Clinical trial • Phase III • Oncology
BGB-16673 for Chronic lymphocytic leukemia | Small lymphocytic lymphoma
Phase III trial of BGB-16673 for Chronic lymphocytic leukemia | Small lymphocytic lymphoma.
Overview
- Trial Therapeutic Area
- Oncology
- Trial Disease
- Chronic lymphocytic leukemia | Small lymphocytic lymphoma
- Trial Stage
- Phase III
- Drug Modality
- Small molecule
Key dates
- Initial CTIS Submission Date
- 24-07-2025
- First CTIS Authorization Date
- 18-11-2025
Trial design
Randomised, open-label, jaypirca (pirtobrutinib) 100 mg film-coated tablets (comparator). dosing/schedule not specified in the available record.-controlled Phase III trial in Austria, Belgium, France and others.
- Randomised
- Yes
- Open Label
- Yes
- Comparator
- Jaypirca (pirtobrutinib) 100 mg film-coated tablets (comparator). Dosing/schedule not specified in the available record.
- Target Sample Size
- 325
Eligibility
Recruits 325 Vulnerable population not selected; consent expected from adult participants. No assent/parental consent procedures are described in the available record..
- Vulnerable Population
- Vulnerable population not selected; consent expected from adult participants. No assent/parental consent procedures are described in the available record.
Inclusion criteria
- {"criterion_text":"- Confirmed diagnosis of CLL or SLL, requiring treatment, based on 2018 iwCLL criteria.\n- Previously received treatment for CLL/SLL with a covalent Bruton tyrosine kinase inhibitor (cBTKi). Patients should have disease relapsed after or refractory to at least 1 line of therapy including a cBTKi.\n- Patients with SLL must have measurable disease by computed tomography/magnetic resonance imaging, defined as ≥ 1 lymph node > 1.5 cm in longest diameter and measurable in 2 perpendicular diameters."}
Exclusion criteria
- {"criterion_text":"- Known prolymphocytic leukemia or history of, or currently suspected, Richter’s transformation.\n- Current or history of central nervous system involvement including the brain, spinal cord, leptomeninges, and cerebrospinal fluid (as documented by imaging, cytology, or biopsy) by CLL/SLL.\n- History of ischemic stroke or intracranial hemorrhage within 6 months before first dose of study drug.\n- Prior exposure to any Bruton tyrosine kinase (BTK) protein degraders or non covalent BTKi (ncBTKi). Patients who discontinue cBTKi due solely to toxicity are not eligible\n- History of known bleeding disorder such as hemophilia A, hemophilia B, von Willebrand disease, or history of spontaneous bleeding requiring blood transfusion or other medical intervention."}
Endpoints
Primary endpoints
- {"endpoint_text":"- PFS, defined as time from the date of randomization to the date of first disease progression or death, whichever occurs first, as determined by IRC using modified 2018 International Workshop on Chronic Lymphocytic Leukemia (iwCLL) criteria for patients with chronic lymphocytic leukemia (CLL) and Lugano classification for patients with small lymphocytic lymphoma (SLL)","definition_or_measurement_approach":"Defined as time from date of randomization to first disease progression or death, whichever occurs first, determined by Independent Review Committee (IRC) using modified 2018 iwCLL criteria for CLL and Lugano classification for SLL."}
Secondary endpoints
- {"endpoint_text":"- OS, defined as time from the date of randomization to the date of death due to any cause","definition_or_measurement_approach":"Defined as time from date of randomization to date of death due to any cause."}
- {"endpoint_text":"- PFS determined by investigator assessment","definition_or_measurement_approach":"Progression-free survival as determined by investigator assessment."}
- {"endpoint_text":"- Overall response rate (partial response [PR] or better) determined by IRC and by investigator assessment, per modified 2018 iwCLL criteria for patients with CLL and Lugano classification for patients with SLL","definition_or_measurement_approach":"Overall response rate (PR or better) assessed by Independent Review Committee and investigator per modified 2018 iwCLL criteria for CLL and Lugano classification for SLL."}
