Clinical trial • Phase III • Dermatology
ANIFROLUMAB for Cutaneous lupus erythematosus
Phase III trial of ANIFROLUMAB for Cutaneous lupus erythematosus.
Overview
- Trial Therapeutic Area
- Dermatology
- Trial Disease
- Cutaneous lupus erythematosus
- Trial Stage
- Phase III
- Drug Modality
- Monoclonal antibody
Key dates
- Initial CTIS Submission Date
- 29-04-2024
- First CTIS Authorization Date
- 27-08-2024
Trial design
Randomised, open-label, anifrolumab (investigational product) administered subcutaneously once weekly; matching placebo solution for injection in apfs (0.8 ml fill volume) administered subcutaneously once weekly during the double-blind period (day 1/week 0 to week 23); participants randomized 1:1. placebo recipients receive open-label anifrolumab from week 24 to week 51.-controlled Phase III trial in Austria, Bulgaria, Denmark and others.
- Randomised
- Yes
- Open Label
- Yes
- Comparator
- Anifrolumab (investigational product) administered subcutaneously once weekly; Matching placebo solution for injection in aPFS (0.8 mL fill volume) administered subcutaneously once weekly during the double-blind period (Day 1/Week 0 to Week 23); participants randomized 1:1. Placebo recipients receive open-label anifrolumab from Week 24 to Week 51.
- Target Sample Size
- 260
- Trial Duration For Participant
- 448
Eligibility
Recruits 260 Vulnerable population selected. Participants are adults (18–70 years) and informed consent is required via country-specific informed consent forms (multiple country ICFs provided). Multiple country-specific ICF documents and related patient information materials are listed (languages and country-specific ICFs available). No assent procedures for minors are described (minors excluded)..
- Vulnerable Population
- Vulnerable population selected. Participants are adults (18–70 years) and informed consent is required via country-specific informed consent forms (multiple country ICFs provided). Multiple country-specific ICF documents and related patient information materials are listed (languages and country-specific ICFs available). No assent procedures for minors are described (minors excluded).
Inclusion criteria
- {"criterion_text":"- Male and/or female participant must be 18 to 70 years of age inclusive, at the time of signing the ICF.\n- Participants must have a confirmed diagnosis of CLE. Diagnosis must be clinically and histologically confirmed with the following: •\tCLASI-A total score ≥ 10 points at Screening and confirmed at randomization. •\tInadequate response or intolerant to antimalarial therapy. -\tAt least one antimalarial agent used for at least 12 weeks (not continuous is acceptable) prior to Screening. Participants must be on a stable dose of antimalarial agent for at least 2 weeks prior to ICF signature. OR -\tPreviously documented discontinuation of antimalarial agents due to poor tolerability and/or side effects. In case an antimalarial treatment had not been initiated due to medical reasons (in particular the presence of medical contraindications), then at least one of the following medications for CLE must have been tried any time before Screening: •\tTopical calcineurin inhibitors, administered for ≥ 3 months. •\tSystemic glucocorticoids taken for ≥ 6 weeks. •\tA conventional immunosuppressant, including, azathioprine, mycophenolate mofetil (or mycophenolic acid), dapsone, or methotrexate administered for ≥ 3 months.\n- Participants should have no medical history or signs or symptoms of active or prior tuberculosis infection (TB) and the same should reflect in chest radiograph or a chest CT scan result. •\tNo history of latent TB prior to initial Screening Visit. •\tThe participant must undergo an IFN-γ release assay IGRA (e.g., QFT-G test) test for TB.\n- Contraceptive use by males and females should be consistent with local regulations regarding the methods of contraception for those participating in clinical studies.\n- Females who have been or are sexually active with an intact cervix must have documentation of a cervical cancer screening (Pap smear or HPV tests as per local guidelines) with a normal test result within 2 years prior to randomization."}
Exclusion criteria
