}
- {"country":"United Kingdom","full_name":"Perceptive Eclinical Limited","duties_or_roles":"EUB Call center and medical escalation service (sponsor duties code 15)","organisation_type":"Pharmaceutical company"}
- {"country":"Ireland","full_name":"Signant Health Global Solutions Limited (additional entry)","duties_or_roles":"Sponsor duties codes: 7","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Parexel International Corp.","duties_or_roles":"Medical information (Physician Consulting) (sponsor duties code 15)","organisation_type":"Pharmaceutical company"}
Investigational products
- Investigational Product Name
- MK-3543
- Active Substance
- BOMEDEMSTAT
- Modality
- Small molecule
- Routes Of Administration
- ORAL
- Route
- ORAL
- Authorisation Status
- No marketing authorisation number (marketingAuthNumber = '-')
- Maximum Dose
- 175 mg (max daily dose amount listed)
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