- {"endpoint_text":"- Rate of PR with lymphocytosis or higher determined by IRC and by investigator assessment","definition_or_measurement_approach":"Rate of partial response (with lymphocytosis or higher) as determined by IRC and investigator assessment."}
- {"endpoint_text":"- Duration of response determined by IRC and by investigator assessment","definition_or_measurement_approach":"Duration of response assessed by IRC and investigator."}
- {"endpoint_text":"- Time to next anti-CLL/SLL treatment (TTNT)","definition_or_measurement_approach":"Time from randomization to start of next anti-CLL/SLL treatment."}
- {"endpoint_text":"- Incidence and severity of treatment-emergent adverse events (TEAEs), serious TEAEs, and laboratory abnormalities graded according to National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE) v5.0","definition_or_measurement_approach":"Incidence and severity of TEAEs, serious TEAEs and lab abnormalities graded per NCI-CTCAE v5.0."}
- {"endpoint_text":"- Patient-reported symptoms of global health status (GHS), role functioning, and physical functioning, symptom burden and physical condition/fatigue measured by European Organization for Research and Treatment of Cancer (EORTC) quality of life questionnaire IL409 (an itemized version of EORTC quality of life questionnaire core 30 [QLQ-C30] and its CLL module CLL17)","definition_or_measurement_approach":"Patient-reported outcomes measured by EORTC IL409 (itemized QLQ-C30 and CLL17 module) assessing global health status, role and physical functioning, symptom burden and fatigue."}
Recruitment
- Planned Sample Size
- 325
- Recruitment Window Months
- 35
- Consent Approach
- Informed consent to be obtained from participants (adult participants). Subject information and informed consent forms available in multiple languages (examples in the record include English, French, German, Dutch, Italian, Spanish, Polish, Romanian, Swedish). No participant assent or parental consent procedures are described in the available record.
Geography
- Total Number Of Sites
- 63
- Total Number Of Participants
- 196
Austria
- Earliest CTIS Part Ii Submission Date
- 08-09-2025
- Latest Decision Or Authorization Date
- 13-05-2026
- Processing Time Days
- 247
- Number Of Sites
- 5
- Number Of Participants
- 17
Sites
- Site Name
- Noe LGA Gesundheit Region Mitte GmbH
- Department Name
- Internal Medicine I
- Principal Investigator Name
- Petra Pichler-Izmir
- Principal Investigator Email
- petra.pichler-izmir@stpoelten.lknoe.at
- Contact Person Name
- Petra Pichler-Izmir
- Contact Person Email
- petra.pichler-izmir@stpoelten.lknoe.at
- Site Name
- Medical University Of Graz
- Department Name
- Clinical Department for Hematology
- Principal Investigator Name
- Annkristin Heine
- Principal Investigator Email
- annkristin.heine@medunigraz.at
- Contact Person Name
- Annkristin Heine
- Contact Person Email
- annkristin.heine@medunigraz.at
- Site Name
- SCRI CCCIT Ges.m.b.H.
- Department Name
- IIIrd Medical Department
- Principal Investigator Name
- Alexander Egle
- Principal Investigator Email
- a.egle@salk.at
- Contact Person Name
- Alexander Egle
- Contact Person Email
- a.egle@salk.at
- Site Name
- Ordensklinikum Linz GmbH
- Department Name
- Internal Department I
- Principal Investigator Name
- Thomas Bauer
- Principal Investigator Email
- thomas.bauer@ordensklinikum.at
- Contact Person Name
- Thomas Bauer
- Contact Person Email
- thomas.bauer@ordensklinikum.at
- Site Name
- Medizinische Universitaet Innsbruck
- Department Name
- Internal Medicine V, Hematology and Oncology
- Principal Investigator Name
- Jan-Paul Bohn
- Principal Investigator Email
- jan-paul.bohn@i-med.ac.at
- Contact Person Name
- Jan-Paul Bohn