- {"criterion_text":"- History or evidence of suicidal ideation.\n- Any severe case of herpes zoster infection prior to randomization.\n- Any clinical cytomegalovirus (CMV) or Epstein-Barr virus infection that has not been completely resolved.\n- Clinically significant chronic infection within 8 weeks prior to signing the ICF or any infection requiring hospitalization or treatment with IV anti-infectives not completed at least 4 weeks prior to signing the ICF.\n- COVID-19 infection: •\tHistory of severe COVID-19 infection and/or clinically significant unresolved complications due to COVID-19 infection. •\tAny COVID 19 infection within 2 weeks prior to Day 1.\n- Participants who do not meet the study restrictions for prior receipt of anifrolumab, using all biologics, directly acting cytotoxic B cell-depleting therapies (eg, rituximab), and any investigational product.\n- A known history of allergy or reaction to any component of the study intervention formulation or history of anaphylaxis to any human gamma globulin therapy.\n- Any history of an anaphylactic reaction to human proteins, or monoclonal antibodies.\n- At screening, if participants do not meet the eligibility criteria assessed based on laboratory test results e.g. tests for total bilirubin, serum creatinine etc.\n- Severe or life-threatening SLE.\n- Active SLE or Sjögren’s Syndrome.\n- Any active skin conditions other than CLE that may interfere with the study.\n- History of, or current diagnosis of, catastrophic APS within 1 year prior to signing the ICF.\n- History of recurrent infection requiring hospitalization and IV antibiotics.\n- Known history of primary immunodeficiency, splenectomy, or any underlying condition that makes the participant prone to infection, or a positive result for HIV infection at Screening.\n- Confirmed positive test for hepatitis B serology.\n- Presence of active hepatitis C infection."}
Endpoints
Primary endpoints
- {"endpoint_text":"- Number of participants with CLASI-70 response at Week 24.","definition_or_measurement_approach":""}
Secondary endpoints
- {"endpoint_text":"- Total CLASI A score, change from baseline at Week 24.","definition_or_measurement_approach":""}
- {"endpoint_text":"-\tNumber of participants with CLASI-70 response at Week 12. -\tParticipants with ≥ 7 point reduction from baseline in CLASI A total score (yes/no) at Week 12. -\tNumber of participants with CLASI 50 response at Week 12.","definition_or_measurement_approach":""}
- {"endpoint_text":"- Change from baseline at Week 24 in Skindex-29+3 domain scores.","definition_or_measurement_approach":""}
- {"endpoint_text":"-\tTime from IP start date to CLASI 70 response; -\tTime from IP start date to CLASI 50 response.","definition_or_measurement_approach":""}
- {"endpoint_text":"- Number of participants with CLASI 50 response at Week 24.","definition_or_measurement_approach":""}
- {"endpoint_text":"- Number of participants who are primary endpoint responders (CLASI-70 response at Week 24) and sustain CLASI-70 response up to and including Week 52.","definition_or_measurement_approach":""}
- {"endpoint_text":"-\tPharmacokinetic (PK) assessment (Ctrough) for subcutaneously administered anifrolumab in participants with CLE will be performed.","definition_or_measurement_approach":""}
- {"endpoint_text":"-\tPharmacodynamic (PD) assessment for subcutaneously administered anifrolumab in participants with CLE will be performed.","definition_or_measurement_approach":""}
- {"endpoint_text":"-\tThe immunogenicity of subcutaneously administered anifrolumab in participants with CLE will be evaluated.","definition_or_measurement_approach":""}
- {"endpoint_text":"- Number of participants with adverse events.","definition_or_measurement_approach":""}
Recruitment
- Digital Remote Recruitment
- Yes
- Planned Sample Size
- 260
- Recruitment Window Months
- 39
- Consent Approach
- Informed consent is obtained from adult participants (aged 18–70) via country-specific subject information sheets and informed consent forms (ICFs). Multiple country-language ICFs and related consent materials are provided (examples include English, French, German, Spanish, Italian, Dutch, Greek, Polish, Portuguese, Bulgarian, Slovak, Romanian, Danish). No assent for minors is described (minors excluded).
Methods
- Country-specific printed recruitment materials: recruitment brochures, recruitment posters, and patient letters (examples: Slovakia, Denmark, France, Bulgaria, Greece, Spain, Italy, Portugal, Romania, Poland, Austria, Germany, Netherlands).
- Country-specific recruitment procedure documents describing site-based recruitment workflows (e.g., 'Recruitment Procedure Description' and country procedure PDFs).
