Clinical trial • Phase III • Psychiatry
9-(4-cyclohexyloxyphenyl)-7-methyl-3,4-dihydropyrazino[2,1-c][1,2,4]thiadiazine 2,2-dioxide for Major Depressive Disorder
Phase III trial of 9-(4-cyclohexyloxyphenyl)-7-methyl-3,4-dihydropyrazino[2,1-c][1,2,4]thiadiazine 2,2-dioxide for Major Depressive Disorder.
Overview
- Trial Therapeutic Area
- Psychiatry
- Trial Disease
- Major Depressive Disorder
- Trial Stage
- Phase III
- Drug Modality
- Small molecule
Key dates
- Initial CTIS Submission Date
- 12-03-2025
- First CTIS Authorization Date
- 01-07-2025
Trial design
open-label, none/not specified-controlled Phase III trial in Romania, Sweden, Slovakia and others.
- Open Label
- Yes
- Comparator
- None/Not specified
- Target Sample Size
- 286
- Trial Duration For Participant
- 364
Eligibility
Recruits 286 Vulnerable population selected (isVulnerablePopulationSelected = true). Specific details on consent or assent handling are not available in the provided structured data; multiple subject information and informed consent form documents (country-specific versions) are listed but their contents are not extractable from the provided files..
- Vulnerable Population
- Vulnerable population selected (isVulnerablePopulationSelected = true). Specific details on consent or assent handling are not available in the provided structured data; multiple subject information and informed consent form documents (country-specific versions) are listed but their contents are not extractable from the provided files.
Inclusion criteria
- {"criterion_text":"- Subject has a primary diagnosis of recurrent MDD (moderate or severe) or persistent depressive disorder.\n- Subject has had an inadequate response to oral antidepressant treatments in the current episode of depression.\n- Subject must have been taking oral antidepressants for at least 8 weeks and is willing to continue the same oral antidepressants at the same dose and frequency of administration throughout participation in the study.\n- Total MADRS score ≥18 at screening.\n- Willing and able to comply with all study procedures and restrictions in the opinion of the investigator."}
Exclusion criteria
- {"criterion_text":"- A current or prior psychiatric disorder diagnosis in the last 1 year that was the primary focus of treatment other than MDD.\n- Are considered by the investigator to be at imminent risk of suicide or injury to self or others."}
Endpoints
Primary endpoints
- {"endpoint_text":"- The occurrence of adverse events (AEs) up to Week 52.","definition_or_measurement_approach":"Occurrence of adverse events (AEs) collected/reported up to Week 52 (no further detailed measurement approach available in the structured data)."}
Recruitment
- Digital Remote Recruitment
- Yes
- Planned Sample Size
- 286
- Recruitment Window Months
- 58
- Consent Approach
- Informed consent is used; multiple subject information sheets and informed consent form (ICF) documents are listed (country- and language-specific ICFs, pregnancy follow-up ICFs, pregnant partner ICFs, and other participant-facing materials). Documents indicate ICFs available in multiple languages and country versions, but specific age-related assent procedures are not detailed in the structured data (study population described as adults).
Methods
- K1/K2 Recruitment arrangements and patient brochures (country-specific recruitment brochures) - documents present for multiple Member States indicating use of brochures and recruitment materials.
- Social media recruitment tools (Link2Trial) - referenced in recruitment materials (e.g., 'Link2Trial social media recruitment tools MDD' for Netherlands).
- Site presentations and website materials (e.g., BRC presentation/website for site outreach mentioned for Netherlands).
- Digital participant engagement via Mural Link Participant App (participant training, notifications, participant reference guides) referenced in multiple country recruitment documents.