- Contact Person Email
- jan-paul.bohn@i-med.ac.at
Belgium
- Earliest CTIS Part Ii Submission Date
- 13-10-2025
- Latest Decision Or Authorization Date
- 20-11-2025
- Processing Time Days
- 38
- Number Of Sites
- 7
- Number Of Participants
- 16
Sites
- Site Name
- Emmaues
- Department Name
- Hematology
- Principal Investigator Name
- Toine Mercier
- Principal Investigator Email
- toine.mercier@emmaus.be
- Contact Person Name
- Toine Mercier
- Contact Person Email
- toine.mercier@emmaus.be
- Site Name
- AZ Groeninge
- Department Name
- Hematology
- Principal Investigator Name
- Koen Vaneygen
- Principal Investigator Email
- Koen.vaneygen@azgroeninge.be
- Contact Person Name
- Koen Vaneygen
- Contact Person Email
- Koen.vaneygen@azgroeninge.be
- Site Name
- CHC MontLegia
- Department Name
- Hematology
- Principal Investigator Name
- Renaud Roufosse
- Principal Investigator Email
- Renaud.roufosse@chc.be
- Contact Person Name
- Renaud Roufosse
- Contact Person Email
- Renaud.roufosse@chc.be
- Site Name
- Centre Hospitalier Universitaire Dinant Godinne Sainte-Elisabeth-UCL-Namur
- Department Name
- Hematology
- Principal Investigator Name
- Helene Vellemans
- Principal Investigator Email
- helene.vellemans@chuuclnamur.uclouvain.be
- Contact Person Name
- Helene Vellemans
- Contact Person Email
- helene.vellemans@chuuclnamur.uclouvain.be
- Site Name
- UZ GENT
- Department Name
- Hematology
- Principal Investigator Name
- Willem Daneels
- Principal Investigator Email
- Willem.Daneels@uzgent.be
- Contact Person Name
- Willem Daneels
- Contact Person Email
- Willem.Daneels@uzgent.be
- Site Name
- Centre hospitalier universitaire de Liege
- Department Name
- Hematology
- Principal Investigator Name
- Aurelie Jaspers
- Principal Investigator Email
- aurelie.jaspers@chuliege.be
- Contact Person Name
- Aurelie Jaspers
- Contact Person Email
- aurelie.jaspers@chuliege.be
- Site Name
- Institut Jules Bordet
- Department Name
- Hematology
- Principal Investigator Name
- Virginie Dewilde
- Principal Investigator Email
- Virginie.dewilde@hubruxelles.be
- Contact Person Name
- Virginie Dewilde
- Contact Person Email
- Virginie.dewilde@hubruxelles.be
France
- Earliest CTIS Part Ii Submission Date
- 14-10-2025
- Latest Decision Or Authorization Date
- 24-11-2025
- Processing Time Days
- 41
- Number Of Sites
- 8
- Number Of Participants
- 25
Sites
- Site Name
- CHRU De Nancy
- Department Name
- 54
- Principal Investigator Name
- Pierre FEUGIER
- Principal Investigator Email
- xxx@xxx.xx
- Contact Person Name
- Pierre FEUGIER
- Contact Person Email
- xxx@xxx.xx
- Site Name
- Centre Hospitalier Regional Universitaire De Tours
- Department Name
- 37
- Principal Investigator Name
- Caroline DARTIGEAS
- Principal Investigator Email
- xxx@xxx.xx
- Contact Person Name
- Caroline DARTIGEAS
- Contact Person Email
- xxx@xxx.xx
- Site Name
- University Hospital Of Clermont-Ferrand
- Department Name
- 63
- Principal Investigator Name
- Romain GUIEZE
- Principal Investigator Email
- xxx@xxx.xx
- Contact Person Name
- Romain GUIEZE
- Contact Person Email
- xxx@xxx.xx
- Site Name
- Centre Hospitalier Universitaire De Toulouse
- Department Name
- 31
- Principal Investigator Name
- Loïc YSEBAERT
- Principal Investigator Email
- xxx@xxx.xx
- Contact Person Name
- Loïc YSEBAERT
- Contact Person Email
- xxx@xxx.xx
- Site Name
- Centre Henri Becquerel
- Department Name
- 76
- Principal Investigator Name
- Stéphane LEPRETRE
- Principal Investigator Email
- xxx@xxx.xx
- Contact Person Name
- Stéphane LEPRETRE
- Contact Person Email
- xxx@xxx.xx
- Site Name
- Hopital Saint Louis
- Department Name
- 75
- Principal Investigator Name
- Catherine THIEBLEMONT
- Principal Investigator Email
- xxx@xxx.xx
- Contact Person Name
- Catherine THIEBLEMONT
- Contact Person Email
- xxx@xxx.xx
- Site Name
- Institut Bergonie
- Department Name
- 33
- Principal Investigator Name
- Fontanet BIJOU
- Principal Investigator Email
- xxx@xxx.xx
- Contact Person Name
