Clinical trial • Phase I • Neurology

ALN-APP for Early-onset Alzheimer's disease

Phase I trial of ALN-APP for Early-onset Alzheimer's disease. 57 participants.

Overview

Trial Therapeutic Area
Neurology
Trial Disease
Early-onset Alzheimer's disease
Trial Stage
Phase I
Drug Modality
Oligonucleotide

Key dates

Initial CTIS Submission Date
25-01-2024
First CTIS Authorization Date
05-02-2024

Trial design

Phase I trial across 1 site in Netherlands.

Target Sample Size
57

Eligibility

Recruits 57 Vulnerable population selected: patients with early-onset Alzheimer's disease (isVulnerablePopulationSelected = true); consent/assent handling not specified in source..

Vulnerable Population
Vulnerable population selected: patients with early-onset Alzheimer's disease (isVulnerablePopulationSelected = true); consent/assent handling not specified in source.

Recruitment

Planned Sample Size
57
Recruitment Window Months
78

Geography

Total Number Of Sites
1
Total Number Of Participants
57

Netherlands

Earliest CTIS Part Ii Submission Date
01-02-2024
Latest Decision Or Authorization Date
03-07-2025
Processing Time Days
519
Number Of Sites
1
Number Of Participants
6

Sites

Site Name
Brain Research Center Amsterdam B.V.
Department Name
Neurology
Principal Investigator Name
Jort Vijverberg
Principal Investigator Email
j.vijverberg@brainresearchcenter.nl
Contact Person Name
Jort Vijverberg

Sponsor

Primary sponsor

Full Name
Alnylam Pharmaceuticals Inc.
Organisation Type
Pharmaceutical company
Country Of Registered Address
United States

Investigational products

Investigational Product Name
ALN-APP
Modality
Oligonucleotide
First In Human
Yes

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