Geography
- Total Number Of Sites
- 91
- Total Number Of Participants
- 271
Romania
- Earliest CTIS Part Ii Submission Date
- 04-06-2025
- Latest Decision Or Authorization Date
- 07-07-2025
- Processing Time Days
- 33
- Number Of Sites
- 5
- Number Of Participants
- 16
Sites
- Site Name
- Spitalul Clinic De Psihiatrie Si Neurologie Brasov
- Department Name
- Psihiatrie Clinica III
- Contact Person Name
- Petru Ifteni
- Contact Person Email
- petru_ifteni@yahoo.com
- Site Name
- Centru De Evaluare Si Tratament A Toxicodependentelor Pentru Tineri Sf. Stelian
- Department Name
- Psihiatrie
- Contact Person Name
- Traian Barbu
- Contact Person Email
- trabar98@yahoo.com
- Site Name
- Spitalul Clinic Judetean De Urgenta Bihor
- Department Name
- Psihiatrie II
- Contact Person Name
- Alin Petris
- Contact Person Email
- spitalul.judetean@rdsor.ro
- Site Name
- Institutul Privat de Cercetari Melchisedec, pentru Boli Autoimune, Ereditare si Rare - IPCM
- Department Name
- Psihiatrie
- Contact Person Name
- Victor Gheorman
- Contact Person Email
- gheormanv@gmail.com
- Site Name
- Spitalul Clinic De Psihiatrie Prof.Dr.Alexandru Obregia
- Department Name
- Psihiatrie Clinica III
- Contact Person Name
- Mihnea Manea
- Contact Person Email
- mihnea.manea@live.com
Sweden
- Earliest CTIS Part Ii Submission Date
- 28-05-2025
- Latest Decision Or Authorization Date
- 01-07-2025
- Processing Time Days
- 34
- Number Of Sites
- 4
- Number Of Participants
- 29
Sites
- Site Name
- ProbarE i Stockholm AB
- Department Name
- ProbarE i Stockholm AB
- Contact Person Name
- Peter Bosson
- Contact Person Email
- ewa.karlsson@probare.se
- Site Name
- Sahlgrenska University Hospital-Vaestra Goetalandsregionen
- Department Name
- SU/Affektiva FoU-avdelningen
- Contact Person Name
- Michael Ionnou
- Contact Person Email
- michael.ioannou@vgregion.se
- Site Name
- ProbarE i Lund AB
- Department Name
- ProbarE i Lund AB
- Contact Person Name
- Anders Luts
- Contact Person Email
- ewa.karlsson@probare.se
- Site Name
- Region Skane Helsingborg Hospital
- Department Name
- Institutionen för kliniska vetenskaper
- Contact Person Name
- Jonas Eberhard
- Contact Person Email
- jonas.eberhard@med.lu.se
Slovakia
- Earliest CTIS Part Ii Submission Date
- 21-05-2025
- Latest Decision Or Authorization Date
- 01-07-2025
- Processing Time Days
- 41
- Number Of Sites
- 8
- Number Of Participants
- 18
Sites
- Site Name
- Crystal Comfort s.r.o.
- Department Name
- Psychiatricka ambulancia
- Contact Person Name
- Dagmar Breznoscakova
- Contact Person Email
- dbreznoscakova@gmail.com
- Site Name
- PsychoLine s.r.o.
- Department Name
- Psychiatricka ambulancia
- Contact Person Name
- Abdul Mohammad Shinwari
- Contact Person Email
- psycholinesro@gmail.com
- Site Name
- Univerzitna nemocnica L. Pasteura Kosice
- Department Name
- II. Psychiatricka klinika
- Contact Person Name
- Slavka Dubinska
- Contact Person Email
- slavka.dubinska@unlp.sk
- Site Name
- Epamed s.r.o.
- Department Name
- Psychiatricka ambulancia
- Contact Person Name
- Eva Palova
- Contact Person Email
- epamed.ke@gmail.com
- Site Name
- Mentum s.r.o.