- Fontanet BIJOU
- Contact Person Email
- xxx@xxx.xx
- Site Name
- Centre Hospitalier Universitaire De Nantes
- Department Name
- 44
- Principal Investigator Name
- Anne LOK
- Principal Investigator Email
- xxx@xxx.xx
- Contact Person Name
- Anne LOK
- Contact Person Email
- xxx@xxx.xx
Romania
- Earliest CTIS Part Ii Submission Date
- 07-08-2025
- Latest Decision Or Authorization Date
- 24-11-2025
- Processing Time Days
- 109
- Number Of Sites
- 4
- Number Of Participants
- 12
Sites
- Site Name
- Institutul Regional De Oncologie Iasi
- Department Name
- Hematology Clinic
- Principal Investigator Name
- Catalin Doru Danaila
- Principal Investigator Email
- XXX@yahoo.com
- Contact Person Name
- Catalin Doru Danaila
- Contact Person Email
- XXX@yahoo.com
- Site Name
- Institute Of Oncology Prof. Dr. Ion Chiricuta Cluj-Napoca
- Department Name
- Hematology Clinic
- Principal Investigator Name
- Ciprian Tomuleasa
- Principal Investigator Email
- XXX@gmail.com
- Contact Person Name
- Ciprian Tomuleasa
- Contact Person Email
- XXX@gmail.com
- Site Name
- Spitalul Clinic Coltea
- Department Name
- Hematology Clinic
- Principal Investigator Name
- Andrei Colita
- Principal Investigator Email
- XXX@yahoo.com
- Contact Person Name
- Andrei Colita
- Contact Person Email
- XXX@yahoo.com
- Site Name
- Ovidius Clinical Hospital S.R.L.
- Department Name
- Hematology Clinic
- Principal Investigator Name
- Andreea Daniela Caloian
- Principal Investigator Email
- XXX@yahoo.com
- Contact Person Name
- Andreea Daniela Caloian
- Contact Person Email
- XXX@yahoo.com
Spain
- Earliest CTIS Part Ii Submission Date
- 20-10-2025
- Latest Decision Or Authorization Date
- 21-11-2025
- Processing Time Days
- 32
- Number Of Sites
- 8
- Number Of Participants
- 15
Sites
- Site Name
- Hospital Universitario De Burgos
- Department Name
- Hematology and Hematherapy
- Principal Investigator Name
- Francisco Javier Díaz
- Principal Investigator Email
- fcdiaz@saludcastillayleon.es
- Contact Person Name
- Francisco Javier Díaz
- Contact Person Email
- fcdiaz@saludcastillayleon.es
- Site Name
- El Hospital Universitario De Gran Canaria Dr. Negrin
- Department Name
- Hematology
- Principal Investigator Name
- Alexia Suárez Cabrera
- Principal Investigator Email
- asuacab@gobiernodecanarias.org
- Contact Person Name
- Alexia Suárez Cabrera
- Contact Person Email
- asuacab@gobiernodecanarias.org
- Site Name
- Institut Catala D'oncologia
- Department Name
- Hematology
- Principal Investigator Name
- Marta Juliá Arenas
- Principal Investigator Email
- mjulia@iconcologia.net
- Contact Person Name
- Marta Juliá Arenas
- Contact Person Email
- mjulia@iconcologia.net
- Site Name
- University Hospital Virgen Del Rocio S.L.
- Department Name
- Hematology and Hematherapy
- Principal Investigator Name
- Guillermo Rodríguez García
- Principal Investigator Email
- XXX@xxxxx
- Contact Person Name
- Guillermo Rodríguez García
- Contact Person Email
- XXX@xxxxx
- Site Name
- University Hospital Son Espases
- Department Name
- Hematology
- Principal Investigator Name
- Antonio Gutiérrez
- Principal Investigator Email
- antoniom.gutierrez@ssib.es
- Contact Person Name
- Antonio Gutiérrez
- Contact Person Email
- antoniom.gutierrez@ssib.es
- Site Name
- University Hospital Puerta De Hierro De Majadahonda
- Department Name
- Hematology and Hematherapy
- Principal Investigator Name
- José Antonio García Vela
- Principal Investigator Email
- XXX@xxxxx
- Contact Person Name
- José Antonio García Vela
- Contact Person Email
- XXX@xxxxx
- Site Name
- Hospital Universitario Fundacion Jimenez Diaz
- Department Name
- Hematology
- Principal Investigator Name
- Sergio Ramos
- Principal Investigator Email
- sergio.ramos@quironsalud.com
- Contact Person Name
- Sergio Ramos
- Contact Person Email
- sergio.ramos@quironsalud.com
- Site Name
- Hospital Universitario De Sevilla (Virgen Del Rocio) [listed as University Hospital Virgen Del Rocio S.L.]