- Patient-facing digital materials and websites (country-specific recruitment websites and pre-login landing pages described in recruitment documents).
- Consent navigator and other online consent-support materials (country-specific Consent Navigator / Longboat Consent Navigator referenced in recruitment documents).
- Patient-facing flyers and clinical trial leaflets and study information letters (multiple languages/countries) intended for adults with the target condition (CLE).
Geography
- Total Number Of Sites
- 83
- Total Number Of Participants
- 344
Austria
- Earliest CTIS Part Ii Submission Date
- 30-07-2024
- Latest Decision Or Authorization Date
- 13-03-2026
- Processing Time Days
- 591
- Number Of Sites
- 4
- Number Of Participants
- 18
Sites
- Site Name
- Medizinische Universitaet Innsbruck
- Department Name
- #0402: Dermatologie und Venerologie
- Contact Person Name
- Barbara Boeckle
- Contact Person Email
- barbara.boeckle@i-med.ac.at
- Site Name
- Medical University Of Graz
- Department Name
- #0403: Universitätsklinik für Dermatologie und Venerologie
- Contact Person Name
- Wolfgang Salmhofer
- Contact Person Email
- wolfgang.salmhofer@medunigraz.at
- Site Name
- Ordensklinikum Linz GmbH
- Department Name
- #0401: Dermatologie
- Contact Person Name
- Konrad Lehner
- Contact Person Email
- konrad.lehner@ordensklinikum.at
- Site Name
- Klinik Hietzing
- Department Name
- #0405:Abteilung für Dermatologie
- Contact Person Name
- Christian Posch
- Contact Person Email
- Christian.Posch@gesundheitsverbund.at
Bulgaria
- Earliest CTIS Part Ii Submission Date
- 08-08-2024
- Latest Decision Or Authorization Date
- 22-12-2025
- Processing Time Days
- 501
- Number Of Sites
- 2
- Number Of Participants
- 12
Sites
- Site Name
- Diagnostic Consultation Center XX-Sofia EOOD
- Department Name
- #0904
- Contact Person Name
- Tomov Toma
- Contact Person Email
- dr.toma.tomov@abv.bg
- Site Name
- Dkc Fokus-5 Lzip OOD
- Department Name
- #0903
- Contact Person Name
- Grisha Mateev
- Contact Person Email
- grisha_mateev@yahoo.com
Denmark
- Earliest CTIS Part Ii Submission Date
- 09-08-2024
- Latest Decision Or Authorization Date
- 15-12-2025
- Processing Time Days
- 493
- Number Of Sites
- 2
- Number Of Participants
- 10
Sites
- Site Name
- Rigshospitalet
- Department Name
- 2002: Center for Rheumatology and Spine Diseases
- Contact Person Name
- Søren Jacobsen
- Contact Person Email
- soeren.jacobsen.01@regionh.dk
- Site Name
- Aarhus Universitetshospital
- Department Name
- #2001:Department of Dermatology
- Contact Person Name
- Stine Andersen
- Contact Person Email
- STNADE@rm.dk
France
- Earliest CTIS Part Ii Submission Date
- 26-07-2024
- Latest Decision Or Authorization Date
- 15-12-2025
- Processing Time Days
- 507
- Number Of Sites
- 12
- Number Of Participants
- 50
Sites
- Site Name
- Groupe Hospitalier Du Havre
- Department Name
- 2313:Medecine Interne
- Contact Person Name
- Vincent Langlois
- Contact Person Email
- vincent.langlois@ch-havre.fr
- Site Name
- Centre Hospitalier Universitaire Rouen
- Department Name
- #2309:
- Contact Person Name
- Anne-Bénédicte Duval Modeste
- Contact Person Email
- anne-benedicte.duval-modeste@chu-rouen.fr
- Site Name
- Centre Hospitalier Universitaire De Toulouse
- Department Name
- #2302: Dermatology
- Contact Person Name
- Cristina Livideanu
- Contact Person Email
- livideanu.c@chu-toulouse.fr
- Site Name
- Assistance Publique Hopitaux De Paris
- Department Name
- #2304:Dermatologie
- Contact Person Name
- Nicolas Dupin
- Contact Person Email
- nicolas.dupin@aphp.fr
- Site Name
- Hospital Edouard Herriot
- Department Name
- #2301: Dermatologie
- Contact Person Name
- Cécile LESORT
- Contact Person Email
- cecile.lesort@chu-lyon.fr
- Site Name
- Hopitaux Universitaires Pitie Salpetriere
- Department Name
- #2307: Médecine Interne
- Contact Person Name
- Zahir Amoura
- Contact Person Email
- zahir.amoura@aphp.fr
- Site Name
- Hospital Hotel Dieu
- Department Name
- #2312: Clinique dermatologique
- Contact Person Name