- Department Name
- Psychiatricka ambulancia, Site address: Ruzinovska 10, 820 07 Bratislava, Slovak Republic
- Contact Person Name
- Peter Molcan
- Contact Person Email
- molcan@mentum.sk
- Site Name
- Dana Ignjatovičová, spol. s.r.o.,
- Department Name
- Psychiatricka ambulancia, Site address:Cesta k nemocnici 1231/23, 974 01 Banska Bystrica, Slovakia
- Contact Person Name
- Dana Ignjatovicova
- Contact Person Email
- dana.ignjatovicova@gmail.com
- Site Name
- Centrum Zdravia R.B.K. s.r.o.
- Department Name
- Psychiatricka ambulancia, Site address: MUDr. Pribulu 463/15, 089 01 Svidnik, Slovak Republic
- Contact Person Name
- Rastislav Korba
- Contact Person Email
- rastislav.korba@gmail.com
- Site Name
- Nemocnica S Poliklinikou Prievidza So Sidlom V Bojniciach
- Department Name
- Psychiatricke oddelenie
- Contact Person Name
- Martin Garaj
- Contact Person Email
- martin.garaj@hospitalbojnice.sk
Finland
- Earliest CTIS Part Ii Submission Date
- 03-06-2025
- Latest Decision Or Authorization Date
- 02-07-2025
- Processing Time Days
- 29
- Number Of Sites
- 3
- Number Of Participants
- 10
Sites
- Site Name
- Savon Psykiatripalvelu Oy
- Department Name
- Savon Psykiatripalvelu Oy
- Contact Person Name
- Antti Lepola
- Contact Person Email
- antti.lepola@psykiatripalvelu.fi
- Site Name
- Oulu Mentalcare Oy
- Department Name
- Oulu Mentalcare Oy
- Contact Person Name
- Markku Timonen
- Contact Person Email
- markku.timonen@mentalcare.fi
- Site Name
- Mehilaeinen Oy
- Department Name
- Satakunnan Psykiatripalvelu
- Contact Person Name
- Marko Sorvaniemi
- Contact Person Email
- marko.sorvaniemi@fimnet.fi
Croatia
- Earliest CTIS Part Ii Submission Date
- 26-06-2025
- Latest Decision Or Authorization Date
- 07-07-2025
- Processing Time Days
- 11
- Number Of Sites
- 8
- Number Of Participants
- 18
Sites
- Site Name
- Poliklinika Neuron
- Department Name
- Polyclinic Neuron
- Contact Person Name
- Neven Henisberg
- Contact Person Email
- neven.henigsberg@zg.ht.hr
- Site Name
- Clinic for psychiatry Sveti Ivan
- Department Name
- Clinic for Psychiatry
- Contact Person Name
- Igor Filipcic
- Contact Person Email
- igor.filipcic@pbsvi.hr
- Site Name
- Klinika za psihijatriju Vrapce
- Department Name
- Psychiatry
- Contact Person Name
- Miroslav Herceg
- Contact Person Email
- miroslav.herceg@bolnica-vrapce.hr
- Site Name
- KBC Zagreb
- Department Name
- Psychiatry and Psychological medicine
- Contact Person Name
- Alma Mihaljevic-Peles
- Contact Person Email
- almamihaljevic12@gmail.com
- Site Name
- Klinika za psihijatriju Vrapce
- Department Name
- Biological Psychiatry and Psychogeriatrics
- Contact Person Name
- Ninoslav Mimica
- Contact Person Email
- ninoslav.mimica@bolnica-vrapce.hr
- Site Name
- Poliklinika Solmed d.o.o.