- Department Name
- Hematology and Hematherapy
- Principal Investigator Name
- Guillermo Rodríguez García
- Principal Investigator Email
- XXX@xxxxx
- Contact Person Name
- Guillermo Rodríguez García
- Contact Person Email
- XXX@xxxxx
Netherlands
- Earliest CTIS Part Ii Submission Date
- 14-10-2025
- Latest Decision Or Authorization Date
- 21-01-2026
- Processing Time Days
- 99
- Number Of Sites
- 7
- Number Of Participants
- 15
Sites
- Site Name
- Catharina Ziekenhuis Stichting
- Department Name
- Hemato-oncology
- Principal Investigator Name
- Marten Nijziel
- Principal Investigator Email
- marten.nijziel@catherinaziekenhuis.nl
- Contact Person Name
- Marten Nijziel
- Contact Person Email
- marten.nijziel@catherinaziekenhuis.nl
- Site Name
- Groene Hart Ziekenhuis
- Department Name
- Hematology
- Principal Investigator Name
- Henriëtte Levenga
- Principal Investigator Email
- henriette.levenga@ghz.nl
- Contact Person Name
- Henriëtte Levenga
- Contact Person Email
- henriette.levenga@ghz.nl
- Site Name
- Universitair Medisch Centrum Groningen
- Department Name
- Hematology
- Principal Investigator Name
- Mar Bellido
- Principal Investigator Email
- m.bellido@umcg.nl
- Contact Person Name
- Mar Bellido
- Contact Person Email
- m.bellido@umcg.nl
- Site Name
- Universitair Medisch Centrum Utrecht
- Department Name
- Hematology
- Principal Investigator Name
- Sanne de Haart
- Principal Investigator Email
- s.j.dehaart@umcutrecht.nl
- Contact Person Name
- Sanne de Haart
- Contact Person Email
- s.j.dehaart@umcutrecht.nl
- Site Name
- Canisius Wilhelmina Ziekenhuis
- Department Name
- Hematology
- Principal Investigator Name
- Susan de Jonge-Peeters
- Principal Investigator Email
- researchverpleegkundige-oncologie@cwz.nl
- Contact Person Name
- Susan de Jonge-Peeters
- Contact Person Email
- researchverpleegkundige-oncologie@cwz.nl
- Site Name
- Albert Schweitzer Ziekenhuis
- Department Name
- Hematology
- Principal Investigator Name
- Mark-David Levin
- Principal Investigator Email
- m-d.levin@asz.nl
- Contact Person Name
- Mark-David Levin
- Contact Person Email
- m-d.levin@asz.nl
- Site Name
- Canisius Wilhelmina Ziekenhuis (alternate listing)
- Department Name
- Hematology
- Principal Investigator Name
- Susan de Jonge-Peeters
- Principal Investigator Email
- researchverpleegkundige-oncologie@cwz.nl
- Contact Person Name
- Susan de Jonge-Peeters
- Contact Person Email
- researchverpleegkundige-oncologie@cwz.nl
Germany
- Earliest CTIS Part Ii Submission Date
- 14-10-2025
- Latest Decision Or Authorization Date
- 09-12-2025
- Processing Time Days
- 56
- Number Of Sites
- 9
- Number Of Participants
- 26
Sites
- Site Name
- Robert Bosch Gesellschaft fuer medizinische Forschung mbH
- Department Name
- Hämatologie, Onkologie und Palliativmedizin
- Principal Investigator Name
- Nicola Giesen
- Principal Investigator Email
- nicola.giesen@rbk.de
- Contact Person Name
- Nicola Giesen
- Contact Person Email
- nicola.giesen@rbk.de
- Site Name
- Katholisches Klinikum Bochum gGmbH
- Department Name
- Hämatologie und Onkologie
- Principal Investigator Name
- Julia von Tresckow
- Principal Investigator Email
- julia.vontresckow@klinikum-bochum.de
- Contact Person Name
- Julia von Tresckow
- Contact Person Email
- julia.vontresckow@klinikum-bochum.de
- Site Name
- Universitaetsklinikum Bonn AöR
- Department Name
- Medizinische Klinik III, Hämatologie und Onkologie
- Principal Investigator Name
- Ruth-Miriam Körber
- Principal Investigator Email