- Claire Bernier
- Contact Person Email
- claire.bernier@chu-nantes.fr
- Site Name
- Centre Hospitalier Universitaire De Poitiers
- Department Name
- #2308: Pôle Régional de Cancérologie
- Contact Person Name
- Damien Boutin
- Contact Person Email
- damien.boutin@chu-poitiers.fr
- Site Name
- Centre Hospitalier Universitaire De Dijon
- Department Name
- 2315:Dermatologie
- Contact Person Name
- Géraldine Jeudy
- Contact Person Email
- geraldine.jeudy@chu-dijon.fr
- Site Name
- Centre Hospitalier Universitaire De Bordeaux
- Department Name
- 2314:Dermatologie
- Contact Person Name
- Julien Seneschal
- Contact Person Email
- julien.seneschal@chu-bordeaux.fr
- Site Name
- Hopital Saint Louis
- Department Name
- #2306: Dermatologie
- Contact Person Name
- Jean-David Bouaziz
- Contact Person Email
- jean-david.bouaziz@aphp.fr
- Site Name
- Hopitaux Universitaires Pitie Salpetriere (additional listing)
- Department Name
- #2305: Dermatologie
- Contact Person Name
- François Chasset
- Contact Person Email
- francois.chasset@aphp.fr
Germany
- Earliest CTIS Part Ii Submission Date
- 26-07-2024
- Latest Decision Or Authorization Date
- 30-04-2026
- Processing Time Days
- 643
- Number Of Sites
- 12
- Number Of Participants
- 52
Sites
- Site Name
- Philipps-Universitaet Marburg
- Department Name
- #2613: Dermatologie & Allergologie
- Contact Person Name
- Julia Hinterseher
- Contact Person Email
- Julia.hinterseher@uk-gm.de
- Site Name
- St. Josef-Hospital
- Department Name
- #2606: Dermatology
- Contact Person Name
- Falk Bechara
- Contact Person Email
- falk.bechara@klinikum-bochum.de
- Site Name
- Technische Universitaet Dresden
- Department Name
- #2605: Klinik und Poliklinik für Dermatologie
- Contact Person Name
- Susanne Abraham
- Contact Person Email
- susanne.abraham@ukdd.de
- Site Name
- Charite Universitaetsmedizin Berlin KöR
- Department Name
- #2602: Klinik für Dermatologie, Venerologie und Allergologie, Allergologie und Immunologie
- Contact Person Name
- Margitta Worm
- Contact Person Email
- margitta.worm@charite.de
- Site Name
- Universitaetsklinikum Erlangen AöR
- Department Name
- #2611:Hautklinik
- Contact Person Name
- Michael Sticherling
- Contact Person Email
- michael.sticherling@uk-erlangen.de
- Site Name
- Medizinische Hochschule Hannover
- Department Name
- #2603: Klinik für Dermatologie, Allergologie und Venerologie
- Contact Person Name
- Matthias Schefzyk
- Contact Person Email
- schefzyk.matthias@mh-hannover.de
- Site Name
- Helios Universitaetsklinikum Wuppertal
- Department Name
- #2607: Zentrum für Dermatologie, Allergologie und Dermatochirurgie
- Contact Person Name
- Silke Hofmann
- Contact Person Email
- silke.hofmann@helios-gesundheit.de
- Site Name
- Universitaet Leipzig
- Department Name
- #2604: Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie
- Contact Person Name
- Jan-Christoph Simon
- Contact Person Email
- Jan-Christoph.Simon@medizin.uni-leipzig.de
- Site Name
- Universitaetsklinikum Essen AöR
- Department Name
- #2610: Hautklinik
- Contact Person Name
- Frederik Krefting
- Contact Person Email
- frederik.krefting@uk-essen.de
- Site Name
- Medical Center - University Of Freiburg
- Department Name
- 2614: Dermatology
- Contact Person Name
- Franziska Schauer
- Contact Person Email
- franziska.schauer@uniklinik-freiburg.de
- Site Name
- Universitaetsklinikum Regensburg AöR
- Department Name
- #2609: Klinik und Poliklinik für Dermatologie
- Contact Person Name
- Bernadett Kurz
- Contact Person Email
- bernadett.kurz@klinik.uni-regensburg.de
- Site Name
- Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz KöR
- Department Name
- #2601: Hautklinik/ Clinical Research Center
- Contact Person Name
- Miriam Wittmann
- Contact Person Email
- Miriam.Wittmann@unimedizin-mainz.de
Greece
- Earliest CTIS Part Ii Submission Date
- 23-07-2024
- Latest Decision Or Authorization Date
- 17-12-2025
- Processing Time Days
- 512
- Number Of Sites
- 4
- Number Of Participants
- 24
Sites
- Site Name
- Athens Medical Center S.A.