- Department Name
- Poliklinika Solmed
- Contact Person Name
- Vjekoslav Peitl
- Contact Person Email
- vjekoslav.peitl@gmail.com
- Site Name
- KBC Zagreb
- Department Name
- Psychiatry
- Contact Person Name
- Marina Sagud
- Contact Person Email
- msagud@kbc-zagreb.hr
- Site Name
- Klinika za psihijatriju Vrapce
- Department Name
- Affective Disorders
- Contact Person Name
- Porin Makaric
- Contact Person Email
- porin.makaric@bolnica-vrapce.hr
Poland
- Earliest CTIS Part Ii Submission Date
- 26-06-2025
- Latest Decision Or Authorization Date
- 07-07-2025
- Processing Time Days
- 11
- Number Of Sites
- 16
- Number Of Participants
- 32
Sites
- Site Name
- Prywatne Gabinety Lekarskie „Promedicus” Anna Agnieszka Tomczak
- Contact Person Name
- Anna Agnieszka Tomczak
- Contact Person Email
- promedicus@onet.eu
- Site Name
- MłynowaMed Specjalistyczny Psychiatryczny Gabinet Lekarski Joanna Łazarczyk
- Contact Person Name
- Joanna Łazarczyk
- Contact Person Email
- joannalaz@wp.pl
- Site Name
- Centrum Medyczne Luxmed Sp. z o.o.
- Contact Person Name
- Dariusz Malicki
- Contact Person Email
- dariuszmalicki@interia.eu
- Site Name
- Wojewódzki Szpital Zdrowia Psychicznego im. Dr Józefa Bednarza w Świeciu
- Department Name
- Oddział Leczenia Zespołów Abstynencyjnych po Substancjach Psychoaktywnych XIV (Detoksykacji)
- Contact Person Name
- Ewa Gromniak-Haniecka
- Contact Person Email
- ewa.gromniak-haniecka@wp.pl
- Site Name
- Gyncentrum Sp. z o.o.
- Department Name
- NZOZ GynCentrum - Oddział Warszawa
- Contact Person Name
- Marek Jarema
- Contact Person Email
- m.jarema@holsaclinical.com
- Site Name
- Osrodek Badan Klinicznych Clinsante s.c. Ewa Galczak-Nowak, Malgorzata Trzaska
- Department Name
- Ośrodek Badań Klinicznych Clinsante
- Contact Person Name
- Gerard Kowalkowski
- Contact Person Email
- gkowalkowski@wp.pl
- Site Name
- Podlaskie Centrum Psychogeriatrii
- Contact Person Name
- Jacek Dobryniewski
- Contact Person Email
- jacekdobryniewski@gmail.com
- Site Name
- Niepubliczny Zaklad Opieki Zdrowotnej Euromedica Sp. z o.o.
- Department Name
- Niepubliczny Zakład Opieki Zdrowotnej Euromedica
- Contact Person Name
- Barbara Janczewska
- Contact Person Email
- b.janczewskaa@gmail.com
- Site Name
- Gabinet Lekarski Psychiatryczny Ireneusz Kaczorowski
- Contact Person Name
- Ireneusz Kaczorowski
- Contact Person Email
- irek.k@tlen.pl
- Site Name
- Osrodek Badan Klinicznych Clinsante s.c. Ewa Galczak-Nowak Malgorzata Trzaska
- Department Name
- Ośrodek Badań Klinicznych Clinsante
- Contact Person Name
- Agnieszka Bijakowska
- Contact Person Email
- bijak2@wp.pl
- Site Name
- Niepubliczny Zaklad Opieki Psychiatrycznej MENTIS
- Contact Person Name
- Mariusz Perucki
- Contact Person Email
- mariperu@wp.pl
- Site Name
- Care Clinic Sp. z o.o.
- Department Name
- Care Clinic Centrum Medyczne
- Contact Person Name
- Maciej Żerdziński
- Contact Person Email
- avalone@wp.pl
- Site Name
- Centrum Zdrowia Alcea
- Contact Person Name
- Jakub Grabowski
- Contact Person Email
- jakub.grabowski@gumed.edu.pl
- Site Name
- Clinic BBP Bożena Pawełczyk
- Contact Person Name
- Bożena Pawełczyk
- Contact Person Email
- bozena.pawelczyk@clinicbbp.com
- Site Name
- Centrum Badan Klinicznych Pi-House Sp. z o.o.