- ruth-miriam.koerber@ukbonn.de
- Contact Person Name
- Ruth-Miriam Körber
- Contact Person Email
- ruth-miriam.koerber@ukbonn.de
- Site Name
- Medizinische Studiengesellschaft Nord-West GmbH
- Principal Investigator Name
- Jan Janssen
- Principal Investigator Email
- gensch-janssen@t-online.de
- Contact Person Name
- Jan Janssen
- Contact Person Email
- gensch-janssen@t-online.de
- Site Name
- Lübecker Onkologische Schwerpunktpraxis
- Principal Investigator Name
- Jens Kisro
- Principal Investigator Email
- jens.kisro@t-online.de
- Contact Person Name
- Jens Kisro
- Contact Person Email
- jens.kisro@t-online.de
- Site Name
- Staedtisches Klinikum Karlsruhe gGmbH
- Department Name
- Medizinische Klinik III
- Principal Investigator Name
- Henriette Huber
- Principal Investigator Email
- henriette.huber@klinikum-karlsruhe.de
- Contact Person Name
- Henriette Huber
- Contact Person Email
- henriette.huber@klinikum-karlsruhe.de
- Site Name
- Universitaetsklinikum Ulm AöR
- Department Name
- Innere Medizin III
- Principal Investigator Name
- Eugen Tausch
- Principal Investigator Email
- eugen.tausch@uniklin-ulm.de
- Contact Person Name
- Eugen Tausch
- Contact Person Email
- eugen.tausch@uniklin-ulm.de
- Site Name
- GEFOS Gesellschaft fuer onkologische Studien Dortmund mbH
- Principal Investigator Name
- Sandra Ketzler-Henkel
- Principal Investigator Email
- ketzler@onkologie-dortmund.de
- Contact Person Name
- Sandra Ketzler-Henkel
- Contact Person Email
- ketzler@onkologie-dortmund.de
- Site Name
- University Hospital Cologne AöR
- Department Name
- Klinik I für Innere Medizin
- Principal Investigator Name
- Petra Langerbeins
- Principal Investigator Email
- petra.langerbeins@uk-koeln.de
- Contact Person Name
- Petra Langerbeins
- Contact Person Email
- petra.langerbeins@uk-koeln.de
Sweden
- Earliest CTIS Part Ii Submission Date
- 20-10-2025
- Latest Decision Or Authorization Date
- 13-05-2026
- Processing Time Days
- 205
- Number Of Sites
- 2
- Number Of Participants
- 7
Sites
- Site Name
- Sahlgrenska University Hospital-Vaestra Goetalandsregionen
- Department Name
- Hematology
- Principal Investigator Name
- Per-Ola Andersson
- Principal Investigator Email
- per-ola.andersson@vgregion.se
- Contact Person Name
- Per-Ola Andersson
- Contact Person Email
- per-ola.andersson@vgregion.se
- Site Name
- Karolinska University Hospital
- Department Name
- Hematology
- Principal Investigator Name
- Anders Österborg
- Principal Investigator Email
- anders.osterborg@regionstockholm.se
- Contact Person Name
- Anders Österborg
- Contact Person Email
- anders.osterborg@regionstockholm.se
Italy
- Earliest CTIS Part Ii Submission Date
- 02-10-2025
- Latest Decision Or Authorization Date
- 14-05-2026
- Processing Time Days
- 224
- Number Of Sites
- 4
- Number Of Participants
- 20
Sites
- Site Name
- ASST Grande Ospedale Metropolitano Niguarda
- Department Name
- CTU Ematologia
- Principal Investigator Name
- Marina Deodato
- Principal Investigator Email
- marina.deodato@ospedaleniguarda.it
- Contact Person Name
- Marina Deodato
- Contact Person Email
- marina.deodato@ospedaleniguarda.it
- Site Name
- Azienda Ospedaliero-Universitaria Di Bologna IRCCS
- Department Name
- U.O.C. di Ematologia - Pad. 8
- Principal Investigator Name
- Pierluigi Zinzani
- Principal Investigator Email
- pierluigi.zinzani@unibo.it
- Contact Person Name
- Pierluigi Zinzani
- Contact Person Email
- pierluigi.zinzani@unibo.it
- Site Name
- Ospedale San Raffaele S.r.l.