- Department Name
- #3005: Dermatology Department
- Contact Person Name
- Markos Papakonstantis
- Contact Person Email
- markospapakonstantis@gmail.com
- Site Name
- University General Hospital Attikon
- Department Name
- #3001:4th Department of Internal Medicine
- Contact Person Name
- Dimitrios Boumpas
- Contact Person Email
- boumpasd@med.uoc.gr
- Site Name
- Laiko General Hospital Of Athens
- Department Name
- #3002:1st Department of Propaedeutic Internal Medicine
- Contact Person Name
- Maria Tektonidou
- Contact Person Email
- mtektonidou@gmail.com
- Site Name
- Andreas Syngros Hospital Of Venereal And Dermatological Diseases
- Department Name
- #3003: Dermatology Department
- Contact Person Name
- Vassiliki Chasapi
- Contact Person Email
- chasapiresearch@gmail.com
Italy
- Earliest CTIS Part Ii Submission Date
- 22-07-2024
- Latest Decision Or Authorization Date
- 16-12-2025
- Processing Time Days
- 512
- Number Of Sites
- 9
- Number Of Participants
- 40
Sites
- Site Name
- Ospedale San Raffaele S.r.l.
- Department Name
- #4106:Unità Clinica di Immunologia, Reumatologia, Allergologia e Malattie Rare
- Contact Person Name
- Lorenzo Dagna
- Contact Person Email
- dagna.lorenzo@unisr.it
- Site Name
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
- Department Name
- #4107:UOC Dermatologia
- Contact Person Name
- Clara De Simone
- Contact Person Email
- clara.desimone@unicatt.it
- Site Name
- Azienda Socio Sanitaria Territoriale Degli Spedali Civili Di Brescia
- Department Name
- #4103:U.O. Dermatologia
- Contact Person Name
- Piergiacomo Calzavara Pinton
- Contact Person Email
- piergiacomo.calzavarapinton@unibs.it
- Site Name
- Azienda USL IRCCS Di Reggio Emilia
- Department Name
- 4109:Reumatologia
- Contact Person Name
- Carlo Salvarani
- Contact Person Email
- carlo.salvarani@ausl.re.it
- Site Name
- University Hospital Of Ferrara
- Department Name
- #4108:UOC Reumatologia
- Contact Person Name
- Marcello Govoni
- Contact Person Email
- gvl@unife.it
- Site Name
- Azienda Ospedaliera Universitaria Universita' Degli Studi Della Campania Luigi Vanvitelli
- Department Name
- #4105:UOC Reumatologia
- Contact Person Name
- Francesco Ciccia
- Contact Person Email
- francescociccia@tiscali.it
- Site Name
- I.F.O. Istituti Fisioterapici Ospitalieri
- Department Name
- #4102:UOSD Porfirie e Malattie Rare
- Contact Person Name
- MIRIAM TEOLI
- Contact Person Email
- miriam.teoli@ifo.it
- Site Name
- Azienda Ospedaliero Universitaria Delle Marche
- Department Name
- #4104:SOD Clinica di Dermatologia
- Contact Person Name
- Oriana Simonetti
- Contact Person Email
- oriana.simonetti@ospedaliriuniti.marche.it
- Site Name
- Azienda USL Toscana Centro
- Department Name
- #4101:SOS Dermatologia Speciale Medica
- Contact Person Name
- Emiliano Antiga
- Contact Person Email
- emiliano.antiga@unifi.it
Netherlands
- Earliest CTIS Part Ii Submission Date
- 09-08-2024
- Latest Decision Or Authorization Date
- 15-12-2025
- Processing Time Days
- 493