- Contact Person Name
- Katarzyna Binkowska-Michalik
- Contact Person Email
- k.binkmich@pihouse.pl
- Site Name
- INDYWIDUALNA PRAKTYKA LEKARSKA KINGA BOBINSKA
- Contact Person Name
- Kinga Bobińska
- Contact Person Email
- bobinska.gabinet@gmail.com
Bulgaria
- Earliest CTIS Part Ii Submission Date
- 25-03-2025
- Latest Decision Or Authorization Date
- 04-07-2025
- Processing Time Days
- 101
- Number Of Sites
- 10
- Number Of Participants
- 42
Sites
- Site Name
- Medical Center Saint Naum EOOD
- Contact Person Name
- Assen Karadaliev
- Contact Person Email
- karadaliev@hotmail.com
- Site Name
- Medical Center Intermedica Ltd.
- Contact Person Name
- Toni Donchev
- Contact Person Email
- tonyd@abv.bg
- Site Name
- Medical Center Hera EOOD
- Contact Person Name
- Sibila Dimitrova-Mitova
- Contact Person Email
- sibila.dimitrova@heraclinics.com
- Site Name
- Medical Center Lifemed EOOD
- Contact Person Name
- Rozaliya Rangelova
- Contact Person Email
- rrangelova80@gmail.com
- Site Name
- Medical Center Mentalcare Ltd.
- Contact Person Name
- Vasil Kotetarov
- Contact Person Email
- vasilkotetarov@abv.bg
- Site Name
- Medical Center Hera EOOD
- Contact Person Name
- Spiridon Spiridonov
- Contact Person Email
- spiridon.aleksiev@gmail.com
- Site Name
- Diagnostics-Consultancy Center Mladost M Varna OOD
- Contact Person Name
- Petar Petrov
- Contact Person Email
- pmdown@abv.bg
- Site Name
- Diagnostic And Consultation Centre St.Vrach And St.St. Kuzma And Damian OOD
- Contact Person Name
- Petya Dimitrova
- Contact Person Email
- drdimitrova@abv.bg
- Site Name
- Center For Mental Health Ruse EOOD
- Department Name
- Men Dep for treatm of persons with acute psychotic disorders, Women Dep for treatm of persons with
- Contact Person Name
- Desislava Peycheva
- Contact Person Email
- dpeycheva1@gmail.com
- Site Name
- Diagnostics-Consultancy Center Mladost M Varna OOD
- Contact Person Name
- Hristo Kozhuharov
- Contact Person Email
- christokojuharov@abv.bg
Latvia
- Earliest CTIS Part Ii Submission Date
- 27-06-2025
- Latest Decision Or Authorization Date
- 01-07-2025
- Processing Time Days
- 4
- Number Of Sites
- 3
- Number Of Participants
- 7
Sites
- Site Name
- L. Keruze practice in Psychiatry
- Contact Person Name
- Linda Keruze
- Contact Person Email
- lkeruze@inbox.lv
- Site Name
- Slimnica Gintermuiza VSIA
- Contact Person Name
- Ineta Rozina
- Contact Person Email
- ineta29@inbox.lv
- Site Name
- Siguldas Slimnica
- Contact Person Name
- Ilona Paegle
- Contact Person Email
- ilona.paegle@inbox.lv
Lithuania
- Earliest CTIS Part Ii Submission Date
- 05-06-2025
- Latest Decision Or Authorization Date
- 02-07-2025
- Processing Time Days
- 27
- Number Of Sites
- 5