- Department Name
- Strategic Research Program on CLL Department
- Principal Investigator Name
- Paolo Prospero Ghia
- Principal Investigator Email
- ghia.paolo@hsr.it
- Contact Person Name
- Paolo Prospero Ghia
- Contact Person Email
- ghia.paolo@hsr.it
- Site Name
- Azienda Ospedaliera di Padova
- Department Name
- U.O.C. Ematologia
- Principal Investigator Name
- Andrea Visentin
- Principal Investigator Email
- andrea.visentin@aopd.veneto.it
- Contact Person Name
- Andrea Visentin
- Contact Person Email
- andrea.visentin@aopd.veneto.it
Poland
- Earliest CTIS Part Ii Submission Date
- 07-08-2025
- Latest Decision Or Authorization Date
- 15-05-2026
- Processing Time Days
- 281
- Number Of Sites
- 9
- Number Of Participants
- 43
Sites
- Site Name
- Wojewodzki Szpital Zespolony Im.L.Rydygiera W Toruniu
- Department Name
- Oddział Hematologii
- Principal Investigator Name
- Weronika PISZCZEK
- Principal Investigator Email
- x@x
- Contact Person Name
- Weronika PISZCZEK
- Contact Person Email
- x@x
- Site Name
- Narodowy Instytut Onkologii Im. Marii Sklodowskiej-Curie
- Department Name
- Klinika Nowotworów Układu Chłonnego
- Principal Investigator Name
- Ewa PASZKIEWICZ-KOZIK
- Principal Investigator Email
- x@x
- Contact Person Name
- Ewa PASZKIEWICZ-KOZIK
- Contact Person Email
- x@x
- Site Name
- Szpital Kliniczny Ministerstwa Spraw Wewnetrznych I Administracji Z Warminsko-Mazurskim Centrum Onkologii W Olsztynie
- Department Name
- Oddział Kliniczny Hematologii i Chorób Wewnętrznych z Ośrodkiem Transplantacji Szpiku
- Principal Investigator Name
- Janusz HAŁKA
- Principal Investigator Email
- x@x
- Contact Person Name
- Janusz HAŁKA
- Contact Person Email
- x@x
- Site Name
- Uniwersytecki Szpital Kliniczny Nr 1 W Lublinie
- Department Name
- Klinika Hematoonkologii i Transplantacji Szpiku
- Principal Investigator Name
- Waldemar TOMCZAK
- Principal Investigator Email
- x@x
- Contact Person Name
- Waldemar TOMCZAK
- Contact Person Email
- x@x
- Site Name
- Wojewodzkie Wielospecjalistyczne Centrum Onkologii I Traumatologii Im M.Kopernika W Lodzi
- Department Name
- Oddział Hematologii Ogólnej i Chorób Wewnętrznych
- Principal Investigator Name
- Tadeusz ROBAK
- Principal Investigator Email
- x@x
- Contact Person Name
- Tadeusz ROBAK
- Contact Person Email
- x@x
- Site Name
- Copernicus Podmiot Leczniczy Sp. z o.o.
- Department Name
- Wojewódzkie Centrum Onkologii, Oddział Onkologii Klinicznej/Chemioterapii
- Principal Investigator Name
- Hanna CIEPŁUCH
- Principal Investigator Email
- x@x
- Contact Person Name
- Hanna CIEPŁUCH
- Contact Person Email
- x@x
- Site Name
- Uniwersytecki Szpital Kliniczny Im. Jana Mikulicza-Radeckiego We Wroclawiu
- Department Name
- Klinika Hematologii, Terapii Komórkowych i Chorób Wewnętrznych
- Principal Investigator Name
- Tomasz WRÓBEL
- Principal Investigator Email
- x@x
- Contact Person Name
- Tomasz WRÓBEL
- Contact Person Email
- x@x
- Site Name
- Swietokrzyskie Centrum Onkologii Samodzielny Publiczny Zaklad Opieki Zdrowotnej W Kielcach
- Department Name
- Klinika Hematologii i Transplantacji Szpiku
- Principal Investigator Name
- Paweł STECKIEWICZ
- Principal Investigator Email
- badania.kliniczne@onkol.kielce.pl
- Contact Person Name
- Paweł STECKIEWICZ
- Contact Person Email
- badania.kliniczne@onkol.kielce.pl
Sponsor
Primary sponsor
- Full Name
- BeOne Medicines AG
- Organisation Type
- Pharmaceutical company
- Country Of Registered Address
- Switzerland
Contract research organisations
- Name
- PPD Development LP
- Responsibilities
- PK sample storage for Germany; PK sample testing for Germany
- Name
- 4g Clinical LLC
- Responsibilities
- code:3
- Name
- Clinchoice Inc.