- Number Of Sites
- 3
- Number Of Participants
- 8
Sites
- Site Name
- Radboud universitair medisch centrum Stichting
- Department Name
- #5002:Dermatology
- Contact Person Name
- Elke De Jong
- Contact Person Email
- Elke.deJong@radboudumc.nl
- Site Name
- Amphia Hospital
- Department Name
- #5004:Dermatology
- Contact Person Name
- Sebastiaan Prens
- Contact Person Email
- BPrens@amphia.nl
- Site Name
- Erasmus Universitair Medisch Centrum Rotterdam (Erasmus MC)
- Department Name
- #5001:Dermatology
- Contact Person Name
- Hok Bing Thio
- Contact Person Email
- h.thio@erasmusmc.nl
Poland
- Earliest CTIS Part Ii Submission Date
- 25-07-2024
- Latest Decision Or Authorization Date
- 22-12-2025
- Processing Time Days
- 515
- Number Of Sites
- 9
- Number Of Participants
- 32
Sites
- Site Name
- Prywatny Gabinet Dermatologiczny Dr Elzbieta Klujszo
- Department Name
- #5709:Dermatology
- Contact Person Name
- Elzbieta Klujszo
- Contact Person Email
- klujszoe@gmail.com
- Site Name
- Gyncentrum Sp. z o.o.
- Department Name
- #5703: Dermatology
- Contact Person Name
- Marcin Zakrzewski
- Contact Person Email
- m.zakrzewski@gyncentrum.pl
- Site Name
- Panstwowy Instytut Medyczny Ministerstwa Spraw Wewnetrznych I Administracji
- Department Name
- #5702:Klinika Dermatologii
- Contact Person Name
- Irena Walecka-Herniczek
- Contact Person Email
- irena.walecka@cskmswia.gov.pl
- Site Name
- Narodowy Instytut Geriatrii Reumatologii I Rehabilitacji Im Prof. Dr Hab. Med. Eleonory Reicher
- Department Name
- #5707:Dermatology
- Contact Person Name
- Brygida Kwiatkowska
- Contact Person Email
- kwiatkowskabrygida@gmail.com
- Site Name
- Klinika Ambroziak Sp. z o.o.
- Department Name
- #5701:Dermatology
- Contact Person Name
- Bartłomiej Kwiek
- Contact Person Email
- principal@klinikaambroziak.pl
- Site Name
- Labderm Essence Sp. z o.o.
- Department Name
- #5706:Dermatology
- Contact Person Name
- Beata Bergler - Czop
- Contact Person Email
- bbergler-czop@sum.edu.pl
- Site Name
- Derm-Art
- Department Name
- #5708:Dermatology
- Contact Person Name
- Waldemar Placek
- Contact Person Email
- w.placek@wp.pl
- Site Name
- Miejski Szpital Zespolony W Olsztynie
- Department Name
- #5705:Klinika Dermatologii
- Contact Person Name
- Agnieszka Owczarczyk - Saczonek
- Contact Person Email
- aganek@wp.pl
- Site Name
- Uniwersytecki Szpital Kliniczny Im.Fryderyka Chopina W Rzeszowie
- Department Name
- 5710:Klinika Dermatologii
- Contact Person Name
- Adam Reich
- Contact Person Email
- adamandrzejreich@gmail.com
Portugal
- Earliest CTIS Part Ii Submission Date
- 20-03-2025
- Latest Decision Or Authorization Date
- 17-12-2025
- Processing Time Days
- 272
- Number Of Sites
- 4
- Number Of Participants
- 16
Sites
- Site Name
- CCAB Centro Clinico Academico Braga Associacao
- Department Name
- 5804: Dermatologia
- Contact Person Name
- Celeste Brito
- Contact Person Email
- celeste.brito@hb.min-saude.pt
- Site Name
- Unidade Local De Saude De Santo Antonio E.P.E.
