Clinical Trial Intelligence

Which European Sites Lead Phase III Cell Therapy Trial Activity in CTIS?

June 7, 2026

Across 57 Phase III cell therapy records, European activity is concentrated in a small set of high-repeat hospital networks. Hospital Universitari Vall d’Hebron is the leading named site with 13 site participations, followed by Centre Hospitalier Universitaire de Lille with 12. Oncology dominates the high-volume site pattern, especially multiple myeloma and B-cell malignancy programs.

57
Phase III cell therapy records
13
Top site participations: Vall d’Hebron
12
CHU Lille site participations
Myeloma
Largest oncology disease cluster

Top 10 European Sites by Phase III Cell Therapy Participation

The top 10 named sites account for 81 site participations. Spain, France, Germany, and Italy dominate this leadership tier, reflecting the concentration of advanced cell therapy infrastructure in large oncology and haematology centers.

Top 10 named site participations
Hospital Universitari Vall d’Hebron
13
CHU Lille
12
Ospedale / San Raffaele
9
Charité Universitätsmedizin Berlin
8
Universitätsklinikum Würzburg
8
Institut Català d’Oncologia
7
University Medical Center Hamburg-Eppendorf
6
Hospital Universitario 12 de Octubre
6
Clinica Universidad de Navarra
6
CHU Nantes
6
Site participation = one named site appearing in one CTIS trial-country record
Interpretation

The leading sites are not isolated high-enrolling centers; they are repeat participants across multiple disease areas, especially haematology-oncology cell therapy programs.

Which Countries Carry the Largest Operational Load?

Country-level participation is led by the large EU5 oncology networks. The strongest recurring country signals are Spain, Germany, France, Italy, and the Netherlands, which together anchor most of the high-repeat site list and the largest planned-patient allocations.

Country-level intensity
Country
Site signal
Patient signal
Spain
Very high
High
Germany
Very high
High
France
Very high
Medium-high
Italy
High
Medium-high
Netherlands
Medium
High
Country signal combines repeated named-site activity and planned participant allocation
Interpretation

Spain, Germany, and France provide the broadest site footprint, while the Netherlands shows a stronger patient-allocation signal in selected later records, including pancreatic cancer and myeloma programs.

Which Oncology Diseases Drive Site Activity?

Among oncology records, multiple myeloma is the dominant disease group, followed by B-cell lymphoma / B-cell leukemia programs. Solid tumor cell therapy appears, but with fewer repeat sites and more concentrated country allocation.

Oncology disease group concentration
Multiple myeloma
Highest
B-cell lymphoma / leukemia
High
Melanoma
Mid
Solid tumors / epithelial tumors
Mid
Glioblastoma
Low
Disease grouping based on trial disease labels in oncology cell therapy records
Interpretation

The Phase III cell therapy landscape remains haematology-heavy. Multiple myeloma and B-cell malignancies drive most repeat participation, while solid tumor programs are more selective and site-concentrated.

How Does Activity Shift Across 2024–2026?

The cohort includes 34 records in 2024, 16 in 2025, and 7 in 2026. 2024 therefore represents 34/57 records, or 59.6% of the analyzed Phase III cell therapy cohort.

Records by authorization year