- Responsibilities
- code:6
- Name
- Medidata Solutions Inc.
- Responsibilities
- code:7
- Name
- Perceptive Informatics Inc.
- Responsibilities
- code:13
Third parties
- {"country":"United States","full_name":"Predicine Inc.","duties_or_roles":"code:4","organisation_type":"Hospital/Clinic/Other health care facility"}
- {"country":"United States","full_name":"Clinchoice Inc.","duties_or_roles":"code:6","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Medidata Solutions Inc.","duties_or_roles":"code:7","organisation_type":"Non-Pharmaceutical company"}
- {"country":"United States","full_name":"Adaptive Biotechnologies Corp.","duties_or_roles":"code:15; value: MRD testing; code:4","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"4g Clinical LLC","duties_or_roles":"code:3","organisation_type":"Non-Pharmaceutical company"}
- {"country":"United States","full_name":"Beone Medicines USA Inc.","duties_or_roles":"code:15; value: Biomarker Sample storage","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Perceptive Informatics Inc.","duties_or_roles":"code:13","organisation_type":"Pharmaceutical company"}
- {"country":"Germany","full_name":"University Hospital Cologne AöR","duties_or_roles":"code:4","organisation_type":"Hospital/Clinic/Other health care facility"}
- {"country":"United States","full_name":"Laboratory Corporation Of America Holdings","duties_or_roles":"code:4","organisation_type":"Laboratory/Research/Testing facility"}
- {"country":"United States","full_name":"PPD Development LP","duties_or_roles":"code:15; value: PK sample storage for Germany","organisation_type":"Pharmaceutical company"}
- {"country":"Switzerland","full_name":"Labcorp Central Laboratory Services SARL","duties_or_roles":"code:4","organisation_type":"Pharmaceutical company"}
- {"country":"United Kingdom","full_name":"Iqvia Laboratories Limited","duties_or_roles":"code:15; value: Potential lab for pharmacodynamic testing","organisation_type":"Non-Pharmaceutical company"}
- {"country":"United States","full_name":"Burning Rock Dx LLC","duties_or_roles":"code:14","organisation_type":"Pharmaceutical company"}
- {"country":"Germany","full_name":"Fisher Clinical Services GmbH","duties_or_roles":"code:14","organisation_type":"Pharmaceutical company"}
- {"country":"Germany","full_name":"Universitaetsklinikum Ulm AöR","duties_or_roles":"code:4","organisation_type":"Hospital/Clinic/Other health care facility"}
- {"country":"China","full_name":"Wuxi Apptec Co. Ltd.","duties_or_roles":"code:4","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Burning Rock Dx LLC (alternate entry)","duties_or_roles":"code:15; value: Biomarker sample storage","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Medable Inc.","duties_or_roles":"code:7","organisation_type":"Non-Pharmaceutical company"}
- {"country":"United States","full_name":"PPD Development LP (alternate entry)","duties_or_roles":"code:15; value: PK sample testing for Germany","organisation_type":"Pharmaceutical company"}
Investigational products
- Investigational Product Name
- BGB-16673
- Active Substance
- BGB-16673
- Modality
- Small molecule
- Routes Of Administration
- ORAL USE
- Route
- ORAL
- Authorisation Status
- Investigational (not marketed for this indication in record)
- Maximum Dose
- 200 mg (maxDailyDoseAmount reported)
- Investigational Product Name
- Jaypirca 100 mg film-coated tablets
- Active Substance
- PIRTOBRUTINIB
- Modality
- Small molecule
- Routes Of Administration
- ORAL USE
- Route
- ORAL
- Authorisation Status
- Authorised (marketing authorisation EU/1/23/1738/006 reported)
- Starting Dose
- 100 mg
- Maximum Dose
- 200 mg (maxDailyDoseAmount reported)
Related trials
Other published trials that may interest you.
- PIRTOBRUTINIB for Chronic lymphocytic leukemia | Small lymphocytic lymphoma
- BGB-16673 for Chronic lymphocytic leukemia | Small lymphocytic lymphoma
- RITUXIMAB for Chronic lymphocytic leukemia | Small lymphocytic lymphoma
- LISAFTOCLAX for Chronic lymphocytic leukemia | Small lymphocytic lymphoma
- LISAFTOCLAX for Chronic lymphocytic leukemia | Small lymphocytic lymphoma