- Department Name
- 5802:Dermatologia
- Contact Person Name
- Tiago Torres
- Contact Person Email
- Tiagotorres.dermatologia@chporto.min-saude.pt
- Site Name
- Unidade Local De Saude De Coimbra E.P.E.
- Department Name
- 5801: Dermatologia
- Contact Person Name
- Maria Margarida Martins Goncalo
- Contact Person Email
- 7200@chuc.min-saude.pt
- Site Name
- Unidade Local De Saude De Santa Maria E.P.E.
- Department Name
- 5803: Dermatologia
- Contact Person Name
- Joana Antunes
- Contact Person Email
- joana.antunes@chln.min-saude.pt
Romania
- Earliest CTIS Part Ii Submission Date
- 02-04-2025
- Latest Decision Or Authorization Date
- 19-12-2025
- Processing Time Days
- 261
- Number Of Sites
- 3
- Number Of Participants
- 20
Sites
- Site Name
- Spitalul Clinic Judetean Mures
- Department Name
- 6101: Dermatology
- Contact Person Name
- Silviu Morariu
- Contact Person Email
- silviu_morariu@yahoo.com
- Site Name
- Cabinet Medical Individual Lauderma
- Department Name
- 6104: Dermatology
- Contact Person Name
- Laura Gheuca-Solovastru
- Contact Person Email
- drmagdadinu@yahoo.com
- Site Name
- Spitalul Clinic Colentina Bucuresti
- Department Name
- 6105: Dermatology 2
- Contact Person Name
- Magdalena CONSTANTIN
- Contact Person Email
- drmagdadinu@yahoo.com
Slovakia
- Earliest CTIS Part Ii Submission Date
- 17-04-2025
- Latest Decision Or Authorization Date
- 15-12-2025
- Processing Time Days
- 242
- Number Of Sites
- 2
- Number Of Participants
- 8
Sites
- Site Name
- Narodny Ustav Reumatickych Chorob
- Department Name
- 6703: Ustav reumatickych chorob
- Contact Person Name
- Olga Lukacova
- Contact Person Email
- olga.lukacova@nurch.sk
- Site Name
- Univerzitna nemocnica L. Pasteura Kosice
- Department Name
- 6704: Klinika dermatovenerologie
- Contact Person Name
- Janette Baloghova
- Contact Person Email
- janettebaloghova@gmail.com
Spain
- Earliest CTIS Part Ii Submission Date
- 11-06-2024
- Latest Decision Or Authorization Date
- 18-12-2025
- Processing Time Days
- 556
- Number Of Sites
- 17
- Number Of Participants
- 54
Sites
- Site Name
- El Hospital Universitario De Gran Canaria Dr. Negrin
- Department Name
- #7013:Dermatología
- Contact Person Name
- Carolina Medina Gil
- Contact Person Email
- carolina.medina.gil@gmail.com
- Site Name
- Hospital Universitari Vall D Hebron
- Department Name
- #7001:Reumatologia
- Contact Person Name
- Josefina Cortés Hernández
- Contact Person Email
- fina.cortes@vhir.org
- Site Name
- Complexo Hospitalario Universitario De Vigo
- Department Name
- #7008:Reumatología
- Contact Person Name
- José Pego Reigosa
- Contact Person Email
- jose.maria.pego.reigosa@sergas.es
- Site Name
- Hospital Universitario Dr Peset Aleixandre
- Department Name
- #7005:Dermatology
- Contact Person Name
- Andrea Estébanez Corrales
- Contact Person Email
- Andreaestebanez_7@hotmail.com
- Site Name
- Hospital General Universitario De Valencia
- Department Name
- #7009:Reumatología
- Contact Person Name
- Cristina Campos Fernandez
- Contact Person Email
- campos_crifer@gva.es
- Site Name
- Hospital Universitario Virgen De Las Nieves
- Department Name
- #7010:Dermatologia
- Contact Person Name
- Manuel Sanchez Diaz
- Contact Person Email
- manuel.sanchez.diaz.sspa@juntadeandalucia.es
- Site Name
- Hospital Universitario Puerta De Hierro De Majadahonda
- Department Name
- #7014:Dermatología
- Contact Person Name
- Rita Cabeza Martinez
- Contact Person Email