- Number Of Participants
- 18
Sites
- Site Name
- Vilnius City Mental Health Center
- Department Name
- psichiatrijos
- Contact Person Name
- Jolita Valantiejienė
- Contact Person Email
- jolivalant@gmail.com
- Site Name
- Romuvos klinika UAB
- Department Name
- psichiatrijos
- Contact Person Name
- Daiva Deltuvienė
- Contact Person Email
- daiva.deltuviene@gmail.com
- Site Name
- Respublikine Klaipedos ligonine VšĮ
- Department Name
- psichiatrijos
- Contact Person Name
- Loreta Šiaudvytytė
- Contact Person Email
- loretasiaud@gmail.com
- Site Name
- Saules seimos medicinos centras UAB
- Department Name
- psichiatrijos
- Contact Person Name
- Simona Kušleikienė
- Contact Person Email
- s.kusleikiene@ssmc.lt
- Site Name
- Lietuvos sveikatos mokslu universiteto Kauno ligonine
- Department Name
- psichiatrijos
- Contact Person Name
- Dalia Vijūnė
- Contact Person Email
- gudeikiene@yahoo.com
Belgium
- Earliest CTIS Part Ii Submission Date
- 23-06-2025
- Latest Decision Or Authorization Date
- 01-07-2025
- Processing Time Days
- 8
- Number Of Sites
- 3
- Number Of Participants
- 10
Sites
- Site Name
- Az Sint-Lucas
- Department Name
- Psychiatry
- Contact Person Name
- Thomas Santy
- Contact Person Email
- thomas.santy@stlucas.be
- Site Name
- Anima
- Department Name
- Psychiatry
- Contact Person Name
- Erik Buntinx
- Contact Person Email
- erik.buntinx@anima-alken.be
- Site Name
- Meclinas
- Department Name
- Psychiatry
- Contact Person Name
- Claudia Cornelist
- Contact Person Email
- claudia.cornelis@meclinas.com
Czechia
- Earliest CTIS Part Ii Submission Date
- 26-06-2025
- Latest Decision Or Authorization Date
- 02-07-2025
- Processing Time Days
- 6
- Number Of Sites
- 8
- Number Of Participants
- 21
Sites
- Site Name
- Medical Services Prague s.r.o.
- Department Name
- Psychiatry
- Contact Person Name
- Erik Herman
- Contact Person Email
- erik.herman@seznam.cz
- Site Name
- INEP medical s.r.o.
- Department Name
- Psychiatry
- Contact Person Name
- Alexander Nawka
- Contact Person Email
- nawka@inep.cz
- Site Name
- Psychiatricka ambulance MUDr Marta Ondrusova
- Department Name
- Psychiatry
- Contact Person Name
- Marta Ondrušová
- Contact Person Email
- MOndrusova@seznam.cz
- Site Name
- Clintrial s.r.o.
- Department Name
- Psychiatry
- Contact Person Name
- Zdeněk Šolle
- Contact Person Email
- zdenek.solle@clintrial.cz
- Site Name
- Neuropsychiatrie Petrska s.r.o.
- Department Name
- Psychiatry
- Contact Person Name
- Aleš Urban
- Contact Person Email
- ordinace@psychiatrie-urban.cz
- Site Name
- Praglandia s.r.o.
- Department Name
- Psychiatry
- Contact Person Name
- Radka Šafandová
- Contact Person Email
- r.safand@praglandia.cz
- Site Name
- A-Shine s.r.o.