- ritacabeza@gmail.com
- Site Name
- Hospital De La Santa Creu I Sant Pau
- Department Name
- #7007:Dermatologia
- Contact Person Name
- Esther Roé Crespo
- Contact Person Email
- eroe@santpau.cat
- Site Name
- Hospital Universitario Ramon Y Cajal
- Department Name
- #7011:Demartología
- Contact Person Name
- Maria Elena de las Heras Alonso
- Contact Person Email
- Elena.heras@salud.madrid.org
- Site Name
- Complexo Hospitalario Universitario A Coruna
- Department Name
- #7016:Reumatologia e Immunologia
- Contact Person Name
- Mercedes Freire González
- Contact Person Email
- Mercedes.Freire.Gonzalez@sergas.es
- Site Name
- Bellvitge University Hospital
- Department Name
- #7004:Dermatología
- Contact Person Name
- Ignasi Figueras Nart
- Contact Person Email
- ifigueras@bellvitgehospital.cat
- Site Name
- Hospital Universitario Fundacion Jimenez Diaz
- Department Name
- #7017:Dermatología
- Contact Person Name
- María del Rosario Haro Ramos
- Contact Person Email
- rharo@fjd.es
- Site Name
- Hospital Universitario Virgen De Valme
- Department Name
- #7012:Reumatología
- Contact Person Name
- Rosalía Martínez Pérez
- Contact Person Email
- rosalia.martinez.perez@gmail.com
- Site Name
- Hospital Universitario De Salamanca
- Department Name
- #7006:Dermatologia
- Contact Person Name
- Susana Gómez Castro
- Contact Person Email
- sgomezc@saluscastillayleon.es
- Site Name
- Hospital Universitario De La Princesa
- Department Name
- #7002:Dermatología
- Contact Person Name
- María Luisa Martos
- Contact Person Email
- Luisa.martos@gironsalud.es
- Site Name
- Hospital Universitario 12 De Octubre
- Department Name
- #7003:Dermatología
- Contact Person Name
- Jon Fulgencio Barbarin
- Contact Person Email
- jonfulgencio@hotmail.com
- Site Name
- Hospital General Universitario De Castellon
- Department Name
- #7015:Reumatología
- Contact Person Name
- Arantxa Conesa Mateos
- Contact Person Email
- arantxaconesa@hotmail.com
Sponsor
Primary sponsor
- Full Name
- AstraZeneca AB
- Organisation Type
- Pharmaceutical company
- Country Of Registered Address
- Sweden
Contract research organisations
- Name
- Parexel International (IRL) Limited
- Responsibilities
- Logistic expertise, Electronical Patient Reported Outcomes, Clinical Reported Outcomes, Skin Photography Equipment and Services, Recruitment services, eTMF management, Translation services
- Name
- Excelya Greece CRO Single Member S.A.
Third parties
- {"country":"Ireland","full_name":"Parexel International (IRL) Limited","duties_or_roles":"Logistic expertise, Electronical Patient Reported Outcomes, Clinical Reported Outcomes, Skin Photography Equipment and Services, Recruitment services, eTMF management, Translation services","organisation_type":"Pharmaceutical company"}
- {"country":"Greece","full_name":"Excelya Greece CRO Single Member S.A.","duties_or_roles":"","organisation_type":"Pharmaceutical company"}
Investigational products
- Investigational Product Name
- Anifrolumab
- Active Substance
- ANIFROLUMAB
- Modality
- Monoclonal antibody
- Routes Of Administration
- SUBCUTANEOUS INJECTION
- Route
- SUBCUTANEOUS INJECTION
- Authorisation Status
- prodAuthStatus: 1
- Frequency
- Once weekly
- Investigational Product Name
- Matching placebo solution for injection in aPFS; 0.8 mL fill volume
- Modality
- Other
- Frequency
- Once weekly (during double-blind period)
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