- Department Name
- Psychiatry
- Contact Person Name
- Luboš Janů
- Contact Person Email
- lubos.janu@seznam.cz
- Site Name
- Narodni Ustav Dusevniho Zdravi
- Department Name
- Psychiatry
- Contact Person Name
- Barbora Kohútová
- Contact Person Email
- barbora.kohutova@nudz.cz
Estonia
- Earliest CTIS Part Ii Submission Date
- 29-01-2026
- Latest Decision Or Authorization Date
- 13-02-2026
- Processing Time Days
- 15
- Number Of Sites
- 3
- Number Of Participants
- 5
Sites
- Site Name
- Tartu University Hospital
- Department Name
- Psychiatry
- Contact Person Name
- Roman Pihlakas
- Contact Person Email
- roman.pihlakas@kliinikum.ee
- Site Name
- Marienthali Kliinik OÜ
- Contact Person Name
- Anu Arold
- Contact Person Email
- anu.arold@mppk.ee
- Site Name
- Arstikeskus Confido AS
- Contact Person Name
- Mari-Liis Laanetu
- Contact Person Email
- info@confido.ee
Italy
- Earliest CTIS Part Ii Submission Date
- 12-12-2025
- Latest Decision Or Authorization Date
- 21-01-2026
- Processing Time Days
- 40
- Number Of Sites
- 3
- Number Of Participants
- 5
Sites
- Site Name
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
- Department Name
- Psychiatry Department
- Contact Person Name
- Gabriele Sani
- Contact Person Email
- gabriele.sani@unicatt.it
- Site Name
- Ospedale San Raffaele S.r.l.
- Department Name
- Mood Disorder Unit
- Contact Person Name
- Raffaella Zanardi
- Contact Person Email
- zanardi.raffaella@hsr.it
- Site Name
- Azienda Ospedaliera Universitaria Citta Della Salute E Della Scienza Di Torino
- Department Name
- Department of Neuroscience and Mental Health
- Contact Person Name
- Paola Rocca
- Contact Person Email
- paola.rocca@unito.it
Spain
- Earliest CTIS Part Ii Submission Date
- 23-03-2026
- Latest Decision Or Authorization Date
- 27-03-2026
- Processing Time Days
- 4
- Number Of Sites
- 3
- Number Of Participants
- 5
Sites
- Site Name
- Hestia Palau S.L.
- Department Name
- Psychiatry
- Contact Person Name
- Elena Ros
- Contact Person Email
- e.ros@bcnneuroscience.com
- Site Name
- Hospital Universitario Fundacion Alcorcon
- Department Name
- Psychiatry
- Contact Person Name
- Francisco Montañes
- Contact Person Email
- francisco.montanes@salud.madrid.org
- Site Name
- Hospital Universitari Vall D Hebron
- Department Name
- Psychiatry
- Contact Person Name
- Julia Vendrell
- Contact Person Email
- julia.vendrell@vallhebron.cat
Netherlands
- Earliest CTIS Part Ii Submission Date
- 19-06-2025
- Latest Decision Or Authorization Date
- 01-07-2025
- Processing Time Days
- 12
- Number Of Sites
- 4
- Number Of Participants
- 22
Sites
- Site Name
- Universitair Medisch Centrum Groningen
- Department Name
- Psychiatry
- Contact Person Name
- Robert Schoevers
- Contact Person Email
- r.a.schoevers@umcg.nl
- Site Name
- Brain Research Center Den Bosch B.V.
- Department Name
- Psychiatry
- Contact Person Name
- Roel Mocking
- Contact Person Email
- r.j.mocking@amsterdamumc.nl
- Site Name
- Leids Universitair Medisch Centrum (LUMC)
- Department Name
- Psychiatry
- Contact Person Name
- Nic van der Wee
- Contact Person Email
- n.j.a.van_der_wee@lumc.nl
- Site Name
- Brain Research Center Amsterdam B.V.
- Department Name
- Psychiatry
- Contact Person Name
- Roel Mocking
- Contact Person Email
- r.j.mocking@amsterdamumc.nl
Hungary
- Earliest CTIS Part Ii Submission Date
- 16-05-2025
- Latest Decision Or Authorization Date
- 07-07-2025
- Processing Time Days
- 52
- Number Of Sites
- 5
- Number Of Participants
- 13
Sites
- Site Name
- Obudai Egeszseguegyi Centrum Kft.
- Department Name
- -
- Contact Person Name
- Gyöngyi Szabó
- Contact Person Email
- gyongyi.szabo@oec.hu
- Site Name
- Dr. Mathe Es Tarsa Bt.
- Department Name
- -
- Contact Person Name
- Éva Máthé
- Contact Person Email
- matheevazs@gmail.com
- Site Name
- Nyiro Gyula Orszagos Pszichiatriai Es Addiktologiai Intezet
- Department Name
- "C" Pszichiátriai Osztály
- Contact Person Name
- Csaba Almási
- Contact Person Email
- imrecsabaalmasi@gmail.com
- Site Name
- Semmelweis University
- Department Name
- Pszichiatriai es Pszichoterapias Klinika
- Contact Person Name
- Csilla Katalin Bolyos
- Contact Person Email
- bolyos.csilla@semmelweis.hu
- Site Name
- Gyoengyosi Bugat Pal Koerhaz
- Department Name
- Rehabilitációs Elmegyógyászati Osztály
- Contact Person Name
- Tibor Kelemen
- Contact Person Email
- tibor.kelemen.clinexpert@gmail.com
Sponsor
Primary sponsor
- Full Name
- Neurocrine Biosciences Inc.
- Organisation Type
- Pharmaceutical company
- Country Of Registered Address
- United States
Contract research organisations
- Name
- Signant Health Global LLC
- Responsibilities
- eCOA/eConsent and patient-facing electronic data capture tools (sponsor duty code 3 shown)
- Name
- Medidata Solutions Inc.
- Responsibilities
- eClinical platform services (sponsor duty code 7 shown)
- Name
- IQVIA Limited
- Responsibilities
- Operational CRO services including cardiac services & supplying ECG machines and other listed duties (codes 1,12,15,2,5)
- Name
- Cytel Inc.
- Responsibilities
- Statistical/adjudication support (Adjudication Committee listed)
- Name
- Q Squared Solutions Limited
- Responsibilities
- Clinical operations support (sponsor duty code 4 shown)
Third parties
- {"country":"United States","full_name":"Signant Health Global LLC","duties_or_roles":"Code 3 (listed as sponsor duty) - electronic data capture / patient-facing eCOA vendor (Signant) (responsibility code provided in structured data)","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Medidata Solutions Inc.","duties_or_roles":"Code 7 (listed as sponsor duty) - eClinical platform responsibilities (Medidata) (responsibility code provided in structured data)","organisation_type":"Non-Pharmaceutical company"}
- {"country":"United States","full_name":"Epilepsy Study Consortium Inc.","duties_or_roles":"Adjudication Committee (listed value for sponsor duty)","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Eresearchtechnology Inc.","duties_or_roles":"Code 7 (listed as sponsor duty)","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Massachusetts General Hospital","duties_or_roles":"Treatment history determination","organisation_type":"Hospital/Clinic/Other health care facility"}
- {"country":"United States","full_name":"Cytel Inc.","duties_or_roles":"Adjudication Committee (listed value)","organisation_type":"Non-Pharmaceutical company"}
- {"country":"United Kingdom","full_name":"Q Squared Solutions Limited","duties_or_roles":"Code 4 (listed as sponsor duty)","organisation_type":"Non-Pharmaceutical company"}
- {"country":"United Kingdom","full_name":"IQVIA Limited","duties_or_roles":"Multiple sponsor duties including code 1, 12, 15 (Cardiac Services & supplying ECG machines), code 2, code 5 (various operational and clinical services)","organisation_type":"Pharmaceutical company"}
- {"country":"United States","full_name":"Marken LLP","duties_or_roles":"Direct to Patient IP delivery","organisation_type":"Pharmaceutical company"}
Investigational products
- Investigational Product Name
- NBI-1065845
- Active Substance
- 9-(4-cyclohexyloxyphenyl)-7-methyl-3,4-dihydropyrazino[2,1-c][1,2,4]thiadiazine 2,2-dioxide
- Modality
- Small molecule
- Routes Of Administration
- ORAL
- Route
- ORAL
- Authorisation Status
- Not authorised in the population involved (investigational for this trial)
- Combination Treatment
- Yes
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